4ege - Revision history

OCA at 15:01, 14 March 2024

OCA — Thu, 14 Mar 2024 15:01:02 GMT

←Older revision		Revision as of 15:01, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ege]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_ulcerans_Agy99 Mycobacterium ulcerans Agy99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EGE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ege]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_ulcerans_Agy99 Mycobacterium ulcerans Agy99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EGE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [https://pdbe.org/4ege PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [https://www.ebi.ac.uk/pdbsum/4ege PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ege ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [https://pdbe.org/4ege PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [https://www.ebi.ac.uk/pdbsum/4ege PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ege ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/A0PQS3_MYCUA A0PQS3_MYCUA]]	+	[https://www.uniprot.org/uniprot/A0PQS3_MYCUA A0PQS3_MYCUA]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.	+
-		+
-	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4ege" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mycobacterium ulcerans Agy99]]		[[Category: Mycobacterium ulcerans Agy99]]

OCA at 07:10, 28 September 2022

OCA — Wed, 28 Sep 2022 07:10:15 GMT

←Older revision		Revision as of 07:10, 28 September 2022
Line 1:		Line 1:

	==Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans==		==Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans==
-	<StructureSection load='4ege' size='340' side='right' caption='[[4ege]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4ege' size='340' side='right'caption='[[4ege]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ege]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mycua Mycua~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EGE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ege]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_ulcerans_Agy99 Mycobacterium ulcerans Agy99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EGE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepE, MUL_2321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=362242 MYCUA])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [https://pdbe.org/4ege PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [https://www.ebi.ac.uk/pdbsum/4ege PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ege ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [~~http~~://pdbe.org/4ege PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ege PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ege ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/A0PQS3_MYCUA A0PQS3_MYCUA]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycua~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Structural genomic]]~~	+	[[Category: Mycobacterium ulcerans Agy99]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Ssgcid~~]]	+

OCA at 18:49, 1 February 2017

OCA — Wed, 01 Feb 2017 18:49:48 GMT

←Older revision		Revision as of 18:49, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans==		==Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans==
	<StructureSection load='4ege' size='340' side='right' caption='[[4ege]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4ege' size='340' side='right' caption='[[4ege]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepE, MUL_2321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=362242 MYCUA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepE, MUL_2321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=362242 MYCUA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [http://www.ebi.ac.uk/pdbsum/4ege PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [http://pdbe.org/4ege PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [http://www.ebi.ac.uk/pdbsum/4ege PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ege ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ege" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:15, 22 April 2015

OCA — Wed, 22 Apr 2015 07:15:03 GMT

←Older revision		Revision as of 07:15, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='4ege' size='340' side='right' caption='[[4ege]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4ege' size='340' side='right' caption='[[4ege]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ege]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_ulcerans Mycobacterium ulcerans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ege]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycua Mycua]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepE, MUL_2321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1809 Mycobacterium ulcerans~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepE, MUL_2321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=362242 MYCUA])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [http://www.ebi.ac.uk/pdbsum/4ege PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [http://www.ebi.ac.uk/pdbsum/4ege PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.
		+
		+	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium ulcerans~~]]	+	[[Category: Mycua]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]

OCA at 13:22, 4 January 2015

OCA — Sun, 04 Jan 2015 13:22:44 GMT

←Older revision		Revision as of 13:22, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ege]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_ulcerans Mycobacterium ulcerans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ege]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_ulcerans Mycobacterium ulcerans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepE, MUL_2321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1809 Mycobacterium ulcerans])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepE, MUL_2321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1809 Mycobacterium ulcerans])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [http://www.ebi.ac.uk/pdbsum/4ege PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [http://www.ebi.ac.uk/pdbsum/4ege PDBsum]</span></td></tr>
-	<table>	+	</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium ulcerans]]		[[Category: Mycobacterium ulcerans]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]

OCA at 08:30, 5 June 2014

OCA — Thu, 05 Jun 2014 08:30:13 GMT

←Older revision		Revision as of 08:30, 5 June 2014
Line 1:		Line 1:
-	~~[[Image:4ege.jpg\|left\|200px]]~~	+	==Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans==
-		+	<StructureSection load='4ege' size='340' side='right' caption='[[4ege]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~<!--~~	+	== Structural highlights ==
-	~~The line below this paragraph, containing "STRUCTURE_4ege", creates the "Structure Box" on the page.~~	+	<table><tr><td colspan='2'>[[4ege]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_ulcerans Mycobacterium ulcerans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGE FirstGlance]. <br>
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepE, MUL_2321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1809 Mycobacterium ulcerans])</td></tr>
-	~~or leave the SCENE parameter empty for the default display.~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ege FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ege OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ege RCSB], [http://www.ebi.ac.uk/pdbsum/4ege PDBsum]</span></td></tr>
-	~~-->~~	+	<table>
-	~~{{STRUCTURE_4ege\| PDB=4ege \| SCENE= }}~~	+	__TOC__
-		+	</StructureSection>
-	===Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans===	+
-		+
-		+
-	==~~About this Structure~~==	+
-	[[4ege]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_ulcerans Mycobacterium ulcerans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA].	+
	[[Category: Mycobacterium ulcerans]]		[[Category: Mycobacterium ulcerans]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA at 09:29, 25 April 2012

OCA — Wed, 25 Apr 2012 09:29:17 GMT

←Older revision		Revision as of 09:29, 25 April 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ege.jpg\|left\|200px]]

-	The ~~entry 4ege~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4ege", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4ege\| PDB=4ege \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans===

-	~~Description: Crystal~~ Structure ~~of Dipeptidase PepE~~ from Mycobacterium ulcerans	+
		+	==About this Structure==
		+	[[4ege]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_ulcerans Mycobacterium ulcerans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGE OCA].
		+	[[Category: Mycobacterium ulcerans]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]

OCA: Protected "4ege" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2012 06:42:18 GMT

Protected "4ege" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:42, 11 April 2012

OCA: New page: '''Unreleased structure''' The entry 4ege is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal Structure of Dipeptidase PepE from...

OCA — Wed, 11 Apr 2012 06:42:18 GMT

New page: '''Unreleased structure''' The entry 4ege is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal Structure of Dipeptidase PepE from...

New page

'''Unreleased structure'''

The entry 4ege is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans