4egx - Revision history

OCA at 13:47, 8 November 2023

OCA — Wed, 08 Nov 2023 13:47:44 GMT

←Older revision		Revision as of 13:47, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4egx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EGX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4egx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EGX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4egx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egx OCA], [https://pdbe.org/4egx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4egx RCSB], [https://www.ebi.ac.uk/pdbsum/4egx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4egx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4egx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egx OCA], [https://pdbe.org/4egx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4egx RCSB], [https://www.ebi.ac.uk/pdbsum/4egx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4egx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref>	+	[https://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Motor for anterograde axonal transport of synaptic vesicle precursors (By similarity).	+	[https://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN] Motor for anterograde axonal transport of synaptic vesicle precursors (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:10, 28 September 2022

OCA — Wed, 28 Sep 2022 07:10:52 GMT

←Older revision		Revision as of 07:10, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of KIF1A CC1-FHA tandem==		==Crystal structure of KIF1A CC1-FHA tandem==
-	<StructureSection load='4egx' size='340' side='right' caption='[[4egx]], [[Resolution\|resolution]] 2.51Å' scene=''>	+	<StructureSection load='4egx' size='340' side='right'caption='[[4egx]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4egx]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EGX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4egx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EGX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ejq\|4ejq]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4egx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egx OCA], [https://pdbe.org/4egx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4egx RCSB], [https://www.ebi.ac.uk/pdbsum/4egx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4egx ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF1A, ATSV, C2orf20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4egx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egx OCA], [~~http~~://pdbe.org/4egx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4egx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4egx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4egx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref>	+	[[https://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Motor for anterograde axonal transport of synaptic vesicle precursors (By similarity).	+	[[https://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Motor for anterograde axonal transport of synaptic vesicle precursors (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4egx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4egx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Feng, W]]	+	[[Category: Large Structures]]
-	[[Category: Huo, L]]	+	[[Category: Feng W]]
-	[[Category: Xu, T]]	+	[[Category: Huo L]]
-	[[Category: Yu, J]]	+	[[Category: Xu T]]
-	[[Category: Yue, Y]]	+	[[Category: Yu J]]
-	[[Category: Zhang, M]]	+	[[Category: Yue Y]]
-	~~[[Category: Fha domain]]~~	+	[[Category: Zhang M]]
-	~~[[Category: Transport protein~~]]	+

OCA at 14:59, 11 August 2016

OCA — Thu, 11 Aug 2016 14:59:06 GMT

←Older revision		Revision as of 14:59, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of KIF1A CC1-FHA tandem==		==Crystal structure of KIF1A CC1-FHA tandem==
	<StructureSection load='4egx' size='340' side='right' caption='[[4egx]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='4egx' size='340' side='right' caption='[[4egx]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4egx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4egx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ejq\|4ejq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ejq\|4ejq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF1A, ATSV, C2orf20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF1A, ATSV, C2orf20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4egx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4egx RCSB], [http://www.ebi.ac.uk/pdbsum/4egx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4egx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egx OCA], [http://pdbe.org/4egx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4egx RCSB], [http://www.ebi.ac.uk/pdbsum/4egx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4egx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Motor for anterograde axonal transport of synaptic vesicle precursors (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4egx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Feng, W]]		[[Category: Feng, W]]
	[[Category: Huo, L]]		[[Category: Huo, L]]

OCA at 13:16, 5 January 2015

OCA — Mon, 05 Jan 2015 13:16:16 GMT

←Older revision		Revision as of 13:16, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4egx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4egx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ejq\|4ejq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ejq\|4ejq]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF1A, ATSV, C2orf20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF1A, ATSV, C2orf20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4egx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4egx RCSB], [http://www.ebi.ac.uk/pdbsum/4egx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4egx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4egx RCSB], [http://www.ebi.ac.uk/pdbsum/4egx PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Feng, W.]]	+	[[Category: Feng, W]]
-	[[Category: Huo, L.]]	+	[[Category: Huo, L]]
-	[[Category: Xu, T.]]	+	[[Category: Xu, T]]
-	[[Category: Yu, J.]]	+	[[Category: Yu, J]]
-	[[Category: Yue, Y.]]	+	[[Category: Yue, Y]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
	[[Category: Fha domain]]		[[Category: Fha domain]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 07:50, 9 July 2014

OCA — Wed, 09 Jul 2014 07:50:44 GMT

←Older revision		Revision as of 07:50, 9 July 2014
Line 1:		Line 1:
-	[[~~Image:~~4egx.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of KIF1A CC1-FHA tandem==
		+	<StructureSection load='4egx' size='340' side='right' caption='[[4egx]], [[Resolution\|resolution]] 2.51Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4egx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ejq\|4ejq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF1A, ATSV, C2orf20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4egx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4egx RCSB], [http://www.ebi.ac.uk/pdbsum/4egx PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kinesin-3 KIF1A plays prominent roles in axonal transport and synaptogenesis. KIF1A adopts a monomeric form in vitro but acts as a processive dimer in vivo. The mechanism underlying the motor dimerization is poorly understood. Here, we find that the CC1-FHA tandem of KIF1A exists as a stable dimer. The structure of CC1-FHA reveals that the linker between CC1 and FHA unexpectedly forms a beta-finger hairpin, which integrates CC1 with FHA assembling a CC1-FHA homodimer. More importantly, dissociation of the CC1-FHA dimer unleashes CC1 and the beta-finger, which are both essential for the motor inhibition. Thus, dimerization of the CC1-FHA tandem not only promotes the KIF1A dimer formation but also may trigger the motor activity via sequestering the CC1/beta-finger region. The CC1-FHA tandem likely functions as a hub for controlling the dimerization and activation of KIF1A, which may represent a new paradigm for the kinesin regulation shared by other kinesin-3 motors.

-	~~{{STRUCTURE_4egx\| PDB=4egx \| SCENE= }}~~	+	The CC1-FHA Tandem as a Central Hub for Controlling the Dimerization and Activation of Kinesin-3 KIF1A.,Huo L, Yue Y, Ren J, Yu J, Liu J, Yu Y, Ye F, Xu T, Zhang M, Feng W Structure. 2012 Sep 5;20(9):1550-61. Epub 2012 Aug 2. PMID:22863567<ref>PMID:22863567</ref>

-	~~===Crystal structure~~ of ~~KIF1A CC1-FHA tandem===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22863567}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4egx]] is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Feng, W.]]		[[Category: Feng, W.]]

OCA at 06:17, 3 October 2012

OCA — Wed, 03 Oct 2012 06:17:12 GMT

←Older revision		Revision as of 06:17, 3 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4egx.jpg\|left\|200px]]

-	~~The entry~~ 4egx ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4egx\| PDB=4egx \| SCENE= }}

-	~~Authors: Yu, J., Huo, L., Yue, Y., Xu, T., Zhang, M., Feng, W.~~	+	===Crystal structure of KIF1A CC1-FHA tandem===

-	~~Description: Crystal~~ structure ~~of KIF1A CC1~~-~~FHA tandem~~	+	{{ABSTRACT_PUBMED_22863567}}
		+
		+	==About this Structure==
		+	[[4egx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGX OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Feng, W.]]
		+	[[Category: Huo, L.]]
		+	[[Category: Xu, T.]]
		+	[[Category: Yu, J.]]
		+	[[Category: Yue, Y.]]
		+	[[Category: Zhang, M.]]
		+	[[Category: Fha domain]]
		+	[[Category: Transport protein]]

OCA at 18:54, 2 May 2012

OCA — Wed, 02 May 2012 18:54:59 GMT

←Older revision		Revision as of 18:54, 2 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4egx is ON HOLD	+	The entry 4egx is ON HOLD until Paper Publication

	Authors: Yu, J., Huo, L., Yue, Y., Xu, T., Zhang, M., Feng, W.		Authors: Yu, J., Huo, L., Yue, Y., Xu, T., Zhang, M., Feng, W.

	Description: Crystal structure of KIF1A CC1-FHA tandem		Description: Crystal structure of KIF1A CC1-FHA tandem

OCA at 08:52, 25 April 2012

OCA — Wed, 25 Apr 2012 08:52:41 GMT

←Older revision		Revision as of 08:52, 25 April 2012
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	The entry 4egx is ON HOLD		The entry 4egx is ON HOLD

-	Authors: Yu, ~~Jiang~~, Huo, ~~Lin~~, Yue, ~~Yang~~, Xu, ~~Tao~~, Zhang, ~~Mingjie~~, Feng, ~~Wei~~	+	Authors: Yu, J., Huo, L., Yue, Y., Xu, T., Zhang, M., Feng, W.

	Description: Crystal structure of KIF1A CC1-FHA tandem		Description: Crystal structure of KIF1A CC1-FHA tandem

OCA: Protected "4egx" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2012 06:42:46 GMT

Protected "4egx" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:42, 11 April 2012

OCA: New page: '''Unreleased structure''' The entry 4egx is ON HOLD Authors: Yu, Jiang, Huo, Lin, Yue, Yang, Xu, Tao, Zhang, Mingjie, Feng, Wei Description: Crystal structure of KIF1A CC1-FHA tandem

OCA — Wed, 11 Apr 2012 06:42:45 GMT

New page: '''Unreleased structure''' The entry 4egx is ON HOLD Authors: Yu, Jiang, Huo, Lin, Yue, Yang, Xu, Tao, Zhang, Mingjie, Feng, Wei Description: Crystal structure of KIF1A CC1-FHA tandem

New page

'''Unreleased structure'''

The entry 4egx is ON HOLD

Authors: Yu, Jiang, Huo, Lin, Yue, Yang, Xu, Tao, Zhang, Mingjie, Feng, Wei

Description: Crystal structure of KIF1A CC1-FHA tandem