4ehd - Revision history

OCA at 07:11, 28 September 2022

OCA — Wed, 28 Sep 2022 07:11:20 GMT

←Older revision		Revision as of 07:11, 28 September 2022
Line 1:		Line 1:

	==Allosteric Modulation of Caspase-3 through Mutagenesis==		==Allosteric Modulation of Caspase-3 through Mutagenesis==
-	<StructureSection load='4ehd' size='340' side='right' caption='[[4ehd]], [[Resolution\|resolution]] 1.58Å' scene=''>	+	<StructureSection load='4ehd' size='340' side='right'caption='[[4ehd]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ehd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EHD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ehd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHD FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehf\|4ehf]], [[4ehh\|4ehh]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehd OCA], [https://pdbe.org/4ehd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehd RCSB], [https://www.ebi.ac.uk/pdbsum/4ehd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehd ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ehd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehd OCA], [~~http~~://pdbe.org/4ehd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ehd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ehd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehd ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>	+	[[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4ehd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ehd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Caspase 3D structures\|Caspase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caspase-3~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Clark~~, A C~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Mattos, C]]	+	[[Category: Clark AC]]
-	[[Category: Schipper~~, J L~~]]	+	[[Category: Mattos C]]
-	[[Category: Swartz, P]]	+	[[Category: Schipper JL]]
-	[[Category: Walters, J]]	+	[[Category: Swartz P]]
-	~~[[Category: Allosteric inhibition]]~~	+	[[Category: Walters J]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Caspase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Protein ensemble~~]]	+

OCA at 08:04, 15 November 2017

OCA — Wed, 15 Nov 2017 08:04:11 GMT

←Older revision		Revision as of 08:04, 15 November 2017
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	</div>		</div>
	<div class="pdbe-citations 4ehd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ehd" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Caspase\|Caspase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:59, 5 August 2016

OCA — Fri, 05 Aug 2016 06:59:10 GMT

←Older revision		Revision as of 06:59, 5 August 2016
Line 1:		Line 1:
		+
	==Allosteric Modulation of Caspase-3 through Mutagenesis==		==Allosteric Modulation of Caspase-3 through Mutagenesis==
	<StructureSection load='4ehd' size='340' side='right' caption='[[4ehd]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='4ehd' size='340' side='right' caption='[[4ehd]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ehd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ehd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHD FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehf\|4ehf]], [[4ehh\|4ehh]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehf\|4ehf]], [[4ehh\|4ehh]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehd RCSB], [http://www.ebi.ac.uk/pdbsum/4ehd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehd OCA], [http://pdbe.org/4ehd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ehd RCSB], [http://www.ebi.ac.uk/pdbsum/4ehd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ehd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Caspase-3]]		[[Category: Caspase-3]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Clark, A C]]		[[Category: Clark, A C]]
	[[Category: Mattos, C]]		[[Category: Mattos, C]]

OCA at 16:41, 25 December 2014

OCA — Thu, 25 Dec 2014 16:41:48 GMT

←Older revision		Revision as of 16:41, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ehd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ehd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehf\|4ehf]], [[4ehh\|4ehh]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehf\|4ehf]], [[4ehh\|4ehh]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehd RCSB], [http://www.ebi.ac.uk/pdbsum/4ehd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehd RCSB], [http://www.ebi.ac.uk/pdbsum/4ehd PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Caspase-3]]		[[Category: Caspase-3]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Clark, A C.]]	+	[[Category: Clark, A C]]
-	[[Category: Mattos, C.]]	+	[[Category: Mattos, C]]
-	[[Category: Schipper, J L.]]	+	[[Category: Schipper, J L]]
-	[[Category: Swartz, P.]]	+	[[Category: Swartz, P]]
-	[[Category: Walters, J.]]	+	[[Category: Walters, J]]
	[[Category: Allosteric inhibition]]		[[Category: Allosteric inhibition]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA at 07:33, 5 June 2014

OCA — Thu, 05 Jun 2014 07:33:24 GMT

←Older revision		Revision as of 07:33, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4ehd.~~png~~\|~~left~~\|~~200px~~]]	+	==Allosteric Modulation of Caspase-3 through Mutagenesis==
		+	<StructureSection load='4ehd' size='340' side='right' caption='[[4ehd]], [[Resolution\|resolution]] 1.58Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ehd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehf\|4ehf]], [[4ehh\|4ehh]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehd RCSB], [http://www.ebi.ac.uk/pdbsum/4ehd PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A mutation in the allosteric site of the caspase-3 dimer interface of V266 to histidine abolishes activity of the enzyme, and models predict that the mutation mimics the action of small molecule allosteric inhibitors by preventing formation of the active site. Mutations were coupled to H266 at two sites in the interface, E124A and Y197C. We present data from X-ray crystallography, enzymatic activity and molecular dynamics simulations for seven proteins, consisting of single, double, and triple mutants. The data demonstrate that considering allosteric inhibition of caspase-3 as a shift between discrete "off-state" or "on-state" conformations is insufficient. While H266 is accommodated in the interface, the structural defects are propagated to the active site through a helix on the protein surface. A more comprehensive view of allosteric regulation of caspase-3 requires the representation of an ensemble of inactive states and shows that subtle structural changes lead to the population of the inactive ensemble.

-	~~{{STRUCTURE_4ehd\| PDB=4ehd \| SCENE= }}~~	+	Allosteric Modulation of Caspase-3 through Mutagenesis.,Walters J, Schipper JL, Swartz P, Mattos C, Clark AC Biosci Rep. 2012 May 18. PMID:22607239<ref>PMID:22607239</ref>

-	~~===Allosteric Modulation~~ of ~~Caspase-3 through Mutagenesis===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22607239}}~~	+	==See Also==
-		+	*[[Caspase\|Caspase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4ehd~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHD OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:022607239<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Caspase-3]]		[[Category: Caspase-3]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 04:29, 18 July 2012

OCA — Wed, 18 Jul 2012 04:29:03 GMT

←Older revision		Revision as of 04:29, 18 July 2012
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-	[[Image:4ehd.~~jpg~~\|left\|200px]]	+	[[Image:4ehd.png\|left\|200px]]

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	{{STRUCTURE_4ehd\| PDB=4ehd \| SCENE= }}		{{STRUCTURE_4ehd\| PDB=4ehd \| SCENE= }}

	===Allosteric Modulation of Caspase-3 through Mutagenesis===		===Allosteric Modulation of Caspase-3 through Mutagenesis===

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	{{ABSTRACT_PUBMED_22607239}}		{{ABSTRACT_PUBMED_22607239}}

OCA at 07:38, 6 June 2012

OCA — Wed, 06 Jun 2012 07:38:34 GMT

←Older revision		Revision as of 07:38, 6 June 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4ehd.jpg\|left\|200px]]

-	The ~~entry 4ehd~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4ehd", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4ehd\| PDB=4ehd \| SCENE= }}

-	~~Authors: Walters, J., Schipper, J.L., Swartz, P., Mattos, C., Clark, A.C.~~	+	===Allosteric Modulation of Caspase-3 through Mutagenesis===

-	~~Description~~: ~~Allosteric Modulation of~~ Caspase-3 ~~through Mutagenesis~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22607239}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22607239 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22607239}}
		+
		+	==About this Structure==
		+	[[4ehd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHD OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022607239</ref><references group="xtra"/>
		+	[[Category: Caspase-3]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Clark, A C.]]
		+	[[Category: Mattos, C.]]
		+	[[Category: Schipper, J L.]]
		+	[[Category: Swartz, P.]]
		+	[[Category: Walters, J.]]
		+	[[Category: Allosteric inhibition]]
		+	[[Category: Apoptosis]]
		+	[[Category: Caspase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Protein ensemble]]

OCA at 18:55, 2 May 2012

OCA — Wed, 02 May 2012 18:55:16 GMT

←Older revision		Revision as of 18:55, 2 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ehd is ON HOLD	+	The entry 4ehd is ON HOLD until Paper Publication

	Authors: Walters, J., Schipper, J.L., Swartz, P., Mattos, C., Clark, A.C.		Authors: Walters, J., Schipper, J.L., Swartz, P., Mattos, C., Clark, A.C.

	Description: Allosteric Modulation of Caspase-3 through Mutagenesis		Description: Allosteric Modulation of Caspase-3 through Mutagenesis

OCA: Protected "4ehd" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2012 06:43:12 GMT

Protected "4ehd" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:43, 11 April 2012

OCA: New page: '''Unreleased structure''' The entry 4ehd is ON HOLD Authors: Walters, J., Schipper, J.L., Swartz, P., Mattos, C., Clark, A.C. Description: Allosteric Modulation of Caspase-3 through M...

OCA — Wed, 11 Apr 2012 06:43:12 GMT

New page: '''Unreleased structure''' The entry 4ehd is ON HOLD Authors: Walters, J., Schipper, J.L., Swartz, P., Mattos, C., Clark, A.C. Description: Allosteric Modulation of Caspase-3 through M...

New page

'''Unreleased structure'''

The entry 4ehd is ON HOLD

Authors: Walters, J., Schipper, J.L., Swartz, P., Mattos, C., Clark, A.C.

Description: Allosteric Modulation of Caspase-3 through Mutagenesis