4emo - Revision history

OCA at 07:18, 28 September 2022

OCA — Wed, 28 Sep 2022 07:18:25 GMT

←Older revision		Revision as of 07:18, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of the PH domain of SHARPIN==		==Crystal structure of the PH domain of SHARPIN==
-	<StructureSection load='4emo' size='340' side='right' caption='[[4emo]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4emo' size='340' side='right'caption='[[4emo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4emo]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EMO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4emo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EMO FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSEC0216, SHARPIN, SIPL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4emo OCA], [https://pdbe.org/4emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4emo RCSB], [https://www.ebi.ac.uk/pdbsum/4emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4emo ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4emo OCA], [~~http~~://pdbe.org/4emo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4emo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4emo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4emo ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SHRPN_HUMAN SHRPN_HUMAN]] Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.<ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref>	+	[[https://www.uniprot.org/uniprot/SHRPN_HUMAN SHRPN_HUMAN]] Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.<ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Dikic, I]]	+	[[Category: Large Structures]]
-	[[Category: Haire~~, L F~~]]	+	[[Category: Dikic I]]
-	[[Category: Rittinger, K]]	+	[[Category: Haire LF]]
-	[[Category: Stieglitz, B]]	+	[[Category: Rittinger K]]
-	~~[[Category: Hoil-1l]]~~	+	[[Category: Stieglitz B]]
-	~~[[Category: Hoip]]~~	+
-	~~[[Category: Linear ubiquitin]]~~	+
-	~~[[Category: Lubac]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Sipl1~~]]	+

OCA at 04:57, 5 August 2016

OCA — Fri, 05 Aug 2016 04:57:53 GMT

←Older revision		Revision as of 04:57, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the PH domain of SHARPIN==		==Crystal structure of the PH domain of SHARPIN==
	<StructureSection load='4emo' size='340' side='right' caption='[[4emo]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4emo' size='340' side='right' caption='[[4emo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4emo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EMO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4emo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EMO FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSEC0216, SHARPIN, SIPL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSEC0216, SHARPIN, SIPL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4emo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4emo RCSB], [http://www.ebi.ac.uk/pdbsum/4emo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4emo OCA], [http://pdbe.org/4emo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4emo RCSB], [http://www.ebi.ac.uk/pdbsum/4emo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4emo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4emo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dikic, I]]		[[Category: Dikic, I]]
	[[Category: Haire, L F]]		[[Category: Haire, L F]]

OCA at 15:57, 25 December 2014

OCA — Thu, 25 Dec 2014 15:57:27 GMT

←Older revision		Revision as of 15:57, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4emo.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the PH domain of SHARPIN==
		+	<StructureSection load='4emo' size='340' side='right' caption='[[4emo]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4emo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EMO FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSEC0216, SHARPIN, SIPL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4emo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4emo RCSB], [http://www.ebi.ac.uk/pdbsum/4emo PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SHRPN_HUMAN SHRPN_HUMAN]] Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.<ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	E3 ubiquitin ligase complex called LUBAC (linear ubiquitin chain assembly complex) that catalyses the formation of linear ubiquitin chains and regulates immune and apoptopic signalling pathways. The C-terminal half of SHARPIN contains ubiquitin like domain (UBL) and Npl4-zinc finger (NZF) domains that mediate the interaction with the LUBAC subunit HOIP and ubiquitin, respectively. In contrast, the N-terminal region does not show any homology with known protein interaction domains but has been suggested to be responsible for self-association of SHARPIN, presumably via a coiled-coil region. We have determined the crystal structure of the N-terminal portion of SHARPIN, which adopts the highly conserved pleckstrin homology (PH) superfold that is often used as a scaffold to create protein interaction modules. We show that in SHARPIN this domain does not appear to be used as a ligand recognition domain since it lacks many of the surface properties that are present in other PH fold-based interaction modules. Instead it acts as a dimerization module extending the functional applications of this superfold.

-	~~{{STRUCTURE_4emo\| PDB=4emo \| SCENE= }}~~	+	Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold.,Stieglitz B, Haire LF, Dikic I, Rittinger K J Biol Chem. 2012 May 1. PMID:22549881<ref>PMID:22549881</ref>

-	~~===Crystal structure~~ of the ~~PH domain of SHARPIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22549881}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4emo]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4EMO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022549881<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dikic, I.]]	+	[[Category: Dikic, I]]
-	[[Category: Haire, L F.]]	+	[[Category: Haire, L F]]
-	[[Category: Rittinger, K.]]	+	[[Category: Rittinger, K]]
-	[[Category: Stieglitz, B.]]	+	[[Category: Stieglitz, B]]
	[[Category: Hoil-1l]]		[[Category: Hoil-1l]]
	[[Category: Hoip]]		[[Category: Hoip]]

OCA at 06:18, 25 July 2012

OCA — Wed, 25 Jul 2012 06:18:35 GMT

←Older revision		Revision as of 06:18, 25 July 2012
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	[[Image:4emo.png\|left\|200px]]		[[Image:4emo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_4emo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4emo\| PDB=4emo \| SCENE= }}		{{STRUCTURE_4emo\| PDB=4emo \| SCENE= }}

	===Crystal structure of the PH domain of SHARPIN===		===Crystal structure of the PH domain of SHARPIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22549881}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22549881 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_22549881}}		{{ABSTRACT_PUBMED_22549881}}

OCA at 08:22, 16 May 2012

OCA — Wed, 16 May 2012 08:22:17 GMT

←Older revision		Revision as of 08:22, 16 May 2012
Line 1:		Line 1:
-	[[Image:4emo.~~jpg~~\|left\|200px]]	+	[[Image:4emo.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of the PH domain of SHARPIN===		===Crystal structure of the PH domain of SHARPIN===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22549881}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22549881 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22549881}}

	==About this Structure==		==About this Structure==
	[[4emo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMO OCA].		[[4emo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMO OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022549881</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dikic, I.]]		[[Category: Dikic, I.]]

OCA at 19:30, 2 May 2012

OCA — Wed, 02 May 2012 19:30:53 GMT

←Older revision		Revision as of 19:30, 2 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4emo.jpg\|left\|200px]]

-	The ~~entry 4emo~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4emo", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4emo\| PDB=4emo \| SCENE= }}

-	~~Authors: Stieglitz, B., Haire, L.F., Dikic, I., Rittinger, K.~~	+	===Crystal structure of the PH domain of SHARPIN===

-	~~Description: Crystal~~ structure ~~of the PH domain of SHARPIN~~	+
		+	==About this Structure==
		+	[[4emo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMO OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Dikic, I.]]
		+	[[Category: Haire, L F.]]
		+	[[Category: Rittinger, K.]]
		+	[[Category: Stieglitz, B.]]
		+	[[Category: Hoil-1l]]
		+	[[Category: Hoip]]
		+	[[Category: Linear ubiquitin]]
		+	[[Category: Lubac]]
		+	[[Category: Protein binding]]
		+	[[Category: Sipl1]]

OCA: Protected "4emo" [edit=sysop:move=sysop]

OCA — Wed, 18 Apr 2012 07:35:51 GMT

Protected "4emo" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:35, 18 April 2012

OCA: New page: '''Unreleased structure''' The entry 4emo is ON HOLD Authors: Stieglitz, B., Haire, L.F., Dikic, I., Rittinger, K. Description: Crystal structure of the PH domain of SHARPIN

OCA — Wed, 18 Apr 2012 07:35:50 GMT

New page: '''Unreleased structure''' The entry 4emo is ON HOLD Authors: Stieglitz, B., Haire, L.F., Dikic, I., Rittinger, K. Description: Crystal structure of the PH domain of SHARPIN

New page

'''Unreleased structure'''

The entry 4emo is ON HOLD

Authors: Stieglitz, B., Haire, L.F., Dikic, I., Rittinger, K.

Description: Crystal structure of the PH domain of SHARPIN