4eqi - Revision history

OCA at 15:07, 14 March 2024

OCA — Thu, 14 Mar 2024 15:07:29 GMT

←Older revision		Revision as of 15:07, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eqi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_fonticola Serratia fonticola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EQI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eqi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_fonticola Serratia fonticola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EQI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.38Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eqi OCA], [https://pdbe.org/4eqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eqi RCSB], [https://www.ebi.ac.uk/pdbsum/4eqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eqi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eqi OCA], [https://pdbe.org/4eqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eqi RCSB], [https://www.ebi.ac.uk/pdbsum/4eqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eqi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q6JP75_SERFO Q6JP75_SERFO]		[https://www.uniprot.org/uniprot/Q6JP75_SERFO Q6JP75_SERFO]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Carbapenems are the most potent beta-lactam antibiotics and key drugs for treating infections by Gram-negative bacteria. In such organisms, beta-lactam resistance arises principally from beta-lactamase production. Although carbapenems escape the activity of most beta-lactamases, due in the class A enzymes to slow deacylation of the covalent acylenzyme intermediate, carbapenem-hydrolyzing class A beta-lactamases are now disseminating in clinically relevant bacteria. The reasons why carbapenems are substrates for these enzymes, but inhibit other class A beta-lactamases, remain to be fully established. Here, we present crystal structures of the class A carbapenemase SFC-1 from Serratia fonticola and of complexes of its Ser70 Ala (Michaelis) and Glu166 Ala (acylenzyme) mutants with the carbapenem meropenem. These are the first crystal structures of carbapenem complexes of a class A carbapenemase. Our data reveal that, in the SFC-1 acylenzyme complex, the meropenem 6alpha-1R-hydroxyethyl group interacts with Asn132, but not with the deacylating water molecule. Molecular dynamics simulations indicate that this mode of binding occurs in both the Michaelis and acylenzyme complexes of wild-type SFC-1. In carbapenem-inhibited class A beta-lactamases, it is proposed that the deacylating water molecule is deactivated by interaction with the carbapenem 6alpha-1R-hydroxyethyl substituent. Structural comparisons with such enzymes suggest that in SFC-1 subtle repositioning of key residues (Ser70, Ser130, Asn132 and Asn170) enlarges the active site, permitting rotation of the carbapenem 6alpha-1R-hydroxyethyl group and abolishing this contact. Our data show that SFC-1, and by implication other such carbapenem-hydrolyzing enzymes, uses Asn132 to orient bound carbapenems for efficient deacylation and prevent their interaction with the deacylating water molecule.
-
-	The basis for carbapenem hydrolysis by class A beta-lactamases: a combined investigation using crystallography and simulations.,Fonseca F, Chudyk EI, van der Kamp MW, Correia A, Mulholland AJ, Spencer J J Am Chem Soc. 2012 Nov 7;134(44):18275-85. doi: 10.1021/ja304460j. Epub 2012 Oct, 29. PMID:23030300<ref>PMID:23030300</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4eqi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]		*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:09, 7 October 2022

OCA — Fri, 07 Oct 2022 04:09:13 GMT

←Older revision		Revision as of 04:09, 7 October 2022
Line 1:		Line 1:

	==Crystal structure of serratia fonticola carbapenemase SFC-1==		==Crystal structure of serratia fonticola carbapenemase SFC-1==
-	<StructureSection load='4eqi' size='340' side='right' caption='[[4eqi]], [[Resolution\|resolution]] 1.38Å' scene=''>	+	<StructureSection load='4eqi' size='340' side='right'caption='[[4eqi]], [[Resolution\|resolution]] 1.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4eqi]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_29844 Atcc 29844~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EQI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4eqi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_fonticola Serratia fonticola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EQI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ev4\|4ev4]], [[4euz\|4euz]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eqi OCA], [https://pdbe.org/4eqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eqi RCSB], [https://www.ebi.ac.uk/pdbsum/4eqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eqi ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BLASFC-1, SFC-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47917 ATCC 29844])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eqi OCA], [~~http~~://pdbe.org/4eqi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eqi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eqi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eqi ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6JP75_SERFO Q6JP75_SERFO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 29844~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Beta-lactamase~~]]	+	[[Category: Serratia fonticola]]
-	[[Category: Fonseca, F]]	+	[[Category: Fonseca F]]
-	[[Category: Spencer, J]]	+	[[Category: Spencer J]]
-	~~[[Category: Antibiotic resistance]]~~	+
-	~~[[Category: Carbapenemase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 00:32, 5 August 2016

OCA — Fri, 05 Aug 2016 00:32:40 GMT

←Older revision		Revision as of 00:32, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of serratia fonticola carbapenemase SFC-1==		==Crystal structure of serratia fonticola carbapenemase SFC-1==
	<StructureSection load='4eqi' size='340' side='right' caption='[[4eqi]], [[Resolution\|resolution]] 1.38Å' scene=''>		<StructureSection load='4eqi' size='340' side='right' caption='[[4eqi]], [[Resolution\|resolution]] 1.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4eqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Serratia_fonticola Serratia fonticola~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EQI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4eqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29844 Atcc 29844]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EQI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ev4\|4ev4]], [[4euz\|4euz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ev4\|4ev4]], [[4euz\|4euz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BLASFC-1, SFC-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47917 ~~Serratia fonticola~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BLASFC-1, SFC-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47917 ATCC 29844])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eqi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eqi RCSB], [http://www.ebi.ac.uk/pdbsum/4eqi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eqi OCA], [http://pdbe.org/4eqi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eqi RCSB], [http://www.ebi.ac.uk/pdbsum/4eqi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eqi ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4eqi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 29844]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Serratia fonticola]]
	[[Category: Fonseca, F]]		[[Category: Fonseca, F]]
	[[Category: Spencer, J]]		[[Category: Spencer, J]]

OCA at 11:19, 21 December 2014

OCA — Sun, 21 Dec 2014 11:19:41 GMT

←Older revision		Revision as of 11:19, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4eqi\| PDB~~=4eqi \| ~~SCENE~~= }}	+	==Crystal structure of serratia fonticola carbapenemase SFC-1==
-	===~~Crystal~~ structure ~~of serratia~~ fonticola ~~carbapenemase~~ SFC-1===	+	<StructureSection load='4eqi' size='340' side='right' caption='[[4eqi]], [[Resolution\|resolution]] 1.38Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23030300}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4eqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_fonticola Serratia fonticola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EQI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ev4\|4ev4]], [[4euz\|4euz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BLASFC-1, SFC-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47917 Serratia fonticola])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eqi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eqi RCSB], [http://www.ebi.ac.uk/pdbsum/4eqi PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Carbapenems are the most potent beta-lactam antibiotics and key drugs for treating infections by Gram-negative bacteria. In such organisms, beta-lactam resistance arises principally from beta-lactamase production. Although carbapenems escape the activity of most beta-lactamases, due in the class A enzymes to slow deacylation of the covalent acylenzyme intermediate, carbapenem-hydrolyzing class A beta-lactamases are now disseminating in clinically relevant bacteria. The reasons why carbapenems are substrates for these enzymes, but inhibit other class A beta-lactamases, remain to be fully established. Here, we present crystal structures of the class A carbapenemase SFC-1 from Serratia fonticola and of complexes of its Ser70 Ala (Michaelis) and Glu166 Ala (acylenzyme) mutants with the carbapenem meropenem. These are the first crystal structures of carbapenem complexes of a class A carbapenemase. Our data reveal that, in the SFC-1 acylenzyme complex, the meropenem 6alpha-1R-hydroxyethyl group interacts with Asn132, but not with the deacylating water molecule. Molecular dynamics simulations indicate that this mode of binding occurs in both the Michaelis and acylenzyme complexes of wild-type SFC-1. In carbapenem-inhibited class A beta-lactamases, it is proposed that the deacylating water molecule is deactivated by interaction with the carbapenem 6alpha-1R-hydroxyethyl substituent. Structural comparisons with such enzymes suggest that in SFC-1 subtle repositioning of key residues (Ser70, Ser130, Asn132 and Asn170) enlarges the active site, permitting rotation of the carbapenem 6alpha-1R-hydroxyethyl group and abolishing this contact. Our data show that SFC-1, and by implication other such carbapenem-hydrolyzing enzymes, uses Asn132 to orient bound carbapenems for efficient deacylation and prevent their interaction with the deacylating water molecule.

-	~~==About this Structure==~~	+	The basis for carbapenem hydrolysis by class A beta-lactamases: a combined investigation using crystallography and simulations.,Fonseca F, Chudyk EI, van der Kamp MW, Correia A, Mulholland AJ, Spencer J J Am Chem Soc. 2012 Nov 7;134(44):18275-85. doi: 10.1021/ja304460j. Epub 2012 Oct, 29. PMID:23030300<ref>PMID:23030300</ref>
-	~~[[4eqi]] is~~ a ~~2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Serratia_fonticola Serratia fonticola]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4EQI OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Beta-lactamase\|Beta-lactamase]]		*[[Beta-lactamase\|Beta-lactamase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023030300</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Serratia fonticola]]		[[Category: Serratia fonticola]]
-	[[Category: Fonseca, F.]]	+	[[Category: Fonseca, F]]
-	[[Category: Spencer, J.]]	+	[[Category: Spencer, J]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
-	[[Category: Beta-lactamase]]
	[[Category: Carbapenemase]]		[[Category: Carbapenemase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 04:51, 28 August 2013

OCA — Wed, 28 Aug 2013 04:51:50 GMT

←Older revision		Revision as of 04:51, 28 August 2013
Line 1:		Line 1:
-	[[Image:4eqi.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_4eqi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4eqi\| PDB=4eqi \| SCENE= }}		{{STRUCTURE_4eqi\| PDB=4eqi \| SCENE= }}
-
	===Crystal structure of serratia fonticola carbapenemase SFC-1===		===Crystal structure of serratia fonticola carbapenemase SFC-1===
-		+	{{ABSTRACT_PUBMED_23030300}}

	==About this Structure==		==About this Structure==
	[[4eqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_fonticola Serratia fonticola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQI OCA].		[[4eqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_fonticola Serratia fonticola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQI OCA].
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023030300</ref><references group="xtra"/><references/>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Serratia fonticola]]		[[Category: Serratia fonticola]]

OCA at 06:18, 23 May 2012

OCA — Wed, 23 May 2012 06:18:10 GMT

←Older revision		Revision as of 06:18, 23 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4eqi.jpg\|left\|200px]]

-	The ~~entry 4eqi~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4eqi", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4eqi\| PDB=4eqi \| SCENE= }}

-	~~Authors: Fonseca, F., Spencer, J.~~	+	===Crystal structure of serratia fonticola carbapenemase SFC-1===

-	~~Description: Crystal~~ structure ~~of serratia~~ fonticola ~~carbapenemase SFC~~-1	+
		+	==About this Structure==
		+	[[4eqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_fonticola Serratia fonticola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQI OCA].
		+	[[Category: Beta-lactamase]]
		+	[[Category: Serratia fonticola]]
		+	[[Category: Fonseca, F.]]
		+	[[Category: Spencer, J.]]
		+	[[Category: Antibiotic resistance]]
		+	[[Category: Beta-lactamase]]
		+	[[Category: Carbapenemase]]
		+	[[Category: Hydrolase]]

OCA at 08:49, 9 May 2012

OCA — Wed, 09 May 2012 08:49:06 GMT

←Older revision		Revision as of 08:49, 9 May 2012
Line 5:		Line 5:
	Authors: Fonseca, F., Spencer, J.		Authors: Fonseca, F., Spencer, J.

-	Description: ~~CRYSTAL STRUCTURE OF SERRATIA FONTICOLA CARBAPENEMASE~~ SFC-1	+	Description: Crystal structure of serratia fonticola carbapenemase SFC-1

OCA: Protected "4eqi" [edit=sysop:move=sysop]

OCA — Wed, 25 Apr 2012 08:57:26 GMT

Protected "4eqi" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:57, 25 April 2012

OCA: New page: '''Unreleased structure''' The entry 4eqi is ON HOLD Authors: Fonseca, F., Spencer, J. Description: CRYSTAL STRUCTURE OF SERRATIA FONTICOLA CARBAPENEMASE SFC-1

OCA — Wed, 25 Apr 2012 08:57:25 GMT

New page: '''Unreleased structure''' The entry 4eqi is ON HOLD Authors: Fonseca, F., Spencer, J. Description: CRYSTAL STRUCTURE OF SERRATIA FONTICOLA CARBAPENEMASE SFC-1

New page

'''Unreleased structure'''

The entry 4eqi is ON HOLD

Authors: Fonseca, F., Spencer, J.

Description: CRYSTAL STRUCTURE OF SERRATIA FONTICOLA CARBAPENEMASE SFC-1