4erp - Revision history

OCA at 15:08, 14 March 2024

OCA — Thu, 14 Mar 2024 15:08:08 GMT

←Older revision		Revision as of 15:08, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4erp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ERP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4erp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ERP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4erp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4erp OCA], [https://pdbe.org/4erp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4erp RCSB], [https://www.ebi.ac.uk/pdbsum/4erp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4erp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4erp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4erp OCA], [https://pdbe.org/4erp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4erp RCSB], [https://www.ebi.ac.uk/pdbsum/4erp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4erp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.		[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair and are successful targets for anticancer drugs such as clofarabine and gemcitabine. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits into alpha4beta4 rings. Here, we present the first X-ray structure of a gemcitabine-inhibited E. coli RNR and show that the previously described alpha4beta4 rings can interlock to form an unprecedented (alpha4beta4)2 megacomplex. This complex is also seen in a higher-resolution dATP-inhibited RNR structure presented here, which employs a distinct crystal lattice from that observed in the gemcitabine-inhibited case. With few reported examples of protein catenanes, we use data from small-angle X-ray scattering and electron microscopy to both understand the solution conditions that contribute to concatenation in RNRs as well as present a mechanism for the formation of these unusual structures.
-
-	Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.,Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL Structure. 2012 Aug 8;20(8):1374-83. Epub 2012 Jun 21. PMID:22727814<ref>PMID:22727814</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4erp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ribonucleotide reductase 3D structures\|Ribonucleotide reductase 3D structures]]		*[[Ribonucleotide reductase 3D structures\|Ribonucleotide reductase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:10, 7 October 2022

OCA — Fri, 07 Oct 2022 04:10:54 GMT

←Older revision		Revision as of 04:10, 7 October 2022
Line 1:		Line 1:

	==Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex==		==Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex==
-	<StructureSection load='4erp' size='340' side='right' caption='[[4erp]], [[Resolution\|resolution]] 4.45Å' scene=''>	+	<StructureSection load='4erp' size='340' side='right'caption='[[4erp]], [[Resolution\|resolution]] 4.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4erp]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ERP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4erp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ERP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4erm\|4erm]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4erp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4erp OCA], [https://pdbe.org/4erp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4erp RCSB], [https://www.ebi.ac.uk/pdbsum/4erp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4erp ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2234, dnaF, JW2228, nrdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), b2235, ftsB, JW2229, nrdB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4erp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4erp OCA], [~~http~~://pdbe.org/4erp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4erp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4erp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4erp ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines. [[http://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.	+	[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Ribonucleotide reductase\|Ribonucleotide reductase]]	+	*[[Ribonucleotide reductase 3D structures\|Ribonucleotide reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: ~~Ribonucleoside-diphosphate reductase~~]]	+	[[Category: Large Structures]]
-	[[Category: Drennan~~, C L~~]]	+	[[Category: Drennan CL]]
-	[[Category: Zimanyi~~, C M]]~~	+	[[Category: Zimanyi CM]]
-	~~[[Category: Alpha/beta barrel]]~~	+
-	~~[[Category: Atp cone]]~~	+
-	~~[[Category: Cytosol]]~~	+
-	~~[[Category: Diiron center]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Protein-protein complex]]~~	+
-	~~[[Category: Ribonucleotide reduction]]~~	+
-	~~[[Category: Rnr alpha]]~~	+
-	~~[[Category: Rnr beta]]~~	+
-	~~[[Category: Thioredoxin~~]]	+

OCA at 06:32, 5 August 2016

OCA — Fri, 05 Aug 2016 06:32:17 GMT

←Older revision		Revision as of 06:32, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex==		==Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex==
	<StructureSection load='4erp' size='340' side='right' caption='[[4erp]], [[Resolution\|resolution]] 4.45Å' scene=''>		<StructureSection load='4erp' size='340' side='right' caption='[[4erp]], [[Resolution\|resolution]] 4.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4erp]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12 Escherichia coli k-12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ERP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4erp]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ERP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4erm\|4erm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4erm\|4erm]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2234, dnaF, JW2228, nrdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ~~Escherichia coli K-12~~]), b2235, ftsB, JW2229, nrdB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ~~Escherichia coli K-12~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2234, dnaF, JW2228, nrdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), b2235, ftsB, JW2229, nrdB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4erp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4erp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4erp RCSB], [http://www.ebi.ac.uk/pdbsum/4erp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4erp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4erp OCA], [http://pdbe.org/4erp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4erp RCSB], [http://www.ebi.ac.uk/pdbsum/4erp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4erp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4erp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli k-12~~]]	+	[[Category: Ecoli]]
	[[Category: Ribonucleoside-diphosphate reductase]]		[[Category: Ribonucleoside-diphosphate reductase]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]

OCA at 16:32, 25 December 2014

OCA — Thu, 25 Dec 2014 16:32:34 GMT

←Older revision		Revision as of 16:32, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4erp.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex==
		+	<StructureSection load='4erp' size='340' side='right' caption='[[4erp]], [[Resolution\|resolution]] 4.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4erp]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ERP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4erm\|4erm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2234, dnaF, JW2228, nrdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12]), b2235, ftsB, JW2229, nrdB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4erp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4erp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4erp RCSB], [http://www.ebi.ac.uk/pdbsum/4erp PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines. [[http://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair and are successful targets for anticancer drugs such as clofarabine and gemcitabine. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits into alpha4beta4 rings. Here, we present the first X-ray structure of a gemcitabine-inhibited E. coli RNR and show that the previously described alpha4beta4 rings can interlock to form an unprecedented (alpha4beta4)2 megacomplex. This complex is also seen in a higher-resolution dATP-inhibited RNR structure presented here, which employs a distinct crystal lattice from that observed in the gemcitabine-inhibited case. With few reported examples of protein catenanes, we use data from small-angle X-ray scattering and electron microscopy to both understand the solution conditions that contribute to concatenation in RNRs as well as present a mechanism for the formation of these unusual structures.

-	~~{{STRUCTURE_4erp\| PDB=4erp \| SCENE= }}~~	+	Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.,Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL Structure. 2012 Aug 8;20(8):1374-83. Epub 2012 Jun 21. PMID:22727814<ref>PMID:22727814</ref>

-	~~===Crystal structure of~~ a ~~gemcitabine-diphosphate inhibited E~~. ~~coli class Ia ribonucleotide reductase complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22727814}}~~	+	==See Also==
-		+	*[[Ribonucleotide reductase\|Ribonucleotide reductase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4erp~~]] ~~is a 8 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERP OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]
	[[Category: Ribonucleoside-diphosphate reductase]]		[[Category: Ribonucleoside-diphosphate reductase]]
-	[[Category: Drennan, C L.]]	+	[[Category: Drennan, C L]]
-	[[Category: Zimanyi, C M.]]	+	[[Category: Zimanyi, C M]]
	[[Category: Alpha/beta barrel]]		[[Category: Alpha/beta barrel]]
	[[Category: Atp cone]]		[[Category: Atp cone]]

OCA at 06:46, 24 October 2012

OCA — Wed, 24 Oct 2012 06:46:54 GMT

←Older revision		Revision as of 06:46, 24 October 2012
Line 1:		Line 1:
-	[[Image:4erp.~~jpg~~\|left\|200px]]	+	[[Image:4erp.png\|left\|200px]]

	{{STRUCTURE_4erp\| PDB=4erp \| SCENE= }}		{{STRUCTURE_4erp\| PDB=4erp \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex===		===Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex===

		+	{{ABSTRACT_PUBMED_22727814}}

	==About this Structure==		==About this Structure==

OCA at 07:48, 4 July 2012

OCA — Wed, 04 Jul 2012 07:48:31 GMT

←Older revision		Revision as of 07:48, 4 July 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4erp.jpg\|left\|200px]]

-	~~The entry~~ 4erp ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4erp\| PDB=4erp \| SCENE= }}

-	~~Authors: Zimanyi, C.M., Drennan, C.L~~.	+	===Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex===

-	~~Description: Crystal structure of~~ a ~~gemcitabine~~-~~diphosphate inhibited E~~. coli ~~class Ia ribonucleotide~~ reductase complex	+
		+	==About this Structure==
		+	[[4erp]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERP OCA].
		+	[[Category: Escherichia coli k-12]]
		+	[[Category: Ribonucleoside-diphosphate reductase]]
		+	[[Category: Drennan, C L.]]
		+	[[Category: Zimanyi, C M.]]
		+	[[Category: Alpha/beta barrel]]
		+	[[Category: Atp cone]]
		+	[[Category: Cytosol]]
		+	[[Category: Diiron center]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Protein-protein complex]]
		+	[[Category: Ribonucleotide reduction]]
		+	[[Category: Rnr alpha]]
		+	[[Category: Rnr beta]]
		+	[[Category: Thioredoxin]]

OCA at 05:28, 30 May 2012

OCA — Wed, 30 May 2012 05:28:20 GMT

←Older revision		Revision as of 05:28, 30 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4erp is ON HOLD	+	The entry 4erp is ON HOLD until Paper Publication

	Authors: Zimanyi, C.M., Drennan, C.L.		Authors: Zimanyi, C.M., Drennan, C.L.

	Description: Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex		Description: Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex

OCA: Protected "4erp" [edit=sysop:move=sysop]

OCA — Wed, 02 May 2012 18:57:22 GMT

Protected "4erp" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:57, 2 May 2012

OCA: New page: '''Unreleased structure''' The entry 4erp is ON HOLD Authors: Zimanyi, C.M., Drennan, C.L. Description: Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonu...

OCA — Wed, 02 May 2012 18:57:21 GMT

New page: '''Unreleased structure''' The entry 4erp is ON HOLD Authors: Zimanyi, C.M., Drennan, C.L. Description: Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonu...

New page

'''Unreleased structure'''

The entry 4erp is ON HOLD

Authors: Zimanyi, C.M., Drennan, C.L.

Description: Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex