4f8h - Revision history

OCA at 15:18, 14 March 2024

OCA — Thu, 14 Mar 2024 15:18:53 GMT

←Older revision		Revision as of 15:18, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4f8h]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F8H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4f8h]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F8H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMD:TETRADECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>LMD</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RKE:(R)-KETAMINE'>RKE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.99Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMD:TETRADECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>LMD</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RKE:(R)-KETAMINE'>RKE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8h OCA], [https://pdbe.org/4f8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f8h RCSB], [https://www.ebi.ac.uk/pdbsum/4f8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f8h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8h OCA], [https://pdbe.org/4f8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f8h RCSB], [https://www.ebi.ac.uk/pdbsum/4f8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f8h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>		[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but a structural understanding of anesthetic action on pLGICs remains elusive. GLIC, a prokaryotic pLGIC, can be inhibited by anesthetics, including ketamine. The ketamine concentration leading to half-maximal inhibition of GLIC (58 muM) is comparable to that on neuronal nicotinic acetylcholine receptors. A 2.99 A resolution X-ray structure of GLIC bound with ketamine revealed ketamine binding to an intersubunit cavity that partially overlaps with the homologous antagonist-binding site in pLGICs. The functional relevance of the identified ketamine site was highlighted by profound changes in GLIC activation upon cysteine substitution of the cavity-lining residue N152. The relevance is also evidenced by changes in ketamine inhibition upon the subsequent chemical labeling of N152C. The results provide structural insight into the molecular recognition of ketamine and are valuable for understanding the actions of anesthetics and other allosteric modulators on pLGICs.
-
-	Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine.,Pan J, Chen Q, Willenbring D, Mowrey D, Kong XP, Cohen A, Divito CB, Xu Y, Tang P Structure. 2012 Sep 5;20(9):1463-9. PMID:22958642<ref>PMID:22958642</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4f8h" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 04:41, 7 October 2022

OCA — Fri, 07 Oct 2022 04:41:12 GMT

←Older revision		Revision as of 04:41, 7 October 2022
Line 1:		Line 1:

	==X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel==		==X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel==
-	<StructureSection load='4f8h' size='340' side='right' caption='[[4f8h]], [[Resolution\|resolution]] 2.99Å' scene=''>	+	<StructureSection load='4f8h' size='340' side='right'caption='[[4f8h]], [[Resolution\|resolution]] 2.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4f8h]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Glovi Glovi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4F8H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4f8h]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F8H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMD:TETRADECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>LMD</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RKE:(R)-KETAMINE'>RKE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMD:TETRADECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>LMD</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RKE:(R)-KETAMINE'>RKE</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=251221 GLOVI])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8h OCA], [https://pdbe.org/4f8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f8h RCSB], [https://www.ebi.ac.uk/pdbsum/4f8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f8h ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4f8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8h OCA], [~~http~~://pdbe.org/4f8h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4f8h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4f8h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4f8h ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>	+	[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Ion channels\|Ion channels]]	+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glovi~~]]	+	[[Category: Gloeobacter violaceus PCC 7421]]
-	[[Category: Chen, Q]]	+	[[Category: Large Structures]]
-	[[Category: Cohen, A]]	+	[[Category: Chen Q]]
-	[[Category: Kong~~, X P~~]]	+	[[Category: Cohen A]]
-	[[Category: Pan~~, J J~~]]	+	[[Category: Kong XP]]
-	[[Category: Tang, P]]	+	[[Category: Pan JJ]]
-	[[Category: Willenbring, D]]	+	[[Category: Tang P]]
-	[[Category: Xu, Y]]	+	[[Category: Willenbring D]]
-	~~[[Category: Anesthetic]]~~	+	[[Category: Xu Y]]
-	~~[[Category: Ion channel]]~~	+
-	~~[[Category: Ketamine]]~~	+
-	~~[[Category: Pentameric ligand-gated ion channel]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 14:18, 4 August 2016

OCA — Thu, 04 Aug 2016 14:18:49 GMT

←Older revision		Revision as of 14:18, 4 August 2016
Line 1:		Line 1:
		+
	==X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel==		==X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel==
	<StructureSection load='4f8h' size='340' side='right' caption='[[4f8h]], [[Resolution\|resolution]] 2.99Å' scene=''>		<StructureSection load='4f8h' size='340' side='right' caption='[[4f8h]], [[Resolution\|resolution]] 2.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4f8h]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gloeobacter_violaceus Gloeobacter violaceus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F8H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4f8h]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F8H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMD:TETRADECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>LMD</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RKE:(R)-KETAMINE'>RKE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMD:TETRADECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>LMD</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RKE:(R)-KETAMINE'>RKE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~33072 Gloeobacter violaceus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=251221 GLOVI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f8h RCSB], [http://www.ebi.ac.uk/pdbsum/4f8h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8h OCA], [http://pdbe.org/4f8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f8h RCSB], [http://www.ebi.ac.uk/pdbsum/4f8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f8h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4f8h" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gloeobacter violaceus~~]]	+	[[Category: Glovi]]
	[[Category: Chen, Q]]		[[Category: Chen, Q]]
	[[Category: Cohen, A]]		[[Category: Cohen, A]]

OCA at 15:33, 24 December 2014

OCA — Wed, 24 Dec 2014 15:33:33 GMT

←Older revision		Revision as of 15:33, 24 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4f8h.~~png~~\|~~left~~\|~~200px~~]]	+	==X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel==
		+	<StructureSection load='4f8h' size='340' side='right' caption='[[4f8h]], [[Resolution\|resolution]] 2.99Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4f8h]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F8H FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMD:TETRADECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>LMD</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RKE:(R)-KETAMINE'>RKE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33072 Gloeobacter violaceus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f8h RCSB], [http://www.ebi.ac.uk/pdbsum/4f8h PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but a structural understanding of anesthetic action on pLGICs remains elusive. GLIC, a prokaryotic pLGIC, can be inhibited by anesthetics, including ketamine. The ketamine concentration leading to half-maximal inhibition of GLIC (58 muM) is comparable to that on neuronal nicotinic acetylcholine receptors. A 2.99 A resolution X-ray structure of GLIC bound with ketamine revealed ketamine binding to an intersubunit cavity that partially overlaps with the homologous antagonist-binding site in pLGICs. The functional relevance of the identified ketamine site was highlighted by profound changes in GLIC activation upon cysteine substitution of the cavity-lining residue N152. The relevance is also evidenced by changes in ketamine inhibition upon the subsequent chemical labeling of N152C. The results provide structural insight into the molecular recognition of ketamine and are valuable for understanding the actions of anesthetics and other allosteric modulators on pLGICs.

-	~~{{STRUCTURE_4f8h\| PDB=4f8h \| SCENE= }}~~	+	Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine.,Pan J, Chen Q, Willenbring D, Mowrey D, Kong XP, Cohen A, Divito CB, Xu Y, Tang P Structure. 2012 Sep 5;20(9):1463-9. PMID:22958642<ref>PMID:22958642</ref>

-	~~===X-ray Structure~~ of the ~~Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22958642}}~~	+	==See Also==
-		+	*[[Ion channels\|Ion channels]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4f8h~~]] ~~is a 5 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8H OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Gloeobacter violaceus]]		[[Category: Gloeobacter violaceus]]
-	[[Category: Chen, Q.]]	+	[[Category: Chen, Q]]
-	[[Category: Cohen, A.]]	+	[[Category: Cohen, A]]
-	[[Category: Kong, X P.]]	+	[[Category: Kong, X P]]
-	[[Category: Pan, J J.]]	+	[[Category: Pan, J J]]
-	[[Category: Tang, P.]]	+	[[Category: Tang, P]]
-	[[Category: Willenbring, D.]]	+	[[Category: Willenbring, D]]
-	[[Category: Xu, Y.]]	+	[[Category: Xu, Y]]
	[[Category: Anesthetic]]		[[Category: Anesthetic]]
	[[Category: Ion channel]]		[[Category: Ion channel]]

OCA at 20:32, 26 September 2012

OCA — Wed, 26 Sep 2012 20:32:26 GMT

←Older revision		Revision as of 20:32, 26 September 2012
Line 1:		Line 1:
-	[[Image:4f8h.~~jpg~~\|left\|200px]]	+	[[Image:4f8h.png\|left\|200px]]

	{{STRUCTURE_4f8h\| PDB=4f8h \| SCENE= }}		{{STRUCTURE_4f8h\| PDB=4f8h \| SCENE= }}
Line 5:		Line 5:
	===X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel===		===X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel===

		+	{{ABSTRACT_PUBMED_22958642}}

	==About this Structure==		==About this Structure==

OCA at 05:25, 29 August 2012

OCA — Wed, 29 Aug 2012 05:25:29 GMT

←Older revision		Revision as of 05:25, 29 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4f8h.jpg\|left\|200px]]

-	~~The entry~~ 4f8h ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4f8h\| PDB=4f8h \| SCENE= }}

-	~~Authors: Pan, J.J., Chen, Q., Willenbring, D., Kong,~~ X~~.P., Cohen, A., Xu, Y., Tang, P.~~	+	===X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel===

-	~~Description~~: X-~~ray Structure of the~~ Anesthetic Ketamine ~~Bound to the GLIC~~ Pentameric ~~Ligand~~-gated ~~Ion Channel~~	+
		+	==About this Structure==
		+	[[4f8h]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8H OCA].
		+	[[Category: Gloeobacter violaceus]]
		+	[[Category: Chen, Q.]]
		+	[[Category: Cohen, A.]]
		+	[[Category: Kong, X P.]]
		+	[[Category: Pan, J J.]]
		+	[[Category: Tang, P.]]
		+	[[Category: Willenbring, D.]]
		+	[[Category: Xu, Y.]]
		+	[[Category: Anesthetic]]
		+	[[Category: Ion channel]]
		+	[[Category: Ketamine]]
		+	[[Category: Pentameric ligand-gated ion channel]]
		+	[[Category: Transport protein]]

OCA at 05:48, 13 June 2012

OCA — Wed, 13 Jun 2012 05:48:03 GMT

←Older revision		Revision as of 05:48, 13 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4f8h is ON HOLD	+	The entry 4f8h is ON HOLD until Paper Publication

	Authors: Pan, J.J., Chen, Q., Willenbring, D., Kong, X.P., Cohen, A., Xu, Y., Tang, P.		Authors: Pan, J.J., Chen, Q., Willenbring, D., Kong, X.P., Cohen, A., Xu, Y., Tang, P.

	Description: X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel		Description: X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel

OCA: Protected "4f8h" [edit=sysop:move=sysop]

OCA — Wed, 23 May 2012 05:45:49 GMT

Protected "4f8h" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:45, 23 May 2012

OCA: New page: '''Unreleased structure''' The entry 4f8h is ON HOLD Authors: Pan, J.J., Chen, Q., Willenbring, D., Kong, X.P., Cohen, A., Xu, Y., Tang, P. Description: X-ray Structure of the Anesthet...

OCA — Wed, 23 May 2012 05:45:47 GMT

New page: '''Unreleased structure''' The entry 4f8h is ON HOLD Authors: Pan, J.J., Chen, Q., Willenbring, D., Kong, X.P., Cohen, A., Xu, Y., Tang, P. Description: X-ray Structure of the Anesthet...

New page

'''Unreleased structure'''

The entry 4f8h is ON HOLD

Authors: Pan, J.J., Chen, Q., Willenbring, D., Kong, X.P., Cohen, A., Xu, Y., Tang, P.

Description: X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel