4fhq - Revision history

OCA at 15:25, 14 March 2024

OCA — Thu, 14 Mar 2024 15:25:02 GMT

←Older revision		Revision as of 15:25, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fhq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FHQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fhq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FHQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [https://pdbe.org/4fhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [https://www.ebi.ac.uk/pdbsum/4fhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fhq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.251Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [https://pdbe.org/4fhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [https://www.ebi.ac.uk/pdbsum/4fhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fhq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref>		[https://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Many immune ligands and receptors are potential drug targets, which delicately manipulate a wide range of immune responses. We describe here the successful application of an efficient method to dramatically improve the heterologous expression levels in Drosophila Schneider 2 cells, which enables the high-throughput production of several important immune ligands/receptors for raising antibodies, and for the structural and functional analyses. As an example, we purified the protein and characterized the structure of the immune receptor herpesvirus entry mediator (HVEM, TNFRSF14). HVEM is a member of tumor necrosis factor receptor superfamily, which is recognized by herpes simplex virus glycoprotein D (gD) and facilitates viral entry. HVEM participates in a range of interactions with other cell surface molecules, including LIGHT, BTLA, and CD160 to modulate a wide range of immune processes in CD4+ and CD8+ T cells, as well as NK cells. Due to the involvement of HVEM in these diverse signaling interactions, crystal structures of HVEM in complex with gD or BTLA have been previously reported. Here, we report the structure of HVEM in the absence of any ligands.
-
-	Increased Heterologous Protein Expression in Drosophila S2 Cells for Massive Production of Immune Ligands/Receptors and Structural Analysis of Human HVEM.,Liu W, Vigdorovich V, Zhan C, Patskovsky Y, Bonanno JB, Nathenson SG, Almo SC Mol Biotechnol. 2015 Jul 23. PMID:26202493<ref>PMID:26202493</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4fhq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 19:49, 19 October 2022

OCA — Wed, 19 Oct 2022 19:49:37 GMT

←Older revision		Revision as of 19:49, 19 October 2022
Line 1:		Line 1:

	==Crystal Structure of HVEM==		==Crystal Structure of HVEM==
-	<StructureSection load='4fhq' size='340' side='right' caption='[[4fhq]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='4fhq' size='340' side='right'caption='[[4fhq]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fhq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FHQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fhq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FHQ FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw2\|2aw2]], [[1jma\|1jma]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [https://pdbe.org/4fhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [https://www.ebi.ac.uk/pdbsum/4fhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fhq ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HVEA, HVEM, TNFRSF14, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [~~http~~://pdbe.org/4fhq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fhq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fhq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN]] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref>	+	[https://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:

	==See Also==		==See Also==
-	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]	+	*[[Tumor necrosis factor receptor 3D structures\|Tumor necrosis factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Almo, S C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bhosle, R C~~]]	+	[[Category: Almo SC]]
-	[[Category: ~~IFN, Atoms-to-Animals:.The Immune Function Network~~]]	+	[[Category: Bhosle RC]]
-	[[Category: Liu, W]]	+	[[Category: Liu W]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Nathenson SG]]
-	[[Category: Nathenson~~, S G~~]]	+	[[Category: Patskovsky Y]]
-	[[Category: Patskovsky, Y]]	+	[[Category: Zhan C]]
-	[[Category: Zhan, C]]	+
-	~~[[Category: Atoms-to-animals: the immune function network]]~~	+
-	~~[[Category: Btla]]~~	+
-	~~[[Category: Cd160]]~~	+
-	~~[[Category: Cysteine rich domain]]~~	+
-	~~[[Category: Gd of hsv]]~~	+
-	~~[[Category: Ifn]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Tnf receptor]]~~	+
-	~~[[Category: Tnf14]]~~	+
-	~~[[Category: Tnfrsf~~]]	+

OCA at 17:35, 16 November 2017

OCA — Thu, 16 Nov 2017 17:35:47 GMT

←Older revision		Revision as of 17:35, 16 November 2017
Line 1:		Line 1:
		+
	==Crystal Structure of HVEM==		==Crystal Structure of HVEM==
	<StructureSection load='4fhq' size='340' side='right' caption='[[4fhq]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4fhq' size='340' side='right' caption='[[4fhq]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw2\|2aw2]], [[1jma\|1jma]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw2\|2aw2]], [[1jma\|1jma]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HVEA, HVEM, TNFRSF14, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HVEA, HVEM, TNFRSF14, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [http://pdbe.org/4fhq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [http://www.ebi.ac.uk/pdbsum/4fhq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [http://pdbe.org/4fhq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [http://www.ebi.ac.uk/pdbsum/4fhq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fhq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:11, 30 September 2015

OCA — Wed, 30 Sep 2015 06:11:02 GMT

←Older revision		Revision as of 06:11, 30 September 2015
Line 5:		Line 5:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw2\|2aw2]], [[1jma\|1jma]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw2\|2aw2]], [[1jma\|1jma]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HVEA, HVEM, TNFRSF14, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HVEA, HVEM, TNFRSF14, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [http://www.ebi.ac.uk/pdbsum/4fhq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [http://pdbe.org/4fhq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [http://www.ebi.ac.uk/pdbsum/4fhq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4fhq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:32, 2 September 2015

OCA — Wed, 02 Sep 2015 06:32:32 GMT

←Older revision		Revision as of 06:32, 2 September 2015
Line 2:		Line 2:
	<StructureSection load='4fhq' size='340' side='right' caption='[[4fhq]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4fhq' size='340' side='right' caption='[[4fhq]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fhq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FHQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fhq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FHQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw2\|2aw2]], [[1jma\|1jma]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw2\|2aw2]], [[1jma\|1jma]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HVEA, HVEM, TNFRSF14, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HVEA, HVEM, TNFRSF14, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [http://www.ebi.ac.uk/pdbsum/4fhq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [http://www.ebi.ac.uk/pdbsum/4fhq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN]] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref>		[[http://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN]] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many immune ligands and receptors are potential drug targets, which delicately manipulate a wide range of immune responses. We describe here the successful application of an efficient method to dramatically improve the heterologous expression levels in Drosophila Schneider 2 cells, which enables the high-throughput production of several important immune ligands/receptors for raising antibodies, and for the structural and functional analyses. As an example, we purified the protein and characterized the structure of the immune receptor herpesvirus entry mediator (HVEM, TNFRSF14). HVEM is a member of tumor necrosis factor receptor superfamily, which is recognized by herpes simplex virus glycoprotein D (gD) and facilitates viral entry. HVEM participates in a range of interactions with other cell surface molecules, including LIGHT, BTLA, and CD160 to modulate a wide range of immune processes in CD4+ and CD8+ T cells, as well as NK cells. Due to the involvement of HVEM in these diverse signaling interactions, crystal structures of HVEM in complex with gD or BTLA have been previously reported. Here, we report the structure of HVEM in the absence of any ligands.
		+
		+	Increased Heterologous Protein Expression in Drosophila S2 Cells for Massive Production of Immune Ligands/Receptors and Structural Analysis of Human HVEM.,Liu W, Vigdorovich V, Zhan C, Patskovsky Y, Bonanno JB, Nathenson SG, Almo SC Mol Biotechnol. 2015 Jul 23. PMID:26202493<ref>PMID:26202493</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+
		+	==See Also==
		+	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Bhosle, R C]]		[[Category: Bhosle, R C]]

OCA at 15:00, 24 December 2014

OCA — Wed, 24 Dec 2014 15:00:51 GMT

←Older revision		Revision as of 15:00, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fhq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FHQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fhq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FHQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw2\|2aw2]], [[1jma\|1jma]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw2\|2aw2]], [[1jma\|1jma]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HVEA, HVEM, TNFRSF14, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HVEA, HVEM, TNFRSF14, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [http://www.ebi.ac.uk/pdbsum/4fhq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [http://www.ebi.ac.uk/pdbsum/4fhq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN]] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Almo, S C.]]	+	[[Category: Almo, S C]]
-	[[Category: Bhosle, R C.]]	+	[[Category: Bhosle, R C]]
-	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]	+	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
-	[[Category: Liu, W.]]	+	[[Category: Liu, W]]
-	[[Category: ~~NYSGRC, New York~~ Structural ~~Genomics Research Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Nathenson, S G.]]	+	[[Category: Nathenson, S G]]
-	[[Category: Patskovsky, Y.]]	+	[[Category: Patskovsky, Y]]
-	[[Category: Zhan, C.]]	+	[[Category: Zhan, C]]
	[[Category: Atoms-to-animals: the immune function network]]		[[Category: Atoms-to-animals: the immune function network]]
	[[Category: Btla]]		[[Category: Btla]]
	[[Category: Cd160]]		[[Category: Cd160]]
-	[[Category: Cysteine rich domain]]
	[[Category: Cysteine rich domain]]		[[Category: Cysteine rich domain]]
	[[Category: Gd of hsv]]		[[Category: Gd of hsv]]
Line 27:		Line 30:
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Membrane]]		[[Category: Membrane]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
	[[Category: Psi-biology]]		[[Category: Psi-biology]]
	[[Category: Receptor]]		[[Category: Receptor]]
-	[[Category: Structural genomic]]
	[[Category: Tnf receptor]]		[[Category: Tnf receptor]]
	[[Category: Tnf14]]		[[Category: Tnf14]]
	[[Category: Tnfrsf]]		[[Category: Tnfrsf]]

OCA at 07:30, 5 June 2014

OCA — Thu, 05 Jun 2014 07:30:03 GMT

←Older revision		Revision as of 07:30, 5 June 2014
Line 1:		Line 1:
-	~~[[Image:4fhq.png\|left\|200px]]~~	+	==Crystal Structure of HVEM==
-		+	<StructureSection load='4fhq' size='340' side='right' caption='[[4fhq]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~{{STRUCTURE_4fhq\| PDB=4fhq \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4fhq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FHQ FirstGlance]. <br>
-	===Crystal Structure of HVEM===	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw2\|2aw2]], [[1jma\|1jma]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HVEA, HVEM, TNFRSF14, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fhq RCSB], [http://www.ebi.ac.uk/pdbsum/4fhq PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[4fhq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA].	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]

OCA at 06:04, 25 July 2012

OCA — Wed, 25 Jul 2012 06:04:55 GMT

←Older revision		Revision as of 06:04, 25 July 2012
Line 1:		Line 1:
-	[[Image:4fhq.~~jpg~~\|left\|200px]]	+	[[Image:4fhq.png\|left\|200px]]

	{{STRUCTURE_4fhq\| PDB=4fhq \| SCENE= }}		{{STRUCTURE_4fhq\| PDB=4fhq \| SCENE= }}
Line 13:		Line 13:
	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]		[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
	[[Category: Liu, W.]]		[[Category: Liu, W.]]
		+	[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
	[[Category: Nathenson, S G.]]		[[Category: Nathenson, S G.]]
	[[Category: Patskovsky, Y.]]		[[Category: Patskovsky, Y.]]

OCA at 05:32, 18 July 2012

OCA — Wed, 18 Jul 2012 05:32:04 GMT

←Older revision		Revision as of 05:32, 18 July 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4fhq.jpg\|left\|200px]]

-	~~The entry~~ 4fhq ~~is ON HOLD~~	+	{{STRUCTURE_4fhq\| PDB=4fhq \| SCENE= }}

-	~~Authors: Liu, W., Zhan, C., Patskovsky, Y., Bhosle, R.C., Nathenson, S.G., Almo, S.C., Atoms-to-Animals: The Immune Function Network (IFN)~~	+	===Crystal Structure of HVEM===

-	~~Description: Crystal~~ Structure of ~~HVEM~~	+
		+	==About this Structure==
		+	[[4fhq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHQ OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Almo, S C.]]
		+	[[Category: Bhosle, R C.]]
		+	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
		+	[[Category: Liu, W.]]
		+	[[Category: Nathenson, S G.]]
		+	[[Category: Patskovsky, Y.]]
		+	[[Category: Zhan, C.]]
		+	[[Category: Atoms-to-animals: the immune function network]]
		+	[[Category: Btla]]
		+	[[Category: Cd160]]
		+	[[Category: Cysteine rich domain]]
		+	[[Category: Cysteine rich domain]]
		+	[[Category: Gd of hsv]]
		+	[[Category: Ifn]]
		+	[[Category: Immune system]]
		+	[[Category: Membrane]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-biology]]
		+	[[Category: Receptor]]
		+	[[Category: Structural genomic]]
		+	[[Category: Tnf receptor]]
		+	[[Category: Tnf14]]
		+	[[Category: Tnfrsf]]

OCA: Protected "4fhq" [edit=sysop:move=sysop]

OCA — Wed, 13 Jun 2012 05:53:01 GMT

Protected "4fhq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:53, 13 June 2012