4fj2 - Revision history

OCA at 15:26, 14 March 2024

OCA — Thu, 14 Mar 2024 15:26:36 GMT

←Older revision		Revision as of 15:26, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fj2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Curvularia_lunata Curvularia lunata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FJ2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fj2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Curvularia_lunata Curvularia lunata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FJ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QSO:5,7-DIHYDROXY-3-(4-METHOXYPHENYL)-4H-CHROMEN-4-ONE'>QSO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QSO:5,7-DIHYDROXY-3-(4-METHOXYPHENYL)-4H-CHROMEN-4-ONE'>QSO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [https://pdbe.org/4fj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [https://www.ebi.ac.uk/pdbsum/4fj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fj2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [https://pdbe.org/4fj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [https://www.ebi.ac.uk/pdbsum/4fj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fj2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/O93874_COCLU O93874_COCLU]		[https://www.uniprot.org/uniprot/O93874_COCLU O93874_COCLU]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Phytoestrogens are plant-derived compounds that functionally and structurally mimic mammalian estrogens. Phytoestrogens have broad inhibitory activities toward several steroidogenic enzymes, such as the 17beta-hydroxysteroid dehydrogenases (17beta-HSDs), which modulate the biological potency of androgens and estrogens in mammals. However, to date, no crystallographic data are available to explain phytoestrogens binding to mammalian 17beta-HSDs. NADP(H)-dependent 17beta-HSD from the filamentous fungus Cochliobolus lunatus (17beta-HSDcl) has been the subject of extensive biochemical, kinetic and quantitative structure-activity relationship studies that have shown that the flavonols are the most potent inhibitors. In the present study, we investigated the structure-activity relationships of the ternary complexes between the holo form of 17beta-HSDcl and the flavonols kaempferol and 3,7-dihydroxyflavone, in comparison with the isoflavones genistein and biochanin A. Crystallographic data are accompanied by kinetic analysis of the inhibition mechanisms for six flavonols (3-hydroxyflavone, 3,7-dihydroxyflavone, kaempferol, quercetin, fisetin, myricetin), one flavanone (naringenin), one flavone (luteolin), and two isoflavones (genistein, biochanin A). The kinetics analysis shows that the degree of hydroxylation of ring B significantly influences the overall inhibitory efficacy of the flavonols. A distinct binding mode defines the interactions between 17beta-HSDcl and the flavones and isoflavones. Moreover, the complex with biochanin A reveals an unusual binding mode that appears to account for its greater inhibition of 17beta-HSDcl with respect to genistein. Overall, these data provide a blueprint for identification of the distinct molecular determinants that underpin 17beta-HSD inhibition by phytoestrogens.
-
-	Structural basis for inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17beta-HSDcl.,Cassetta A, Stojan J, Krastanova I, Kristan K, Brunskole Svegelj M, Lamba D, Rizner TL J Steroid Biochem Mol Biol. 2017 Jul;171:80-93. doi: 10.1016/j.jsbmb.2017.02.020., Epub 2017 Mar 1. PMID:28259640<ref>PMID:28259640</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4fj2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Hydroxysteroid dehydrogenase 3D structures\|Hydroxysteroid dehydrogenase 3D structures]]		*[[Hydroxysteroid dehydrogenase 3D structures\|Hydroxysteroid dehydrogenase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 19:51, 19 October 2022

OCA — Wed, 19 Oct 2022 19:51:32 GMT

←Older revision		Revision as of 19:51, 19 October 2022
Line 1:		Line 1:

	==Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and biochanin A==		==Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and biochanin A==
-	<StructureSection load='4fj2' size='340' side='right' caption='[[4fj2]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4fj2' size='340' side='right'caption='[[4fj2]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fj2]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Coclu Coclu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FJ2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FJ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fj2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Curvularia_lunata Curvularia lunata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FJ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QSO:5,7-DIHYDROXY-3-(4-METHOXYPHENYL)-4H-CHROMEN-4-ONE'>QSO</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QSO:5,7-DIHYDROXY-3-(4-METHOXYPHENYL)-4H-CHROMEN-4-ONE'>QSO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3is3\|3is3]], [[3qwf\|3qwf]], [[3itd\|3itd]], [[3qwi\|3qwi]], [[3qwh\|3qwh]], [[4fiz\|4fiz]], [[4fj0\|4fj0]], [[4fj1\|4fj1]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [https://pdbe.org/4fj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [https://www.ebi.ac.uk/pdbsum/4fj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fj2 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">17HSDcl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5503 COCLU])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/17-beta-estradiol_17-dehydrogenase 17-beta-estradiol 17-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [~~http~~://pdbe.org/4fj2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fj2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fj2 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O93874_COCLU O93874_COCLU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4fj2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4fj2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hydroxysteroid dehydrogenase 3D structures\|Hydroxysteroid dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~17-beta-estradiol 17-dehydrogenase~~]]	+	[[Category: Curvularia lunata]]
-	[[Category: ~~Coclu~~]]	+	[[Category: Large Structures]]
-	[[Category: Cassetta, A]]	+	[[Category: Cassetta A]]
-	[[Category: Krastanova, I]]	+	[[Category: Krastanova I]]
-	[[Category: Lamba, D]]	+	[[Category: Lamba D]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]~~	+
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Short chain dehydrogenase/reductase~~]]	+

OCA at 16:34, 20 October 2017

OCA — Fri, 20 Oct 2017 16:34:35 GMT

←Older revision		Revision as of 16:34, 20 October 2017
Line 10:		Line 10:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [http://pdbe.org/4fj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [http://www.ebi.ac.uk/pdbsum/4fj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fj2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [http://pdbe.org/4fj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [http://www.ebi.ac.uk/pdbsum/4fj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fj2 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phytoestrogens are plant-derived compounds that functionally and structurally mimic mammalian estrogens. Phytoestrogens have broad inhibitory activities toward several steroidogenic enzymes, such as the 17beta-hydroxysteroid dehydrogenases (17beta-HSDs), which modulate the biological potency of androgens and estrogens in mammals. However, to date, no crystallographic data are available to explain phytoestrogens binding to mammalian 17beta-HSDs. NADP(H)-dependent 17beta-HSD from the filamentous fungus Cochliobolus lunatus (17beta-HSDcl) has been the subject of extensive biochemical, kinetic and quantitative structure-activity relationship studies that have shown that the flavonols are the most potent inhibitors. In the present study, we investigated the structure-activity relationships of the ternary complexes between the holo form of 17beta-HSDcl and the flavonols kaempferol and 3,7-dihydroxyflavone, in comparison with the isoflavones genistein and biochanin A. Crystallographic data are accompanied by kinetic analysis of the inhibition mechanisms for six flavonols (3-hydroxyflavone, 3,7-dihydroxyflavone, kaempferol, quercetin, fisetin, myricetin), one flavanone (naringenin), one flavone (luteolin), and two isoflavones (genistein, biochanin A). The kinetics analysis shows that the degree of hydroxylation of ring B significantly influences the overall inhibitory efficacy of the flavonols. A distinct binding mode defines the interactions between 17beta-HSDcl and the flavones and isoflavones. Moreover, the complex with biochanin A reveals an unusual binding mode that appears to account for its greater inhibition of 17beta-HSDcl with respect to genistein. Overall, these data provide a blueprint for identification of the distinct molecular determinants that underpin 17beta-HSD inhibition by phytoestrogens.

-	==~~See Also~~==	+	Structural basis for inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17beta-HSDcl.,Cassetta A, Stojan J, Krastanova I, Kristan K, Brunskole Svegelj M, Lamba D, Rizner TL J Steroid Biochem Mol Biol. 2017 Jul;171:80-93. doi: 10.1016/j.jsbmb.2017.02.020., Epub 2017 Mar 1. PMID:28259640<ref>PMID:28259640</ref>
-	*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4fj2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:18, 11 August 2016

OCA — Thu, 11 Aug 2016 08:18:30 GMT

←Older revision		Revision as of 08:18, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and biochanin A==		==Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and biochanin A==
	<StructureSection load='4fj2' size='340' side='right' caption='[[4fj2]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4fj2' size='340' side='right' caption='[[4fj2]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">17HSDcl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5503 COCLU])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">17HSDcl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5503 COCLU])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/17-beta-estradiol_17-dehydrogenase 17-beta-estradiol 17-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/17-beta-estradiol_17-dehydrogenase 17-beta-estradiol 17-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [http://www.ebi.ac.uk/pdbsum/4fj2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [http://pdbe.org/4fj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [http://www.ebi.ac.uk/pdbsum/4fj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fj2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:39, 25 January 2015

OCA — Sun, 25 Jan 2015 09:39:30 GMT

←Older revision		Revision as of 09:39, 25 January 2015
Line 2:		Line 2:
	<StructureSection load='4fj2' size='340' side='right' caption='[[4fj2]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4fj2' size='340' side='right' caption='[[4fj2]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fj2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FJ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fj2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coclu Coclu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FJ2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QSO:5,7-DIHYDROXY-3-(4-METHOXYPHENYL)-4H-CHROMEN-4-ONE'>QSO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QSO:5,7-DIHYDROXY-3-(4-METHOXYPHENYL)-4H-CHROMEN-4-ONE'>QSO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3is3\|3is3]], [[3qwf\|3qwf]], [[3itd\|3itd]], [[3qwi\|3qwi]], [[3qwh\|3qwh]], [[4fiz\|4fiz]], [[4fj0\|4fj0]], [[4fj1\|4fj1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3is3\|3is3]], [[3qwf\|3qwf]], [[3itd\|3itd]], [[3qwi\|3qwi]], [[3qwh\|3qwh]], [[4fiz\|4fiz]], [[4fj0\|4fj0]], [[4fj1\|4fj1]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">17HSDcl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5503 COCLU])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/17-beta-estradiol_17-dehydrogenase 17-beta-estradiol 17-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/17-beta-estradiol_17-dehydrogenase 17-beta-estradiol 17-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [http://www.ebi.ac.uk/pdbsum/4fj2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [http://www.ebi.ac.uk/pdbsum/4fj2 PDBsum]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: 17-beta-estradiol 17-dehydrogenase]]		[[Category: 17-beta-estradiol 17-dehydrogenase]]
-	[[Category: Cassetta, A.]]	+	[[Category: Coclu]]
-	[[Category: Krastanova, I.]]	+	[[Category: Cassetta, A]]
-	[[Category: Lamba, D.]]	+	[[Category: Krastanova, I]]
		+	[[Category: Lamba, D]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
	[[Category: Short chain dehydrogenase/reductase]]		[[Category: Short chain dehydrogenase/reductase]]

OCA at 09:35, 29 October 2014

OCA — Wed, 29 Oct 2014 09:35:13 GMT

←Older revision		Revision as of 09:35, 29 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4fj2\| PDB=4fj2 \| SCENE= }}~~	+	==Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and biochanin A==
-	===Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and biochanin A===	+	<StructureSection load='4fj2' size='340' side='right' caption='[[4fj2]], [[Resolution\|resolution]] 2.50Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[4fj2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FJ2 FirstGlance]. <br>
-	[[4fj2]] is a 4 chain structure ~~with sequence~~ from [http://en.wikipedia.org/wiki/~~Curvularia_lunata Curvularia lunata~~]. ~~Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~4FJ2~~ OCA].	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QSO:5,7-DIHYDROXY-3-(4-METHOXYPHENYL)-4H-CHROMEN-4-ONE'>QSO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3is3\|3is3]], [[3qwf\|3qwf]], [[3itd\|3itd]], [[3qwi\|3qwi]], [[3qwh\|3qwh]], [[4fiz\|4fiz]], [[4fj0\|4fj0]], [[4fj1\|4fj1]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/17-beta-estradiol_17-dehydrogenase 17-beta-estradiol 17-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fj2 RCSB], [http://www.ebi.ac.uk/pdbsum/4fj2 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: 17-beta-estradiol 17-dehydrogenase]]		[[Category: 17-beta-estradiol 17-dehydrogenase]]
-	[[Category: Curvularia lunata]]
	[[Category: Cassetta, A.]]		[[Category: Cassetta, A.]]
	[[Category: Krastanova, I.]]		[[Category: Krastanova, I.]]

OCA at 14:14, 3 July 2013

OCA — Wed, 03 Jul 2013 14:14:48 GMT

←Older revision		Revision as of 14:14, 3 July 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4fj2\| PDB=4fj2 \| SCENE= }}
		+	===Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and biochanin A===

-	~~The entry~~ 4fj2 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4fj2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Curvularia_lunata Curvularia lunata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FJ2 OCA].
-	~~Authors~~: Cassetta, A., Lamba, D.~~, Krastanova, I.~~	+	[[Category: 17-beta-estradiol 17-dehydrogenase]]
-		+	[[Category: Curvularia lunata]]
-	~~Description~~: ~~Crystal structure of the ternary complex between a fungal 17beta~~-~~hydroxysteroid~~ dehydrogenase ~~(Holo form) and biochanin A~~	+	[[Category: Cassetta, A.]]
		+	[[Category: Krastanova, I.]]
		+	[[Category: Lamba, D.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
		+	[[Category: Rossmann fold]]
		+	[[Category: Short chain dehydrogenase/reductase]]

OCA at 07:16, 4 July 2012

OCA — Wed, 04 Jul 2012 07:16:41 GMT

←Older revision		Revision as of 07:16, 4 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4fj2 is ON HOLD	+	The entry 4fj2 is ON HOLD until Paper Publication

	Authors: Cassetta, A., Lamba, D., Krastanova, I.		Authors: Cassetta, A., Lamba, D., Krastanova, I.

	Description: Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and biochanin A		Description: Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and biochanin A

OCA: Protected "4fj2" [edit=sysop:move=sysop]

OCA — Wed, 20 Jun 2012 07:26:52 GMT

Protected "4fj2" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 20 June 2012

OCA: New page: '''Unreleased structure''' The entry 4fj2 is ON HOLD Authors: Cassetta, A., Lamba, D., Krastanova, I. Description: Crystal structure of the ternary complex between a fungal 17beta-hydr...

OCA — Wed, 20 Jun 2012 07:26:51 GMT

New page: '''Unreleased structure''' The entry 4fj2 is ON HOLD Authors: Cassetta, A., Lamba, D., Krastanova, I. Description: Crystal structure of the ternary complex between a fungal 17beta-hydr...

New page

'''Unreleased structure'''

The entry 4fj2 is ON HOLD

Authors: Cassetta, A., Lamba, D., Krastanova, I.

Description: Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and biochanin A