4fka - Revision history

OCA at 15:27, 14 March 2024

OCA — Thu, 14 Mar 2024 15:27:12 GMT

←Older revision		Revision as of 15:27, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fka]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FKA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fka]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FKA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.08Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fka OCA], [https://pdbe.org/4fka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fka RCSB], [https://www.ebi.ac.uk/pdbsum/4fka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fka ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fka OCA], [https://pdbe.org/4fka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fka RCSB], [https://www.ebi.ac.uk/pdbsum/4fka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fka ProSAT]</span></td></tr>
	</table>		</table>

OCA at 19:54, 19 October 2022

OCA — Wed, 19 Oct 2022 19:54:27 GMT

←Older revision		Revision as of 19:54, 19 October 2022
Line 3:		Line 3:
	<StructureSection load='4fka' size='340' side='right'caption='[[4fka]], [[Resolution\|resolution]] 1.08Å' scene=''>		<StructureSection load='4fka' size='340' side='right'caption='[[4fka]], [[Resolution\|resolution]] 1.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fka]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FKA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fka]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FKA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3exx\|3exx]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fka OCA], [https://pdbe.org/4fka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fka RCSB], [https://www.ebi.ac.uk/pdbsum/4fka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fka ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fka OCA], [~~http~~://pdbe.org/4fka PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fka RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fka PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fka ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[~~http~~://omim.org/entry/176730 176730]].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[~~http~~://omim.org/entry/125852 125852]]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[~~http~~://omim.org/entry/606176 606176]]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[~~http~~://omim.org/entry/613370 613370]]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>	+	[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[https://omim.org/entry/176730 176730].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[https://omim.org/entry/125852 125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[https://omim.org/entry/606176 606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[https://omim.org/entry/613370 613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	+	[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

	==See Also==		==See Also==
-	*[[~~Molecular Playground/~~Insulin\|~~Molecular Playground/~~Insulin]]	+	*[[Insulin 3D Structures\|Insulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 20:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Matkovic-Calogovic, D]]	+	[[Category: Matkovic-Calogovic D]]
-	[[Category: Prugovecki, B]]	+	[[Category: Prugovecki B]]
-	[[Category: Pulic, I]]	+	[[Category: Pulic I]]
-	[[Category: Toth, M]]	+	[[Category: Toth M]]
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Manganese-insulin derivative~~]]	+

OCA at 07:44, 27 March 2019

OCA — Wed, 27 Mar 2019 07:44:48 GMT

←Older revision		Revision as of 07:44, 27 March 2019
Line 1:		Line 1:

	==High resolution structure of the manganese derivative of insulin==		==High resolution structure of the manganese derivative of insulin==
-	<StructureSection load='4fka' size='340' side='right' caption='[[4fka]], [[Resolution\|resolution]] 1.08Å' scene=''>	+	<StructureSection load='4fka' size='340' side='right'caption='[[4fka]], [[Resolution\|resolution]] 1.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fka]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FKA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fka]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FKA FirstGlance]. <br>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Matkovic-Calogovic, D]]		[[Category: Matkovic-Calogovic, D]]
	[[Category: Prugovecki, B]]		[[Category: Prugovecki, B]]

OCA at 20:05, 15 December 2016

OCA — Thu, 15 Dec 2016 20:05:12 GMT

←Older revision		Revision as of 20:05, 15 December 2016
Line 1:		Line 1:
		+
	==High resolution structure of the manganese derivative of insulin==		==High resolution structure of the manganese derivative of insulin==
	<StructureSection load='4fka' size='340' side='right' caption='[[4fka]], [[Resolution\|resolution]] 1.08Å' scene=''>		<StructureSection load='4fka' size='340' side='right' caption='[[4fka]], [[Resolution\|resolution]] 1.08Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3exx\|3exx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3exx\|3exx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fka OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fka RCSB], [http://www.ebi.ac.uk/pdbsum/4fka PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fka OCA], [http://pdbe.org/4fka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fka RCSB], [http://www.ebi.ac.uk/pdbsum/4fka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fka ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 16:58, 9 December 2014

OCA — Tue, 09 Dec 2014 16:58:40 GMT

←Older revision		Revision as of 16:58, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4fka.~~jpg~~\|~~left~~\|~~200px~~]]	+	==High resolution structure of the manganese derivative of insulin==
		+	<StructureSection load='4fka' size='340' side='right' caption='[[4fka]], [[Resolution\|resolution]] 1.08Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4fka]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FKA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3exx\|3exx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fka OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fka RCSB], [http://www.ebi.ac.uk/pdbsum/4fka PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[http://omim.org/entry/176730 176730]].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[http://omim.org/entry/125852 125852]]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[http://omim.org/entry/606176 606176]]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[http://omim.org/entry/613370 613370]]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

-	~~{{STRUCTURE_4fka\| PDB~~=~~4fka \| SCENE= }}~~	+	==See Also==
-		+	*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]
-	~~===High resolution structure of the manganese derivative of insulin~~===	+	== References ==
-		+	<references/>
-		+	__TOC__
-	==~~About this Structure~~==	+	</StructureSection>
-	~~[[4fka]] is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKA OCA].~~	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Matkovic-Calogovic, D.]]	+	[[Category: Matkovic-Calogovic, D]]
-	[[Category: Prugovecki, B.]]	+	[[Category: Prugovecki, B]]
-	[[Category: Pulic, I.]]	+	[[Category: Pulic, I]]
-	[[Category: Toth, M.]]	+	[[Category: Toth, M]]
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Manganese-insulin derivative]]		[[Category: Manganese-insulin derivative]]

OCA at 10:41, 13 February 2013

OCA — Wed, 13 Feb 2013 10:41:51 GMT

←Older revision		Revision as of 10:41, 13 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4fka.jpg\|left\|200px]]

-	~~The entry~~ 4fka ~~is ON HOLD~~	+	{{STRUCTURE_4fka\| PDB=4fka \| SCENE= }}

-	~~Authors: Prugovecki, B., Pulic, I., Toth, M., Matkovic-Calogovic, D.~~	+	===High resolution structure of the manganese derivative of insulin===

-	~~Description: High resolution~~ structure ~~of the manganese derivative of~~ insulin	+
		+	==About this Structure==
		+	[[4fka]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKA OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Matkovic-Calogovic, D.]]
		+	[[Category: Prugovecki, B.]]
		+	[[Category: Pulic, I.]]
		+	[[Category: Toth, M.]]
		+	[[Category: Hormone]]
		+	[[Category: Manganese-insulin derivative]]

OCA: Protected "4fka" [edit=sysop:move=sysop]

OCA — Wed, 20 Jun 2012 07:28:10 GMT

Protected "4fka" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:28, 20 June 2012

OCA: New page: '''Unreleased structure''' The entry 4fka is ON HOLD Authors: Prugovecki, B., Pulic, I., Toth, M., Matkovic-Calogovic, D. Description: High resolution structure of the manganese deriva...

OCA — Wed, 20 Jun 2012 07:28:09 GMT

New page: '''Unreleased structure''' The entry 4fka is ON HOLD Authors: Prugovecki, B., Pulic, I., Toth, M., Matkovic-Calogovic, D. Description: High resolution structure of the manganese deriva...

New page

'''Unreleased structure'''

The entry 4fka is ON HOLD

Authors: Prugovecki, B., Pulic, I., Toth, M., Matkovic-Calogovic, D.

Description: High resolution structure of the manganese derivative of insulin