4fm8 - Revision history

OCA at 19:58, 19 October 2022

OCA — Wed, 19 Oct 2022 19:58:29 GMT

←Older revision		Revision as of 19:58, 19 October 2022
Line 1:		Line 1:

	==Crystal Structure of BACE with Compound 12a==		==Crystal Structure of BACE with Compound 12a==
-	<StructureSection load='4fm8' size='340' side='right' caption='[[4fm8]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4fm8' size='340' side='right'caption='[[4fm8]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fm8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FM8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FM8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fm8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FM8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0UQ:(5R,7S)-1-(3-FLUOROPHENYL)-3,7-DIMETHYL-8-[3-(PROPAN-2-YLOXY)BENZYL]-2-THIA-1,3,8-TRIAZASPIRO[4.5]DECANE+2,2-DIOXIDE'>0UQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0UQ:(5R,7S)-1-(3-FLUOROPHENYL)-3,7-DIMETHYL-8-[3-(PROPAN-2-YLOXY)BENZYL]-2-THIA-1,3,8-TRIAZASPIRO[4.5]DECANE+2,2-DIOXIDE'>0UQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fm8 OCA], [https://pdbe.org/4fm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fm8 RCSB], [https://www.ebi.ac.uk/pdbsum/4fm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fm8 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fm8 OCA], [~~http~~://pdbe.org/4fm8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fm8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fm8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fm8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Memapsin 2~~]]	+	[[Category: Large Structures]]
-	[[Category: Vajdos~~, F F~~]]	+	[[Category: Vajdos FF]]
-	[[Category: Varghese~~, A H]]~~	+	[[Category: Varghese AH]]
-	~~[[Category: Aspartyl protease]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 09:14, 4 August 2016

OCA — Thu, 04 Aug 2016 09:14:14 GMT

←Older revision		Revision as of 09:14, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of BACE with Compound 12a==		==Crystal Structure of BACE with Compound 12a==
	<StructureSection load='4fm8' size='340' side='right' caption='[[4fm8]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4fm8' size='340' side='right' caption='[[4fm8]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fm8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FM8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fm8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FM8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0UQ:(5R,7S)-1-(3-FLUOROPHENYL)-3,7-DIMETHYL-8-[3-(PROPAN-2-YLOXY)BENZYL]-2-THIA-1,3,8-TRIAZASPIRO[4.5]DECANE+2,2-DIOXIDE'>0UQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0UQ:(5R,7S)-1-(3-FLUOROPHENYL)-3,7-DIMETHYL-8-[3-(PROPAN-2-YLOXY)BENZYL]-2-THIA-1,3,8-TRIAZASPIRO[4.5]DECANE+2,2-DIOXIDE'>0UQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4fm8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fm8 OCA], [http://pdbe.org/4fm8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4fm8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fm8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4fm8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Vajdos, F F]]		[[Category: Vajdos, F F]]

OCA at 07:42, 25 December 2014

OCA — Thu, 25 Dec 2014 07:42:44 GMT

←Older revision		Revision as of 07:42, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4fm8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4fm8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:27, 21 December 2014

OCA — Sun, 21 Dec 2014 11:27:52 GMT

←Older revision		Revision as of 11:27, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4fm8~~\| ~~PDB~~=4fm8 \| ~~SCENE~~= }}	+	==Crystal Structure of BACE with Compound 12a==
-	===~~Crystal Structure of~~ BACE with ~~Compound 12a~~===	+	<StructureSection load='4fm8' size='340' side='right' caption='[[4fm8]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22984865}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4fm8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FM8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0UQ:(5R,7S)-1-(3-FLUOROPHENYL)-3,7-DIMETHYL-8-[3-(PROPAN-2-YLOXY)BENZYL]-2-THIA-1,3,8-TRIAZASPIRO[4.5]DECANE+2,2-DIOXIDE'>0UQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4fm8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	beta-Secretase (BACE-1) is an attractive therapeutic target for the treatment and prevention of Alzheimer's disease (AD). Herein, we describe the discovery of a novel class of BACE-1 inhibitors represented by sulfamide 14g, using a medicinal chemistry strategy to optimize CNS penetration by minimizing hydrogen bond donors (HBD) and reducing P-glycoprotein (P-gp) mediated efflux. We have also taken advantage of the combination of structure based drug design (SBDD) to guide the optimization of the sulfamide analogs and the in-silico tool WaterMap to explain the observed SAR. Compound 14g is a potent inhibitor of BACE-1 with excellent permeability and a moderate P-gp liability. Administration of 14g to mice produced a significant, dose-dependent reduction in central AbetaX-40 levels at a free drug exposure equivalent to the whole cell IC(50) (100 nM). Furthermore, studies in the P-gp knock-out mouse provided evidence that efflux transporters impacted the amount of Abeta lowering versus that observed in wild-type (WT) mouse at equivalent dose.

-	~~==Function==~~	+	Spirocyclic Sulfamides as BACE-1 Inhibitors for the Treatment of Alzheimer's Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies to Identify Centrally Efficacious Inhibitors.,Brodney MA, Barreiro G, Ogilvie K, Hajos-Korcsok E, Murray JC, Vajdos FF, Ambroise C, Christoffersen C, Fisher KE, Lanyon L, Liu J, Nolan CE, Withka JM, Borzilleri KA, Efremov IV, Oborski CE, Varghese AH, O'Neill BT J Med Chem. 2012 Sep 17. PMID:22984865<ref>PMID:22984865</ref>
-	~~[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible~~ for the ~~proteolytic processing~~ of ~~the amyloid precursor protein (APP). Cleaves at the N-terminus~~ of ~~the A-beta peptide sequence~~, ~~between residues 671~~ and ~~672 of APP~~, ~~leads to the generation and extracellular release of beta~~-~~cleaved soluble APP~~, ~~and a corresponding cell-associated~~ C~~-terminal fragment which is later released by gamma-secretase~~.~~<ref>~~PMID:~~10677483</ref>~~ <ref>PMID:~~20354142~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4fm8]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4FM8 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:022984865</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Beta secretase\|Beta secretase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Vajdos, F F.]]	+	[[Category: Vajdos, F F]]
-	[[Category: Varghese, A H.]]	+	[[Category: Varghese, A H]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 08:29, 19 June 2013

OCA — Wed, 19 Jun 2013 08:29:56 GMT

←Older revision		Revision as of 08:29, 19 June 2013
Line 1:		Line 1:
-	[[Image:4fm8.jpg\|left\|200px]]
-
	{{STRUCTURE_4fm8\| PDB=4fm8 \| SCENE= }}		{{STRUCTURE_4fm8\| PDB=4fm8 \| SCENE= }}
-
	===Crystal Structure of BACE with Compound 12a===		===Crystal Structure of BACE with Compound 12a===
-
	{{ABSTRACT_PUBMED_22984865}}		{{ABSTRACT_PUBMED_22984865}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

	==About this Structure==		==About this Structure==
	[[4fm8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FM8 OCA].		[[4fm8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FM8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022984865</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]

OCA at 06:12, 3 October 2012

OCA — Wed, 03 Oct 2012 06:12:35 GMT

←Older revision		Revision as of 06:12, 3 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4fm8.jpg\|left\|200px]]

-	~~The entry~~ 4fm8 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4fm8\| PDB=4fm8 \| SCENE= }}

-	~~Authors: Vajdos, F.F., Varghese, A.H.~~	+	===Crystal Structure of BACE with Compound 12a===

-	~~Description: Crystal~~ Structure ~~of BACE~~ with ~~Compound 12a~~	+	{{ABSTRACT_PUBMED_22984865}}
		+
		+	==About this Structure==
		+	[[4fm8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FM8 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Memapsin 2]]
		+	[[Category: Vajdos, F F.]]
		+	[[Category: Varghese, A H.]]
		+	[[Category: Aspartyl protease]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 05:02, 18 July 2012

OCA — Wed, 18 Jul 2012 05:02:02 GMT

←Older revision		Revision as of 05:02, 18 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4fm8 is ON HOLD	+	The entry 4fm8 is ON HOLD until Paper Publication

	Authors: Vajdos, F.F., Varghese, A.H.		Authors: Vajdos, F.F., Varghese, A.H.

	Description: Crystal Structure of BACE with Compound 12a		Description: Crystal Structure of BACE with Compound 12a

OCA: Protected "4fm8" [edit=sysop:move=sysop]

OCA — Wed, 27 Jun 2012 05:26:35 GMT

Protected "4fm8" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 27 June 2012

OCA: New page: '''Unreleased structure''' The entry 4fm8 is ON HOLD Authors: Vajdos, F.F., Varghese, A.H. Description: Crystal Structure of BACE with Compound 12a

OCA — Wed, 27 Jun 2012 05:26:34 GMT

New page: '''Unreleased structure''' The entry 4fm8 is ON HOLD Authors: Vajdos, F.F., Varghese, A.H. Description: Crystal Structure of BACE with Compound 12a

New page

'''Unreleased structure'''

The entry 4fm8 is ON HOLD

Authors: Vajdos, F.F., Varghese, A.H.

Description: Crystal Structure of BACE with Compound 12a