4fmj - Revision history

OCA at 19:58, 19 October 2022

OCA — Wed, 19 Oct 2022 19:58:50 GMT

←Older revision		Revision as of 19:58, 19 October 2022
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-	~~{{Large structure}}~~	+
	==Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide==		==Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide==
-	<StructureSection load='4fmj' size='340' side='right' caption='[[4fmj]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4fmj' size='340' side='right'caption='[[4fmj]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fmj]] is a 20 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Merkel_cell_polyomavirus Merkel cell polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FMJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fmj]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Merkel_cell_polyomavirus Merkel cell polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FMJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=~~GOL~~:~~GLYCEROL~~'>~~GOL~~</scene>, <scene name='pdbligand=~~SIA~~:~~O-SIALIC+ACID~~'>~~SIA~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-~~D-GALACTOSE~~'>~~GAL~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fmg\|4fmg]], [[4fmh\|4fmh]], [[4fmi\|4fmi]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmj OCA], [https://pdbe.org/4fmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fmj RCSB], [https://www.ebi.ac.uk/pdbsum/4fmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fmj ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=493803 Merkel cell polyomavirus])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmj OCA], [~~http~~://pdbe.org/4fmj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fmj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fmj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fmj ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~{{Large structure}}~~	+	== Function ==
		+	[https://www.uniprot.org/uniprot/C0JPK1_9POLY C0JPK1_9POLY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4fmj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4fmj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Merkel cell polyomavirus]]		[[Category: Merkel cell polyomavirus]]
-	[[Category: Hengel, H]]	+	[[Category: Hengel H]]
-	[[Category: Neu, U]]	+	[[Category: Neu U]]
-	[[Category: Stehle, T]]	+	[[Category: Stehle T]]
-	~~[[Category: Encapsidation]]~~	+
-	~~[[Category: Jelly roll]]~~	+
-	~~[[Category: Receptor binding]]~~	+
-	~~[[Category: Sialylated oligosaccharide]]~~	+
-	~~[[Category: Viral capsid protein]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 14:06, 4 August 2016

OCA — Thu, 04 Aug 2016 14:06:26 GMT

←Older revision		Revision as of 14:06, 4 August 2016
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		+	{{Large structure}}
	==Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide==		==Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide==
	<StructureSection load='4fmj' size='340' side='right' caption='[[4fmj]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4fmj' size='340' side='right' caption='[[4fmj]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fmg\|4fmg]], [[4fmh\|4fmh]], [[4fmi\|4fmi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fmg\|4fmg]], [[4fmh\|4fmh]], [[4fmi\|4fmi]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=493803 Merkel cell polyomavirus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=493803 Merkel cell polyomavirus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fmj RCSB], [http://www.ebi.ac.uk/pdbsum/4fmj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmj OCA], [http://pdbe.org/4fmj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fmj RCSB], [http://www.ebi.ac.uk/pdbsum/4fmj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fmj ProSAT]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4fmj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:38, 18 December 2014

OCA — Thu, 18 Dec 2014 08:38:22 GMT

←Older revision		Revision as of 08:38, 18 December 2014
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-	~~{{Large structure}}~~	+	==Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide==
-	~~{{STRUCTURE_4fmj\| PDB~~=4fmj \| ~~SCENE~~= }}	+	<StructureSection load='4fmj' size='340' side='right' caption='[[4fmj]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	===Merkel cell polyomavirus VP1 ~~in complex with GD1a oligosaccharide~~===	+	== Structural highlights ==
-	~~{{ABSTRACT_PUBMED_22910713}}~~	+	<table><tr><td colspan='2'>[[4fmj]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Merkel_cell_polyomavirus Merkel cell polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FMJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fmg\|4fmg]], [[4fmh\|4fmh]], [[4fmi\|4fmi]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=493803 Merkel cell polyomavirus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fmj RCSB], [http://www.ebi.ac.uk/pdbsum/4fmj PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals. Conflicting reports suggest that cellular glycans containing sialic acid (Neu5Ac) may play a role in MCPyV infectious entry. To address this question, we solved X-ray structures of the MCPyV major capsid protein VP1 both alone and in complex with several sialylated oligosaccharides. A shallow binding site on the apical surface of the VP1 capsomer recognizes the disaccharide Neu5Ac-alpha2,3-Gal through a complex network of interactions. MCPyV engages Neu5Ac in an orientation and with contacts that differ markedly from those observed in other polyomavirus complexes with sialylated receptors. Mutations in the Neu5Ac binding site abolish MCPyV infection, highlighting the relevance of the Neu5Ac interaction for MCPyV entry. Our study thus provides a powerful platform for the development of MCPyV-specific vaccines and antivirals. Interestingly, engagement of sialic acid does not interfere with initial attachment of MCPyV to cells, consistent with a previous proposal that attachment is mediated by a class of non-sialylated carbohydrates called glycosaminoglycans. Our results therefore suggest a model in which sialylated glycans serve as secondary, post-attachment co-receptors during MCPyV infectious entry. Since cell-surface glycans typically serve as primary attachment receptors for many viruses, we identify here a new role for glycans in mediating, and perhaps even modulating, post-attachment entry processes.

-	~~==About this Structure==~~	+	Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection.,Neu U, Hengel H, Blaum BS, Schowalter RM, Macejak D, Gilbert M, Wakarchuk WW, Imamura A, Ando H, Kiso M, Arnberg N, Garcea RL, Peters T, Buck CB, Stehle T PLoS Pathog. 2012 Jul;8(7):e1002738. Epub 2012 Jul 26. PMID:22910713<ref>PMID:22910713</ref>
-	~~[[4fmj]] is~~ a ~~20 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Merkel_cell_polyomavirus Merkel cell polyomavirus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4FMJ OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Merkel cell polyomavirus]]		[[Category: Merkel cell polyomavirus]]
-	[[Category: Hengel, H.]]	+	[[Category: Hengel, H]]
-	[[Category: Neu, U.]]	+	[[Category: Neu, U]]
-	[[Category: Stehle, T.]]	+	[[Category: Stehle, T]]
	[[Category: Encapsidation]]		[[Category: Encapsidation]]
	[[Category: Jelly roll]]		[[Category: Jelly roll]]

OCA at 08:24, 11 March 2013

OCA — Mon, 11 Mar 2013 08:24:41 GMT

←Older revision		Revision as of 08:24, 11 March 2013
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-	~~[[Image:4fmj.jpg\|left\|200px]]~~	+	{{Large structure}}
-		+
	{{STRUCTURE_4fmj\| PDB=4fmj \| SCENE= }}		{{STRUCTURE_4fmj\| PDB=4fmj \| SCENE= }}
-
	===Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide===		===Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide===
-
	{{ABSTRACT_PUBMED_22910713}}		{{ABSTRACT_PUBMED_22910713}}

OCA at 05:23, 5 September 2012

OCA — Wed, 05 Sep 2012 05:23:44 GMT

←Older revision		Revision as of 05:23, 5 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4fmj.jpg\|left\|200px]]

-	~~The entry~~ 4fmj ~~is ON HOLD~~	+	{{STRUCTURE_4fmj\| PDB=4fmj \| SCENE= }}

-	~~Authors: Neu, U., Hengel, H., Stehle, T.~~	+	===Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide===

-	~~Description~~: Merkel cell polyomavirus ~~VP1 in complex with GD1a~~ oligosaccharide	+	{{ABSTRACT_PUBMED_22910713}}
		+
		+	==About this Structure==
		+	[[4fmj]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Merkel_cell_polyomavirus Merkel cell polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMJ OCA].
		+	[[Category: Merkel cell polyomavirus]]
		+	[[Category: Hengel, H.]]
		+	[[Category: Neu, U.]]
		+	[[Category: Stehle, T.]]
		+	[[Category: Encapsidation]]
		+	[[Category: Jelly roll]]
		+	[[Category: Receptor binding]]
		+	[[Category: Sialylated oligosaccharide]]
		+	[[Category: Viral capsid protein]]
		+	[[Category: Viral protein]]

OCA: Protected "4fmj" [edit=sysop:move=sysop]

OCA — Wed, 27 Jun 2012 05:26:53 GMT

Protected "4fmj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 27 June 2012

OCA: New page: '''Unreleased structure''' The entry 4fmj is ON HOLD Authors: Neu, U., Hengel, H., Stehle, T. Description: Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide

OCA — Wed, 27 Jun 2012 05:26:52 GMT

New page: '''Unreleased structure''' The entry 4fmj is ON HOLD Authors: Neu, U., Hengel, H., Stehle, T. Description: Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide

New page

'''Unreleased structure'''

The entry 4fmj is ON HOLD

Authors: Neu, U., Hengel, H., Stehle, T.

Description: Merkel cell polyomavirus VP1 in complex with GD1a oligosaccharide