4fqn - Revision history

OCA at 11:23, 1 March 2024

OCA — Fri, 01 Mar 2024 11:23:01 GMT

←Older revision		Revision as of 11:23, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fqn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fqn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqn OCA], [https://pdbe.org/4fqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqn RCSB], [https://www.ebi.ac.uk/pdbsum/4fqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqn ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqn OCA], [https://pdbe.org/4fqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqn RCSB], [https://www.ebi.ac.uk/pdbsum/4fqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqn ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 10:		Line 11:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).		[https://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Cerebral cavernous malformations (CCM) are neurovascular dysplasias affecting up to 0.5% of the population. Mutations in the CCM2 gene are associated with acquisition of CCM. We identify a previously uncharacterized domain at the C-terminus of CCM2 and determine its 1.9A resolution crystal structure. Because this domain is structurally homologous to the N-terminal domain of harmonin, we name it the CCM2 harmonin-homology domain or HHD. CCM2 HHD is observed in two conformations, and we employ analytical ultracentrifugation to test its oligomerization. Additionally, CCM2 HHD contains an unusually long 13-residue 3(10) helix. This study provides the first structural characterization of CCM2. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: CCM2binds to CCM3 by pull down (View interaction) CCM2 and CCM2bind by X-ray crystallography (View interaction) CCM2 and CCM2bind by molecular sieving (View interaction).
-
-	Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus.,Fisher OS, Zhang R, Li X, Murphy JW, Demeler B, Boggon TJ FEBS Lett. 2013 Jan 31;587(3):272-7. doi: 10.1016/j.febslet.2012.12.011. Epub, 2012 Dec 22. PMID:23266514<ref>PMID:23266514</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4fqn" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:06, 19 October 2022

OCA — Wed, 19 Oct 2022 20:06:12 GMT

←Older revision		Revision as of 20:06, 19 October 2022
Line 1:		Line 1:

	==Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)==		==Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)==
-	<StructureSection load='4fqn' size='340' side='right' caption='[[4fqn]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4fqn' size='340' side='right'caption='[[4fqn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fqn]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fqn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQN FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C7orf22, CCM2, PP10187 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqn OCA], [https://pdbe.org/4fqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqn RCSB], [https://www.ebi.ac.uk/pdbsum/4fqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqn OCA], [~~http~~://pdbe.org/4fqn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fqn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fqn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).	+	[https://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Boggon~~, T J~~]]	+	[[Category: Large Structures]]
-	[[Category: Fisher~~, O S~~]]	+	[[Category: Boggon TJ]]
-	[[Category: Li, X]]	+	[[Category: Fisher OS]]
-	[[Category: Murphy~~, J W~~]]	+	[[Category: Li X]]
-	[[Category: Zhang, R]]	+	[[Category: Murphy JW]]
-	~~[[Category: Harmonin-homology domain]]~~	+	[[Category: Zhang R]]
-	~~[[Category: Helical domain]]~~	+
-	~~[[Category: Homo-dimer]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein-protein interaction~~]]	+

OCA at 19:55, 15 December 2016

OCA — Thu, 15 Dec 2016 19:55:17 GMT

←Older revision		Revision as of 19:55, 15 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)==		==Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)==
	<StructureSection load='4fqn' size='340' side='right' caption='[[4fqn]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4fqn' size='340' side='right' caption='[[4fqn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQN FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C7orf22, CCM2, PP10187 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C7orf22, CCM2, PP10187 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fqn RCSB], [http://www.ebi.ac.uk/pdbsum/4fqn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqn OCA], [http://pdbe.org/4fqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fqn RCSB], [http://www.ebi.ac.uk/pdbsum/4fqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4fqn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Boggon, T J]]		[[Category: Boggon, T J]]
	[[Category: Fisher, O S]]		[[Category: Fisher, O S]]

OCA at 15:47, 9 December 2014

OCA — Tue, 09 Dec 2014 15:47:22 GMT

←Older revision		Revision as of 15:47, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4fqn.~~png~~\|~~left\|200px~~]]	+	==Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)==
		+	<StructureSection load='4fqn' size='340' side='right' caption='[[4fqn]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4fqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQN FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C7orf22, CCM2, PP10187 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fqn RCSB], [http://www.ebi.ac.uk/pdbsum/4fqn PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cerebral cavernous malformations (CCM) are neurovascular dysplasias affecting up to 0.5% of the population. Mutations in the CCM2 gene are associated with acquisition of CCM. We identify a previously uncharacterized domain at the C-terminus of CCM2 and determine its 1.9A resolution crystal structure. Because this domain is structurally homologous to the N-terminal domain of harmonin, we name it the CCM2 harmonin-homology domain or HHD. CCM2 HHD is observed in two conformations, and we employ analytical ultracentrifugation to test its oligomerization. Additionally, CCM2 HHD contains an unusually long 13-residue 3(10) helix. This study provides the first structural characterization of CCM2. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: CCM2binds to CCM3 by pull down (View interaction) CCM2 and CCM2bind by X-ray crystallography (View interaction) CCM2 and CCM2bind by molecular sieving (View interaction).

-	~~{{STRUCTURE_4fqn\| PDB=4fqn \| SCENE= }}~~	+	Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus.,Fisher OS, Zhang R, Li X, Murphy JW, Demeler B, Boggon TJ FEBS Lett. 2013 Jan 31;587(3):272-7. doi: 10.1016/j.febslet.2012.12.011. Epub, 2012 Dec 22. PMID:23266514<ref>PMID:23266514</ref>

-	~~===Crystal structure~~ of the ~~CCM2 C-terminal Harmonin Homology Domain (HHD)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23266514}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4fqn]] is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Boggon, T J.]]	+	[[Category: Boggon, T J]]
-	[[Category: Fisher, O S.]]	+	[[Category: Fisher, O S]]
-	[[Category: Li, X.]]	+	[[Category: Li, X]]
-	[[Category: Murphy, J W.]]	+	[[Category: Murphy, J W]]
-	[[Category: Zhang, R.]]	+	[[Category: Zhang, R]]
	[[Category: Harmonin-homology domain]]		[[Category: Harmonin-homology domain]]
	[[Category: Helical domain]]		[[Category: Helical domain]]

OCA at 13:24, 27 February 2013

OCA — Wed, 27 Feb 2013 13:24:39 GMT

←Older revision		Revision as of 13:24, 27 February 2013
Line 5:		Line 5:
	===Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)===		===Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)===

		+	{{ABSTRACT_PUBMED_23266514}}

	==About this Structure==		==About this Structure==

OCA at 09:30, 13 February 2013

OCA — Wed, 13 Feb 2013 09:30:07 GMT

←Older revision		Revision as of 09:30, 13 February 2013
Line 1:		Line 1:
-	[[Image:4fqn.~~jpg~~\|left\|200px]]	+	[[Image:4fqn.png\|left\|200px]]

	{{STRUCTURE_4fqn\| PDB=4fqn \| SCENE= }}		{{STRUCTURE_4fqn\| PDB=4fqn \| SCENE= }}

OCA at 11:36, 19 December 2012

OCA — Wed, 19 Dec 2012 11:36:08 GMT

←Older revision		Revision as of 11:36, 19 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4fqn.jpg\|left\|200px]]

-	~~The entry~~ 4fqn ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4fqn\| PDB=4fqn \| SCENE= }}

-	~~Authors: Fisher, O.S., Zhang, R., Li, X., Murphy, J.W., Boggon, T.J.~~	+	===Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)===

-	~~Description~~: ~~Protein~~ X	+
		+	==About this Structure==
		+	[[4fqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Boggon, T J.]]
		+	[[Category: Fisher, O S.]]
		+	[[Category: Li, X.]]
		+	[[Category: Murphy, J W.]]
		+	[[Category: Zhang, R.]]
		+	[[Category: Harmonin-homology domain]]
		+	[[Category: Helical domain]]
		+	[[Category: Homo-dimer]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein-protein interaction]]

OCA at 05:02, 18 July 2012

OCA — Wed, 18 Jul 2012 05:02:39 GMT

←Older revision		Revision as of 05:02, 18 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4fqn is ON HOLD	+	The entry 4fqn is ON HOLD until Paper Publication

	Authors: Fisher, O.S., Zhang, R., Li, X., Murphy, J.W., Boggon, T.J.		Authors: Fisher, O.S., Zhang, R., Li, X., Murphy, J.W., Boggon, T.J.

	Description: Protein X		Description: Protein X

OCA: Protected "4fqn" [edit=sysop:move=sysop]

OCA — Wed, 04 Jul 2012 07:19:44 GMT

Protected "4fqn" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:19, 4 July 2012

OCA: New page: '''Unreleased structure''' The entry 4fqn is ON HOLD Authors: Fisher, O.S., Zhang, R., Li, X., Murphy, J.W., Boggon, T.J. Description: Protein X

OCA — Wed, 04 Jul 2012 07:19:44 GMT

New page: '''Unreleased structure''' The entry 4fqn is ON HOLD Authors: Fisher, O.S., Zhang, R., Li, X., Murphy, J.W., Boggon, T.J. Description: Protein X

New page

'''Unreleased structure'''

The entry 4fqn is ON HOLD

Authors: Fisher, O.S., Zhang, R., Li, X., Murphy, J.W., Boggon, T.J.

Description: Protein X