4fqp - Revision history

OCA at 15:31, 14 March 2024

OCA — Thu, 14 Mar 2024 15:31:49 GMT

←Older revision		Revision as of 15:31, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqp OCA], [https://pdbe.org/4fqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqp RCSB], [https://www.ebi.ac.uk/pdbsum/4fqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqp OCA], [https://pdbe.org/4fqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqp RCSB], [https://www.ebi.ac.uk/pdbsum/4fqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PVR_HUMAN PVR_HUMAN] Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.<ref>PMID:15471548</ref> <ref>PMID:15607800</ref>		[https://www.uniprot.org/uniprot/PVR_HUMAN PVR_HUMAN] Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.<ref>PMID:15471548</ref> <ref>PMID:15607800</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Nectins are immunoglobulin superfamily glycoproteins that mediate intercellular adhesion in many vertebrate tissues. Homophilic and heterophilic interactions between nectin family members help mediate tissue patterning. We determined the homophilic binding affinities and heterophilic specificities of all four nectins and the related protein nectin-like 5 (Necl-5) from human and mouse, revealing a range of homophilic interaction strengths and a defined heterophilic specificity pattern. To understand the molecular basis of their adhesion and specificity, we determined the crystal structures of natively glycosylated full ectodomains or adhesive fragments of all four nectins and Necl-5. All of the crystal structures revealed dimeric nectins bound through a stereotyped interface that was previously proposed to represent a cis dimer. However, conservation of this interface and the results of targeted cross-linking experiments showed that this dimer probably represents the adhesive trans interaction. The structure of the dimer provides a simple molecular explanation for the adhesive binding specificity of nectins.
-
-	Nectin ectodomain structures reveal a canonical adhesive interface.,Harrison OJ, Vendome J, Brasch J, Jin X, Hong S, Katsamba PS, Ahlsen G, Troyanovsky RB, Troyanovsky SM, Honig B, Shapiro L Nat Struct Mol Biol. 2012 Aug 19. doi: 10.1038/nsmb.2366. PMID:22902367<ref>PMID:22902367</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4fqp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:06, 19 October 2022

OCA — Wed, 19 Oct 2022 20:06:18 GMT

←Older revision		Revision as of 20:06, 19 October 2022
Line 1:		Line 1:

	==Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)==		==Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)==
-	<StructureSection load='4fqp' size='340' side='right' caption='[[4fqp]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<StructureSection load='4fqp' size='340' side='right'caption='[[4fqp]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fqp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FQP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA~~</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG~~</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4fmf\|4fmf]], [[4fmk\|4fmk]], [[4fn0\|4fn0]], [[4fom\|4fom]], [[4frw\|4frw]], [[4fs0\|4fs0]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqp OCA], [https://pdbe.org/4fqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqp RCSB], [https://www.ebi.ac.uk/pdbsum/4fqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqp ProSAT]</span></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">PVR, PVS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqp OCA], [~~http~~://pdbe.org/4fqp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fqp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fqp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqp ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PVR_HUMAN PVR_HUMAN]] Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.<ref>PMID:15471548</ref> <ref>PMID:15607800</ref>	+	[https://www.uniprot.org/uniprot/PVR_HUMAN PVR_HUMAN] Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.<ref>PMID:15471548</ref> <ref>PMID:15607800</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Brasch, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Harrison, O~~ J]]	+	[[Category: Brasch J]]
-	[[Category: ~~Jin, X~~]]	+	[[Category: Harrison OJ]]
-	[[Category: ~~Shapiro, L~~]]	+	[[Category: Jin X]]
-	[[Category: ~~Cell adhesion]]~~	+	[[Category: Shapiro L]]
-	~~[[Category: Ig domain]]~~	+
-	~~[[Category: Immunoglobulin-like domain]]~~	+
-	~~[[Category: Viral entry receptor~~]]	+

OCA at 14:41, 4 August 2016

OCA — Thu, 04 Aug 2016 14:41:29 GMT

←Older revision		Revision as of 14:41, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)==		==Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)==
	<StructureSection load='4fqp' size='340' side='right' caption='[[4fqp]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='4fqp' size='340' side='right' caption='[[4fqp]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fmf\|4fmf]], [[4fmk\|4fmk]], [[4fn0\|4fn0]], [[4fom\|4fom]], [[4frw\|4frw]], [[4fs0\|4fs0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fmf\|4fmf]], [[4fmk\|4fmk]], [[4fn0\|4fn0]], [[4fom\|4fom]], [[4frw\|4frw]], [[4fs0\|4fs0]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVR, PVS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVR, PVS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fqp RCSB], [http://www.ebi.ac.uk/pdbsum/4fqp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqp OCA], [http://pdbe.org/4fqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fqp RCSB], [http://www.ebi.ac.uk/pdbsum/4fqp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4fqp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Brasch, J]]		[[Category: Brasch, J]]
	[[Category: Harrison, O J]]		[[Category: Harrison, O J]]

OCA at 10:13, 25 December 2014

OCA — Thu, 25 Dec 2014 10:13:00 GMT

←Older revision		Revision as of 10:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fmf\|4fmf]], [[4fmk\|4fmk]], [[4fn0\|4fn0]], [[4fom\|4fom]], [[4frw\|4frw]], [[4fs0\|4fs0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fmf\|4fmf]], [[4fmk\|4fmk]], [[4fn0\|4fn0]], [[4fom\|4fom]], [[4frw\|4frw]], [[4fs0\|4fs0]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVR, PVS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVR, PVS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fqp RCSB], [http://www.ebi.ac.uk/pdbsum/4fqp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fqp RCSB], [http://www.ebi.ac.uk/pdbsum/4fqp PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PVR_HUMAN PVR_HUMAN]] Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.<ref>PMID:15471548</ref> <ref>PMID:15607800</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Brasch, J.]]	+	[[Category: Brasch, J]]
-	[[Category: Harrison, O J.]]	+	[[Category: Harrison, O J]]
-	[[Category: Jin, X.]]	+	[[Category: Jin, X]]
-	[[Category: Shapiro, L.]]	+	[[Category: Shapiro, L]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Ig domain]]		[[Category: Ig domain]]
	[[Category: Immunoglobulin-like domain]]		[[Category: Immunoglobulin-like domain]]
	[[Category: Viral entry receptor]]		[[Category: Viral entry receptor]]

OCA at 06:53, 25 June 2014

OCA — Wed, 25 Jun 2014 06:53:38 GMT

←Older revision		Revision as of 06:53, 25 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4fqp.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)==
		+	<StructureSection load='4fqp' size='340' side='right' caption='[[4fqp]], [[Resolution\|resolution]] 3.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4fqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fmf\|4fmf]], [[4fmk\|4fmk]], [[4fn0\|4fn0]], [[4fom\|4fom]], [[4frw\|4frw]], [[4fs0\|4fs0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVR, PVS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fqp RCSB], [http://www.ebi.ac.uk/pdbsum/4fqp PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nectins are immunoglobulin superfamily glycoproteins that mediate intercellular adhesion in many vertebrate tissues. Homophilic and heterophilic interactions between nectin family members help mediate tissue patterning. We determined the homophilic binding affinities and heterophilic specificities of all four nectins and the related protein nectin-like 5 (Necl-5) from human and mouse, revealing a range of homophilic interaction strengths and a defined heterophilic specificity pattern. To understand the molecular basis of their adhesion and specificity, we determined the crystal structures of natively glycosylated full ectodomains or adhesive fragments of all four nectins and Necl-5. All of the crystal structures revealed dimeric nectins bound through a stereotyped interface that was previously proposed to represent a cis dimer. However, conservation of this interface and the results of targeted cross-linking experiments showed that this dimer probably represents the adhesive trans interaction. The structure of the dimer provides a simple molecular explanation for the adhesive binding specificity of nectins.

-	~~{{STRUCTURE_4fqp\| PDB=4fqp \| SCENE= }}~~	+	Nectin ectodomain structures reveal a canonical adhesive interface.,Harrison OJ, Vendome J, Brasch J, Jin X, Hong S, Katsamba PS, Ahlsen G, Troyanovsky RB, Troyanovsky SM, Honig B, Shapiro L Nat Struct Mol Biol. 2012 Aug 19. doi: 10.1038/nsmb.2366. PMID:22902367<ref>PMID:22902367</ref>

-	~~===Crystal structure~~ of ~~human Nectin-like 5 full ectodomain (D1-D3)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22902367}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4fqp]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brasch, J.]]		[[Category: Brasch, J.]]

OCA at 05:23, 5 September 2012

OCA — Wed, 05 Sep 2012 05:23:56 GMT

←Older revision		Revision as of 05:23, 5 September 2012
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-	[[Image:4fqp.~~jpg~~\|left\|200px]]	+	[[Image:4fqp.png\|left\|200px]]

	{{STRUCTURE_4fqp\| PDB=4fqp \| SCENE= }}		{{STRUCTURE_4fqp\| PDB=4fqp \| SCENE= }}
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	===Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)===		===Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)===

		+	{{ABSTRACT_PUBMED_22902367}}

	==About this Structure==		==About this Structure==

OCA at 06:08, 22 August 2012

OCA — Wed, 22 Aug 2012 06:08:02 GMT

←Older revision		Revision as of 06:08, 22 August 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4fqp.jpg\|left\|200px]]

-	~~The entry~~ 4fqp ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4fqp\| PDB=4fqp \| SCENE= }}

-	~~Authors: Harrison, O.J., Jin, X., Brasch, J., Shapiro, L.~~	+	===Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)===

-	~~Description: Crystal~~ structure ~~of human Nectin~~-~~like 5 full ectodomain (D1~~-~~D3)~~	+
		+	==About this Structure==
		+	[[4fqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQP OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Brasch, J.]]
		+	[[Category: Harrison, O J.]]
		+	[[Category: Jin, X.]]
		+	[[Category: Shapiro, L.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Ig domain]]
		+	[[Category: Immunoglobulin-like domain]]
		+	[[Category: Viral entry receptor]]

OCA at 04:54, 8 August 2012

OCA — Wed, 08 Aug 2012 04:54:16 GMT

←Older revision		Revision as of 04:54, 8 August 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4fqp is ON HOLD	+	The entry 4fqp is ON HOLD until Paper Publication

	Authors: Harrison, O.J., Jin, X., Brasch, J., Shapiro, L.		Authors: Harrison, O.J., Jin, X., Brasch, J., Shapiro, L.

	Description: Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)		Description: Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)

OCA: Protected "4fqp" [edit=sysop:move=sysop]

OCA — Wed, 04 Jul 2012 07:19:48 GMT

Protected "4fqp" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:19, 4 July 2012

OCA: New page: '''Unreleased structure''' The entry 4fqp is ON HOLD Authors: Harrison, O.J., Jin, X., Brasch, J., Shapiro, L. Description: Crystal structure of human Nectin-like 5 full ectodomain (D1...

OCA — Wed, 04 Jul 2012 07:19:47 GMT

New page: '''Unreleased structure''' The entry 4fqp is ON HOLD Authors: Harrison, O.J., Jin, X., Brasch, J., Shapiro, L. Description: Crystal structure of human Nectin-like 5 full ectodomain (D1...

New page

'''Unreleased structure'''

The entry 4fqp is ON HOLD

Authors: Harrison, O.J., Jin, X., Brasch, J., Shapiro, L.

Description: Crystal structure of human Nectin-like 5 full ectodomain (D1-D3)