4frj - Revision history

OCA at 20:07, 19 October 2022

OCA — Wed, 19 Oct 2022 20:07:31 GMT

←Older revision		Revision as of 20:07, 19 October 2022
Line 1:		Line 1:

	==Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l==		==Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l==
-	<StructureSection load='4frj' size='340' side='right' caption='[[4frj]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='4frj' size='340' side='right'caption='[[4frj]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4frj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FRJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4frj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FRJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DWB:(4S)-2-(5-CHLORO-2-FLUOROPHENYL)-7-METHOXYSPIRO[1,3-OXAZOLE-4,9-XANTHEN]-2-AMINE'>DWB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DWB:(4S)-2-(5-CHLORO-2-FLUOROPHENYL)-7-METHOXYSPIRO[1,3-OXAZOLE-4,9-XANTHEN]-2-AMINE'>DWB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fri\|4fri]], [[4frk\|4frk]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4frj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frj OCA], [https://pdbe.org/4frj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4frj RCSB], [https://www.ebi.ac.uk/pdbsum/4frj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4frj ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4frj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frj OCA], [~~http~~://pdbe.org/4frj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4frj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4frj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4frj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Memapsin 2~~]]	+	[[Category: Large Structures]]
-	[[Category: Long~~, A M~~]]	+	[[Category: Long AM]]
-	[[Category: Whittington~~, D A]]~~	+	[[Category: Whittington DA]]
-	~~[[Category: Alzheimer's disease]]~~	+
-	~~[[Category: Aspartic protease]]~~	+
-	~~[[Category: Hydrolase-inhibitor complex]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 19:27, 5 August 2016

OCA — Fri, 05 Aug 2016 19:27:43 GMT

←Older revision		Revision as of 19:27, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l==		==Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l==
	<StructureSection load='4frj' size='340' side='right' caption='[[4frj]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4frj' size='340' side='right' caption='[[4frj]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4frj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FRJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4frj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FRJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DWB:(4S)-2-(5-CHLORO-2-FLUOROPHENYL)-7-METHOXYSPIRO[1,3-OXAZOLE-4,9-XANTHEN]-2-AMINE'>DWB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DWB:(4S)-2-(5-CHLORO-2-FLUOROPHENYL)-7-METHOXYSPIRO[1,3-OXAZOLE-4,9-XANTHEN]-2-AMINE'>DWB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fri\|4fri]], [[4frk\|4frk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fri\|4fri]], [[4frk\|4frk]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4frj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4frj RCSB], [http://www.ebi.ac.uk/pdbsum/4frj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4frj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frj OCA], [http://pdbe.org/4frj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4frj RCSB], [http://www.ebi.ac.uk/pdbsum/4frj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4frj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4frj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Long, A M]]		[[Category: Long, A M]]

OCA at 05:13, 25 December 2014

OCA — Thu, 25 Dec 2014 05:13:05 GMT

←Older revision		Revision as of 05:13, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4frj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4frj RCSB], [http://www.ebi.ac.uk/pdbsum/4frj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4frj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4frj RCSB], [http://www.ebi.ac.uk/pdbsum/4frj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:15, 9 December 2014

OCA — Tue, 09 Dec 2014 16:15:50 GMT

←Older revision		Revision as of 16:15, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4frj.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l==
		+	<StructureSection load='4frj' size='340' side='right' caption='[[4frj]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4frj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FRJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DWB:(4S)-2-(5-CHLORO-2-FLUOROPHENYL)-7-METHOXYSPIRO[1,3-OXAZOLE-4,9-XANTHEN]-2-AMINE'>DWB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fri\|4fri]], [[4frk\|4frk]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4frj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4frj RCSB], [http://www.ebi.ac.uk/pdbsum/4frj PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A structure- and property-based drug design approach was employed to identify aminooxazoline xanthenes as potent and selective human beta-secretase inhibitors. These compounds exhibited good enzyme, cell potency, and selectivity against the structurally related aspartyl protease cathepsin D. Our efforts resulted in the identification of a potent, orally bioavailable CNS penetrant compound that exhibited in vivo efficacy. A single oral dose of compound 11a resulted in a robust reduction of CNS Abeta40 in naive rats.

-	~~{{STRUCTURE_4frj\| PDB=4frj \| SCENE= }}~~	+	Structure and Property Based Design of Aminooxazoline Xanthenes as Selective and Orally Efficacious, CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer's Disease.,Huang H, La DS, Cheng AC, Whittington DA, Patel VF, Chen K, Dineen TA, Epstein O, Graceffa R, Hickman D, Kiang YH, Louie S, Luo Y, Wahl R, Wen P, Wood S, Fremeau B J Med Chem. 2012 Aug 28. PMID:22928914<ref>PMID:22928914</ref>

-	~~===Crystal structure~~ of ~~BACE1 in complex with aminooxazoline xanthene 9l===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22928914}}~~	+	==See Also==
-		+	*[[Beta secretase\|Beta secretase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4frj~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRJ OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Long, A M.]]	+	[[Category: Long, A M]]
-	[[Category: Whittington, D A.]]	+	[[Category: Whittington, D A]]
	[[Category: Alzheimer's disease]]		[[Category: Alzheimer's disease]]
	[[Category: Aspartic protease]]		[[Category: Aspartic protease]]
	[[Category: Hydrolase-inhibitor complex]]		[[Category: Hydrolase-inhibitor complex]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 21:33, 12 December 2012

OCA — Wed, 12 Dec 2012 21:33:26 GMT

←Older revision		Revision as of 21:33, 12 December 2012
Line 1:		Line 1:
-	[[Image:4frj.~~jpg~~\|left\|200px]]	+	[[Image:4frj.png\|left\|200px]]

	{{STRUCTURE_4frj\| PDB=4frj \| SCENE= }}		{{STRUCTURE_4frj\| PDB=4frj \| SCENE= }}

OCA at 05:16, 12 September 2012

OCA — Wed, 12 Sep 2012 05:16:14 GMT

←Older revision		Revision as of 05:16, 12 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4frj.jpg\|left\|200px]]

-	~~The entry~~ 4frj ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4frj\| PDB=4frj \| SCENE= }}

-	~~Authors: Whittington, D.A., Long, A.M.~~	+	===Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l===

-	~~Description: Crystal~~ structure ~~of BACE1 in complex~~ with ~~aminooxazoline xanthene 9l~~	+	{{ABSTRACT_PUBMED_22928914}}
		+
		+	==About this Structure==
		+	[[4frj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRJ OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Memapsin 2]]
		+	[[Category: Long, A M.]]
		+	[[Category: Whittington, D A.]]
		+	[[Category: Alzheimer's disease]]
		+	[[Category: Aspartic protease]]
		+	[[Category: Hydrolase-inhibitor complex]]
		+	[[Category: Membrane protein]]

OCA at 06:46, 25 July 2012

OCA — Wed, 25 Jul 2012 06:46:48 GMT

←Older revision		Revision as of 06:46, 25 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4frj is ON HOLD	+	The entry 4frj is ON HOLD until Paper Publication

	Authors: Whittington, D.A., Long, A.M.		Authors: Whittington, D.A., Long, A.M.

	Description: Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l		Description: Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l

OCA: Protected "4frj" [edit=sysop:move=sysop]

OCA — Wed, 04 Jul 2012 07:20:38 GMT

Protected "4frj" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:20, 4 July 2012

OCA: New page: '''Unreleased structure''' The entry 4frj is ON HOLD Authors: Whittington, D.A., Long, A.M. Description: Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l

OCA — Wed, 04 Jul 2012 07:20:38 GMT

New page: '''Unreleased structure''' The entry 4frj is ON HOLD Authors: Whittington, D.A., Long, A.M. Description: Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l

New page

'''Unreleased structure'''

The entry 4frj is ON HOLD

Authors: Whittington, D.A., Long, A.M.

Description: Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l