4ftf - Revision history

OCA at 20:09, 19 October 2022

OCA — Wed, 19 Oct 2022 20:09:47 GMT

←Older revision		Revision as of 20:09, 19 October 2022
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	==Structure of the Type II secretion system pilotin AspS from Vibrio cholerae==		==Structure of the Type II secretion system pilotin AspS from Vibrio cholerae==
-	<StructureSection load='4ftf' size='340' side='right' caption='[[4ftf]], [[Resolution\|resolution]] 1.48Å' scene=''>	+	<StructureSection load='4ftf' size='340' side='right'caption='[[4ftf]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ftf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Vibrio_cholera_569b~~ Vibrio ~~cholera 569b~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FTF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FTF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ftf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_569B Vibrio cholerae 569B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FTF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VC395_1821, VC_1703 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44104 Vibrio cholera 569B])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ftf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ftf OCA], [https://pdbe.org/4ftf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ftf RCSB], [https://www.ebi.ac.uk/pdbsum/4ftf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ftf ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ftf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ftf OCA], [~~http~~://pdbe.org/4ftf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ftf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ftf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ftf ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9KRD9_VIBCH Q9KRD9_VIBCH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio cholera 569b~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Evans, T J~~]]	+	[[Category: Vibrio cholerae 569B]]
-	[[Category: ~~Korotkov, K V~~]]	+	[[Category: Evans TJ]]
-	[[Category: ~~Lipoprotein]]~~	+	[[Category: Korotkov KV]]
-	~~[[Category: Outer membrane]]~~	+
-	~~[[Category: Pfamb pb000779]]~~	+
-	~~[[Category: Pilotin]]~~	+
-	~~[[Category: Protein secretion]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Secretin]]~~	+
-	~~[[Category: Secretin binding~~]]	+

OCA at 20:03, 15 December 2016

OCA — Thu, 15 Dec 2016 20:03:25 GMT

←Older revision		Revision as of 20:03, 15 December 2016
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		+
	==Structure of the Type II secretion system pilotin AspS from Vibrio cholerae==		==Structure of the Type II secretion system pilotin AspS from Vibrio cholerae==
	<StructureSection load='4ftf' size='340' side='right' caption='[[4ftf]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='4ftf' size='340' side='right' caption='[[4ftf]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ftf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Vibrio_cholerae_569b~~ Vibrio ~~cholerae~~ 569b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FTF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ftf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholera_569b Vibrio cholera 569b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FTF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VC395_1821, VC_1703 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44104 Vibrio ~~cholerae~~ 569B])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VC395_1821, VC_1703 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44104 Vibrio cholera 569B])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ftf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ftf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ftf RCSB], [http://www.ebi.ac.uk/pdbsum/4ftf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ftf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ftf OCA], [http://pdbe.org/4ftf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ftf RCSB], [http://www.ebi.ac.uk/pdbsum/4ftf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ftf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ftf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Vibrio ~~cholerae~~ 569b]]	+	[[Category: Vibrio cholera 569b]]
	[[Category: Evans, T J]]		[[Category: Evans, T J]]
	[[Category: Korotkov, K V]]		[[Category: Korotkov, K V]]

OCA at 15:09, 9 December 2014

OCA — Tue, 09 Dec 2014 15:09:40 GMT

←Older revision		Revision as of 15:09, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4ftf.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of the Type II secretion system pilotin AspS from Vibrio cholerae==
		+	<StructureSection load='4ftf' size='340' side='right' caption='[[4ftf]], [[Resolution\|resolution]] 1.48Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ftf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae_569b Vibrio cholerae 569b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FTF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VC395_1821, VC_1703 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44104 Vibrio cholerae 569B])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ftf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ftf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ftf RCSB], [http://www.ebi.ac.uk/pdbsum/4ftf PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Type II Secretion System (T2SS) is a molecular machine that drives the secretion of fully-folded protein substrates across the bacterial outer membrane. A key element in the machinery is the secretin: an integral, multimeric outer membrane protein that forms the secretion pore. We show that three distinct forms of T2SSs can be distinguished based on the sequence characteristics of their secretin pores. Detailed comparative analysis of two of these, the Klebsiella-type and Vibrio-type, showed them to be further distinguished by the pilotin that mediates their transport and assembly into the outer membrane. We have determined the crystal structure of the novel pilotin AspS from Vibrio cholerae, demonstrating convergent evolution wherein AspS is functionally equivalent and yet structurally unrelated to the pilotins found in Klebsiella and other bacteria. AspS binds to a specific targeting sequence in the Vibrio-type secretins, enhances the kinetics of secretin assembly, and homologs of AspS are found in all species of Vibrio as well those few strains of Escherichia and Shigella that have acquired a Vibrio-type T2SS.

-	~~{{STRUCTURE_4ftf\| PDB=4ftf \| SCENE= }}~~	+	Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS.,Dunstan RA, Heinz E, Wijeyewickrema LC, Pike RN, Purcell AW, Evans TJ, Praszkier J, Robins-Browne RM, Strugnell RA, Korotkov KV, Lithgow T PLoS Pathog. 2013 Jan;9(1):e1003117. doi: 10.1371/journal.ppat.1003117. Epub 2013, Jan 10. PMID:23326233<ref>PMID:23326233</ref>

-	~~===Structure~~ of the ~~Type II secretion system pilotin AspS from Vibrio cholerae===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23326233}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4ftf]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Vibrio_cholerae_569b Vibrio cholerae 569b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FTF OCA].~~	+	</StructureSection>
	[[Category: Vibrio cholerae 569b]]		[[Category: Vibrio cholerae 569b]]
-	[[Category: Evans, T J.]]	+	[[Category: Evans, T J]]
-	[[Category: Korotkov, K V.]]	+	[[Category: Korotkov, K V]]
	[[Category: Lipoprotein]]		[[Category: Lipoprotein]]
	[[Category: Outer membrane]]		[[Category: Outer membrane]]

OCA at 12:55, 6 February 2013

OCA — Wed, 06 Feb 2013 12:55:35 GMT

←Older revision		Revision as of 12:55, 6 February 2013
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-	[[Image:4ftf.~~jpg~~\|left\|200px]]	+	[[Image:4ftf.png\|left\|200px]]

	{{STRUCTURE_4ftf\| PDB=4ftf \| SCENE= }}		{{STRUCTURE_4ftf\| PDB=4ftf \| SCENE= }}
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	===Structure of the Type II secretion system pilotin AspS from Vibrio cholerae===		===Structure of the Type II secretion system pilotin AspS from Vibrio cholerae===

		+	{{ABSTRACT_PUBMED_23326233}}

	==About this Structure==		==About this Structure==

OCA at 14:38, 28 November 2012

OCA — Wed, 28 Nov 2012 14:38:39 GMT

←Older revision		Revision as of 14:38, 28 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ftf.jpg\|left\|200px]]

-	~~The entry~~ 4ftf ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4ftf\| PDB=4ftf \| SCENE= }}

-	~~Authors: Korotkov, K.V., Evans, T.J.~~	+	===Structure of the Type II secretion system pilotin AspS from Vibrio cholerae===

-	~~Description:~~ Structure of secretion ~~system protein~~	+
		+	==About this Structure==
		+	[[4ftf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae_569b Vibrio cholerae 569b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FTF OCA].
		+	[[Category: Vibrio cholerae 569b]]
		+	[[Category: Evans, T J.]]
		+	[[Category: Korotkov, K V.]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Outer membrane]]
		+	[[Category: Pfamb pb000779]]
		+	[[Category: Pilotin]]
		+	[[Category: Protein secretion]]
		+	[[Category: Protein transport]]
		+	[[Category: Secretin]]
		+	[[Category: Secretin binding]]

OCA at 06:47, 25 July 2012

OCA — Wed, 25 Jul 2012 06:47:11 GMT

←Older revision		Revision as of 06:47, 25 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ftf is ON HOLD	+	The entry 4ftf is ON HOLD until Paper Publication

	Authors: Korotkov, K.V., Evans, T.J.		Authors: Korotkov, K.V., Evans, T.J.

	Description: Structure of secretion system protein		Description: Structure of secretion system protein

OCA: Protected "4ftf" [edit=sysop:move=sysop]

OCA — Wed, 04 Jul 2012 07:22:32 GMT

Protected "4ftf" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:22, 4 July 2012

OCA: New page: '''Unreleased structure''' The entry 4ftf is ON HOLD Authors: Korotkov, K.V., Evans, T.J. Description: Structure of secretion system protein

OCA — Wed, 04 Jul 2012 07:22:31 GMT

New page: '''Unreleased structure''' The entry 4ftf is ON HOLD Authors: Korotkov, K.V., Evans, T.J. Description: Structure of secretion system protein

New page

'''Unreleased structure'''

The entry 4ftf is ON HOLD

Authors: Korotkov, K.V., Evans, T.J.

Description: Structure of secretion system protein