4fxm - Revision history

OCA at 15:35, 14 March 2024

OCA — Thu, 14 Mar 2024 15:35:53 GMT

←Older revision		Revision as of 15:35, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FXM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FXM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MMP:N-METHYLMESOPORPHYRIN'>MMP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.651Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MMP:N-METHYLMESOPORPHYRIN'>MMP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxm OCA], [https://pdbe.org/4fxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fxm RCSB], [https://www.ebi.ac.uk/pdbsum/4fxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxm OCA], [https://pdbe.org/4fxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fxm RCSB], [https://www.ebi.ac.uk/pdbsum/4fxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxm ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	N-Methyl mesoporphyrin IX (NMM) is exceptionally selective for G-quadruplexes (GQ) relative to duplex DNA and, as such, has found a wide range of applications in biology and chemistry. In addition, NMM is selective for parallel versus antiparallel GQ folds, as was recently demonstrated in our laboratory. Here, we present the X-ray crystal structure of a complex between NMM and human telomeric DNA dAGGG(TTAGGG)(3), Tel22, determined in two space groups, P2(1)2(1)2 and P6, at 1.65 and 2.15 A resolution, respectively. The former is the highest resolution structure of the human telomeric GQ DNA reported to date. The biological unit contains a Tel22 dimer of 5'-5' stacked parallel-stranded quadruplexes capped on both ends with NMM, supporting the spectroscopically determined 1:1 stoichiometry. NMM is capable of adjusting its macrocycle geometry to closely match that of the terminal G-tetrad required for efficient pi-pi stacking. The out-of-plane N-methyl group of NMM fits perfectly into the center of the parallel GQ core where it aligns with potassium ions. In contrast, the interaction of the N-methyl group with duplex DNA or antiparallel GQ would lead to steric clashes that prevent NMM from binding to these structures, thus explaining its unique selectivity. On the basis of the biochemical data, binding of NMM to Tel22 does not rely on relatively nonspecific electrostatic interactions, which characterize most canonical GQ ligands, but rather it is hydrophobic in nature. The structural features observed in the NMM-Tel22 complex described here will serve as guidelines for developing new quadruplex ligands that have excellent affinity and precisely defined selectivity.
-
-	Optimized End-Stacking Provides Specificity of N-Methyl Mesoporphyrin IX for Human Telomeric G-Quadruplex DNA.,Nicoludis JM, Miller ST, Jeffrey PD, Barrett SP, Rablen PR, Lawton TJ, Yatsunyk LA J Am Chem Soc. 2012 Dec 19;134(50):20446-56. doi: 10.1021/ja3088746. Epub 2012, Dec 11. PMID:23181361<ref>PMID:23181361</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4fxm" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:14, 19 October 2022

OCA — Wed, 19 Oct 2022 20:14:35 GMT

←Older revision		Revision as of 20:14, 19 October 2022
Line 3:		Line 3:
	<StructureSection load='4fxm' size='340' side='right'caption='[[4fxm]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4fxm' size='340' side='right'caption='[[4fxm]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fxm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FXM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FXM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MMP:N-METHYLMESOPORPHYRIN'>MMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MMP:N-METHYLMESOPORPHYRIN'>MMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxm OCA], [~~http~~://pdbe.org/4fxm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fxm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fxm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxm OCA], [https://pdbe.org/4fxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fxm RCSB], [https://www.ebi.ac.uk/pdbsum/4fxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jeffrey, P]]	+	[[Category: Jeffrey P]]
-	[[Category: Lawton~~, T J~~]]	+	[[Category: Lawton TJ]]
-	[[Category: Miller~~, S T~~]]	+	[[Category: Miller ST]]
-	[[Category: Nicoludis~~, J M~~]]	+	[[Category: Nicoludis JM]]
-	[[Category: Rosenzweig~~, A C~~]]	+	[[Category: Rosenzweig AC]]
-	[[Category: Yatsunyk~~, L A]]~~	+	[[Category: Yatsunyk LA]]
-	~~[[Category: Dna]]~~	+
-	~~[[Category: N-methyl mesoporphyrin ix]]~~	+
-	~~[[Category: Parallel quadruplex~~]]	+

OCA at 07:51, 27 March 2019

OCA — Wed, 27 Mar 2019 07:51:50 GMT

←Older revision		Revision as of 07:51, 27 March 2019
Line 1:		Line 1:

	==Crystal structure of the complex of a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212)==		==Crystal structure of the complex of a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212)==
-	<StructureSection load='4fxm' size='340' side='right' caption='[[4fxm]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='4fxm' size='340' side='right'caption='[[4fxm]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fxm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FXM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fxm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FXM FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Jeffrey, P]]		[[Category: Jeffrey, P]]
	[[Category: Lawton, T J]]		[[Category: Lawton, T J]]

OCA at 19:48, 15 December 2016

OCA — Thu, 15 Dec 2016 19:48:39 GMT

←Older revision		Revision as of 19:48, 15 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of the complex of a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212)==		==Crystal structure of the complex of a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212)==
	<StructureSection load='4fxm' size='340' side='right' caption='[[4fxm]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4fxm' size='340' side='right' caption='[[4fxm]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4fxm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FXM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fxm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FXM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MMP:N-METHYLMESOPORPHYRIN'>MMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MMP:N-METHYLMESOPORPHYRIN'>MMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fxm RCSB], [http://www.ebi.ac.uk/pdbsum/4fxm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxm OCA], [http://pdbe.org/4fxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fxm RCSB], [http://www.ebi.ac.uk/pdbsum/4fxm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4fxm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:11, 9 December 2014

OCA — Tue, 09 Dec 2014 17:11:16 GMT

←Older revision		Revision as of 17:11, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4fxm.~~jpg~~\|~~left\|200px~~]]	+	==Crystal structure of the complex of a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212)==
		+	<StructureSection load='4fxm' size='340' side='right' caption='[[4fxm]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4fxm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FXM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MMP:N-METHYLMESOPORPHYRIN'>MMP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fxm RCSB], [http://www.ebi.ac.uk/pdbsum/4fxm PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N-Methyl mesoporphyrin IX (NMM) is exceptionally selective for G-quadruplexes (GQ) relative to duplex DNA and, as such, has found a wide range of applications in biology and chemistry. In addition, NMM is selective for parallel versus antiparallel GQ folds, as was recently demonstrated in our laboratory. Here, we present the X-ray crystal structure of a complex between NMM and human telomeric DNA dAGGG(TTAGGG)(3), Tel22, determined in two space groups, P2(1)2(1)2 and P6, at 1.65 and 2.15 A resolution, respectively. The former is the highest resolution structure of the human telomeric GQ DNA reported to date. The biological unit contains a Tel22 dimer of 5'-5' stacked parallel-stranded quadruplexes capped on both ends with NMM, supporting the spectroscopically determined 1:1 stoichiometry. NMM is capable of adjusting its macrocycle geometry to closely match that of the terminal G-tetrad required for efficient pi-pi stacking. The out-of-plane N-methyl group of NMM fits perfectly into the center of the parallel GQ core where it aligns with potassium ions. In contrast, the interaction of the N-methyl group with duplex DNA or antiparallel GQ would lead to steric clashes that prevent NMM from binding to these structures, thus explaining its unique selectivity. On the basis of the biochemical data, binding of NMM to Tel22 does not rely on relatively nonspecific electrostatic interactions, which characterize most canonical GQ ligands, but rather it is hydrophobic in nature. The structural features observed in the NMM-Tel22 complex described here will serve as guidelines for developing new quadruplex ligands that have excellent affinity and precisely defined selectivity.

-	~~{{STRUCTURE_4fxm\| PDB=4fxm \| SCENE= }}~~	+	Optimized End-Stacking Provides Specificity of N-Methyl Mesoporphyrin IX for Human Telomeric G-Quadruplex DNA.,Nicoludis JM, Miller ST, Jeffrey PD, Barrett SP, Rablen PR, Lawton TJ, Yatsunyk LA J Am Chem Soc. 2012 Dec 19;134(50):20446-56. doi: 10.1021/ja3088746. Epub 2012, Dec 11. PMID:23181361<ref>PMID:23181361</ref>

-	~~===Crystal structure~~ of the ~~complex~~ of ~~a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23181361}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4fxm]] is a 1 chain structure. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA].~~	+	</StructureSection>
-	[[Category: Jeffrey, P.]]	+	[[Category: Jeffrey, P]]
-	[[Category: Lawton, T J.]]	+	[[Category: Lawton, T J]]
-	[[Category: Miller, S T.]]	+	[[Category: Miller, S T]]
-	[[Category: Nicoludis, J M.]]	+	[[Category: Nicoludis, J M]]
-	[[Category: Rosenzweig, A C.]]	+	[[Category: Rosenzweig, A C]]
-	[[Category: Yatsunyk, L A.]]	+	[[Category: Yatsunyk, L A]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: N-methyl mesoporphyrin ix]]		[[Category: N-methyl mesoporphyrin ix]]
	[[Category: Parallel quadruplex]]		[[Category: Parallel quadruplex]]

OCA at 07:00, 2 January 2013

OCA — Wed, 02 Jan 2013 07:00:23 GMT

←Older revision		Revision as of 07:00, 2 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4fxm.jpg\|left\|200px]]

-	~~The entry~~ 4fxm ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4fxm\| PDB=4fxm \| SCENE= }}

-	~~Authors: Nicoludis, J.M., Miller, S.T., Jeffrey, P., Lawton, T.J., Rosenzweig, A.C., Yatsunyk, L.A.~~	+	===Crystal structure of the complex of a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212)===

-	~~Description: Crystal structure of the complex of~~ a ~~human telomeric repeat G~~-~~quadruplex and~~ N-methyl mesoporphyrin ~~IX (P21212)~~	+	{{ABSTRACT_PUBMED_23181361}}
		+
		+	==About this Structure==
		+	[[4fxm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXM OCA].
		+	[[Category: Jeffrey, P.]]
		+	[[Category: Lawton, T J.]]
		+	[[Category: Miller, S T.]]
		+	[[Category: Nicoludis, J M.]]
		+	[[Category: Rosenzweig, A C.]]
		+	[[Category: Yatsunyk, L A.]]
		+	[[Category: Dna]]
		+	[[Category: N-methyl mesoporphyrin ix]]
		+	[[Category: Parallel quadruplex]]

OCA at 04:42, 29 August 2012

OCA — Wed, 29 Aug 2012 04:42:49 GMT

←Older revision		Revision as of 04:42, 29 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4fxm is ON HOLD	+	The entry 4fxm is ON HOLD until Paper Publication

	Authors: Nicoludis, J.M., Miller, S.T., Jeffrey, P., Lawton, T.J., Rosenzweig, A.C., Yatsunyk, L.A.		Authors: Nicoludis, J.M., Miller, S.T., Jeffrey, P., Lawton, T.J., Rosenzweig, A.C., Yatsunyk, L.A.

	Description: Crystal structure of the complex of a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212)		Description: Crystal structure of the complex of a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212)

OCA: Protected "4fxm" [edit=sysop:move=sysop]

OCA — Wed, 11 Jul 2012 07:52:50 GMT

Protected "4fxm" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:52, 11 July 2012

OCA: New page: '''Unreleased structure''' The entry 4fxm is ON HOLD Authors: Nicoludis, J.M., Miller, S.T., Jeffrey, P., Lawton, T.J., Rosenzweig, A.C., Yatsunyk, L.A. Description: Crystal structure ...

OCA — Wed, 11 Jul 2012 07:52:49 GMT

New page: '''Unreleased structure''' The entry 4fxm is ON HOLD Authors: Nicoludis, J.M., Miller, S.T., Jeffrey, P., Lawton, T.J., Rosenzweig, A.C., Yatsunyk, L.A. Description: Crystal structure ...

New page

'''Unreleased structure'''

The entry 4fxm is ON HOLD

Authors: Nicoludis, J.M., Miller, S.T., Jeffrey, P., Lawton, T.J., Rosenzweig, A.C., Yatsunyk, L.A.

Description: Crystal structure of the complex of a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212)