4g0j - Revision history

OCA at 11:24, 1 March 2024

OCA — Fri, 01 Mar 2024 11:24:34 GMT

←Older revision		Revision as of 11:24, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g0j]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_11_rotavirus_(serotype_3_/_strain_SA11-Ramig) Simian 11 rotavirus (serotype 3 / strain SA11-Ramig)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0J FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g0j]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_11_rotavirus_(serotype_3_/_strain_SA11-Ramig) Simian 11 rotavirus (serotype 3 / strain SA11-Ramig)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0j OCA], [https://pdbe.org/4g0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0j RCSB], [https://www.ebi.ac.uk/pdbsum/4g0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0j ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.398Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0j OCA], [https://pdbe.org/4g0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0j RCSB], [https://www.ebi.ac.uk/pdbsum/4g0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/NSP2_ROTSR NSP2_ROTSR] Involved in genome replication and packaging. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where replication intermediates are assembled and RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activity activities. The unwiding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. Unlike typical helicases, NSP2 requires neither a divalent cation nor a nucleotide energy source for helix destabilization. The RTPase activity may account for the absence of the 5'-terminal gamma-phosphate on the minus-strands of dsRNA genome segments (By similarity).		[https://www.uniprot.org/uniprot/NSP2_ROTSR NSP2_ROTSR] Involved in genome replication and packaging. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where replication intermediates are assembled and RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activity activities. The unwiding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. Unlike typical helicases, NSP2 requires neither a divalent cation nor a nucleotide energy source for helix destabilization. The RTPase activity may account for the absence of the 5'-terminal gamma-phosphate on the minus-strands of dsRNA genome segments (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Rotavirus non-structural protein NSP2, a functional octamer, is critical for the formation of viroplasms, which are exclusive sites for replication and packaging of segmented double-stranded RNA (dsRNA) rotavirus genome. As a component of replication intermediates, NSP2 is also implicated in various replication-related activities. In addition to sequence-independent single-stranded RNA binding and helix-destabilizing activities, NSP2 exhibits monomer-associated nucleoside and 5' RNA triphosphatase (NTPase/RTPase) activities which are mediated by a conserved H225 residue within a narrow enzymatic cleft. Lack of a 5' gamma-phosphate is a common feature of the (-)RNA of the packaged dsRNA segments in RV. Strikingly, all (-)RNAs (in group A RV) have a 5' GG dinucleotide sequence. As the only rotavirus protein with 5' RTPase activity, NSP2 is implicated in the removal of the gamma-phosphate from the rotavirus minus-strand RNA. To understand how NSP2, despite its sequence-independent RNA binding property, recognizes minus-strand RNA to hydrolyze the gamma-phosphate within the catalytic cleft, we determined a crystal structure of NSP2 in complex with the 5' consensus sequence of minus-strand rotavirus RNA. Our studies show that the 5' GG of the bound oligoribonucleotide interacts extensively with highly conserved residues in the NSP2 enzymatic cleft. While these residues provide GG-specific interactions, surface plasmon resonance studies suggest that the C-terminal helix and other basic residues outside the enzymatic cleft account for sequence-independent RNA binding of NSP2. A novel observation from our studies, which may have implications in viroplasm formation, is that the C-terminal helix of NSP2 exhibits two distinct conformations and engages in domain swapping interactions, which result in the formation of NSP2 octamer chains.
-
-	Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' -GG Sequence for RTPase activity.,Hu L, Chow DC, Patton JT, Palzkill T, Estes MK, Prasad BV J Virol. 2012 Jul 18. PMID:22811529<ref>PMID:22811529</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4g0j" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:17, 19 October 2022

OCA — Wed, 19 Oct 2022 20:17:53 GMT

←Older revision		Revision as of 20:17, 19 October 2022
Line 3:		Line 3:
	<StructureSection load='4g0j' size='340' side='right'caption='[[4g0j]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='4g0j' size='340' side='right'caption='[[4g0j]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g0j]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Rotsr Rotsr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G0J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g0j]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_11_rotavirus_(serotype_3_/_strain_SA11-Ramig) Simian 11 rotavirus (serotype 3 / strain SA11-Ramig)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0j OCA], [~~http~~://pdbe.org/4g0j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g0j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g0j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0j ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0j OCA], [https://pdbe.org/4g0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0j RCSB], [https://www.ebi.ac.uk/pdbsum/4g0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NSP2_ROTSR NSP2_ROTSR]] Involved in genome replication and packaging. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where replication intermediates are assembled and RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activity activities. The unwiding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. Unlike typical helicases, NSP2 requires neither a divalent cation nor a nucleotide energy source for helix destabilization. The RTPase activity may account for the absence of the 5'-terminal gamma-phosphate on the minus-strands of dsRNA genome segments (By similarity).	+	[https://www.uniprot.org/uniprot/NSP2_ROTSR NSP2_ROTSR] Involved in genome replication and packaging. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where replication intermediates are assembled and RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activity activities. The unwiding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. Unlike typical helicases, NSP2 requires neither a divalent cation nor a nucleotide energy source for helix destabilization. The RTPase activity may account for the absence of the 5'-terminal gamma-phosphate on the minus-strands of dsRNA genome segments (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Rotsr]]~~	+	[[Category: Hu L]]
-	[[Category: Hu, L]]	+	[[Category: Prasad BVV]]
-	[[Category: Prasad~~, B V.V]]~~	+
-	~~[[Category: Host cell cytoplasm]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase activity]]~~	+
-	~~[[Category: Metal ion binding]]~~	+
-	~~[[Category: Nucleotide binding]]~~	+
-	~~[[Category: Rna binding]]~~	+
-	~~[[Category: Rna triphosphatase~~]]	+

OCA at 07:52, 27 March 2019

OCA — Wed, 27 Mar 2019 07:52:27 GMT

←Older revision		Revision as of 07:52, 27 March 2019
Line 1:		Line 1:

	==Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity==		==Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity==
-	<StructureSection load='4g0j' size='340' side='right' caption='[[4g0j]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<StructureSection load='4g0j' size='340' side='right'caption='[[4g0j]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g0j]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Rotsr Rotsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G0J FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g0j]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Rotsr Rotsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G0J FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rotsr]]		[[Category: Rotsr]]
	[[Category: Hu, L]]		[[Category: Hu, L]]

OCA at 18:53, 5 August 2016

OCA — Fri, 05 Aug 2016 18:53:16 GMT

←Older revision		Revision as of 18:53, 5 August 2016
Line 1:		Line 1:
		+
	==Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity==		==Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity==
	<StructureSection load='4g0j' size='340' side='right' caption='[[4g0j]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='4g0j' size='340' side='right' caption='[[4g0j]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g0j]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Rotsr Rotsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G0J FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g0j]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Rotsr Rotsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G0J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g0j RCSB], [http://www.ebi.ac.uk/pdbsum/4g0j PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0j OCA], [http://pdbe.org/4g0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g0j RCSB], [http://www.ebi.ac.uk/pdbsum/4g0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g0j" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:07, 25 December 2014

OCA — Thu, 25 Dec 2014 21:07:48 GMT

←Older revision		Revision as of 21:07, 25 December 2014
Line 1:		Line 1:
-	[[~~Image~~:4g0j.~~png\|left\|200px~~]]	+	==Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity==
		+	<StructureSection load='4g0j' size='340' side='right' caption='[[4g0j]], [[Resolution\|resolution]] 3.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g0j]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Rotsr Rotsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G0J FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g0j RCSB], [http://www.ebi.ac.uk/pdbsum/4g0j PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NSP2_ROTSR NSP2_ROTSR]] Involved in genome replication and packaging. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where replication intermediates are assembled and RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activity activities. The unwiding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. Unlike typical helicases, NSP2 requires neither a divalent cation nor a nucleotide energy source for helix destabilization. The RTPase activity may account for the absence of the 5'-terminal gamma-phosphate on the minus-strands of dsRNA genome segments (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rotavirus non-structural protein NSP2, a functional octamer, is critical for the formation of viroplasms, which are exclusive sites for replication and packaging of segmented double-stranded RNA (dsRNA) rotavirus genome. As a component of replication intermediates, NSP2 is also implicated in various replication-related activities. In addition to sequence-independent single-stranded RNA binding and helix-destabilizing activities, NSP2 exhibits monomer-associated nucleoside and 5' RNA triphosphatase (NTPase/RTPase) activities which are mediated by a conserved H225 residue within a narrow enzymatic cleft. Lack of a 5' gamma-phosphate is a common feature of the (-)RNA of the packaged dsRNA segments in RV. Strikingly, all (-)RNAs (in group A RV) have a 5' GG dinucleotide sequence. As the only rotavirus protein with 5' RTPase activity, NSP2 is implicated in the removal of the gamma-phosphate from the rotavirus minus-strand RNA. To understand how NSP2, despite its sequence-independent RNA binding property, recognizes minus-strand RNA to hydrolyze the gamma-phosphate within the catalytic cleft, we determined a crystal structure of NSP2 in complex with the 5' consensus sequence of minus-strand rotavirus RNA. Our studies show that the 5' GG of the bound oligoribonucleotide interacts extensively with highly conserved residues in the NSP2 enzymatic cleft. While these residues provide GG-specific interactions, surface plasmon resonance studies suggest that the C-terminal helix and other basic residues outside the enzymatic cleft account for sequence-independent RNA binding of NSP2. A novel observation from our studies, which may have implications in viroplasm formation, is that the C-terminal helix of NSP2 exhibits two distinct conformations and engages in domain swapping interactions, which result in the formation of NSP2 octamer chains.

-	~~{{STRUCTURE_4g0j\| PDB=4g0j \| SCENE= }}~~	+	Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' -GG Sequence for RTPase activity.,Hu L, Chow DC, Patton JT, Palzkill T, Estes MK, Prasad BV J Virol. 2012 Jul 18. PMID:22811529<ref>PMID:22811529</ref>

-	~~===Crystallographic Analysis~~ of ~~Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22811529}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4g0j]] is a 10 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Simian_11_rotavirus Simian 11 rotavirus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA].~~	+	</StructureSection>
-		+	[[Category: Rotsr]]
-	==~~Reference~~==	+	[[Category: Hu, L]]
-	<~~ref group="xtra">PMID:022811529<~~/~~ref~~><~~references group="xtra"~~/>	+	[[Category: Prasad, B V.V]]
-	[[Category: ~~Simian 11 rotavirus~~]]	+
-	[[Category: Hu, L.]]	+
-	[[Category: Prasad, B V.V.]]	+
	[[Category: Host cell cytoplasm]]		[[Category: Host cell cytoplasm]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 20:56, 26 September 2012

OCA — Wed, 26 Sep 2012 20:56:43 GMT

←Older revision		Revision as of 20:56, 26 September 2012
Line 1:		Line 1:
-	[[Image:4g0j.~~jpg~~\|left\|200px]]	+	[[Image:4g0j.png\|left\|200px]]

	{{STRUCTURE_4g0j\| PDB=4g0j \| SCENE= }}		{{STRUCTURE_4g0j\| PDB=4g0j \| SCENE= }}

OCA at 05:53, 22 August 2012

OCA — Wed, 22 Aug 2012 05:53:02 GMT

←Older revision		Revision as of 05:53, 22 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g0j.jpg\|left\|200px]]

-	~~The entry~~ 4g0j ~~is ON HOLD~~	+	{{STRUCTURE_4g0j\| PDB=4g0j \| SCENE= }}

-	~~Authors: Hu, L., Prasad, B.V.V.~~	+	===Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity===

-	~~Description~~: ~~Crystallographic Analysis of Rotavirus NSP2~~-~~RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase~~ activity	+	{{ABSTRACT_PUBMED_22811529}}
		+
		+	==About this Structure==
		+	[[4g0j]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_11_rotavirus Simian 11 rotavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0J OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022811529</ref><references group="xtra"/>
		+	[[Category: Simian 11 rotavirus]]
		+	[[Category: Hu, L.]]
		+	[[Category: Prasad, B V.V.]]
		+	[[Category: Host cell cytoplasm]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase activity]]
		+	[[Category: Metal ion binding]]
		+	[[Category: Nucleotide binding]]
		+	[[Category: Rna binding]]
		+	[[Category: Rna triphosphatase]]

OCA: Protected "4g0j" [edit=sysop:move=sysop]

OCA — Wed, 18 Jul 2012 05:07:06 GMT

Protected "4g0j" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:07, 18 July 2012

OCA: New page: '''Unreleased structure''' The entry 4g0j is ON HOLD Authors: Hu, L., Prasad, B.V.V. Description: Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition o...

OCA — Wed, 18 Jul 2012 05:07:05 GMT

New page: '''Unreleased structure''' The entry 4g0j is ON HOLD Authors: Hu, L., Prasad, B.V.V. Description: Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition o...

New page

'''Unreleased structure'''

The entry 4g0j is ON HOLD

Authors: Hu, L., Prasad, B.V.V.

Description: Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity