4g0u - Revision history

OCA at 13:55, 8 November 2023

OCA — Wed, 08 Nov 2023 13:55:08 GMT

←Older revision		Revision as of 13:55, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g0u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g0u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASW:N-[4-(ACRIDIN-9-YLAMINO)-3-METHOXYPHENYL]METHANESULFONAMIDE'>ASW</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASW:N-[4-(ACRIDIN-9-YLAMINO)-3-METHOXYPHENYL]METHANESULFONAMIDE'>ASW</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0u OCA], [https://pdbe.org/4g0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0u RCSB], [https://www.ebi.ac.uk/pdbsum/4g0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0u OCA], [https://pdbe.org/4g0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0u RCSB], [https://www.ebi.ac.uk/pdbsum/4g0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0u ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:18, 19 October 2022

OCA — Wed, 19 Oct 2022 20:18:36 GMT

←Older revision		Revision as of 20:18, 19 October 2022
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	==Human topoisomerase IIbeta in complex with DNA and amsacrine==		==Human topoisomerase IIbeta in complex with DNA and amsacrine==
-	<StructureSection load='4g0u' size='340' side='right' caption='[[4g0u]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4g0u' size='340' side='right'caption='[[4g0u]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g0u]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G0U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g0u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASW:N-[4-(ACRIDIN-9-YLAMINO)-3-METHOXYPHENYL]METHANESULFONAMIDE'>ASW</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASW:N-[4-(ACRIDIN-9-YLAMINO)-3-METHOXYPHENYL]METHANESULFONAMIDE'>ASW</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qx3\|3qx3]], [[4g0v\|4g0v]], [[4g0w\|4g0w]], [[4j3n\|4j3n]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0u OCA], [https://pdbe.org/4g0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0u RCSB], [https://www.ebi.ac.uk/pdbsum/4g0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0u ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOP2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0u OCA], [~~http~~://pdbe.org/4g0u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g0u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g0u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN]] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>	+	[https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4g0u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4g0u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Topoisomerase 3D structures\|Topoisomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Chan, N L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Li, T K~~]]	+	[[Category: Chan NL]]
-	[[Category: Li~~, Y C~~]]	+	[[Category: Li TK]]
-	[[Category: ~~Wu, C C~~]]	+	[[Category: Li YC]]
-	[[Category: ~~Coiled-coil domain]]~~	+	[[Category: Wu CC]]
-	~~[[Category: Dna-binding and cleavage]]~~	+
-	~~[[Category: Isomerase-dna-isomerase inhibitor complex]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Toprim domain]]~~	+
-	~~[[Category: Winged-helix domain~~]]	+

OCA at 14:58, 15 November 2017

OCA — Wed, 15 Nov 2017 14:58:16 GMT

←Older revision		Revision as of 14:58, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4g0u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4g0u" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Topoisomerase\|Topoisomerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:17, 4 August 2016

OCA — Thu, 04 Aug 2016 23:17:18 GMT

←Older revision		Revision as of 23:17, 4 August 2016
Line 1:		Line 1:
		+
	==Human topoisomerase IIbeta in complex with DNA and amsacrine==		==Human topoisomerase IIbeta in complex with DNA and amsacrine==
	<StructureSection load='4g0u' size='340' side='right' caption='[[4g0u]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4g0u' size='340' side='right' caption='[[4g0u]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOP2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOP2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g0u RCSB], [http://www.ebi.ac.uk/pdbsum/4g0u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0u OCA], [http://pdbe.org/4g0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g0u RCSB], [http://www.ebi.ac.uk/pdbsum/4g0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g0u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 20:36, 24 December 2014

OCA — Wed, 24 Dec 2014 20:36:17 GMT

←Older revision		Revision as of 20:36, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4g0u\| PDB=4g0u \| SCENE= }}~~	+	==Human topoisomerase IIbeta in complex with DNA and amsacrine==
-	===Human topoisomerase IIbeta in complex with DNA and amsacrine===	+	<StructureSection load='4g0u' size='340' side='right' caption='[[4g0u]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24038465}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4g0u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G0U FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASW:N-[4-(ACRIDIN-9-YLAMINO)-3-METHOXYPHENYL]METHANESULFONAMIDE'>ASW</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qx3\|3qx3]], [[4g0v\|4g0v]], [[4g0w\|4g0w]], [[4j3n\|4j3n]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOP2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g0u RCSB], [http://www.ebi.ac.uk/pdbsum/4g0u PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN]] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>		[[http://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN]] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type II topoisomerases (Top2s) alter DNA topology via the formation of an enzyme-DNA adduct termed cleavage complex, which harbors a transient double-strand break in one DNA to allow the passage of another. Agents targeting human Top2s are clinically active anticancer drugs whose trapping of Top2-mediated DNA breakage effectively induces genome fragmentation and cell death. To understand the structural basis of this drug action, we previously determined the structure of human Top2 beta-isoform forming a cleavage complex with the drug etoposide and DNA, and described the insertion of drug into DNA cleavage site and drug-induced decoupling of catalytic groups. By developing a post-crystallization drug replacement procedure that simplifies structural characterization of drug-stabilized cleavage complexes, we have extended the analysis toward other structurally distinct drugs, m-AMSA and mitoxantrone. Besides the expected drug intercalation, a switch in ribose puckering in the 3'-nucleotide of the cleavage site was robustly observed in the new structures, representing a new mechanism for trapping the Top2 cleavage complex. Analysis of drug-binding modes and the conformational landscapes of the drug-binding pockets provide rationalization of the drugs' structural-activity relationships and explain why Top2 mutants exhibit differential effects toward each drug. Drug design guidelines were proposed to facilitate the development of isoform-specific Top2-targeting anticancer agents.

-	~~==About this Structure==~~	+	On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs.,Wu CC, Li YC, Wang YR, Li TK, Chan NL Nucleic Acids Res. 2013 Sep 14. PMID:24038465<ref>PMID:24038465</ref>
-	~~[[4g0u]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4G0U OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Topoisomerase\|Topoisomerase]]		*[[Topoisomerase\|Topoisomerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024038465</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Chan, N L.]]	+	[[Category: Chan, N L]]
-	[[Category: Li, T K.]]	+	[[Category: Li, T K]]
-	[[Category: Li, Y C.]]	+	[[Category: Li, Y C]]
-	[[Category: Wu, C C.]]	+	[[Category: Wu, C C]]
	[[Category: Coiled-coil domain]]		[[Category: Coiled-coil domain]]
	[[Category: Dna-binding and cleavage]]		[[Category: Dna-binding and cleavage]]

OCA at 14:24, 12 March 2014

OCA — Wed, 12 Mar 2014 14:24:46 GMT

←Older revision		Revision as of 14:24, 12 March 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4g0u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0U OCA].	+	[[4g0u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0U OCA].

	==See Also==		==See Also==
Line 14:		Line 14:
	==Reference==		==Reference==
	<ref group="xtra">PMID:024038465</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024038465</ref><references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chan, N L.]]		[[Category: Chan, N L.]]
	[[Category: Li, T K.]]		[[Category: Li, T K.]]

OCA at 05:53, 2 October 2013

OCA — Wed, 02 Oct 2013 05:53:49 GMT

←Older revision		Revision as of 05:53, 2 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4g0u\| PDB=4g0u \| SCENE= }}		{{STRUCTURE_4g0u\| PDB=4g0u \| SCENE= }}
	===Human topoisomerase IIbeta in complex with DNA and amsacrine===		===Human topoisomerase IIbeta in complex with DNA and amsacrine===
		+	{{ABSTRACT_PUBMED_24038465}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4g0u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0U OCA].		[[4g0u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0U OCA].
		+
		+	==See Also==
		+	*[[Topoisomerase\|Topoisomerase]]

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024038465</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chan, N L.]]		[[Category: Chan, N L.]]

OCA at 05:02, 18 July 2013

OCA — Thu, 18 Jul 2013 05:02:48 GMT

←Older revision		Revision as of 05:02, 18 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4g0u\| PDB=4g0u \| SCENE= }}
		+	===Human topoisomerase IIbeta in complex with DNA and amsacrine===

-	~~The entry 4g0u~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN]] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>

-	~~Authors~~: ~~Wu, C~~.C.~~, Li, T~~.~~K., Li, Y~~.C.~~, Chan, N~~.L.	+	==About this Structure==
		+	[[4g0u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0U OCA].

-	~~Description~~: ~~Human topoisomerase IIbeta in complex with DNA~~ and ~~amsacrine~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Chan, N L.]]
		+	[[Category: Li, T K.]]
		+	[[Category: Li, Y C.]]
		+	[[Category: Wu, C C.]]
		+	[[Category: Coiled-coil domain]]
		+	[[Category: Dna-binding and cleavage]]
		+	[[Category: Isomerase-dna-isomerase inhibitor complex]]
		+	[[Category: Nucleus]]
		+	[[Category: Toprim domain]]
		+	[[Category: Winged-helix domain]]

OCA at 06:29, 17 October 2012

OCA — Wed, 17 Oct 2012 06:29:09 GMT

←Older revision		Revision as of 06:29, 17 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g0u is ON HOLD	+	The entry 4g0u is ON HOLD until Paper Publication

	Authors: Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.		Authors: Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.

	Description: Human topoisomerase IIbeta in complex with DNA and amsacrine		Description: Human topoisomerase IIbeta in complex with DNA and amsacrine

OCA: Protected "4g0u" [edit=sysop:move=sysop]

OCA — Wed, 18 Jul 2012 05:07:24 GMT

Protected "4g0u" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:07, 18 July 2012