4g1t - Revision history

OCA at 19:23, 29 May 2024

OCA — Wed, 29 May 2024 19:23:19 GMT

←Older revision		Revision as of 19:23, 29 May 2024
Line 1:		Line 1:

	==Crystal structure of interferon-stimulated gene 54==		==Crystal structure of interferon-stimulated gene 54==
-	<StructureSection load='4g1t' size='340' side='right'caption='[[4g1t]]' scene=''>	+	<StructureSection load='4g1t' size='340' side='right'caption='[[4g1t]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g1t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G1T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [https://pdbe.org/4g1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [https://www.ebi.ac.uk/pdbsum/4g1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1t ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [https://pdbe.org/4g1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [https://www.ebi.ac.uk/pdbsum/4g1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1t ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IFIT2_HUMAN IFIT2_HUMAN] IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.<ref>PMID:21190939</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interferon-stimulated gene 56 (ISG56) family members play important roles in blocking viral replication and regulating cellular functions, however, their underlying molecular mechanisms are largely unclear. Here, we present the crystal structure of ISG54, an ISG56 family protein with a novel RNA-binding structure. The structure shows that ISG54 monomers have 9 tetratricopeptide repeat-like motifs and associate to form domain-swapped dimers. The C-terminal part folds into a super-helical structure and has an extensively positively-charged nucleotide-binding channel on its inner surface. EMSA results show that ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation. Mutagenesis and functional studies show that this RNA-binding ability is important to its antiviral activity. Our results suggest a new mechanism underlying the antiviral activity of this interferon-inducible gene 56 family member.Cell Research advance online publication 24 July 2012; doi:10.1038/cr.2012.111.
		+
		+	Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.,Yang Z, Liang H, Zhou Q, Li Y, Chen H, Ye W, Chen D, Fleming J, Shu H, Liu Y Cell Res. 2012 Jul 24. doi: 10.1038/cr.2012.111. PMID:22825553<ref>PMID:22825553</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4g1t" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen D]]		[[Category: Chen D]]

OCA at 10:42, 31 August 2022

OCA — Wed, 31 Aug 2022 10:42:03 GMT

←Older revision		Revision as of 10:42, 31 August 2022
Line 1:		Line 1:

	==Crystal structure of interferon-stimulated gene 54==		==Crystal structure of interferon-stimulated gene 54==
-	<StructureSection load='4g1t' size='340' side='right'caption='[[4g1t]]~~, [[Resolution\|resolution]] 2.80Å~~' scene=''>	+	<StructureSection load='4g1t' size='340' side='right'caption='[[4g1t]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[4g1t]] is a 2 chain structure.~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G1T FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [https://pdbe.org/4g1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [https://www.ebi.ac.uk/pdbsum/4g1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1t ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [https://pdbe.org/4g1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [https://www.ebi.ac.uk/pdbsum/4g1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1t ProSAT]</span></td></tr>
	</table>		</table>
-	== Function ==
-	[[https://www.uniprot.org/uniprot/IFIT2_HUMAN IFIT2_HUMAN]] IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.<ref>PMID:21190939</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Interferon-stimulated gene 56 (ISG56) family members play important roles in blocking viral replication and regulating cellular functions, however, their underlying molecular mechanisms are largely unclear. Here, we present the crystal structure of ISG54, an ISG56 family protein with a novel RNA-binding structure. The structure shows that ISG54 monomers have 9 tetratricopeptide repeat-like motifs and associate to form domain-swapped dimers. The C-terminal part folds into a super-helical structure and has an extensively positively-charged nucleotide-binding channel on its inner surface. EMSA results show that ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation. Mutagenesis and functional studies show that this RNA-binding ability is important to its antiviral activity. Our results suggest a new mechanism underlying the antiviral activity of this interferon-inducible gene 56 family member.Cell Research advance online publication 24 July 2012; doi:10.1038/cr.2012.111.
-
-	Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.,Yang Z, Liang H, Zhou Q, Li Y, Chen H, Ye W, Chen D, Fleming J, Shu H, Liu Y Cell Res. 2012 Jul 24. doi: 10.1038/cr.2012.111. PMID:22825553<ref>PMID:22825553</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4g1t" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, D]]	+	[[Category: Chen D]]
-	[[Category: Chen, H]]	+	[[Category: Chen H]]
-	[[Category: Fleming, J]]	+	[[Category: Fleming J]]
-	[[Category: Li, Y]]	+	[[Category: Li Y]]
-	[[Category: Liang, H]]	+	[[Category: Liang H]]
-	[[Category: Liu, Y]]	+	[[Category: Liu Y]]
-	[[Category: Shu, H]]	+	[[Category: Shu H]]
-	[[Category: Yang, Z]]	+	[[Category: Yang Z]]
-	[[Category: Ye, W]]	+	[[Category: Ye W]]
-	[[Category: Zhou, Q]]	+	[[Category: Zhou Q]]
-	~~[[Category: All alpha helix]]~~	+
-	~~[[Category: Antiviral protein]]~~	+
-	~~[[Category: Antivirus]]~~	+
-	~~[[Category: Isg~~]]	+

OCA at 05:01, 25 August 2022

OCA — Thu, 25 Aug 2022 05:01:36 GMT

←Older revision		Revision as of 05:01, 25 August 2022
Line 1:		Line 1:

	==Crystal structure of interferon-stimulated gene 54==		==Crystal structure of interferon-stimulated gene 54==
-	<StructureSection load='4g1t' size='340' side='right' caption='[[4g1t]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4g1t' size='340' side='right'caption='[[4g1t]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g1t]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g1t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G1T FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIT2, G10P2, IFI54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [https://pdbe.org/4g1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [https://www.ebi.ac.uk/pdbsum/4g1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1t ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [~~http~~://pdbe.org/4g1t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g1t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1t ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IFIT2_HUMAN IFIT2_HUMAN]] IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.<ref>PMID:21190939</ref>	+	[[https://www.uniprot.org/uniprot/IFIT2_HUMAN IFIT2_HUMAN]] IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.<ref>PMID:21190939</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
	[[Category: Chen, D]]		[[Category: Chen, D]]
	[[Category: Chen, H]]		[[Category: Chen, H]]

OCA at 15:50, 11 August 2016

OCA — Thu, 11 Aug 2016 15:50:42 GMT

←Older revision		Revision as of 15:50, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of interferon-stimulated gene 54==		==Crystal structure of interferon-stimulated gene 54==
	<StructureSection load='4g1t' size='340' side='right' caption='[[4g1t]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4g1t' size='340' side='right' caption='[[4g1t]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G1T FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIT2, G10P2, IFI54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIT2, G10P2, IFI54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [http://www.ebi.ac.uk/pdbsum/4g1t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [http://pdbe.org/4g1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [http://www.ebi.ac.uk/pdbsum/4g1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1t ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IFIT2_HUMAN IFIT2_HUMAN]] IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.<ref>PMID:21190939</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g1t" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, D]]		[[Category: Chen, D]]
	[[Category: Chen, H]]		[[Category: Chen, H]]

OCA at 14:31, 4 January 2015

OCA — Sun, 04 Jan 2015 14:31:09 GMT

←Older revision		Revision as of 14:31, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G1T FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G1T FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIT2, G10P2, IFI54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIT2, G10P2, IFI54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [http://www.ebi.ac.uk/pdbsum/4g1t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [http://www.ebi.ac.uk/pdbsum/4g1t PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, D.]]	+	[[Category: Chen, D]]
-	[[Category: Chen, H.]]	+	[[Category: Chen, H]]
-	[[Category: Fleming, J.]]	+	[[Category: Fleming, J]]
-	[[Category: Li, Y.]]	+	[[Category: Li, Y]]
-	[[Category: Liang, H.]]	+	[[Category: Liang, H]]
-	[[Category: Liu, Y.]]	+	[[Category: Liu, Y]]
-	[[Category: Shu, H.]]	+	[[Category: Shu, H]]
-	[[Category: Yang, Z.]]	+	[[Category: Yang, Z]]
-	[[Category: Ye, W.]]	+	[[Category: Ye, W]]
-	[[Category: Zhou, Q.]]	+	[[Category: Zhou, Q]]
	[[Category: All alpha helix]]		[[Category: All alpha helix]]
	[[Category: Antiviral protein]]		[[Category: Antiviral protein]]
	[[Category: Antivirus]]		[[Category: Antivirus]]
	[[Category: Isg]]		[[Category: Isg]]

OCA at 10:27, 16 June 2014

OCA — Mon, 16 Jun 2014 10:27:57 GMT

←Older revision		Revision as of 10:27, 16 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4g1t.~~jpg~~\|~~left\|200px~~]]	+	==Crystal structure of interferon-stimulated gene 54==
		+	<StructureSection load='4g1t' size='340' side='right' caption='[[4g1t]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G1T FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIT2, G10P2, IFI54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g1t RCSB], [http://www.ebi.ac.uk/pdbsum/4g1t PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interferon-stimulated gene 56 (ISG56) family members play important roles in blocking viral replication and regulating cellular functions, however, their underlying molecular mechanisms are largely unclear. Here, we present the crystal structure of ISG54, an ISG56 family protein with a novel RNA-binding structure. The structure shows that ISG54 monomers have 9 tetratricopeptide repeat-like motifs and associate to form domain-swapped dimers. The C-terminal part folds into a super-helical structure and has an extensively positively-charged nucleotide-binding channel on its inner surface. EMSA results show that ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation. Mutagenesis and functional studies show that this RNA-binding ability is important to its antiviral activity. Our results suggest a new mechanism underlying the antiviral activity of this interferon-inducible gene 56 family member.Cell Research advance online publication 24 July 2012; doi:10.1038/cr.2012.111.

-	~~{{STRUCTURE_4g1t\| PDB=4g1t \| SCENE= }}~~	+	Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.,Yang Z, Liang H, Zhou Q, Li Y, Chen H, Ye W, Chen D, Fleming J, Shu H, Liu Y Cell Res. 2012 Jul 24. doi: 10.1038/cr.2012.111. PMID:22825553<ref>PMID:22825553</ref>

-	~~===Crystal structure~~ of ~~interferon-stimulated gene 54===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22825553}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4g1t]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022825553<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, D.]]		[[Category: Chen, D.]]

OCA at 05:46, 15 August 2012

OCA — Wed, 15 Aug 2012 05:46:14 GMT

←Older revision		Revision as of 05:46, 15 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g1t.jpg\|left\|200px]]

-	~~The entry~~ 4g1t ~~is ON HOLD~~	+	{{STRUCTURE_4g1t\| PDB=4g1t \| SCENE= }}

-	~~Authors: Yang, Z., Liang, H., Zhou, Q., Li, Y., Chen, H., Ye, W., Chen, D., Fleming, J., Shu, H., Liu, Y.~~	+	===Crystal structure of interferon-stimulated gene 54===

-	~~Description: Crystal~~ structure ~~of interferon~~-~~stimulated gene 54~~	+	{{ABSTRACT_PUBMED_22825553}}
		+
		+	==About this Structure==
		+	[[4g1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1T OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022825553</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Chen, D.]]
		+	[[Category: Chen, H.]]
		+	[[Category: Fleming, J.]]
		+	[[Category: Li, Y.]]
		+	[[Category: Liang, H.]]
		+	[[Category: Liu, Y.]]
		+	[[Category: Shu, H.]]
		+	[[Category: Yang, Z.]]
		+	[[Category: Ye, W.]]
		+	[[Category: Zhou, Q.]]
		+	[[Category: All alpha helix]]
		+	[[Category: Antiviral protein]]
		+	[[Category: Antivirus]]
		+	[[Category: Isg]]

OCA at 04:56, 8 August 2012

OCA — Wed, 08 Aug 2012 04:56:46 GMT

←Older revision		Revision as of 04:56, 8 August 2012
Line 3:		Line 3:
	The entry 4g1t is ON HOLD		The entry 4g1t is ON HOLD

-	Authors: ~~Zhenlin~~ Yang, ~~Huanhuan~~ Liang, ~~Qian~~ Zhou, ~~Ying~~ Li, ~~Haiwei~~ Chen, ~~Wen~~ Ye, ~~Danying~~ Chen, ~~Joy~~ Fleming, ~~Hongbing~~ Shu, ~~Yingfang~~ Liu	+	Authors: Yang, Z., Liang, H., Zhou, Q., Li, Y., Chen, H., Ye, W., Chen, D., Fleming, J., Shu, H., Liu, Y.

	Description: Crystal structure of interferon-stimulated gene 54		Description: Crystal structure of interferon-stimulated gene 54

OCA: Protected "4g1t" [edit=sysop:move=sysop]

OCA — Wed, 18 Jul 2012 05:08:20 GMT

Protected "4g1t" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:08, 18 July 2012

OCA: New page: '''Unreleased structure''' The entry 4g1t is ON HOLD Authors: Zhenlin Yang, Huanhuan Liang, Qian Zhou, Ying Li, Haiwei Chen, Wen Ye, Danying Chen, Joy Fleming, Hongbing Shu, Yingfang Li...

OCA — Wed, 18 Jul 2012 05:08:19 GMT

New page: '''Unreleased structure''' The entry 4g1t is ON HOLD Authors: Zhenlin Yang, Huanhuan Liang, Qian Zhou, Ying Li, Haiwei Chen, Wen Ye, Danying Chen, Joy Fleming, Hongbing Shu, Yingfang Li...

New page

'''Unreleased structure'''

The entry 4g1t is ON HOLD

Authors: Zhenlin Yang, Huanhuan Liang, Qian Zhou, Ying Li, Haiwei Chen, Wen Ye, Danying Chen, Joy Fleming, Hongbing Shu, Yingfang Liu

Description: Crystal structure of interferon-stimulated gene 54