4g27 - Revision history

OCA at 11:25, 1 March 2024

OCA — Fri, 01 Mar 2024 11:25:10 GMT

←Older revision		Revision as of 11:25, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G27 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PHU:1-PHENYLUREA'>PHU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PHU:1-PHENYLUREA'>PHU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g27 OCA], [https://pdbe.org/4g27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g27 RCSB], [https://www.ebi.ac.uk/pdbsum/4g27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g27 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g27 OCA], [https://pdbe.org/4g27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g27 RCSB], [https://www.ebi.ac.uk/pdbsum/4g27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.		[https://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Small- and intermediate-conductance Ca(2+)-activated potassium channels, activated by Ca(2+)-bound calmodulin, have an important role in regulating membrane excitability. These channels are also linked to clinical abnormalities. A tremendous amount of effort has been devoted to developing small molecule compounds targeting these channels. However, these compounds often suffer from low potency and lack of selectivity, hindering their potential for clinical use. A key contributing factor is the lack of knowledge of the binding site(s) for these compounds. Here we demonstrate by X-ray crystallography that the binding pocket for the compounds of the 1-ethyl-2-benzimidazolinone (1-EBIO) class is located at the calmodulin-channel interface. We show that, based on structure data and molecular docking, mutations of the channel can effectively change the potency of these compounds. Our results provide insight into the molecular nature of the binding pocket and its contribution to the potency and selectivity of the compounds of the 1-EBIO class.
-
-	Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels.,Zhang M, Pascal JM, Schumann M, Armen RS, Zhang JF Nat Commun. 2012 Aug 28;3:1021. doi: 10.1038/ncomms2017. PMID:22929778<ref>PMID:22929778</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4g27" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Calmodulin 3D structures\|Calmodulin 3D structures]]		*[[Calmodulin 3D structures\|Calmodulin 3D structures]]
	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]		*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:21, 19 October 2022

OCA — Wed, 19 Oct 2022 20:21:25 GMT

←Older revision		Revision as of 20:21, 19 October 2022
Line 1:		Line 1:

	==Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea==		==Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea==
-	<StructureSection load='4g27' size='340' side='right' caption='[[4g27]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='4g27' size='340' side='right'caption='[[4g27]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g27]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G27 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G27 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PHU:1-PHENYLUREA'>PHU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PHU:1-PHENYLUREA'>PHU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sjq\|3sjq]], [[1g4y\|1g4y]], [[4g28\|4g28]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g27 OCA], [https://pdbe.org/4g27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g27 RCSB], [https://www.ebi.ac.uk/pdbsum/4g27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g27 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kcnn2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Calm1, Calm, Cam, Cam1, Calm2, Cam2, Camb, Calm3, Cam3, Camc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g27 OCA], [~~http~~://pdbe.org/4g27 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g27 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g27 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g27 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT]] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.	+	[https://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4g27" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4g27" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Calmodulin 3D structures\|Calmodulin 3D structures]]
		+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pascal, J M~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Zhang, J F~~]]	+	[[Category: Pascal JM]]
-	[[Category: Zhang~~, M]]~~	+	[[Category: Zhang J-F]]
-	~~[[Category: Ef hand]]~~	+	[[Category: Zhang M]]
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Metal transport~~-~~calcium binding protein complex~~]]	+
-	[[Category: ~~Protein-protein complex~~]]	+

OCA at 08:23, 15 November 2017

OCA — Wed, 15 Nov 2017 08:23:53 GMT

←Older revision		Revision as of 08:23, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4g27" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4g27" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Calmodulin\|Calmodulin]]
-	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:37, 5 August 2016

OCA — Fri, 05 Aug 2016 21:37:17 GMT

←Older revision		Revision as of 21:37, 5 August 2016
Line 1:		Line 1:
		+
	==Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea==		==Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea==
	<StructureSection load='4g27' size='340' side='right' caption='[[4g27]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4g27' size='340' side='right' caption='[[4g27]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G27 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PHU:1-PHENYLUREA'>PHU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PHU:1-PHENYLUREA'>PHU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sjq\|3sjq]], [[1g4y\|1g4y]], [[4g28\|4g28]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sjq\|3sjq]], [[1g4y\|1g4y]], [[4g28\|4g28]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kcnn2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~]), Calm1, Calm, Cam, Cam1, Calm2, Cam2, Camb, Calm3, Cam3, Camc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kcnn2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Calm1, Calm, Cam, Cam1, Calm2, Cam2, Camb, Calm3, Cam3, Camc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g27 RCSB], [http://www.ebi.ac.uk/pdbsum/4g27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g27 OCA], [http://pdbe.org/4g27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g27 RCSB], [http://www.ebi.ac.uk/pdbsum/4g27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g27" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Pascal, J M]]		[[Category: Pascal, J M]]
	[[Category: Zhang, J F]]		[[Category: Zhang, J F]]

OCA at 22:07, 25 December 2014

OCA — Thu, 25 Dec 2014 22:07:24 GMT

←Older revision		Revision as of 22:07, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4g27.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea==
		+	<StructureSection load='4g27' size='340' side='right' caption='[[4g27]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G27 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PHU:1-PHENYLUREA'>PHU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sjq\|3sjq]], [[1g4y\|1g4y]], [[4g28\|4g28]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kcnn2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), Calm1, Calm, Cam, Cam1, Calm2, Cam2, Camb, Calm3, Cam3, Camc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g27 RCSB], [http://www.ebi.ac.uk/pdbsum/4g27 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT]] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Small- and intermediate-conductance Ca(2+)-activated potassium channels, activated by Ca(2+)-bound calmodulin, have an important role in regulating membrane excitability. These channels are also linked to clinical abnormalities. A tremendous amount of effort has been devoted to developing small molecule compounds targeting these channels. However, these compounds often suffer from low potency and lack of selectivity, hindering their potential for clinical use. A key contributing factor is the lack of knowledge of the binding site(s) for these compounds. Here we demonstrate by X-ray crystallography that the binding pocket for the compounds of the 1-ethyl-2-benzimidazolinone (1-EBIO) class is located at the calmodulin-channel interface. We show that, based on structure data and molecular docking, mutations of the channel can effectively change the potency of these compounds. Our results provide insight into the molecular nature of the binding pocket and its contribution to the potency and selectivity of the compounds of the 1-EBIO class.

-	~~{{STRUCTURE_4g27\| PDB=4g27 \| SCENE= }}~~	+	Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels.,Zhang M, Pascal JM, Schumann M, Armen RS, Zhang JF Nat Commun. 2012 Aug 28;3:1021. doi: 10.1038/ncomms2017. PMID:22929778<ref>PMID:22929778</ref>

-	~~===Calcium-calmodulin complexed with the calmodulin binding domain from~~ a ~~small conductance potassium channel splice variant and phenylurea===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22929778}}~~	+	==See Also==
-		+	*[[Calmodulin\|Calmodulin]]
-	==~~About this Structure~~==	+	*[[Potassium Channel\|Potassium Channel]]
-	[[~~4g27~~]] ~~is a 2 chain structure with sequence from~~ [~~http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from~~ [~~http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=4G27 OCA].~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Pascal, J M.]]	+	[[Category: Pascal, J M]]
-	[[Category: Zhang, J F.]]	+	[[Category: Zhang, J F]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
	[[Category: Ef hand]]		[[Category: Ef hand]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]
	[[Category: Metal transport-calcium binding protein complex]]		[[Category: Metal transport-calcium binding protein complex]]
	[[Category: Protein-protein complex]]		[[Category: Protein-protein complex]]

OCA at 05:11, 12 September 2012

OCA — Wed, 12 Sep 2012 05:11:35 GMT

←Older revision		Revision as of 05:11, 12 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g27.jpg\|left\|200px]]

-	~~The entry~~ 4g27 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4g27\| PDB=4g27 \| SCENE= }}

-	~~Authors: Zhang, M., Pascal, J.M., Zhang, J.~~-F.	+	===Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea===

-	~~Description~~: ~~Calcium~~-~~calmodulin complexed with the calmodulin~~ binding ~~domain from a small conductance potassium channel splice variant and phenylurea~~	+	{{ABSTRACT_PUBMED_22929778}}
		+
		+	==About this Structure==
		+	[[4g27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G27 OCA].
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Pascal, J M.]]
		+	[[Category: Zhang, J F.]]
		+	[[Category: Zhang, M.]]
		+	[[Category: Ef hand]]
		+	[[Category: Metal binding protein]]
		+	[[Category: Metal transport-calcium binding protein complex]]
		+	[[Category: Protein-protein complex]]

OCA at 05:30, 22 August 2012

OCA — Wed, 22 Aug 2012 05:30:32 GMT

←Older revision		Revision as of 05:30, 22 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g27 is ON HOLD	+	The entry 4g27 is ON HOLD until Paper Publication

	Authors: Zhang, M., Pascal, J.M., Zhang, J.-F.		Authors: Zhang, M., Pascal, J.M., Zhang, J.-F.

	Description: Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea		Description: Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea

OCA at 05:28, 1 August 2012

OCA — Wed, 01 Aug 2012 05:28:09 GMT

←Older revision		Revision as of 05:28, 1 August 2012
Line 3:		Line 3:
	The entry 4g27 is ON HOLD		The entry 4g27 is ON HOLD

-	Authors: Zhang, M, Pascal, J.M., Zhang, J.-f.	+	Authors: Zhang, M., Pascal, J.M., Zhang, J.-F.

	Description: Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea		Description: Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea

OCA: Protected "4g27" [edit=sysop:move=sysop]

OCA — Wed, 18 Jul 2012 05:08:43 GMT

Protected "4g27" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:08, 18 July 2012

OCA: New page: '''Unreleased structure''' The entry 4g27 is ON HOLD Authors: Zhang, M, Pascal, J.M., Zhang, J.-f. Description: Calcium-calmodulin complexed with the calmodulin binding domain from a s...

OCA — Wed, 18 Jul 2012 05:08:42 GMT

New page: '''Unreleased structure''' The entry 4g27 is ON HOLD Authors: Zhang, M, Pascal, J.M., Zhang, J.-f. Description: Calcium-calmodulin complexed with the calmodulin binding domain from a s...

New page

'''Unreleased structure'''

The entry 4g27 is ON HOLD

Authors: Zhang, M, Pascal, J.M., Zhang, J.-f.

Description: Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea