4g2b - Revision history

OCA at 20:21, 19 October 2022

OCA — Wed, 19 Oct 2022 20:21:30 GMT

←Older revision		Revision as of 20:21, 19 October 2022
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	==Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI==		==Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI==
-	<StructureSection load='4g2b' size='340' side='right' caption='[[4g2b]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4g2b' size='340' side='right'caption='[[4g2b]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Salty Salty~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G2B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2B FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g29\|4g29]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [https://pdbe.org/4g2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [https://www.ebi.ac.uk/pdbsum/4g2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2b ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sseI, srfH, STM1051 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [~~http~~://pdbe.org/4g2b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g2b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2b ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SSEI_SALTY SSEI_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6.<ref>PMID:17095609</ref> <ref>PMID:19956712</ref>	+	[https://www.uniprot.org/uniprot/SSEI_SALTY SSEI_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6.<ref>PMID:17095609</ref> <ref>PMID:19956712</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Salty~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bhaskaran, S S~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-	[[Category: ~~Stebbins, C E~~]]	+	[[Category: Bhaskaran SS]]
-	[[Category: ~~Cysteine protease superfamily]]~~	+	[[Category: Stebbins CE]]
-	~~[[Category: Protein binding~~]]	+

OCA at 12:31, 5 August 2016

OCA — Fri, 05 Aug 2016 12:31:53 GMT

←Older revision		Revision as of 12:31, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI==		==Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI==
	<StructureSection load='4g2b' size='340' side='right' caption='[[4g2b]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4g2b' size='340' side='right' caption='[[4g2b]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2B FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g29\|4g29]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g29\|4g29]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sseI, srfH, STM1051 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 ~~Salmonella enterica subsp. enterica serovar Typhimurium str. LT2~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sseI, srfH, STM1051 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [http://www.ebi.ac.uk/pdbsum/4g2b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [http://pdbe.org/4g2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [http://www.ebi.ac.uk/pdbsum/4g2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g2b" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Salmonella enterica subsp. enterica serovar typhimurium str. lt2~~]]	+	[[Category: Salty]]
	[[Category: Bhaskaran, S S]]		[[Category: Bhaskaran, S S]]
	[[Category: Stebbins, C E]]		[[Category: Stebbins, C E]]
	[[Category: Cysteine protease superfamily]]		[[Category: Cysteine protease superfamily]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 02:28, 25 December 2014

OCA — Thu, 25 Dec 2014 02:28:39 GMT

←Older revision		Revision as of 02:28, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [http://www.ebi.ac.uk/pdbsum/4g2b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [http://www.ebi.ac.uk/pdbsum/4g2b PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SSEI_SALTY SSEI_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6.<ref>PMID:17095609</ref> <ref>PMID:19956712</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:24, 9 December 2014

OCA — Tue, 09 Dec 2014 17:24:30 GMT

←Older revision		Revision as of 17:24, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4g2b.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI==
		+	<StructureSection load='4g2b' size='340' side='right' caption='[[4g2b]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2B FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g29\|4g29]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sseI, srfH, STM1051 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [http://www.ebi.ac.uk/pdbsum/4g2b PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SseI is secreted into host cells by Salmonella and contributes to the establishment of systemic infections. The crystal structure of the C-terminal domain of SseI has been solved to 1.70 A resolution, revealing it to be a member of the cysteine protease superfamily with a catalytic triad consisting of Cys178, His216 and Asp231 that is critical to its virulence activities. Structure-based analysis revealed that SseI is likely to possess either acyl hydrolase or acyltransferase activity, placing this virulence factor in the rapidly growing class of enzymes of this family utilized by bacterial pathogens inside eukaryotic cells.

-	~~{{STRUCTURE_4g2b\| PDB=4g2b \| SCENE= }}~~	+	Structure of the catalytic domain of the Salmonella virulence factor SseI.,Bhaskaran SS, Stebbins CE Acta Crystallogr D Biol Crystallogr. 2012 Dec;68(Pt 12):1613-21. doi:, 10.1107/S0907444912039042. Epub 2012 Nov 9. PMID:23151626<ref>PMID:23151626</ref>

-	~~===Structure~~ of the ~~Catalytic Domain~~ of ~~the Salmonella Virulence Factor SseI===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23151626}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4g2b]] is a 2 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA].	+	</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]
-	[[Category: Bhaskaran, S S.]]	+	[[Category: Bhaskaran, S S]]
-	[[Category: Stebbins, C E.]]	+	[[Category: Stebbins, C E]]
	[[Category: Cysteine protease superfamily]]		[[Category: Cysteine protease superfamily]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 14:29, 28 November 2012

OCA — Wed, 28 Nov 2012 14:29:14 GMT

←Older revision		Revision as of 14:29, 28 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g2b.jpg\|left\|200px]]

-	~~The entry~~ 4g2b ~~is ON HOLD~~	+	{{STRUCTURE_4g2b\| PDB=4g2b \| SCENE= }}

-	~~Authors: Stebbins, C.E., Bhaskaran, S.S.~~	+	===Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI===

-	~~Description:~~ Structure ~~of the Catalytic Domain of the~~ Salmonella ~~Virulence Factor SseI~~	+	{{ABSTRACT_PUBMED_23151626}}
		+
		+	==About this Structure==
		+	[[4g2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA].
		+	[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]
		+	[[Category: Bhaskaran, S S.]]
		+	[[Category: Stebbins, C E.]]
		+	[[Category: Cysteine protease superfamily]]
		+	[[Category: Protein binding]]

OCA: Protected "4g2b" [edit=sysop:move=sysop]

OCA — Wed, 18 Jul 2012 05:08:50 GMT

Protected "4g2b" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:08, 18 July 2012

OCA: New page: '''Unreleased structure''' The entry 4g2b is ON HOLD Authors: Stebbins, C.E., Bhaskaran, S.S. Description: Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI

OCA — Wed, 18 Jul 2012 05:08:49 GMT

New page: '''Unreleased structure''' The entry 4g2b is ON HOLD Authors: Stebbins, C.E., Bhaskaran, S.S. Description: Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI

New page

'''Unreleased structure'''

The entry 4g2b is ON HOLD

Authors: Stebbins, C.E., Bhaskaran, S.S.

Description: Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI