4g35 - Revision history

OCA at 20:22, 19 October 2022

OCA — Wed, 19 Oct 2022 20:22:27 GMT

←Older revision		Revision as of 20:22, 19 October 2022
Line 1:		Line 1:

	==Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.==		==Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.==
-	<StructureSection load='4g35' size='340' side='right' caption='[[4g35]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4g35' size='340' side='right'caption='[[4g35]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g35]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G35 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G35 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4BP:4,4-BIS(BROMOMETHYL)BIPHENYL'>4BP</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4BP:4,4-BIS(BROMOMETHYL)BIPHENYL'>4BP</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g35 OCA], [https://pdbe.org/4g35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g35 RCSB], [https://www.ebi.ac.uk/pdbsum/4g35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g35 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g35 OCA], [~~http~~://pdbe.org/4g35 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g35 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g35 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g35 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.	+	[https://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4g35" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4g35" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: Drake, E]]	+	[[Category: Mus musculus]]
-	[[Category: Edwardraja, S]]	+	[[Category: Drake E]]
-	[[Category: Gulick~~, A M~~]]	+	[[Category: Edwardraja S]]
-	[[Category: Lin, Q]]	+	[[Category: Gulick AM]]
-	~~[[Category: Apoptosis]]~~	+	[[Category: Lin Q]]
-	~~[[Category: Apoptosis-inhibitor complex]]~~	+
-	~~[[Category: Bcl-2 family]]~~	+
-	~~[[Category: Bh3 domain~~]]	+

OCA at 13:10, 4 August 2016

OCA — Thu, 04 Aug 2016 13:10:28 GMT

←Older revision		Revision as of 13:10, 4 August 2016
Line 1:		Line 1:
		+
	==Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.==		==Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.==
	<StructureSection load='4g35' size='340' side='right' caption='[[4g35]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4g35' size='340' side='right' caption='[[4g35]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G35 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G35 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4BP:4,4-BIS(BROMOMETHYL)BIPHENYL'>4BP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4BP:4,4-BIS(BROMOMETHYL)BIPHENYL'>4BP</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g35 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g35 RCSB], [http://www.ebi.ac.uk/pdbsum/4g35 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g35 OCA], [http://pdbe.org/4g35 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g35 RCSB], [http://www.ebi.ac.uk/pdbsum/4g35 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g35 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g35" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Drake, E]]		[[Category: Drake, E]]
	[[Category: Edwardraja, S]]		[[Category: Edwardraja, S]]

OCA at 14:53, 24 December 2014

OCA — Wed, 24 Dec 2014 14:53:26 GMT

←Older revision		Revision as of 14:53, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g35 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g35 RCSB], [http://www.ebi.ac.uk/pdbsum/4g35 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g35 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g35 RCSB], [http://www.ebi.ac.uk/pdbsum/4g35 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:46, 21 December 2014

OCA — Sun, 21 Dec 2014 11:46:01 GMT

←Older revision		Revision as of 11:46, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4g35\| PDB=4g35 \| SCENE= }}~~	+	==Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.==
-	===Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.===	+	<StructureSection load='4g35' size='340' side='right' caption='[[4g35]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22920569}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G35 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4BP:4,4-BIS(BROMOMETHYL)BIPHENYL'>4BP</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g35 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g35 RCSB], [http://www.ebi.ac.uk/pdbsum/4g35 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Direct chemical modifications provide a simple and effective means to "translate" bioactive helical peptides into potential therapeutics targeting intracellular protein-protein interactions. We previously showed that distance-matching bisaryl cross-linkers can reinforce peptide helices containing two cysteines at the i and i+7 positions and confer cell permeability to the cross-linked peptides. Here we report the first crystal structure of a biphenyl-cross-linked Noxa peptide in complex with its target Mcl-1 at 2.0 A resolution. Guided by this structure, we remodeled the surface of this cross-linked peptide through side-chain substitution and N-methylation and obtained a pair of cross-linked peptides with substantially increased helicity, cell permeability, proteolytic stability, and cell-killing activity in Mcl-1-overexpressing U937 cells.

-	~~==Function==~~	+	Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors.,Muppidi A, Doi K, Edwardraja S, Drake EJ, Gulick AM, Wang HG, Lin Q J Am Chem Soc. 2012 Sep 12;134(36):14734-7. doi: 10.1021/ja306864v. Epub 2012 Sep, 4. PMID:22920569<ref>PMID:22920569</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival~~, ~~and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4g35]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022920569</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Drake, E.]]	+	[[Category: Drake, E]]
-	[[Category: Edwardraja, S.]]	+	[[Category: Edwardraja, S]]
-	[[Category: Gulick, A M.]]	+	[[Category: Gulick, A M]]
-	[[Category: Lin, Q.]]	+	[[Category: Lin, Q]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Apoptosis-inhibitor complex]]		[[Category: Apoptosis-inhibitor complex]]
	[[Category: Bcl-2 family]]		[[Category: Bcl-2 family]]
	[[Category: Bh3 domain]]		[[Category: Bh3 domain]]

OCA at 08:02, 30 June 2013

OCA — Sun, 30 Jun 2013 08:02:04 GMT

←Older revision		Revision as of 08:02, 30 June 2013
Line 1:		Line 1:
-	[[Image:4g35.jpg\|left\|200px]]
-
	{{STRUCTURE_4g35\| PDB=4g35 \| SCENE= }}		{{STRUCTURE_4g35\| PDB=4g35 \| SCENE= }}
-
	===Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.===		===Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.===
-
	{{ABSTRACT_PUBMED_22920569}}		{{ABSTRACT_PUBMED_22920569}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.

	==About this Structure==		==About this Structure==
	[[4g35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA].		[[4g35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022920569</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Drake, E.]]		[[Category: Drake, E.]]

OCA at 10:52, 5 December 2012

OCA — Wed, 05 Dec 2012 10:52:13 GMT

←Older revision		Revision as of 10:52, 5 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g35.jpg\|left\|200px]]

-	~~The entry~~ 4g35 ~~is ON HOLD~~	+	{{STRUCTURE_4g35\| PDB=4g35 \| SCENE= }}

-	~~Authors: Drake, E., Edwardraja, S., Lin, Q., Gulick, A.M~~.	+	===Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.===

-	~~Description~~: ~~Mcl~~-~~1 in~~ complex ~~with a biphenyl cross~~-~~linked Noxa peptide.~~	+	{{ABSTRACT_PUBMED_22920569}}
		+
		+	==About this Structure==
		+	[[4g35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Drake, E.]]
		+	[[Category: Edwardraja, S.]]
		+	[[Category: Gulick, A M.]]
		+	[[Category: Lin, Q.]]
		+	[[Category: Apoptosis]]
		+	[[Category: Apoptosis-inhibitor complex]]
		+	[[Category: Bcl-2 family]]
		+	[[Category: Bh3 domain]]

OCA at 06:50, 10 October 2012

OCA — Wed, 10 Oct 2012 06:50:33 GMT

←Older revision		Revision as of 06:50, 10 October 2012
Line 3:		Line 3:
	The entry 4g35 is ON HOLD		The entry 4g35 is ON HOLD

-	Authors: Drake, ~~Eric~~ , Edwardraja, ~~Selvakumar~~ , Lin, ~~Qing~~ , Gulick, ~~Andrew~~ M.	+	Authors: Drake, E., Edwardraja, S., Lin, Q., Gulick, A.M.

	Description: Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.		Description: Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.

OCA: Protected "4g35" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 06:50:45 GMT

Protected "4g35" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:50, 25 July 2012

OCA: New page: '''Unreleased structure''' The entry 4g35 is ON HOLD Authors: Drake, Eric , Edwardraja, Selvakumar , Lin, Qing , Gulick, Andrew M. Description: Mcl-1 in complex with a biphenyl cross-l...

OCA — Wed, 25 Jul 2012 06:50:44 GMT

New page: '''Unreleased structure''' The entry 4g35 is ON HOLD Authors: Drake, Eric , Edwardraja, Selvakumar , Lin, Qing , Gulick, Andrew M. Description: Mcl-1 in complex with a biphenyl cross-l...

New page

'''Unreleased structure'''

The entry 4g35 is ON HOLD

Authors: Drake, Eric , Edwardraja, Selvakumar , Lin, Qing , Gulick, Andrew M.

Description: Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.