4g3n - Revision history

OCA at 15:38, 14 March 2024

OCA — Thu, 14 Mar 2024 15:38:43 GMT

←Older revision		Revision as of 15:38, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3N FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3n OCA], [https://pdbe.org/4g3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3n RCSB], [https://www.ebi.ac.uk/pdbsum/4g3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3n ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3n OCA], [https://pdbe.org/4g3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3n RCSB], [https://www.ebi.ac.uk/pdbsum/4g3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.		[https://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	In contrast to most bacteria which possess two type II topoisomerases (Topo IV and DNA gyrase), Mycobacterium tuberculosis possesses only one, DNA gyrase, which is functionally a hybrid enzyme. Functional differences between the two type IIA topoisomerases are thought to be specified by a C-terminal DNA binding domain (CTD) which controls DNA recognition. To explore the molecular mechanism responsible for the hybrid functions of the M. tuberculosis DNA gyrase, we conducted a series of sequence analyses and structural and biochemical experiments with the isolated GyrA CTD and the holoenzyme. While the CTD displayed a global structure similar to that of bona fide GyrA and ParC paralogs, it harbors a second key motif similar in all respects to that of the conserved GyrA-box sequence motif. Biochemical assays showed that the GyrA-box is responsible for DNA supercoiling, whereas the second GyrA-box-like motif (GyrA-box-l) is responsible for the enhanced decatenation activity suggesting that the mechanistic originality of M. tuberculosis DNA gyrase depends largely on the particular DNA path around the CTD allowed for by the presence of GyrA-box-l. Our results provide also, through phylogenetic exploration of the entire Corynebacterineae suborder, new and broader insight into the functional diversity of bacterial type IIA topoisomerases.
-
-	The Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes.,Bouige A, Darmon A, Piton J, Roue M, Petrella S, Capton E, Forterre P, Aubry A, Mayer C Biochem J. 2013 Jul 22. PMID:23869946<ref>PMID:23869946</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4g3n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Gyrase 3D Structures\|Gyrase 3D Structures]]		*[[Gyrase 3D Structures\|Gyrase 3D Structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:23, 19 October 2022

OCA — Wed, 19 Oct 2022 20:23:06 GMT

←Older revision		Revision as of 20:23, 19 October 2022
Line 1:		Line 1:

	==Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution==		==Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution==
-	<StructureSection load='4g3n' size='340' side='right' caption='[[4g3n]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='4g3n' size='340' side='right'caption='[[4g3n]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g3n]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G3N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3N FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gyrA, MT0006, mtct10h4.04, MTCY10H4.04, Rv0006, rv006 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3n OCA], [https://pdbe.org/4g3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3n RCSB], [https://www.ebi.ac.uk/pdbsum/4g3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3n ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3n OCA], [~~http~~://pdbe.org/4g3n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g3n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g3n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3n ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.	+	[https://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:

	==See Also==		==See Also==
-	*[[Gyrase\|Gyrase]]	+	*[[Gyrase 3D Structures\|Gyrase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Myctu~~]]	+	[[Category: Large Structures]]
-	[[Category: Aubry, A]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Darmon, A]]	+	[[Category: Aubry A]]
-	[[Category: Mayer, C]]	+	[[Category: Darmon A]]
-	[[Category: Petrella, S]]	+	[[Category: Mayer C]]
-	[[Category: Piton, J]]	+	[[Category: Petrella S]]
-	~~[[Category: Beta-propeller]]~~	+	[[Category: Piton J]]
-	~~[[Category: Dna gyrase c-terminal domain]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Topoisomerase type iia~~]]	+

OCA at 11:42, 4 August 2016

OCA — Thu, 04 Aug 2016 11:42:17 GMT

←Older revision		Revision as of 11:42, 4 August 2016
Line 1:		Line 1:
		+
	==Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution==		==Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution==
	<StructureSection load='4g3n' size='340' side='right' caption='[[4g3n]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4g3n' size='340' side='right' caption='[[4g3n]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G3N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G3N FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gyrA, MT0006, mtct10h4.04, MTCY10H4.04, Rv0006, rv006 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 ~~Mycobacterium tuberculosis H37Rv~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gyrA, MT0006, mtct10h4.04, MTCY10H4.04, Rv0006, rv006 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g3n RCSB], [http://www.ebi.ac.uk/pdbsum/4g3n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3n OCA], [http://pdbe.org/4g3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g3n RCSB], [http://www.ebi.ac.uk/pdbsum/4g3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g3n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis h37rv~~]]	+	[[Category: Myctu]]
	[[Category: Aubry, A]]		[[Category: Aubry, A]]
	[[Category: Darmon, A]]		[[Category: Darmon, A]]

OCA at 08:57, 25 December 2014

OCA — Thu, 25 Dec 2014 08:57:37 GMT

←Older revision		Revision as of 08:57, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g3n RCSB], [http://www.ebi.ac.uk/pdbsum/4g3n PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g3n RCSB], [http://www.ebi.ac.uk/pdbsum/4g3n PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:34, 21 December 2014

OCA — Sun, 21 Dec 2014 11:34:10 GMT

←Older revision		Revision as of 11:34, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4g3n\| PDB=4g3n \| SCENE= }}~~	+	==Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution==
-	===Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution===	+	<StructureSection load='4g3n' size='340' side='right' caption='[[4g3n]], [[Resolution\|resolution]] 1.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23869946}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G3N FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gyrA, MT0006, mtct10h4.04, MTCY10H4.04, Rv0006, rv006 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 Mycobacterium tuberculosis H37Rv])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g3n RCSB], [http://www.ebi.ac.uk/pdbsum/4g3n PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In contrast to most bacteria which possess two type II topoisomerases (Topo IV and DNA gyrase), Mycobacterium tuberculosis possesses only one, DNA gyrase, which is functionally a hybrid enzyme. Functional differences between the two type IIA topoisomerases are thought to be specified by a C-terminal DNA binding domain (CTD) which controls DNA recognition. To explore the molecular mechanism responsible for the hybrid functions of the M. tuberculosis DNA gyrase, we conducted a series of sequence analyses and structural and biochemical experiments with the isolated GyrA CTD and the holoenzyme. While the CTD displayed a global structure similar to that of bona fide GyrA and ParC paralogs, it harbors a second key motif similar in all respects to that of the conserved GyrA-box sequence motif. Biochemical assays showed that the GyrA-box is responsible for DNA supercoiling, whereas the second GyrA-box-like motif (GyrA-box-l) is responsible for the enhanced decatenation activity suggesting that the mechanistic originality of M. tuberculosis DNA gyrase depends largely on the particular DNA path around the CTD allowed for by the presence of GyrA-box-l. Our results provide also, through phylogenetic exploration of the entire Corynebacterineae suborder, new and broader insight into the functional diversity of bacterial type IIA topoisomerases.

-	~~==Function==~~	+	The Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes.,Bouige A, Darmon A, Piton J, Roue M, Petrella S, Capton E, Forterre P, Aubry A, Mayer C Biochem J. 2013 Jul 22. PMID:23869946<ref>PMID:23869946</ref>
-	~~[[http://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU]]~~ DNA gyrase ~~negatively supercoils closed circular double~~-~~stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings~~, ~~including catenanes and knotted rings~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4g3n]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Gyrase\|Gyrase]]		*[[Gyrase\|Gyrase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023869946</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
-	[[Category: Aubry, A.]]	+	[[Category: Aubry, A]]
-	[[Category: Darmon, A.]]	+	[[Category: Darmon, A]]
-	[[Category: Mayer, C.]]	+	[[Category: Mayer, C]]
-	[[Category: Petrella, S.]]	+	[[Category: Petrella, S]]
-	[[Category: Piton, J.]]	+	[[Category: Piton, J]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Dna gyrase c-terminal domain]]		[[Category: Dna gyrase c-terminal domain]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Topoisomerase type iia]]		[[Category: Topoisomerase type iia]]

OCA at 05:24, 23 October 2013

OCA — Wed, 23 Oct 2013 05:24:46 GMT

←Older revision		Revision as of 05:24, 23 October 2013
Line 8:		Line 8:
	==About this Structure==		==About this Structure==
	[[4g3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA].		[[4g3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA].
		+
		+	==See Also==
		+	*[[Gyrase\|Gyrase]]

	==Reference==		==Reference==

OCA at 20:56, 7 August 2013

OCA — Wed, 07 Aug 2013 20:56:16 GMT

←Older revision		Revision as of 20:56, 7 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4g3n\| PDB=4g3n \| SCENE= }}
		+	===Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution===
		+	{{ABSTRACT_PUBMED_23869946}}

-	~~The entry 4g3n is ON HOLD until sometime~~ in the ~~future~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.

-	~~Authors~~: ~~Darmon, A~~.~~, Piton, J~~.~~, Petrella, S~~.~~, Aubry, A~~.~~, Mayer, C~~.	+	==About this Structure==
		+	[[4g3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3N OCA].

-	~~Description~~: Mycobacterium tuberculosis ~~gyrase type IIA topoisomerase~~ C-terminal domain ~~at 1.4 A resolution~~	+	==Reference==
		+	<ref group="xtra">PMID:023869946</ref><references group="xtra"/><references/>
		+	[[Category: Mycobacterium tuberculosis h37rv]]
		+	[[Category: Aubry, A.]]
		+	[[Category: Darmon, A.]]
		+	[[Category: Mayer, C.]]
		+	[[Category: Petrella, S.]]
		+	[[Category: Piton, J.]]
		+	[[Category: Beta-propeller]]
		+	[[Category: Dna gyrase c-terminal domain]]
		+	[[Category: Isomerase]]
		+	[[Category: Topoisomerase type iia]]

OCA at 04:01, 1 August 2013

OCA — Thu, 01 Aug 2013 04:01:46 GMT

←Older revision		Revision as of 04:01, 1 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g3n is ON HOLD until ~~Paper Publication~~	+	The entry 4g3n is ON HOLD until sometime in the future

	Authors: Darmon, A., Piton, J., Petrella, S., Aubry, A., Mayer, C.		Authors: Darmon, A., Piton, J., Petrella, S., Aubry, A., Mayer, C.

	Description: Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution		Description: Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution

OCA at 04:48, 12 September 2012

OCA — Wed, 12 Sep 2012 04:48:58 GMT

←Older revision		Revision as of 04:48, 12 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g3n is ON HOLD	+	The entry 4g3n is ON HOLD until Paper Publication

	Authors: Darmon, A., Piton, J., Petrella, S., Aubry, A., Mayer, C.		Authors: Darmon, A., Piton, J., Petrella, S., Aubry, A., Mayer, C.

	Description: Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution		Description: Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution

OCA: Protected "4g3n" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 06:51:15 GMT

Protected "4g3n" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:51, 25 July 2012