4g3o - Revision history

OCA at 15:38, 14 March 2024

OCA — Thu, 14 Mar 2024 15:38:47 GMT

←Older revision		Revision as of 15:38, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3O FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3o OCA], [https://pdbe.org/4g3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3o RCSB], [https://www.ebi.ac.uk/pdbsum/4g3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3o ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3o OCA], [https://pdbe.org/4g3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3o RCSB], [https://www.ebi.ac.uk/pdbsum/4g3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:23, 19 October 2022

OCA — Wed, 19 Oct 2022 20:23:08 GMT

←Older revision		Revision as of 20:23, 19 October 2022
Line 1:		Line 1:

	==Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78)==		==Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78)==
-	<StructureSection load='4g3o' size='340' side='right' caption='[[4g3o]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='4g3o' size='340' side='right'caption='[[4g3o]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g3o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3O FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMFR, RNF45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3o OCA], [https://pdbe.org/4g3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3o RCSB], [https://www.ebi.ac.uk/pdbsum/4g3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3o ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3o OCA], [~~http~~://pdbe.org/4g3o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g3o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g3o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3o ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AMFR_HUMAN AMFR_HUMAN]] E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.<ref>PMID:10456327</ref> <ref>PMID:11724934</ref> <ref>PMID:16168377</ref> <ref>PMID:19103148</ref>	+	[https://www.uniprot.org/uniprot/AMFR_HUMAN AMFR_HUMAN] E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.<ref>PMID:10456327</ref> <ref>PMID:11724934</ref> <ref>PMID:16168377</ref> <ref>PMID:19103148</ref>

	==See Also==		==See Also==
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]	+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Gehring, K~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Kozlov, G]]~~	+	[[Category: Gehring K]]
-	~~[[Category: LePage,~~ K]]	+	[[Category: Kozlov G]]
-	[[Category: ~~All-helical structure~~]]	+	[[Category: LePage K]]
-	[[Category: ~~Bag6]]~~	+
-	~~[[Category: Ligase~~]]	+

OCA at 16:21, 5 August 2016

OCA — Fri, 05 Aug 2016 16:21:56 GMT

←Older revision		Revision as of 16:21, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78)==		==Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78)==
	<StructureSection load='4g3o' size='340' side='right' caption='[[4g3o]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='4g3o' size='340' side='right' caption='[[4g3o]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G3O FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMFR, RNF45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMFR, RNF45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g3o RCSB], [http://www.ebi.ac.uk/pdbsum/4g3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3o OCA], [http://pdbe.org/4g3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g3o RCSB], [http://www.ebi.ac.uk/pdbsum/4g3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~AMFR2_HUMAN AMFR2_HUMAN~~]] E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.<ref>PMID:10456327</ref> <ref>PMID:11724934</ref> <ref>PMID:16168377</ref> <ref>PMID:19103148</ref>	+	[[http://www.uniprot.org/uniprot/AMFR_HUMAN AMFR_HUMAN]] E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.<ref>PMID:10456327</ref> <ref>PMID:11724934</ref> <ref>PMID:16168377</ref> <ref>PMID:19103148</ref>

	==See Also==		==See Also==
Line 15:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gehring, K]]		[[Category: Gehring, K]]
	[[Category: Kozlov, G]]		[[Category: Kozlov, G]]

OCA at 03:56, 25 December 2014

OCA — Thu, 25 Dec 2014 03:56:49 GMT

←Older revision		Revision as of 03:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G3O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G3O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMFR, RNF45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMFR, RNF45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g3o RCSB], [http://www.ebi.ac.uk/pdbsum/4g3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g3o RCSB], [http://www.ebi.ac.uk/pdbsum/4g3o PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AMFR2_HUMAN AMFR2_HUMAN]] E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.<ref>PMID:10456327</ref> <ref>PMID:11724934</ref> <ref>PMID:16168377</ref> <ref>PMID:19103148</ref>

	==See Also==		==See Also==
	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]		*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gehring, K.]]	+	[[Category: Gehring, K]]
-	[[Category: Kozlov, G.]]	+	[[Category: Kozlov, G]]
-	[[Category: LePage, K.]]	+	[[Category: LePage, K]]
	[[Category: All-helical structure]]		[[Category: All-helical structure]]
	[[Category: Bag6]]		[[Category: Bag6]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 07:56, 5 June 2014

OCA — Thu, 05 Jun 2014 07:56:42 GMT

←Older revision		Revision as of 07:56, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4g3o.~~jpg~~\|~~left\|200px~~]]	+	==Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78)==
		+	<StructureSection load='4g3o' size='340' side='right' caption='[[4g3o]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G3O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMFR, RNF45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g3o RCSB], [http://www.ebi.ac.uk/pdbsum/4g3o PDBsum]</span></td></tr>
		+	<table>

-	~~{{STRUCTURE_4g3o\| PDB~~=~~4g3o \| SCENE~~= }}	+	==See Also==
-		+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
-	~~===Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78)===~~	+	__TOC__
-		+	</StructureSection>
-		+
-	~~==About this Structure~~==	+
-	[[~~4g3o~~]] ~~is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA].~~	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gehring, K.]]		[[Category: Gehring, K.]]

OCA: Protected "4g3o" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 07:23:41 GMT

Protected "4g3o" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:23, 25 July 2012

OCA: New page: 200px {{STRUCTURE_4g3o| PDB=4g3o | SCENE= }} ===Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78)=== ==About this Structure== [[4g...

OCA — Wed, 25 Jul 2012 07:23:39 GMT

New page: 200px {{STRUCTURE_4g3o| PDB=4g3o | SCENE= }} ===Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78)=== ==About this Structure== [[4g...

New page

[[Image:4g3o.jpg|left|200px]]

{{STRUCTURE_4g3o| PDB=4g3o | SCENE= }}

===Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78)===

==About this Structure==
[[4g3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3O OCA].
[[Category: Homo sapiens]]
[[Category: Gehring, K.]]
[[Category: Kozlov, G.]]
[[Category: LePage, K.]]
[[Category: All-helical structure]]
[[Category: Bag6]]
[[Category: Ligase]]