4g4q - Revision history

OCA at 20:24, 19 October 2022

OCA — Wed, 19 Oct 2022 20:24:36 GMT

←Older revision		Revision as of 20:24, 19 October 2022
Line 1:		Line 1:

	==MutM containing F114A mutation bound to undamaged DNA==		==MutM containing F114A mutation bound to undamaged DNA==
-	<StructureSection load='4g4q' size='340' side='right' caption='[[4g4q]], [[Resolution\|resolution]] 1.86Å' scene=''>	+	<StructureSection load='4g4q' size='340' side='right'caption='[[4g4q]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g4q]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_12980 Atcc 12980~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g4q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G4Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TX2:5-O-{(R)-HYDROXY[(2-SULFANYLETHYL)AMINO]PHOSPHORYL}THYMIDINE'>TX2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=TX2:5-O-{(R)-HYDROXY[(2-SULFANYLETHYL)AMINO]PHOSPHORYL}THYMIDINE'>TX2</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g4q OCA], [https://pdbe.org/4g4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g4q RCSB], [https://www.ebi.ac.uk/pdbsum/4g4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g4q ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g4n\|4g4n]]~~, ~~[[4g4o\|4g4o]], [[4g4r\|4g4r]]~~<~~/td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">mutM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 ATCC 12980])</td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g4q OCA], [~~http~~://pdbe.org/4g4q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g4q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g4q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g4q ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]	+	[https://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 20:

	==See Also==		==See Also==
-	*[[DNA glycosylase\|DNA glycosylase]]	+	*[[DNA glycosylase 3D structures\|DNA glycosylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 12980~~]]	+	[[Category: Geobacillus stearothermophilus]]
-	[[Category: ~~DNA-formamidopyrimidine glycosylase~~]]	+	[[Category: Large Structures]]
-	[[Category: Qi, Y]]	+	[[Category: Qi Y]]
-	[[Category: Sung~~, R J~~]]	+	[[Category: Sung RJ]]
-	[[Category: Verdine~~, G L~~]]	+	[[Category: Verdine GL]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	~~[[Category: Base extrusion]]~~	+
-	~~[[Category: Disulfide crosslinking]]~~	+
-	~~[[Category: Dna glycosylase]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Hydrolase-dna complex]]~~	+
-	~~[[Category: Lesion recognition~~]]	+

OCA at 22:13, 5 August 2016

OCA — Fri, 05 Aug 2016 22:13:51 GMT

←Older revision		Revision as of 22:13, 5 August 2016
Line 1:		Line 1:
		+
	==MutM containing F114A mutation bound to undamaged DNA==		==MutM containing F114A mutation bound to undamaged DNA==
	<StructureSection load='4g4q' size='340' side='right' caption='[[4g4q]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='4g4q' size='340' side='right' caption='[[4g4q]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g4q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Geobacillus_stearothermophilus Geobacillus stearothermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g4q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G4Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TX2:5-O-{(R)-HYDROXY[(2-SULFANYLETHYL)AMINO]PHOSPHORYL}THYMIDINE'>TX2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TX2:5-O-{(R)-HYDROXY[(2-SULFANYLETHYL)AMINO]PHOSPHORYL}THYMIDINE'>TX2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g4n\|4g4n]], [[4g4o\|4g4o]], [[4g4r\|4g4r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g4n\|4g4n]], [[4g4o\|4g4o]], [[4g4r\|4g4r]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mutM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 ~~Geobacillus stearothermophilus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mutM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 ATCC 12980])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g4q RCSB], [http://www.ebi.ac.uk/pdbsum/4g4q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g4q OCA], [http://pdbe.org/4g4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g4q RCSB], [http://www.ebi.ac.uk/pdbsum/4g4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g4q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g4q" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 12980]]
	[[Category: DNA-formamidopyrimidine glycosylase]]		[[Category: DNA-formamidopyrimidine glycosylase]]
-	[[Category: Geobacillus stearothermophilus]]
	[[Category: Qi, Y]]		[[Category: Qi, Y]]
	[[Category: Sung, R J]]		[[Category: Sung, R J]]

OCA at 22:22, 25 December 2014

OCA — Thu, 25 Dec 2014 22:22:18 GMT

←Older revision		Revision as of 22:22, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4g4q\| PDB=4g4q \| SCENE= }}~~	+	==MutM containing F114A mutation bound to undamaged DNA==
-	===MutM containing F114A mutation bound to undamaged DNA===	+	<StructureSection load='4g4q' size='340' side='right' caption='[[4g4q]], [[Resolution\|resolution]] 1.86Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23404556}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4g4q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G4Q FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TX2:5-O-{(R)-HYDROXY[(2-SULFANYLETHYL)AMINO]PHOSPHORYL}THYMIDINE'>TX2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g4n\|4g4n]], [[4g4o\|4g4o]], [[4g4r\|4g4r]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mutM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g4q RCSB], [http://www.ebi.ac.uk/pdbsum/4g4q PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]		[[http://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MutM is a bacterial DNA glycosylase that serves as the first line of defense against the highly mutagenic 8-oxoguanine (oxoG) lesion, catalyzing glycosidic bond cleavage of oxoG to initiate base excision DNA repair. Previous work has shown that MutM actively interrogates DNA for the presence of an intrahelical oxoG lesion. This interrogation process involves significant buckling and bending of the DNA to promote extrusion of oxoG from the duplex. Structural snapshots have revealed several different highly conserved residues that are prominently inserted into the duplex in the vicinity of the target oxoG before and after base extrusion has occurred. However, the roles of these helix-invading residues during the lesion recognition and base extrusion process remain unclear. In this study we set out to probe the function of residues Phe114 and Met77 in oxoG recognition and repair. Here we report a detailed biochemical and structural characterization of MutM variants containing either a F114A or M77A mutation, both of which showed significant decreases in the efficiency of oxoG repair. These data reveal that Met77 plays an important role in stabilizing the lesion-extruded conformation of the DNA. Phe114, on the other hand, appears to destabilize the intrahelical state of the oxoG lesion, primarily by buckling the target base-pair. We report the observation of a completely unexpected interaction state, in which the target base-pair is ruptured but remains fully intrahelical; this structure vividly illustrates the disruptive influence of MutM on the target base-pair.
		+
		+	Structural and biochemical analysis of DNA helix-invasion by the bacterial 8-oxoguanine DNA glycosylase MutM.,Sung RJ, Zhang M, Qi Y, Verdine GL J Biol Chem. 2013 Feb 12. PMID:23404556<ref>PMID:23404556</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4g4q~~]] ~~is a 3 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4Q OCA].~~	+	*[[DNA glycosylase\|DNA glycosylase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: DNA-formamidopyrimidine glycosylase]]		[[Category: DNA-formamidopyrimidine glycosylase]]
	[[Category: Geobacillus stearothermophilus]]		[[Category: Geobacillus stearothermophilus]]
-	[[Category: Qi, Y.]]	+	[[Category: Qi, Y]]
-	[[Category: Sung, R J.]]	+	[[Category: Sung, R J]]
-	[[Category: Verdine, G L.]]	+	[[Category: Verdine, G L]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
	[[Category: Base extrusion]]		[[Category: Base extrusion]]
	[[Category: Disulfide crosslinking]]		[[Category: Disulfide crosslinking]]

OCA at 09:33, 24 April 2013

OCA — Wed, 24 Apr 2013 09:33:04 GMT

←Older revision		Revision as of 09:33, 24 April 2013
Line 1:		Line 1:
-	[[Image:4g4q.png\|left\|200px]]
-
	{{STRUCTURE_4g4q\| PDB=4g4q \| SCENE= }}		{{STRUCTURE_4g4q\| PDB=4g4q \| SCENE= }}
-
	===MutM containing F114A mutation bound to undamaged DNA===		===MutM containing F114A mutation bound to undamaged DNA===
		+	{{ABSTRACT_PUBMED_23404556}}

-	~~{{ABSTRACT_PUBMED_23404556}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]

	==About this Structure==		==About this Structure==

OCA at 12:50, 27 February 2013

OCA — Wed, 27 Feb 2013 12:50:54 GMT

←Older revision		Revision as of 12:50, 27 February 2013
Line 1:		Line 1:
-	[[Image:4g4q.~~jpg~~\|left\|200px]]	+	[[Image:4g4q.png\|left\|200px]]

	{{STRUCTURE_4g4q\| PDB=4g4q \| SCENE= }}		{{STRUCTURE_4g4q\| PDB=4g4q \| SCENE= }}
Line 5:		Line 5:
	===MutM containing F114A mutation bound to undamaged DNA===		===MutM containing F114A mutation bound to undamaged DNA===

		+	{{ABSTRACT_PUBMED_23404556}}

	==About this Structure==		==About this Structure==

OCA at 13:57, 20 February 2013

OCA — Wed, 20 Feb 2013 13:57:40 GMT

←Older revision		Revision as of 13:57, 20 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g4q.jpg\|left\|200px]]

-	~~The entry~~ 4g4q ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4g4q\| PDB=4g4q \| SCENE= }}

-	~~Authors: Sung, R.J., Zhang, M., Qi, Y., Verdine, G.L.~~	+	===MutM containing F114A mutation bound to undamaged DNA===

-	~~Description~~: ~~MutM containing F114A mutation bound to undamaged~~ DNA	+
		+	==About this Structure==
		+	[[4g4q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4Q OCA].
		+	[[Category: DNA-formamidopyrimidine glycosylase]]
		+	[[Category: Geobacillus stearothermophilus]]
		+	[[Category: Qi, Y.]]
		+	[[Category: Sung, R J.]]
		+	[[Category: Verdine, G L.]]
		+	[[Category: Zhang, M.]]
		+	[[Category: Base extrusion]]
		+	[[Category: Disulfide crosslinking]]
		+	[[Category: Dna glycosylase]]
		+	[[Category: Dna repair]]
		+	[[Category: Hydrolase-dna complex]]
		+	[[Category: Lesion recognition]]

OCA at 06:50, 10 October 2012

OCA — Wed, 10 Oct 2012 06:50:43 GMT

←Older revision		Revision as of 06:50, 10 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g4q is ON HOLD	+	The entry 4g4q is ON HOLD until Paper Publication

	Authors: Sung, R.J., Zhang, M., Qi, Y., Verdine, G.L.		Authors: Sung, R.J., Zhang, M., Qi, Y., Verdine, G.L.

	Description: MutM containing F114A mutation bound to undamaged DNA		Description: MutM containing F114A mutation bound to undamaged DNA

OCA: Protected "4g4q" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 06:52:20 GMT

Protected "4g4q" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:52, 25 July 2012

OCA: New page: '''Unreleased structure''' The entry 4g4q is ON HOLD Authors: Sung, R.J., Zhang, M., Qi, Y., Verdine, G.L. Description: MutM containing F114A mutation bound to undamaged DNA

OCA — Wed, 25 Jul 2012 06:52:19 GMT

New page: '''Unreleased structure''' The entry 4g4q is ON HOLD Authors: Sung, R.J., Zhang, M., Qi, Y., Verdine, G.L. Description: MutM containing F114A mutation bound to undamaged DNA

New page

'''Unreleased structure'''

The entry 4g4q is ON HOLD

Authors: Sung, R.J., Zhang, M., Qi, Y., Verdine, G.L.

Description: MutM containing F114A mutation bound to undamaged DNA