4g5d - Revision history

OCA at 15:39, 14 March 2024

OCA — Thu, 14 Mar 2024 15:39:24 GMT

←Older revision		Revision as of 15:39, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major_strain_Friedlin Leishmania major strain Friedlin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major_strain_Friedlin Leishmania major strain Friedlin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G5D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [https://pdbe.org/4g5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [https://www.ebi.ac.uk/pdbsum/4g5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g5d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [https://pdbe.org/4g5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [https://www.ebi.ac.uk/pdbsum/4g5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g5d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref>		[https://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 A for T. cruzi PGF, 1.25 A for T. cruzi PGF with NADP, 1.6 A for L. major PGF and 1.8 A for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (Rfree of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target.
-
-	Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.,Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):609-14. doi:, 10.1107/S2053230X15006883. Epub 2015 Apr 21. PMID:25945716<ref>PMID:25945716</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4g5d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Prostaglandin F synthase\|Prostaglandin F synthase]]	+	*[[Prostaglandin F synthase 3D structures\|Prostaglandin F synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:25, 19 October 2022

OCA — Wed, 19 Oct 2022 20:25:43 GMT

←Older revision		Revision as of 20:25, 19 October 2022
Line 1:		Line 1:

	==X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH==		==X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH==
-	<StructureSection load='4g5d' size='340' side='right' caption='[[4g5d]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4g5d' size='340' side='right'caption='[[4g5d]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Leishmania_major_mhom/il/81/friedlin~~ Leishmania major ~~mhom/il/81/friedlin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G5D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major_strain_Friedlin Leishmania major strain Friedlin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G5D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f40\|4f40]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [https://pdbe.org/4g5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [https://www.ebi.ac.uk/pdbsum/4g5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g5d ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGFS, LMJF_31_2150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=347515 Leishmania major MHOM/IL/81/Friedlin])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [~~http~~://pdbe.org/4g5d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g5d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g5d ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref>	+	[https://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Leishmania major mhom/il/81/friedlin~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Prostaglandin-F synthase]]~~	+	[[Category: Leishmania major strain Friedlin]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: National institute of allergy and infectious disease]]~~	+
-	~~[[Category: Niaid]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Ssgcid~~]]	+

OCA at 17:24, 9 March 2017

OCA — Thu, 09 Mar 2017 17:24:36 GMT

←Older revision		Revision as of 17:24, 9 March 2017
Line 1:		Line 1:
		+
	==X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH==		==X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH==
	<StructureSection load='4g5d' size='340' side='right' caption='[[4g5d]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4g5d' size='340' side='right' caption='[[4g5d]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGFS, LMJF_31_2150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=347515 Leishmania major MHOM/IL/81/Friedlin])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGFS, LMJF_31_2150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=347515 Leishmania major MHOM/IL/81/Friedlin])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [http://www.ebi.ac.uk/pdbsum/4g5d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [http://pdbe.org/4g5d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [http://www.ebi.ac.uk/pdbsum/4g5d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g5d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g5d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:50, 3 June 2015

OCA — Wed, 03 Jun 2015 06:50:04 GMT

←Older revision		Revision as of 06:50, 3 June 2015
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref>		[[http://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 A for T. cruzi PGF, 1.25 A for T. cruzi PGF with NADP, 1.6 A for L. major PGF and 1.8 A for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (Rfree of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target.
		+
		+	Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.,Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):609-14. doi:, 10.1107/S2053230X15006883. Epub 2015 Apr 21. PMID:25945716<ref>PMID:25945716</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==

OCA at 06:25, 13 May 2015

OCA — Wed, 13 May 2015 06:25:30 GMT

←Older revision		Revision as of 06:25, 13 May 2015
Line 2:		Line 2:
	<StructureSection load='4g5d' size='340' side='right' caption='[[4g5d]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4g5d' size='340' side='right' caption='[[4g5d]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leishmania_major~~ Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G5D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major_mhom/il/81/friedlin Leishmania major mhom/il/81/friedlin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G5D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f40\|4f40]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f40\|4f40]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGFS, LMJF_31_2150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~5664~~ Leishmania major])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGFS, LMJF_31_2150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=347515 Leishmania major MHOM/IL/81/Friedlin])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [http://www.ebi.ac.uk/pdbsum/4g5d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [http://www.ebi.ac.uk/pdbsum/4g5d PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q4Q646_LEIMA Q4Q646_LEIMA~~]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.	+	[[http://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref>

	==See Also==		==See Also==
	*[[Prostaglandin F synthase\|Prostaglandin F synthase]]		*[[Prostaglandin F synthase\|Prostaglandin F synthase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Leishmania major]]	+	[[Category: Leishmania major mhom/il/81/friedlin]]
	[[Category: Prostaglandin-F synthase]]		[[Category: Prostaglandin-F synthase]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 16:14, 24 December 2014

OCA — Wed, 24 Dec 2014 16:14:34 GMT

←Older revision		Revision as of 16:14, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G5D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f40\|4f40]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f40\|4f40]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGFS, LMJF_31_2150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 Leishmania major])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGFS, LMJF_31_2150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 Leishmania major])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [http://www.ebi.ac.uk/pdbsum/4g5d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [http://www.ebi.ac.uk/pdbsum/4g5d PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q4Q646_LEIMA Q4Q646_LEIMA]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.

	==See Also==		==See Also==
Line 16:		Line 18:
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
	[[Category: Prostaglandin-F synthase]]		[[Category: Prostaglandin-F synthase]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: National institute of allergy and infectious disease]]		[[Category: National institute of allergy and infectious disease]]
	[[Category: Niaid]]		[[Category: Niaid]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]

OCA at 10:25, 16 June 2014

OCA — Mon, 16 Jun 2014 10:25:29 GMT

←Older revision		Revision as of 10:25, 16 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4g5d.~~jpg~~\|~~left~~\|~~200px~~]]	+	==X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH==
		+	<StructureSection load='4g5d' size='340' side='right' caption='[[4g5d]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G5D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f40\|4f40]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGFS, LMJF_31_2150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 Leishmania major])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [http://www.ebi.ac.uk/pdbsum/4g5d PDBsum]</span></td></tr>
		+	<table>

-	~~{{STRUCTURE_4g5d\| PDB~~=~~4g5d \| SCENE= }}~~	+	==See Also==
-		+	*[[Prostaglandin F synthase\|Prostaglandin F synthase]]
-	~~===X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH~~===	+	__TOC__
-		+	</StructureSection>
-		+
-	~~==About this Structure==~~	+
-	[[~~4g5d~~]] ~~is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA].~~	+
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
	[[Category: Prostaglandin-F synthase]]		[[Category: Prostaglandin-F synthase]]

OCA at 05:54, 15 August 2012

OCA — Wed, 15 Aug 2012 05:54:15 GMT

←Older revision		Revision as of 05:54, 15 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g5d.jpg\|left\|200px]]

-	~~The entry~~ 4g5d ~~is ON HOLD~~	+	{{STRUCTURE_4g5d\| PDB=4g5d \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH===

-	~~Description: X-ray crystal~~ structure ~~of Prostaglandin f synthase~~ from Leishmania major ~~Friedlin bound to NADPH~~	+
		+	==About this Structure==
		+	[[4g5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA].
		+	[[Category: Leishmania major]]
		+	[[Category: Prostaglandin-F synthase]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: National institute of allergy and infectious disease]]
		+	[[Category: Niaid]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]

OCA: Protected "4g5d" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 06:53:00 GMT

Protected "4g5d" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:53, 25 July 2012

OCA: New page: '''Unreleased structure''' The entry 4g5d is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: X-ray crystal structure of Prostaglandin f...

OCA — Wed, 25 Jul 2012 06:52:59 GMT

New page: '''Unreleased structure''' The entry 4g5d is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: X-ray crystal structure of Prostaglandin f...

New page

'''Unreleased structure'''

The entry 4g5d is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH