4g6f - Revision history

OCA at 20:26, 19 October 2022

OCA — Wed, 19 Oct 2022 20:26:38 GMT

←Older revision		Revision as of 20:26, 19 October 2022
Line 1:		Line 1:

	==Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide==		==Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide==
-	<StructureSection load='4g6f' size='340' side='right' caption='[[4g6f]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4g6f' size='340' side='right'caption='[[4g6f]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g6f]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G6F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g6f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G6F FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHV3-1505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGLV3-1901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6f OCA], [https://pdbe.org/4g6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g6f RCSB], [https://www.ebi.ac.uk/pdbsum/4g6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6f ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6f OCA], [~~http~~://pdbe.org/4g6f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g6f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g6f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6f ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Connors, M~~]]	+	[[Category: Human immunodeficiency virus 1]]
-	[[Category: ~~Huang, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Kwong, P D~~]]	+	[[Category: Connors M]]
-	[[Category: ~~Ofek, G~~]]	+	[[Category: Huang J]]
-	[[Category: ~~Antibody~~]]	+	[[Category: Kwong PD]]
-	[[Category: ~~Immune system]]~~	+	[[Category: Ofek G]]
-	~~[[Category: Immunoglobulin]]~~	+
-	~~[[Category: Mper~~]]	+

OCA at 08:25, 15 November 2017

OCA — Wed, 15 Nov 2017 08:25:06 GMT

←Older revision		Revision as of 08:25, 15 November 2017
Line 1:		Line 1:
		+
	==Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide==		==Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide==
	<StructureSection load='4g6f' size='340' side='right' caption='[[4g6f]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4g6f' size='340' side='right' caption='[[4g6f]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4g6f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g6f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6F FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHV3-1505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGLV3-1901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHV3-1505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGLV3-1901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6f OCA], [http://pdbe.org/4g6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g6f RCSB], [http://www.ebi.ac.uk/pdbsum/4g6f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6f OCA], [http://pdbe.org/4g6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g6f RCSB], [http://www.ebi.ac.uk/pdbsum/4g6f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6f ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:33, 30 September 2015

OCA — Wed, 30 Sep 2015 06:33:42 GMT

←Older revision		Revision as of 06:33, 30 September 2015
Line 2:		Line 2:
	<StructureSection load='4g6f' size='340' side='right' caption='[[4g6f]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4g6f' size='340' side='right' caption='[[4g6f]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g6f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g6f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6F FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHV3-1505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), IGLV3-1901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHV3-1505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGLV3-1901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g6f RCSB], [http://www.ebi.ac.uk/pdbsum/4g6f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6f OCA], [http://pdbe.org/4g6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g6f RCSB], [http://www.ebi.ac.uk/pdbsum/4g6f PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g6f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Connors, M]]		[[Category: Connors, M]]
	[[Category: Huang, J]]		[[Category: Huang, J]]

OCA at 09:31, 10 December 2014

OCA — Wed, 10 Dec 2014 09:31:03 GMT

←Older revision		Revision as of 09:31, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4g6f.~~png~~\|~~left\|200px~~]]	+	==Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide==
		+	<StructureSection load='4g6f' size='340' side='right' caption='[[4g6f]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g6f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6F FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHV3-1505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IGLV3-1901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g6f RCSB], [http://www.ebi.ac.uk/pdbsum/4g6f PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, which neutralizes approximately 98% of tested viruses. An analysis of sera from 78 healthy HIV-1-infected donors demonstrated that 27% contained MPER-specific antibodies and 8% contained 10E8-like specificities. In contrast to other neutralizing MPER antibodies, 10E8 did not bind phospholipids, was not autoreactive, and bound cell-surface envelope. The structure of 10E8 in complex with the complete MPER revealed a site of vulnerability comprising a narrow stretch of highly conserved gp41-hydrophobic residues and a critical arginine or lysine just before the transmembrane region. Analysis of resistant HIV-1 variants confirmed the importance of these residues for neutralization. The highly conserved MPER is a target of potent, non-self-reactive neutralizing antibodies, suggesting that HIV-1 vaccines should aim to induce antibodies to this region of HIV-1 envelope glycoprotein.

-	~~{{STRUCTURE_4g6f\| PDB=4g6f \| SCENE= }}~~	+	Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.,Huang J, Ofek G, Laub L, Louder MK, Doria-Rose NA, Longo NS, Imamichi H, Bailer RT, Chakrabarti B, Sharma SK, Alam SM, Wang T, Yang Y, Zhang B, Migueles SA, Wyatt R, Haynes BF, Kwong PD, Mascola JR, Connors M Nature. 2012 Nov 15;491(7424):406-12. doi: 10.1038/nature11544. Epub 2012 Sep 18. PMID:23151583<ref>PMID:23151583</ref>

-	~~===Crystal Structure~~ of ~~10E8 Fab in Complex with an HIV-1 gp41 Peptide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23151583}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4g6f]] is a 6 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6F OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Connors, M.]]	+	[[Category: Connors, M]]
-	[[Category: Huang, J.]]	+	[[Category: Huang, J]]
-	[[Category: Kwong, P D.]]	+	[[Category: Kwong, P D]]
-	[[Category: Ofek, G.]]	+	[[Category: Ofek, G]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
	[[Category: Mper]]		[[Category: Mper]]

OCA at 21:19, 12 December 2012

OCA — Wed, 12 Dec 2012 21:19:01 GMT

←Older revision		Revision as of 21:19, 12 December 2012
Line 1:		Line 1:
-	[[Image:4g6f.~~jpg~~\|left\|200px]]	+	[[Image:4g6f.png\|left\|200px]]

	{{STRUCTURE_4g6f\| PDB=4g6f \| SCENE= }}		{{STRUCTURE_4g6f\| PDB=4g6f \| SCENE= }}
Line 5:		Line 5:
	===Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide===		===Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide===

		+	{{ABSTRACT_PUBMED_23151583}}

	==About this Structure==		==About this Structure==

OCA at 20:50, 26 September 2012

OCA — Wed, 26 Sep 2012 20:50:34 GMT

←Older revision		Revision as of 20:50, 26 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g6f.jpg\|left\|200px]]

-	~~The entry~~ 4g6f ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4g6f\| PDB=4g6f \| SCENE= }}

-	~~Authors: Ofek, G., Huang, J., Connors, M., Kwong, P.D.~~	+	===Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide===

-	~~Description: Crystal~~ Structure ~~of 10E8 Fab in Complex~~ with ~~an HIV~~-~~1 gp41 Peptide~~	+
		+	==About this Structure==
		+	[[4g6f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6F OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Connors, M.]]
		+	[[Category: Huang, J.]]
		+	[[Category: Kwong, P D.]]
		+	[[Category: Ofek, G.]]
		+	[[Category: Antibody]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin]]
		+	[[Category: Mper]]

OCA at 06:50, 19 September 2012

OCA — Wed, 19 Sep 2012 06:50:37 GMT

←Older revision		Revision as of 06:50, 19 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g6f is ON HOLD	+	The entry 4g6f is ON HOLD until Paper Publication

	Authors: Ofek, G., Huang, J., Connors, M., Kwong, P.D.		Authors: Ofek, G., Huang, J., Connors, M., Kwong, P.D.

	Description: Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide		Description: Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide

OCA: Protected "4g6f" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 06:54:06 GMT

Protected "4g6f" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:54, 25 July 2012

OCA: New page: '''Unreleased structure''' The entry 4g6f is ON HOLD Authors: Ofek, G., Huang, J., Connors, M., Kwong, P.D. Description: Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Pep...

OCA — Wed, 25 Jul 2012 06:54:05 GMT

New page: '''Unreleased structure''' The entry 4g6f is ON HOLD Authors: Ofek, G., Huang, J., Connors, M., Kwong, P.D. Description: Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Pep...

New page

'''Unreleased structure'''

The entry 4g6f is ON HOLD

Authors: Ofek, G., Huang, J., Connors, M., Kwong, P.D.

Description: Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide