4g7y - Revision history

OCA at 20:29, 19 October 2022

OCA — Wed, 19 Oct 2022 20:29:11 GMT

←Older revision		Revision as of 20:29, 19 October 2022
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	<StructureSection load='4g7y' size='340' side='right'caption='[[4g7y]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4g7y' size='340' side='right'caption='[[4g7y]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g7y]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ascidia_intestinalis Ascidia~~ intestinalis] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G7Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g7y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Ciona_intestinalis Ciona intestinalis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G7Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g7v\|4g7v]], [[4g80\|4g80]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g7y OCA], [https://pdbe.org/4g7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g7y RCSB], [https://www.ebi.ac.uk/pdbsum/4g7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g7y ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ci-VSP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7719 Ascidia intestinalis])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g7y OCA], [~~http~~://pdbe.org/4g7y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g7y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g7y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g7y ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q4W8A1_CIOIN Q4W8A1_CIOIN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ascidia~~ intestinalis]]	+	[[Category: Ciona intestinalis]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, Q]]	+	[[Category: Li Q]]
-	~~[[Category: Alpha helix]]~~	+
-	~~[[Category: Fragment antibody]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Sensing voltage]]~~	+
-	~~[[Category: Voltage sensing domain~~]]	+

OCA at 11:54, 17 July 2019

OCA — Wed, 17 Jul 2019 11:54:13 GMT

←Older revision		Revision as of 11:54, 17 July 2019
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	==Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)==		==Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)==
-	<StructureSection load='4g7y' size='340' side='right' caption='[[4g7y]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4g7y' size='340' side='right'caption='[[4g7y]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g7y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascidia_intestinalis Ascidia intestinalis] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G7Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g7y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascidia_intestinalis Ascidia intestinalis] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G7Y FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 4g7y" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4g7y" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Ascidia intestinalis]]		[[Category: Ascidia intestinalis]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Li, Q]]		[[Category: Li, Q]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]

OCA at 07:20, 13 December 2017

OCA — Wed, 13 Dec 2017 07:20:19 GMT

←Older revision		Revision as of 07:20, 13 December 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g7y OCA], [http://pdbe.org/4g7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g7y RCSB], [http://www.ebi.ac.uk/pdbsum/4g7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g7y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g7y OCA], [http://pdbe.org/4g7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g7y RCSB], [http://www.ebi.ac.uk/pdbsum/4g7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g7y ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The transduction of transmembrane electric fields into protein motion has an essential role in the generation and propagation of cellular signals. Voltage-sensing domains (VSDs) carry out these functions through reorientations of positive charges in the S4 helix. Here, we determined crystal structures of the Ciona intestinalis VSD (Ci-VSD) in putatively active and resting conformations. S4 undergoes an ~5-A displacement along its main axis, accompanied by an ~60 degrees rotation. This movement is stabilized by an exchange in countercharge partners in helices S1 and S3 that generates an estimated net charge transfer of ~1 eo. Gating charges move relative to a ''hydrophobic gasket' that electrically divides intra- and extracellular compartments. EPR spectroscopy confirms the limited nature of S4 movement in a membrane environment. These results provide an explicit mechanism for voltage sensing and set the basis for electromechanical coupling in voltage-dependent enzymes and ion channels.
		+
		+	Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.,Li Q, Wanderling S, Paduch M, Medovoy D, Singharoy A, McGreevy R, Villalba-Galea CA, Hulse RE, Roux B, Schulten K, Kossiakoff A, Perozo E Nat Struct Mol Biol. 2014 Mar;21(3):244-52. doi: 10.1038/nsmb.2768. Epub 2014 Feb, 2. PMID:24487958<ref>PMID:24487958</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4g7y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:49, 5 August 2016

OCA — Fri, 05 Aug 2016 20:49:08 GMT

←Older revision		Revision as of 20:49, 5 August 2016
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		+
	==Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)==		==Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)==
	<StructureSection load='4g7y' size='340' side='right' caption='[[4g7y]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4g7y' size='340' side='right' caption='[[4g7y]], [[Resolution\|resolution]] 2.80Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g7v\|4g7v]], [[4g80\|4g80]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g7v\|4g7v]], [[4g80\|4g80]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ci-VSP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7719 Ascidia intestinalis])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ci-VSP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7719 Ascidia intestinalis])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g7y RCSB], [http://www.ebi.ac.uk/pdbsum/4g7y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g7y OCA], [http://pdbe.org/4g7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g7y RCSB], [http://www.ebi.ac.uk/pdbsum/4g7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g7y ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 18:51, 21 December 2014

OCA — Sun, 21 Dec 2014 18:51:19 GMT

←Older revision		Revision as of 18:51, 21 December 2014
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-	~~{{STRUCTURE_4g7y\| PDB=4g7y \| SCENE= }}~~	+	==Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)==
-	===Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)===	+	<StructureSection load='4g7y' size='340' side='right' caption='[[4g7y]], [[Resolution\|resolution]] 2.80Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[4g7y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascidia_intestinalis Ascidia intestinalis] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G7Y FirstGlance]. <br>
-	[[4g7y]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G7Y OCA].	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: Li, Q.]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g7v\|4g7v]], [[4g80\|4g80]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ci-VSP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7719 Ascidia intestinalis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g7y RCSB], [http://www.ebi.ac.uk/pdbsum/4g7y PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ascidia intestinalis]]
		+	[[Category: Human]]
		+	[[Category: Li, Q]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
	[[Category: Fragment antibody]]		[[Category: Fragment antibody]]

OCA at 11:31, 5 February 2014

OCA — Wed, 05 Feb 2014 11:31:16 GMT

←Older revision		Revision as of 11:31, 5 February 2014
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4g7y\| PDB=4g7y \| SCENE= }}
		+	===Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)===

-	~~The entry~~ 4g7y is ~~ON HOLD until Feb 22 2015~~	+	==About this Structure==
-		+	[[4g7y]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G7Y OCA].
-	~~Authors~~: Li, Q.	+	[[Category: Li, Q.]]
-		+	[[Category: Alpha helix]]
-	~~Description~~: ~~Crystal structure of~~ voltage sensing domain ~~of Ci-VSP with fragment antibody (R217E, 2.8 A)~~	+	[[Category: Fragment antibody]]
		+	[[Category: Membrane protein]]
		+	[[Category: Sensing voltage]]
		+	[[Category: Voltage sensing domain]]

OCA at 06:40, 22 January 2014

OCA — Wed, 22 Jan 2014 06:40:25 GMT

←Older revision		Revision as of 06:40, 22 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g7y is ON HOLD until ~~Jan~~ 22 2015	+	The entry 4g7y is ON HOLD until Feb 22 2015

	Authors: Li, Q.		Authors: Li, Q.

	Description: Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)		Description: Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)

OCA at 07:10, 16 October 2013

OCA — Wed, 16 Oct 2013 07:10:31 GMT

←Older revision		Revision as of 07:10, 16 October 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g7y is ON HOLD until ~~Oct 23 2014~~	+	The entry 4g7y is ON HOLD until Jan 22 2015

	Authors: Li, Q.		Authors: Li, Q.

	Description: Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)		Description: Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)

OCA at 12:55, 3 July 2013

OCA — Wed, 03 Jul 2013 12:55:38 GMT

←Older revision		Revision as of 12:55, 3 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g7y is ON HOLD until ~~Paper Publication~~	+	The entry 4g7y is ON HOLD until Oct 23 2014

	Authors: Li, Q.		Authors: Li, Q.

	Description: Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)		Description: Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)

OCA at 13:58, 28 November 2012

OCA — Wed, 28 Nov 2012 13:58:02 GMT

←Older revision		Revision as of 13:58, 28 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g7y is ON HOLD until ~~Jan 20 2014~~	+	The entry 4g7y is ON HOLD until Paper Publication

	Authors: Li, Q.		Authors: Li, Q.

	Description: Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)		Description: Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A)