4g8f - Revision history

OCA at 15:40, 14 March 2024

OCA — Thu, 14 Mar 2024 15:40:44 GMT

←Older revision		Revision as of 15:40, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g8f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G8F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g8f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G8F FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8f OCA], [https://pdbe.org/4g8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g8f RCSB], [https://www.ebi.ac.uk/pdbsum/4g8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g8f ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8f OCA], [https://pdbe.org/4g8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g8f RCSB], [https://www.ebi.ac.uk/pdbsum/4g8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g8f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 10:		Line 11:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TRAC_HUMAN TRAC_HUMAN] Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).<ref>PMID:15040585</ref> <ref>PMID:23524462</ref> <ref>PMID:24600447</ref> <ref>PMID:25493333</ref>		[https://www.uniprot.org/uniprot/TRAC_HUMAN TRAC_HUMAN] Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).<ref>PMID:15040585</ref> <ref>PMID:23524462</ref> <ref>PMID:24600447</ref> <ref>PMID:25493333</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Human T cell antigen receptors (TCRs) pair in millions of combinations to create complex and unique T cell repertoires for each person. Through the use of tetramers to analyze TCRs reactive to the antigen-presenting molecule CD1b, we detected T cells with highly stereotyped TCR alpha-chains present among genetically unrelated patients with tuberculosis. The germline-encoded, mycolyl lipid-reactive (GEM) TCRs had an alpha-chain bearing the variable (V) region TRAV1-2 rearranged to the joining (J) region TRAJ9 with few nontemplated (N)-region additions. Analysis of TCRs by high-throughput sequencing, binding and crystallography showed linkage of TCRalpha sequence motifs to high-affinity recognition of antigen. Thus, the CD1-reactive TCR repertoire is composed of at least two compartments: high-affinity GEM TCRs, and more-diverse TCRs with low affinity for CD1b-lipid complexes. We found high interdonor conservation of TCRs that probably resulted from selection by a nonpolymorphic antigen-presenting molecule and an immunodominant antigen.
-
-	A conserved human T cell population targets mycobacterial antigens presented by CD1b.,Van Rhijn I, Kasmar A, de Jong A, Gras S, Bhati M, Doorenspleet ME, de Vries N, Godfrey DI, Altman JD, de Jager W, Rossjohn J, Moody DB Nat Immunol. 2013 Jun 2;14(7):706-13. doi: 10.1038/ni.2630. Epub 2013 Jun 2. PMID:23727893<ref>PMID:23727893</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4g8f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:41, 26 October 2022

OCA — Wed, 26 Oct 2022 06:41:41 GMT

←Older revision		Revision as of 06:41, 26 October 2022
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	<StructureSection load='4g8f' size='340' side='right'caption='[[4g8f]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4g8f' size='340' side='right'caption='[[4g8f]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g8f]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G8F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g8f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G8F FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g8e\|4g8e]], [[4g8g\|4g8g]], [[4g8i\|4g8i]], [[4g9d\|4g9d]], [[4g9f\|4g9f]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8f OCA], [https://pdbe.org/4g8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g8f RCSB], [https://www.ebi.ac.uk/pdbsum/4g8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g8f ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8f OCA], [~~http~~://pdbe.org/4g8f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g8f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g8f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g8f ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TRAC_HUMAN TRAC_HUMAN] TCR-alpha-beta-positive T-cell deficiency. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRAC_HUMAN TRAC_HUMAN] Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).<ref>PMID:15040585</ref> <ref>PMID:23524462</ref> <ref>PMID:24600447</ref> <ref>PMID:25493333</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[T-cell receptor\|T-cell receptor]]	+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bhati, M]]	+	[[Category: Bhati M]]
-	[[Category: Gras, S]]	+	[[Category: Gras S]]
-	[[Category: Rossjohn, J]]	+	[[Category: Rossjohn J]]
-	~~[[Category: Cd1b]]~~	+
-	~~[[Category: Gmm]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Lipid recognition]]~~	+
-	~~[[Category: T cell]]~~	+
-	~~[[Category: Tcr~~]]	+

OCA at 17:41, 14 August 2019

OCA — Wed, 14 Aug 2019 17:41:23 GMT

←Older revision		Revision as of 17:41, 14 August 2019
Line 1:		Line 1:

	==Crystal Structure of clone42 TCR==		==Crystal Structure of clone42 TCR==
-	<StructureSection load='4g8f' size='340' side='right' caption='[[4g8f]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4g8f' size='340' side='right'caption='[[4g8f]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G8F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G8F FirstGlance]. <br>
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 4g8f" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4g8f" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[T-cell receptor\|T-cell receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bhati, M]]		[[Category: Bhati, M]]
	[[Category: Gras, S]]		[[Category: Gras, S]]

OCA at 07:42, 12 October 2017

OCA — Thu, 12 Oct 2017 07:42:57 GMT

←Older revision		Revision as of 07:42, 12 October 2017
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 4g8f" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4g8f" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[T-cell receptor\|T-cell receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:58, 5 August 2016

OCA — Fri, 05 Aug 2016 12:58:49 GMT

←Older revision		Revision as of 12:58, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of clone42 TCR==		==Crystal Structure of clone42 TCR==
	<StructureSection load='4g8f' size='340' side='right' caption='[[4g8f]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4g8f' size='340' side='right' caption='[[4g8f]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G8F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G8F FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g8e\|4g8e]], [[4g8g\|4g8g]], [[4g8i\|4g8i]], [[4g9d\|4g9d]], [[4g9f\|4g9f]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g8e\|4g8e]], [[4g8g\|4g8g]], [[4g8i\|4g8i]], [[4g9d\|4g9d]], [[4g9f\|4g9f]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g8f RCSB], [http://www.ebi.ac.uk/pdbsum/4g8f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8f OCA], [http://pdbe.org/4g8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g8f RCSB], [http://www.ebi.ac.uk/pdbsum/4g8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g8f ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g8f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bhati, M]]		[[Category: Bhati, M]]
	[[Category: Gras, S]]		[[Category: Gras, S]]

OCA at 10:41, 21 December 2014

OCA — Sun, 21 Dec 2014 10:41:34 GMT

←Older revision		Revision as of 10:41, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4g8f~~\| ~~PDB~~=4g8f \| ~~SCENE~~= }}	+	==Crystal Structure of clone42 TCR==
-	===~~Crystal Structure of clone42 TCR~~===	+	<StructureSection load='4g8f' size='340' side='right' caption='[[4g8f]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23727893}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G8F FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g8e\|4g8e]], [[4g8g\|4g8g]], [[4g8i\|4g8i]], [[4g9d\|4g9d]], [[4g9f\|4g9f]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g8f RCSB], [http://www.ebi.ac.uk/pdbsum/4g8f PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human T cell antigen receptors (TCRs) pair in millions of combinations to create complex and unique T cell repertoires for each person. Through the use of tetramers to analyze TCRs reactive to the antigen-presenting molecule CD1b, we detected T cells with highly stereotyped TCR alpha-chains present among genetically unrelated patients with tuberculosis. The germline-encoded, mycolyl lipid-reactive (GEM) TCRs had an alpha-chain bearing the variable (V) region TRAV1-2 rearranged to the joining (J) region TRAJ9 with few nontemplated (N)-region additions. Analysis of TCRs by high-throughput sequencing, binding and crystallography showed linkage of TCRalpha sequence motifs to high-affinity recognition of antigen. Thus, the CD1-reactive TCR repertoire is composed of at least two compartments: high-affinity GEM TCRs, and more-diverse TCRs with low affinity for CD1b-lipid complexes. We found high interdonor conservation of TCRs that probably resulted from selection by a nonpolymorphic antigen-presenting molecule and an immunodominant antigen.

-	~~==About this Structure==~~	+	A conserved human T cell population targets mycobacterial antigens presented by CD1b.,Van Rhijn I, Kasmar A, de Jong A, Gras S, Bhati M, Doorenspleet ME, de Vries N, Godfrey DI, Altman JD, de Jager W, Rossjohn J, Moody DB Nat Immunol. 2013 Jun 2;14(7):706-13. doi: 10.1038/ni.2630. Epub 2013 Jun 2. PMID:23727893<ref>PMID:23727893</ref>
-	~~[[4g8f]] is a~~ 2 ~~chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4G8F OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:023727893</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[T-cell receptor\|T-cell receptor]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bhati, M.]]	+	[[Category: Bhati, M]]
-	[[Category: Gras, S.]]	+	[[Category: Gras, S]]
-	[[Category: Rossjohn, J.]]	+	[[Category: Rossjohn, J]]
	[[Category: Cd1b]]		[[Category: Cd1b]]
	[[Category: Gmm]]		[[Category: Gmm]]

OCA at 13:59, 3 July 2013

OCA — Wed, 03 Jul 2013 13:59:59 GMT

←Older revision		Revision as of 13:59, 3 July 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4g8f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA].	+	[[4g8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:023727893</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023727893</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
	[[Category: Bhati, M.]]		[[Category: Bhati, M.]]
	[[Category: Gras, S.]]		[[Category: Gras, S.]]

OCA at 09:03, 3 July 2013

OCA — Wed, 03 Jul 2013 09:03:09 GMT

←Older revision		Revision as of 09:03, 3 July 2013
Line 1:		Line 1:
	{{STRUCTURE_4g8f\| PDB=4g8f \| SCENE= }}		{{STRUCTURE_4g8f\| PDB=4g8f \| SCENE= }}
	===Crystal Structure of clone42 TCR===		===Crystal Structure of clone42 TCR===
		+	{{ABSTRACT_PUBMED_23727893}}

	==About this Structure==		==About this Structure==
-	[[4g8f]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA].	+	[[4g8f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA].
-	~~[[Category~~: ~~Homo sapiens]]~~	+
		+	==Reference==
		+	<ref group="xtra">PMID:023727893</ref><references group="xtra"/><references/>
	[[Category: Bhati, M.]]		[[Category: Bhati, M.]]
	[[Category: Gras, S.]]		[[Category: Gras, S.]]

OCA at 07:52, 8 May 2013

OCA — Wed, 08 May 2013 07:52:28 GMT

←Older revision		Revision as of 07:52, 8 May 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4g8f\| PDB=4g8f \| SCENE= }}
		+	===Crystal Structure of clone42 TCR===

-	~~The entry~~ 4g8f is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4g8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8F OCA].
-	~~Authors~~: ~~Gras, S.,~~ Bhati, M., Rossjohn, J.	+	[[Category: Homo sapiens]]
-		+	[[Category: Bhati, M.]]
-	~~Description~~:	+	[[Category: Gras, S.]]
		+	[[Category: Rossjohn, J.]]
		+	[[Category: Cd1b]]
		+	[[Category: Gmm]]
		+	[[Category: Immune system]]
		+	[[Category: Lipid recognition]]
		+	[[Category: T cell]]
		+	[[Category: Tcr]]

OCA at 06:50, 19 September 2012

OCA — Wed, 19 Sep 2012 06:50:49 GMT

←Older revision		Revision as of 06:50, 19 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g8f is ON HOLD	+	The entry 4g8f is ON HOLD until Paper Publication

	Authors: Gras, S., Bhati, M., Rossjohn, J.		Authors: Gras, S., Bhati, M., Rossjohn, J.

	Description:		Description: