4g9k - Revision history

OCA at 11:26, 1 March 2024

OCA — Fri, 01 Mar 2024 11:26:15 GMT

←Older revision		Revision as of 11:26, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G9K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G9K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9k OCA], [https://pdbe.org/4g9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g9k RCSB], [https://www.ebi.ac.uk/pdbsum/4g9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9k OCA], [https://pdbe.org/4g9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g9k RCSB], [https://www.ebi.ac.uk/pdbsum/4g9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/NDI1_YEAST NDI1_YEAST] Catalyzes the oxidation of NADH generated inside the Mitochondrion.		[https://www.uniprot.org/uniprot/NDI1_YEAST NDI1_YEAST] Catalyzes the oxidation of NADH generated inside the Mitochondrion.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Bioenergy is efficiently produced in the mitochondria by the respiratory system consisting of complexes I-V. In various organisms, complex I can be replaced by the alternative NADH-quinone oxidoreductase (NDH-2), which catalyzes the transfer of an electron from NADH via FAD to quinone, without proton pumping. The Ndi1 protein from Saccharomyces cerevisiae is a monotopic membrane protein, directed to the matrix. A number of studies have investigated the potential use of Ndi1 as a therapeutic agent against complex I disorders, and the NDH-2 enzymes have emerged as potential therapeutic targets for treatments against the causative agents of malaria and tuberculosis. Here we present the crystal structures of Ndi1 in its substrate-free, NAD(+)- and ubiquinone- (UQ2) complexed states. The structures reveal that Ndi1 is a peripheral membrane protein forming an intimate dimer, in which packing of the monomeric units within the dimer creates an amphiphilic membrane-anchor domain structure. Crucially, the structures of the Ndi1-NAD(+) and Ndi1-UQ2 complexes show overlapping binding sites for the NAD(+) and quinone substrates.
-
-	The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates.,Iwata M, Lee Y, Yamashita T, Yagi T, Iwata S, Cameron AD, Maher MJ Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15247-52. Epub 2012 Sep 4. PMID:22949654<ref>PMID:22949654</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4g9k" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:43, 26 October 2022

OCA — Wed, 26 Oct 2022 06:43:47 GMT

←Older revision		Revision as of 06:43, 26 October 2022
Line 1:		Line 1:

	==Structure of the Ndi1 protein from Saccharomyces cerevisiae==		==Structure of the Ndi1 protein from Saccharomyces cerevisiae==
-	<StructureSection load='4g9k' size='340' side='right' caption='[[4g9k]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4g9k' size='340' side='right'caption='[[4g9k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g9k]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G9K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G9K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gap\|4gap]], [[4gav\|4gav]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9k OCA], [https://pdbe.org/4g9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g9k RCSB], [https://www.ebi.ac.uk/pdbsum/4g9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9k ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDI1, YML120C, YM7056.06C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADH:ubiquinone_reductase_(non-electrogenic) NADH:ubiquinone reductase (non-electrogenic)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.9 1.6.5.9] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9k OCA], [~~http~~://pdbe.org/4g9k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g9k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g9k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9k ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NDI1_YEAST NDI1_YEAST]] Catalyzes the oxidation of NADH generated inside the Mitochondrion.	+	[https://www.uniprot.org/uniprot/NDI1_YEAST NDI1_YEAST] Catalyzes the oxidation of NADH generated inside the Mitochondrion.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Baker's yeast~~]]	+	[[Category: Large Structures]]
-	[[Category: Cameron~~, A D~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: Iwata, M]]	+	[[Category: Cameron AD]]
-	[[Category: Iwata, S]]	+	[[Category: Iwata M]]
-	[[Category: Lee, Y]]	+	[[Category: Iwata S]]
-	[[Category: Maher~~, M J~~]]	+	[[Category: Lee Y]]
-	[[Category: Yagi, T]]	+	[[Category: Maher MJ]]
-	[[Category: Yamashita, T]]	+	[[Category: Yagi T]]
-	~~[[Category: Membrane]]~~	+	[[Category: Yamashita T]]
-	~~[[Category: Nadh:quinone oxidoreductase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 20:37, 11 August 2016

OCA — Thu, 11 Aug 2016 20:37:25 GMT

←Older revision		Revision as of 20:37, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of the Ndi1 protein from Saccharomyces cerevisiae==		==Structure of the Ndi1 protein from Saccharomyces cerevisiae==
	<StructureSection load='4g9k' size='340' side='right' caption='[[4g9k]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4g9k' size='340' side='right' caption='[[4g9k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G9K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G9K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gap\|4gap]], [[4gav\|4gav]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gap\|4gap]], [[4gav\|4gav]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDI1, YML120C, YM7056.06C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~4932 Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDI1, YML120C, YM7056.06C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADH:ubiquinone_reductase_(non-electrogenic) NADH:ubiquinone reductase (non-electrogenic)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.9 1.6.5.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADH:ubiquinone_reductase_(non-electrogenic) NADH:ubiquinone reductase (non-electrogenic)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.9 1.6.5.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g9k RCSB], [http://www.ebi.ac.uk/pdbsum/4g9k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9k OCA], [http://pdbe.org/4g9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g9k RCSB], [http://www.ebi.ac.uk/pdbsum/4g9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NDI1_YEAST NDI1_YEAST]] Catalyzes the oxidation of NADH generated inside the Mitochondrion.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g9k" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Baker's yeast]]
	[[Category: Cameron, A D]]		[[Category: Cameron, A D]]
	[[Category: Iwata, M]]		[[Category: Iwata, M]]

OCA at 12:32, 5 January 2015

OCA — Mon, 05 Jan 2015 12:32:15 GMT

←Older revision		Revision as of 12:32, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G9K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G9K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gap\|4gap]], [[4gav\|4gav]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gap\|4gap]], [[4gav\|4gav]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDI1, YML120C, YM7056.06C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDI1, YML120C, YM7056.06C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADH:ubiquinone_reductase_(non-electrogenic) NADH:ubiquinone reductase (non-electrogenic)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.9 1.6.5.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADH:ubiquinone_reductase_(non-electrogenic) NADH:ubiquinone reductase (non-electrogenic)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.9 1.6.5.9] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g9k RCSB], [http://www.ebi.ac.uk/pdbsum/4g9k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g9k RCSB], [http://www.ebi.ac.uk/pdbsum/4g9k PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Cameron, A D.]]	+	[[Category: Cameron, A D]]
-	[[Category: Iwata, M.]]	+	[[Category: Iwata, M]]
-	[[Category: Iwata, S.]]	+	[[Category: Iwata, S]]
-	[[Category: Lee, Y.]]	+	[[Category: Lee, Y]]
-	[[Category: Maher, M J.]]	+	[[Category: Maher, M J]]
-	[[Category: Yagi, T.]]	+	[[Category: Yagi, T]]
-	[[Category: Yamashita, T.]]	+	[[Category: Yamashita, T]]
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Nadh:quinone oxidoreductase]]		[[Category: Nadh:quinone oxidoreductase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 07:49, 9 July 2014

OCA — Wed, 09 Jul 2014 07:49:22 GMT

←Older revision		Revision as of 07:49, 9 July 2014
Line 1:		Line 1:
-	[[~~Image:~~4g9k.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of the Ndi1 protein from Saccharomyces cerevisiae==
		+	<StructureSection load='4g9k' size='340' side='right' caption='[[4g9k]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G9K FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gap\|4gap]], [[4gav\|4gav]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDI1, YML120C, YM7056.06C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADH:ubiquinone_reductase_(non-electrogenic) NADH:ubiquinone reductase (non-electrogenic)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.9 1.6.5.9] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g9k RCSB], [http://www.ebi.ac.uk/pdbsum/4g9k PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bioenergy is efficiently produced in the mitochondria by the respiratory system consisting of complexes I-V. In various organisms, complex I can be replaced by the alternative NADH-quinone oxidoreductase (NDH-2), which catalyzes the transfer of an electron from NADH via FAD to quinone, without proton pumping. The Ndi1 protein from Saccharomyces cerevisiae is a monotopic membrane protein, directed to the matrix. A number of studies have investigated the potential use of Ndi1 as a therapeutic agent against complex I disorders, and the NDH-2 enzymes have emerged as potential therapeutic targets for treatments against the causative agents of malaria and tuberculosis. Here we present the crystal structures of Ndi1 in its substrate-free, NAD(+)- and ubiquinone- (UQ2) complexed states. The structures reveal that Ndi1 is a peripheral membrane protein forming an intimate dimer, in which packing of the monomeric units within the dimer creates an amphiphilic membrane-anchor domain structure. Crucially, the structures of the Ndi1-NAD(+) and Ndi1-UQ2 complexes show overlapping binding sites for the NAD(+) and quinone substrates.

-	~~{{STRUCTURE_4g9k\| PDB=4g9k \| SCENE= }}~~	+	The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates.,Iwata M, Lee Y, Yamashita T, Yagi T, Iwata S, Cameron AD, Maher MJ Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15247-52. Epub 2012 Sep 4. PMID:22949654<ref>PMID:22949654</ref>

-	~~===Structure~~ of the ~~Ndi1 protein from Saccharomyces cerevisiae===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22949654}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4g9k]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA].~~	+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Cameron, A D.]]		[[Category: Cameron, A D.]]

OCA at 06:15, 3 October 2012

OCA — Wed, 03 Oct 2012 06:15:00 GMT

←Older revision		Revision as of 06:15, 3 October 2012
Line 1:		Line 1:
-	[[Image:4g9k.~~jpg~~\|left\|200px]]	+	[[Image:4g9k.png\|left\|200px]]

	{{STRUCTURE_4g9k\| PDB=4g9k \| SCENE= }}		{{STRUCTURE_4g9k\| PDB=4g9k \| SCENE= }}
Line 5:		Line 5:
	===Structure of the Ndi1 protein from Saccharomyces cerevisiae===		===Structure of the Ndi1 protein from Saccharomyces cerevisiae===

		+	{{ABSTRACT_PUBMED_22949654}}

	==About this Structure==		==About this Structure==

OCA at 05:42, 5 September 2012

OCA — Wed, 05 Sep 2012 05:42:47 GMT

←Older revision		Revision as of 05:42, 5 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g9k.jpg\|left\|200px]]

-	~~The entry~~ 4g9k ~~is ON HOLD~~	+	{{STRUCTURE_4g9k\| PDB=4g9k \| SCENE= }}

-	~~Authors: Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A.D., Maher, M.J.~~	+	===Structure of the Ndi1 protein from Saccharomyces cerevisiae===

-	~~Description~~: ~~Monotopic membrane protein~~	+
		+	==About this Structure==
		+	[[4g9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9K OCA].
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Cameron, A D.]]
		+	[[Category: Iwata, M.]]
		+	[[Category: Iwata, S.]]
		+	[[Category: Lee, Y.]]
		+	[[Category: Maher, M J.]]
		+	[[Category: Yagi, T.]]
		+	[[Category: Yamashita, T.]]
		+	[[Category: Membrane]]
		+	[[Category: Nadh:quinone oxidoreductase]]
		+	[[Category: Oxidoreductase]]

OCA at 05:32, 22 August 2012

OCA — Wed, 22 Aug 2012 05:32:00 GMT

←Older revision		Revision as of 05:32, 22 August 2012
Line 3:		Line 3:
	The entry 4g9k is ON HOLD		The entry 4g9k is ON HOLD

-	Authors: Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A. D., Maher, M. J.	+	Authors: Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A.D., Maher, M.J.

	Description: Monotopic membrane protein		Description: Monotopic membrane protein

OCA: Protected "4g9k" [edit=sysop:move=sysop]

OCA — Wed, 01 Aug 2012 05:31:53 GMT

Protected "4g9k" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:31, 1 August 2012

OCA: New page: '''Unreleased structure''' The entry 4g9k is ON HOLD Authors: Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A. D., Maher, M. J. Description: Monotopic membrane prote...

OCA — Wed, 01 Aug 2012 05:31:53 GMT

New page: '''Unreleased structure''' The entry 4g9k is ON HOLD Authors: Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A. D., Maher, M. J. Description: Monotopic membrane prote...

New page

'''Unreleased structure'''

The entry 4g9k is ON HOLD

Authors: Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A. D., Maher, M. J.

Description: Monotopic membrane protein