4gaw - Revision history

OCA at 13:58, 8 November 2023

OCA — Wed, 08 Nov 2023 13:58:01 GMT

←Older revision		Revision as of 13:58, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gaw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gaw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaw OCA], [https://pdbe.org/4gaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gaw RCSB], [https://www.ebi.ac.uk/pdbsum/4gaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gaw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaw OCA], [https://pdbe.org/4gaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gaw RCSB], [https://www.ebi.ac.uk/pdbsum/4gaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gaw ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:45, 26 October 2022

OCA — Wed, 26 Oct 2022 06:45:50 GMT

←Older revision		Revision as of 06:45, 26 October 2022
Line 1:		Line 1:

	==Crystal structure of active human granzyme H==		==Crystal structure of active human granzyme H==
-	<StructureSection load='4gaw' size='340' side='right' caption='[[4gaw]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4gaw' size='340' side='right'caption='[[4gaw]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gaw]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gaw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ga7\|4ga7]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaw OCA], [https://pdbe.org/4gaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gaw RCSB], [https://www.ebi.ac.uk/pdbsum/4gaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gaw ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMH, CGL2, CTSGL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaw OCA], [~~http~~://pdbe.org/4gaw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gaw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gaw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gaw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref>	+	[https://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Fan, Z]]	+	[[Category: Large Structures]]
-	[[Category: Li, Q]]	+	[[Category: Fan Z]]
-	[[Category: Sun, F]]	+	[[Category: Li Q]]
-	[[Category: Tong, L]]	+	[[Category: Sun F]]
-	[[Category: Wang, L]]	+	[[Category: Tong L]]
-	[[Category: Wu, L]]	+	[[Category: Wang L]]
-	[[Category: Zhang, K]]	+	[[Category: Wu L]]
-	~~[[Category: Cytolysis]]~~	+	[[Category: Zhang K]]
-	~~[[Category: Cytotoxic granule]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 07:40, 4 August 2016

OCA — Thu, 04 Aug 2016 07:40:52 GMT

←Older revision		Revision as of 07:40, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of active human granzyme H==		==Crystal structure of active human granzyme H==
	<StructureSection load='4gaw' size='340' side='right' caption='[[4gaw]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4gaw' size='340' side='right' caption='[[4gaw]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gaw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gaw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GAW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ga7\|4ga7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ga7\|4ga7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMH, CGL2, CTSGL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMH, CGL2, CTSGL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gaw RCSB], [http://www.ebi.ac.uk/pdbsum/4gaw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaw OCA], [http://pdbe.org/4gaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gaw RCSB], [http://www.ebi.ac.uk/pdbsum/4gaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gaw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gaw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fan, Z]]		[[Category: Fan, Z]]
	[[Category: Li, Q]]		[[Category: Li, Q]]

OCA at 07:05, 24 December 2014

OCA — Wed, 24 Dec 2014 07:05:58 GMT

←Older revision		Revision as of 07:05, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gaw RCSB], [http://www.ebi.ac.uk/pdbsum/4gaw PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gaw RCSB], [http://www.ebi.ac.uk/pdbsum/4gaw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:08, 21 December 2014

OCA — Sun, 21 Dec 2014 11:08:50 GMT

←Older revision		Revision as of 11:08, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gaw\| PDB=4gaw \| SCENE= }}~~	+	==Crystal structure of active human granzyme H==
-	===Crystal structure of active human granzyme H===	+	<StructureSection load='4gaw' size='340' side='right' caption='[[4gaw]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23269243}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gaw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GAW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ga7\|4ga7]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMH, CGL2, CTSGL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gaw RCSB], [http://www.ebi.ac.uk/pdbsum/4gaw PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The granzyme/perforin pathway is a major mechanism for cytotoxic lymphocytes to eliminate virus-infected and tumor cells. The balance between activation and inhibition of the proteolytic cascade must be tightly controlled to avoid self damage. Granzyme H (GzmH) is constitutively expressed in NK cells and induces target cell death; however, how GzmH activity is regulated remains elusive. We reported earlier the crystal structures of inactive D102N-GzmH alone and in complex with its synthetic substrate and inhibitor, as well as defined the mechanisms of substrate recognition and enzymatic activation. In this study, we identified SERPINB1 as a potent intracellular inhibitor for GzmH. Upon cleavage of the reactive center loop at Phe(343), SERPINB1 forms an SDS-stable covalent complex with GzmH. SERPINB1 overexpression suppresses GzmH- or LAK cell-mediated cytotoxicity. We determined the crystal structures of active GzmH and SERPINB1 (LM-DD mutant) in the native conformation to 3.0- and 2.9-A resolution, respectively. Molecular modeling reveals the possible conformational changes in GzmH for the suicide inhibition. Our findings provide new insights into the inhibitory mechanism of SERPINB1 against human GzmH.

-	~~==Function==~~	+	Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H.,Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z J Immunol. 2012 Dec 26. PMID:23269243<ref>PMID:23269243</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites~~. ~~Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>~~PMID:~~22156497</ref>~~ <ref>PMID:23269243</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4gaw]] is~~ a ~~12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023269243</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Granzyme\|Granzyme]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Fan, Z.]]	+	[[Category: Fan, Z]]
-	[[Category: Li, Q.]]	+	[[Category: Li, Q]]
-	[[Category: Sun, F.]]	+	[[Category: Sun, F]]
-	[[Category: Tong, L.]]	+	[[Category: Tong, L]]
-	[[Category: Wang, L.]]	+	[[Category: Wang, L]]
-	[[Category: Wu, L.]]	+	[[Category: Wu, L]]
-	[[Category: Zhang, K.]]	+	[[Category: Zhang, K]]
	[[Category: Cytolysis]]		[[Category: Cytolysis]]
	[[Category: Cytotoxic granule]]		[[Category: Cytotoxic granule]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine protease]]		[[Category: Serine protease]]

OCA at 04:33, 18 July 2013

OCA — Thu, 18 Jul 2013 04:33:26 GMT

←Older revision		Revision as of 04:33, 18 July 2013
Line 1:		Line 1:
-	[[Image:4gaw.jpg\|left\|200px]]
-
	{{STRUCTURE_4gaw\| PDB=4gaw \| SCENE= }}		{{STRUCTURE_4gaw\| PDB=4gaw \| SCENE= }}
-
	===Crystal structure of active human granzyme H===		===Crystal structure of active human granzyme H===
-
	{{ABSTRACT_PUBMED_23269243}}		{{ABSTRACT_PUBMED_23269243}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref>

	==About this Structure==		==About this Structure==
	[[4gaw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA].		[[4gaw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023269243</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fan, Z.]]		[[Category: Fan, Z.]]

OCA at 08:55, 16 January 2013

OCA — Wed, 16 Jan 2013 08:55:55 GMT

←Older revision		Revision as of 08:55, 16 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gaw.jpg\|left\|200px]]

-	~~The entry~~ 4gaw ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gaw\| PDB=4gaw \| SCENE= }}

-	~~Authors: Wang, L., Li, Q., Wu, L., Zhang, K., Tong, L., Sun, F., Fan, Z.~~	+	===Crystal structure of active human granzyme H===

-	~~Description: Crystal~~ structure ~~of active human granzyme H~~	+	{{ABSTRACT_PUBMED_23269243}}
		+
		+	==About this Structure==
		+	[[4gaw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Fan, Z.]]
		+	[[Category: Li, Q.]]
		+	[[Category: Sun, F.]]
		+	[[Category: Tong, L.]]
		+	[[Category: Wang, L.]]
		+	[[Category: Wu, L.]]
		+	[[Category: Zhang, K.]]
		+	[[Category: Cytolysis]]
		+	[[Category: Cytotoxic granule]]
		+	[[Category: Hydrolase]]
		+	[[Category: Serine protease]]

OCA at 06:51, 19 September 2012

OCA — Wed, 19 Sep 2012 06:51:05 GMT

←Older revision		Revision as of 06:51, 19 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gaw is ON HOLD	+	The entry 4gaw is ON HOLD until Paper Publication

	Authors: Wang, L., Li, Q., Wu, L., Zhang, K., Tong, L., Sun, F., Fan, Z.		Authors: Wang, L., Li, Q., Wu, L., Zhang, K., Tong, L., Sun, F., Fan, Z.

	Description: Crystal structure of active human granzyme H		Description: Crystal structure of active human granzyme H

OCA at 04:44, 29 August 2012

OCA — Wed, 29 Aug 2012 04:44:46 GMT

←Older revision		Revision as of 04:44, 29 August 2012
Line 3:		Line 3:
	The entry 4gaw is ON HOLD		The entry 4gaw is ON HOLD

-	Authors: Li Wang, ~~Qian~~ Li, ~~Lianfeng~~ Wu, ~~Kai~~ Zhang, ~~Liang~~ Tong, ~~Fei~~ Sun, ~~Zusen~~ Fan	+	Authors: Wang, L., Li, Q., Wu, L., Zhang, K., Tong, L., Sun, F., Fan, Z.

	Description: Crystal structure of active human granzyme H		Description: Crystal structure of active human granzyme H

OCA: Protected "4gaw" [edit=sysop:move=sysop]

OCA — Wed, 01 Aug 2012 05:33:10 GMT

Protected "4gaw" [edit=sysop:move=sysop]

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Revision as of 05:33, 1 August 2012