4gbc - Revision history

OCA at 06:46, 26 October 2022

OCA — Wed, 26 Oct 2022 06:46:15 GMT

←Older revision		Revision as of 06:46, 26 October 2022
Line 3:		Line 3:
	<StructureSection load='4gbc' size='340' side='right'caption='[[4gbc]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='4gbc' size='340' side='right'caption='[[4gbc]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gbc]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The February 2016 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Insulins'' by David Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2016_2 10.2210/rcsb_pdb/mom_2016_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4GBC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gbc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The February 2016 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Insulins'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2016_2 10.2210/rcsb_pdb/mom_2016_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GBC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gbi\|4gbi]], [[4gbk\|4gbk]], [[4gbl\|4gbl]], [[4gbn\|4gbn]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbc OCA], [https://pdbe.org/4gbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gbc RCSB], [https://www.ebi.ac.uk/pdbsum/4gbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gbc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4gbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbc OCA], [~~http~~://pdbe.org/4gbc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gbc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gbc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gbc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[~~http~~://omim.org/entry/176730 176730]].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[~~http~~://omim.org/entry/125852 125852]]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[~~http~~://omim.org/entry/606176 606176]]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[~~http~~://omim.org/entry/613370 613370]]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>	+	[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[https://omim.org/entry/176730 176730].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[https://omim.org/entry/125852 125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[https://omim.org/entry/606176 606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[https://omim.org/entry/613370 613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	+	[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
-	[[Category: Favero-Retto~~, M P~~]]	+	[[Category: Favero-Retto MP]]
-	[[Category: Lima~~, L M.T R~~]]	+	[[Category: Lima LMTR]]
-	[[Category: Palmieri~~, L C]]~~	+	[[Category: Palmieri LC]]
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: T3r3~~]]	+

OCA at 08:12, 27 May 2020

OCA — Wed, 27 May 2020 08:12:54 GMT

←Older revision		Revision as of 08:12, 27 May 2020
Line 1:		Line 1:

	==Crystal structure of aspart insulin at pH 6.5==		==Crystal structure of aspart insulin at pH 6.5==
-	<StructureSection load='4gbc' size='340' side='right' caption='[[4gbc]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='4gbc' size='340' side='right'caption='[[4gbc]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gbc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The February 2016 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Insulins'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2016_2 10.2210/rcsb_pdb/mom_2016_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GBC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gbc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The February 2016 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Insulins'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2016_2 10.2210/rcsb_pdb/mom_2016_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4GBC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gbi\|4gbi]], [[4gbk\|4gbk]], [[4gbl\|4gbl]], [[4gbn\|4gbn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gbi\|4gbi]], [[4gbk\|4gbk]], [[4gbl\|4gbl]], [[4gbn\|4gbn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbc OCA], [http://pdbe.org/4gbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gbc RCSB], [http://www.ebi.ac.uk/pdbsum/4gbc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gbc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4gbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbc OCA], [http://pdbe.org/4gbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gbc RCSB], [http://www.ebi.ac.uk/pdbsum/4gbc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gbc ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[~~Molecular Playground/~~Insulin\|~~Molecular Playground/~~Insulin]]	+	*[[Insulin 3D Structures\|Insulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	[[Category: Designer Insulins]]		[[Category: Designer Insulins]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Favero-Retto, M P]]		[[Category: Favero-Retto, M P]]

OCA at 06:23, 22 August 2018

OCA — Wed, 22 Aug 2018 06:23:05 GMT

←Older revision		Revision as of 06:23, 22 August 2018
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4gbc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4gbc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:26, 15 November 2017

OCA — Wed, 15 Nov 2017 08:26:46 GMT

←Older revision		Revision as of 08:26, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4gbc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4gbc" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:47, 5 August 2016

OCA — Fri, 05 Aug 2016 13:47:25 GMT

←Older revision		Revision as of 13:47, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of aspart insulin at pH 6.5==		==Crystal structure of aspart insulin at pH 6.5==
	<StructureSection load='4gbc' size='340' side='right' caption='[[4gbc]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='4gbc' size='340' side='right' caption='[[4gbc]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gbc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GBC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gbc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The February 2016 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Insulins'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2016_2 10.2210/rcsb_pdb/mom_2016_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GBC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gbi\|4gbi]], [[4gbk\|4gbk]], [[4gbl\|4gbl]], [[4gbn\|4gbn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gbi\|4gbi]], [[4gbk\|4gbk]], [[4gbl\|4gbl]], [[4gbn\|4gbn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gbc RCSB], [http://www.ebi.ac.uk/pdbsum/4gbc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbc OCA], [http://pdbe.org/4gbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gbc RCSB], [http://www.ebi.ac.uk/pdbsum/4gbc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gbc ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gbc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Designer Insulins]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Favero-Retto, M P]]		[[Category: Favero-Retto, M P]]
	[[Category: Lima, L M.T R]]		[[Category: Lima, L M.T R]]

OCA at 11:28, 21 December 2014

OCA — Sun, 21 Dec 2014 11:28:36 GMT

←Older revision		Revision as of 11:28, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gbc\| PDB=4gbc \| SCENE= }}~~	+	==Crystal structure of aspart insulin at pH 6.5==
-	===Crystal structure of aspart insulin at pH 6.5===	+	<StructureSection load='4gbc' size='340' side='right' caption='[[4gbc]], [[Resolution\|resolution]] 1.78Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23428413}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4gbc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GBC FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gbi\|4gbi]], [[4gbk\|4gbk]], [[4gbl\|4gbl]], [[4gbn\|4gbn]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gbc RCSB], [http://www.ebi.ac.uk/pdbsum/4gbc PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[http://omim.org/entry/176730 176730]].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[http://omim.org/entry/125852 125852]]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[http://omim.org/entry/606176 606176]]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[http://omim.org/entry/613370 613370]]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>		[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[http://omim.org/entry/176730 176730]].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[http://omim.org/entry/125852 125852]]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[http://omim.org/entry/606176 606176]]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[http://omim.org/entry/613370 613370]]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Insulin shows a complex equilibrium between monomers and hexamers, involving varying conformers and association states. We sought to perform a structural characterization of the fast-acting human insulin variant B28Asp ("aspart"). Small-angle X-ray scattering measurements reveal similar globular behavior in both the aspart and regular human insulin, with a Rg of 19A and a Dmax of approximately 50A, indicating similar mean quaternary assembly distribution. Crystallographic assays revealed a T3R3 assembly of the aspart insulin formed by the TR dimer in the asymmetric unit, with all the first 8 residues of the B chain in the R-state monomer in helical conformation and the participation of its B3Asn in the stabilization of the hexamer. Our data provide access to novel structural information on aspart insulin such as an aspart insulin dimer in solution, the aspart insulin in T conformation and a pure R-state conformer establishing a T3R3 assembly, providing further insight on the stepwise conformational transition and assembly of this fast-insulin.

-	~~==Function==~~	+	A T3R3 hexamer of the human insulin variant B28Asp.,Palmieri LC, Favero-Retto MP, Lourenco D, Lima LM Biophys Chem. 2013 Mar-Apr;173-174:1-7. doi: 10.1016/j.bpc.2013.01.003. Epub 2013, Feb 4. PMID:23428413<ref>PMID:23428413</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/INS_HUMAN INS_HUMAN]] Insulin decreases blood glucose concentration~~. ~~It increases cell permeability to monosaccharides, amino acids and fatty acids~~. ~~It accelerates glycolysis~~, ~~the pentose phosphate cycle, and glycogen synthesis in liver~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4gbc]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4GBC OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023428413</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Favero-Retto, M P.]]	+	[[Category: Favero-Retto, M P]]
-	[[Category: Lima, L M.T R.]]	+	[[Category: Lima, L M.T R]]
-	[[Category: Palmieri, L C.]]	+	[[Category: Palmieri, L C]]
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: T3r3]]		[[Category: T3r3]]

OCA at 17:54, 19 June 2013

OCA — Wed, 19 Jun 2013 17:54:39 GMT

←Older revision		Revision as of 17:54, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4gbc\| PDB=4gbc \| SCENE= }}
		+	===Crystal structure of aspart insulin at pH 6.5===
		+	{{ABSTRACT_PUBMED_23428413}}

-	~~The~~ entry ~~4gbc~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[http://omim.org/entry/176730 176730]].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[http://omim.org/entry/125852 125852]]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[http://omim.org/entry/606176 606176]]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[http://omim.org/entry/613370 613370]]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>

-	~~Authors~~: ~~Lima, L~~.M.~~T.R~~., ~~Favero-Retto, M.P~~., ~~Palmieri~~, ~~L.C~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

-	~~Description: Crystal~~ structure ~~of aspart insulin at pH 6~~.5	+	==About this Structure==
		+	[[4gbc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023428413</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Favero-Retto, M P.]]
		+	[[Category: Lima, L M.T R.]]
		+	[[Category: Palmieri, L C.]]
		+	[[Category: Hormone]]
		+	[[Category: T3r3]]

OCA at 05:32, 22 August 2012

OCA — Wed, 22 Aug 2012 05:32:25 GMT

←Older revision		Revision as of 05:32, 22 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gbc is ON HOLD	+	The entry 4gbc is ON HOLD until Paper Publication

	Authors: Lima, L.M.T.R., Favero-Retto, M.P., Palmieri, L.C.		Authors: Lima, L.M.T.R., Favero-Retto, M.P., Palmieri, L.C.

	Description: Crystal structure of aspart insulin at pH 6.5		Description: Crystal structure of aspart insulin at pH 6.5

OCA: Protected "4gbc" [edit=sysop:move=sysop]

OCA — Wed, 01 Aug 2012 05:33:37 GMT

Protected "4gbc" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:33, 1 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gbc is ON HOLD Authors: Lima, L.M.T.R., Favero-Retto, M.P., Palmieri, L.C. Description: Crystal structure of aspart insulin at pH 6.5

OCA — Wed, 01 Aug 2012 05:33:36 GMT

New page: '''Unreleased structure''' The entry 4gbc is ON HOLD Authors: Lima, L.M.T.R., Favero-Retto, M.P., Palmieri, L.C. Description: Crystal structure of aspart insulin at pH 6.5

New page

'''Unreleased structure'''

The entry 4gbc is ON HOLD

Authors: Lima, L.M.T.R., Favero-Retto, M.P., Palmieri, L.C.

Description: Crystal structure of aspart insulin at pH 6.5