4gcl - Revision history

OCA at 11:27, 1 March 2024

OCA — Fri, 01 Mar 2024 11:27:51 GMT

←Older revision		Revision as of 11:27, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gcl]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_UTI89 Escherichia coli UTI89]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GCL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gcl]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_UTI89 Escherichia coli UTI89]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GCL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcl OCA], [https://pdbe.org/4gcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gcl RCSB], [https://www.ebi.ac.uk/pdbsum/4gcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gcl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcl OCA], [https://pdbe.org/4gcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gcl RCSB], [https://www.ebi.ac.uk/pdbsum/4gcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gcl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q1R4V1_ECOUT Q1R4V1_ECOUT] Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity).[HAMAP-Rule:MF_01839][SAAS:SAAS011075_004_088010]		[https://www.uniprot.org/uniprot/Q1R4V1_ECOUT Q1R4V1_ECOUT] Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity).[HAMAP-Rule:MF_01839][SAAS:SAAS011075_004_088010]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The spatial and temporal control of Filamenting temperature sensitive mutant Z (FtsZ) Z-ring formation is crucial for proper cell division in bacteria. In Escherichia coli, the synthetic lethal with a defective Min system (SlmA) protein helps mediate nucleoid occlusion, which prevents chromosome fragmentation by binding FtsZ and inhibiting Z-ring formation over the nucleoid. However, to perform its function, SlmA must be bound to the nucleoid. To deduce the basis for this chromosomal requirement, we performed biochemical, cellular, and structural studies. Strikingly, structures show that SlmA dramatically distorts DNA, allowing it to bind as an orientated dimer-of-dimers. Biochemical data indicate that SlmA dimer-of-dimers can spread along the DNA. Combined structural and biochemical data suggest that this DNA-activated SlmA oligomerization would prevent FtsZ protofilament propagation and bundling. Bioinformatic analyses localize SlmA DNA sites near membrane-tethered chromosomal regions, and cellular studies show that SlmA inhibits FtsZ reservoirs from forming membrane-tethered Z rings. Thus, our combined data indicate that SlmA DNA helps block Z-ring formation over chromosomal DNA by forming higher-order protein-nucleic acid complexes that disable FtsZ filaments from coalescing into proper structures needed for Z-ring creation.
-
-	SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid.,Tonthat NK, Milam SL, Chinnam N, Whitfill T, Margolin W, Schumacher MA Proc Natl Acad Sci U S A. 2013 Jun 10. PMID:23754405<ref>PMID:23754405</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4gcl" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:48, 26 October 2022

OCA — Wed, 26 Oct 2022 06:48:09 GMT

←Older revision		Revision as of 06:48, 26 October 2022
Line 1:		Line 1:

	==structure of no-dna factor==		==structure of no-dna factor==
-	<StructureSection load='4gcl' size='340' side='right' caption='[[4gcl]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='4gcl' size='340' side='right'caption='[[4gcl]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gcl]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecout Ecout~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GCL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gcl]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_UTI89 Escherichia coli UTI89]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GCL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gck\|4gck]], [[4gct\|4gct]], [[4gcu\|4gcu]], [[4gfk\|4gfk]], [[4gfl\|4gfl]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcl OCA], [https://pdbe.org/4gcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gcl RCSB], [https://www.ebi.ac.uk/pdbsum/4gcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gcl ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ttk, slmA, UTI89_C4185 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=364106 ECOUT])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcl OCA], [~~http~~://pdbe.org/4gcl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gcl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gcl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gcl ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q1R4V1_ECOUT Q1R4V1_ECOUT]] Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity).[HAMAP-Rule:MF_01839][SAAS:SAAS011075_004_088010]	+	[https://www.uniprot.org/uniprot/Q1R4V1_ECOUT Q1R4V1_ECOUT] Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity).[HAMAP-Rule:MF_01839][SAAS:SAAS011075_004_088010]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecout~~]]	+	[[Category: Escherichia coli UTI89]]
-	[[Category: ~~Schumacher, M A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Dna binding protein]]~~	+	[[Category: Schumacher MA]]
-	~~[[Category: Dna binding protein-dna complex~~]]	+

OCA at 19:35, 5 August 2016

OCA — Fri, 05 Aug 2016 19:35:13 GMT

←Older revision		Revision as of 19:35, 5 August 2016
Line 1:		Line 1:
		+
	==structure of no-dna factor==		==structure of no-dna factor==
	<StructureSection load='4gcl' size='340' side='right' caption='[[4gcl]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4gcl' size='340' side='right' caption='[[4gcl]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gcl]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_uti89 Escherichia coli uti89~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GCL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gcl]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecout Ecout]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GCL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gck\|4gck]], [[4gct\|4gct]], [[4gcu\|4gcu]], [[4gfk\|4gfk]], [[4gfl\|4gfl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gck\|4gck]], [[4gct\|4gct]], [[4gcu\|4gcu]], [[4gfk\|4gfk]], [[4gfl\|4gfl]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ttk, slmA, UTI89_C4185 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=364106 ~~Escherichia coli UTI89~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ttk, slmA, UTI89_C4185 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=364106 ECOUT])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gcl RCSB], [http://www.ebi.ac.uk/pdbsum/4gcl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcl OCA], [http://pdbe.org/4gcl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gcl RCSB], [http://www.ebi.ac.uk/pdbsum/4gcl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gcl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gcl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli uti89~~]]	+	[[Category: Ecout]]
	[[Category: Schumacher, M A]]		[[Category: Schumacher, M A]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Dna binding protein-dna complex]]		[[Category: Dna binding protein-dna complex]]

OCA at 05:16, 25 December 2014

OCA — Thu, 25 Dec 2014 05:16:00 GMT

←Older revision		Revision as of 05:16, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gcl RCSB], [http://www.ebi.ac.uk/pdbsum/4gcl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gcl RCSB], [http://www.ebi.ac.uk/pdbsum/4gcl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q1R4V1_ECOUT Q1R4V1_ECOUT]] Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity).[HAMAP-Rule:MF_01839][SAAS:SAAS011075_004_088010]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:42, 21 December 2014

OCA — Sun, 21 Dec 2014 10:42:38 GMT

←Older revision		Revision as of 10:42, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gcl\| PDB~~=4gcl \| ~~SCENE~~= }}	+	==structure of no-dna factor==
-	===structure ~~of no~~-~~dna factor~~===	+	<StructureSection load='4gcl' size='340' side='right' caption='[[4gcl]], [[Resolution\|resolution]] 2.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23754405}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gcl]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_uti89 Escherichia coli uti89]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GCL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gck\|4gck]], [[4gct\|4gct]], [[4gcu\|4gcu]], [[4gfk\|4gfk]], [[4gfl\|4gfl]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ttk, slmA, UTI89_C4185 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=364106 Escherichia coli UTI89])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gcl RCSB], [http://www.ebi.ac.uk/pdbsum/4gcl PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The spatial and temporal control of Filamenting temperature sensitive mutant Z (FtsZ) Z-ring formation is crucial for proper cell division in bacteria. In Escherichia coli, the synthetic lethal with a defective Min system (SlmA) protein helps mediate nucleoid occlusion, which prevents chromosome fragmentation by binding FtsZ and inhibiting Z-ring formation over the nucleoid. However, to perform its function, SlmA must be bound to the nucleoid. To deduce the basis for this chromosomal requirement, we performed biochemical, cellular, and structural studies. Strikingly, structures show that SlmA dramatically distorts DNA, allowing it to bind as an orientated dimer-of-dimers. Biochemical data indicate that SlmA dimer-of-dimers can spread along the DNA. Combined structural and biochemical data suggest that this DNA-activated SlmA oligomerization would prevent FtsZ protofilament propagation and bundling. Bioinformatic analyses localize SlmA DNA sites near membrane-tethered chromosomal regions, and cellular studies show that SlmA inhibits FtsZ reservoirs from forming membrane-tethered Z rings. Thus, our combined data indicate that SlmA DNA helps block Z-ring formation over chromosomal DNA by forming higher-order protein-nucleic acid complexes that disable FtsZ filaments from coalescing into proper structures needed for Z-ring creation.

-	~~==Function==~~	+	SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid.,Tonthat NK, Milam SL, Chinnam N, Whitfill T, Margolin W, Schumacher MA Proc Natl Acad Sci U S A. 2013 Jun 10. PMID:23754405<ref>PMID:23754405</ref>
-	~~[[http://www.uniprot.org/uniprot/Q1R4V1_ECOUT Q1R4V1_ECOUT]] Required for nucleoid occlusion (NO) phenomenon, which prevents~~ Z-ring formation ~~and cell division~~ over the nucleoid. ~~Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ~~, ~~and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome~~, ~~preventing FtsZ polymerization at these regions (By similarity)~~.~~[HAMAP-Rule~~:~~MF_01839][SAAS~~:~~SAAS011075_004_088010]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4gcl]] is~~ a ~~12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_uti89 Escherichia coli uti89]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4GCL OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023754405</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli uti89]]		[[Category: Escherichia coli uti89]]
-	[[Category: Schumacher, M A.]]	+	[[Category: Schumacher, M A]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Dna binding protein-dna complex]]		[[Category: Dna binding protein-dna complex]]

OCA at 15:10, 19 June 2013

OCA — Wed, 19 Jun 2013 15:10:39 GMT

←Older revision		Revision as of 15:10, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4gcl\| PDB=4gcl \| SCENE= }}
		+	===structure of no-dna factor===
		+	{{ABSTRACT_PUBMED_23754405}}

-	~~The entry 4gcl is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q1R4V1_ECOUT Q1R4V1_ECOUT]] Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity).[HAMAP-Rule:MF_01839][SAAS:SAAS011075_004_088010]

-	~~Authors~~: ~~Schumacher, M~~.A.	+	==About this Structure==
		+	[[4gcl]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_uti89 Escherichia coli uti89]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCL OCA].

-	~~Description~~: ~~structure of no~~-dna ~~factor~~	+	==Reference==
		+	<ref group="xtra">PMID:023754405</ref><references group="xtra"/><references/>
		+	[[Category: Escherichia coli uti89]]
		+	[[Category: Schumacher, M A.]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Dna binding protein-dna complex]]

OCA at 10:56, 19 December 2012

OCA — Wed, 19 Dec 2012 10:56:10 GMT

←Older revision		Revision as of 10:56, 19 December 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gcl is ON HOLD	+	The entry 4gcl is ON HOLD until Paper Publication

	Authors: Schumacher, M.A.		Authors: Schumacher, M.A.

	Description: structure of no-dna factor		Description: structure of no-dna factor

OCA: Protected "4gcl" [edit=sysop:move=sysop]

OCA — Wed, 08 Aug 2012 05:00:27 GMT

Protected "4gcl" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:00, 8 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gcl is ON HOLD Authors: Schumacher, M.A. Description: structure of no-dna factor

OCA — Wed, 08 Aug 2012 05:00:26 GMT

New page: '''Unreleased structure''' The entry 4gcl is ON HOLD Authors: Schumacher, M.A. Description: structure of no-dna factor

New page

'''Unreleased structure'''

The entry 4gcl is ON HOLD

Authors: Schumacher, M.A.

Description: structure of no-dna factor