4ge1 - Revision history

OCA at 06:50, 26 October 2022

OCA — Wed, 26 Oct 2022 06:50:45 GMT

←Older revision		Revision as of 06:50, 26 October 2022
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	<StructureSection load='4ge1' size='340' side='right'caption='[[4ge1]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4ge1' size='340' side='right'caption='[[4ge1]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ge1]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Rhopr Rhopr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GE1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ge1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GE1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TSS:2-(1H-INDOL-3-YL)ETHANAMINE'>TSS</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TSS:2-(1H-INDOL-3-YL)ETHANAMINE'>TSS</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4get\|4get]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ge1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ge1 OCA], [https://pdbe.org/4ge1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ge1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ge1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ge1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ge1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ge1 OCA], [~~http~~://pdbe.org/4ge1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ge1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ge1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ge1 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q86PT9_RHOPR Q86PT9_RHOPR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rhopr~~]]	+	[[Category: Rhodnius prolixus]]
-	[[Category: Andersen~~, J F~~]]	+	[[Category: Andersen JF]]
-	[[Category: Chang~~, B W~~]]	+	[[Category: Chang BW]]
-	[[Category: Mans~~, B J~~]]	+	[[Category: Mans BJ]]
-	[[Category: Ribeiro~~, J M~~]]	+	[[Category: Ribeiro JM]]
-	[[Category: Xu, X]]	+	[[Category: Xu X]]
-	~~[[Category: Amine-binding protein]]~~	+
-	~~[[Category: Lipocalin binding protein]]~~	+
-	~~[[Category: Norepinephrine]]~~	+
-	~~[[Category: Salivary gland]]~~	+
-	~~[[Category: Serotonin~~]]	+

OCA at 09:17, 5 February 2020

OCA — Wed, 05 Feb 2020 09:17:04 GMT

←Older revision		Revision as of 09:17, 5 February 2020
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	==Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus==		==Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus==
-	<StructureSection load='4ge1' size='340' side='right' caption='[[4ge1]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='4ge1' size='340' side='right'caption='[[4ge1]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ge1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GE1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ge1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GE1 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rhopr]]		[[Category: Rhopr]]
	[[Category: Andersen, J F]]		[[Category: Andersen, J F]]

OCA at 20:28, 11 August 2016

OCA — Thu, 11 Aug 2016 20:28:51 GMT

←Older revision		Revision as of 20:28, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus==		==Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus==
	<StructureSection load='4ge1' size='340' side='right' caption='[[4ge1]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4ge1' size='340' side='right' caption='[[4ge1]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ge1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rhodnius_prolixus Rhodnius prolixus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GE1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ge1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GE1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TSS:2-(1H-INDOL-3-YL)ETHANAMINE'>TSS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TSS:2-(1H-INDOL-3-YL)ETHANAMINE'>TSS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4get\|4get]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4get\|4get]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ge1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ge1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ge1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ge1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ge1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ge1 OCA], [http://pdbe.org/4ge1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ge1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ge1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ge1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ge1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rhodnius prolixus~~]]	+	[[Category: Rhopr]]
	[[Category: Andersen, J F]]		[[Category: Andersen, J F]]
	[[Category: Chang, B W]]		[[Category: Chang, B W]]

OCA at 13:32, 4 January 2015

OCA — Sun, 04 Jan 2015 13:32:03 GMT

←Older revision		Revision as of 13:32, 4 January 2015
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-	[[~~Image:~~4ge1.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus==
		+	<StructureSection load='4ge1' size='340' side='right' caption='[[4ge1]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ge1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GE1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TSS:2-(1H-INDOL-3-YL)ETHANAMINE'>TSS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4get\|4get]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ge1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ge1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ge1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ge1 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteins that bind small-molecule mediators of inflammation and hemostasis are essential for blood-feeding by arthropod vectors of infectious disease. In ticks and triatomine insects, the lipocalin protein family is greatly expanded and members have been shown to bind biogenic amines, eicosanoids and ADP. These compounds are potent mediators of platelet activation, inflammation and vascular tone. In this paper, the structure of the amine-binding protein (ABP) from Rhodnius prolixus, a vector of the trypanosome that causes Chagas disease, is described. ABP binds the biogenic amines serotonin and norepinephrine with high affinity. A complex with tryptamine shows the presence of a binding site for a single ligand molecule in the central cavity of the beta-barrel structure. The cavity contains significant additional volume, suggesting that this protein may have evolved from the related nitrophorin proteins, which bind a much larger heme ligand in the central cavity.

-	~~{{STRUCTURE_4ge1\| PDB=4ge1 \| SCENE= }}~~	+	Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi.,Xu X, Chang BW, Mans BJ, Ribeiro JM, Andersen JF Acta Crystallogr D Biol Crystallogr. 2013 Jan;69(Pt 1):105-13. doi:, 10.1107/S0907444912043326. Epub 2012 Dec 20. PMID:23275168<ref>PMID:23275168</ref>

-	~~===Structure~~ of the ~~tryptamine complex~~ of ~~the amine binding protein of Rhodnius prolixus===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23275168}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4ge1]] is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE1 OCA].~~	+	</StructureSection>
	[[Category: Rhodnius prolixus]]		[[Category: Rhodnius prolixus]]
-	[[Category: Andersen, J F.]]	+	[[Category: Andersen, J F]]
-	[[Category: Chang, B W.]]	+	[[Category: Chang, B W]]
-	[[Category: Mans, B J.]]	+	[[Category: Mans, B J]]
-	[[Category: Ribeiro, J M.]]	+	[[Category: Ribeiro, J M]]
-	[[Category: Xu, X.]]	+	[[Category: Xu, X]]
	[[Category: Amine-binding protein]]		[[Category: Amine-binding protein]]
	[[Category: Lipocalin binding protein]]		[[Category: Lipocalin binding protein]]

OCA at 11:30, 23 January 2013

OCA — Wed, 23 Jan 2013 11:30:58 GMT

←Older revision		Revision as of 11:30, 23 January 2013
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-	[[Image:4ge1.~~jpg~~\|left\|200px]]	+	[[Image:4ge1.png\|left\|200px]]

	{{STRUCTURE_4ge1\| PDB=4ge1 \| SCENE= }}		{{STRUCTURE_4ge1\| PDB=4ge1 \| SCENE= }}
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	===Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus===		===Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus===

		+	{{ABSTRACT_PUBMED_23275168}}

	==About this Structure==		==About this Structure==

OCA at 09:36, 2 January 2013

OCA — Wed, 02 Jan 2013 09:36:36 GMT

←Older revision		Revision as of 09:36, 2 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ge1.jpg\|left\|200px]]

-	~~The entry~~ 4ge1 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4ge1\| PDB=4ge1 \| SCENE= }}

-	~~Authors: Andersen, J.F., Chang, B.W., Xu, X., Mans, B.J., Ribeiro, J.M.~~	+	===Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus===

-	~~Description:~~ Structure ~~of the tryptamine complex of the amine binding protein of~~ Rhodnius prolixus	+
		+	==About this Structure==
		+	[[4ge1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE1 OCA].
		+	[[Category: Rhodnius prolixus]]
		+	[[Category: Andersen, J F.]]
		+	[[Category: Chang, B W.]]
		+	[[Category: Mans, B J.]]
		+	[[Category: Ribeiro, J M.]]
		+	[[Category: Xu, X.]]
		+	[[Category: Amine-binding protein]]
		+	[[Category: Lipocalin binding protein]]
		+	[[Category: Norepinephrine]]
		+	[[Category: Salivary gland]]
		+	[[Category: Serotonin]]

OCA at 06:51, 10 October 2012

OCA — Wed, 10 Oct 2012 06:51:47 GMT

←Older revision		Revision as of 06:51, 10 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ge1 is ON HOLD	+	The entry 4ge1 is ON HOLD until Paper Publication

	Authors: Andersen, J.F., Chang, B.W., Xu, X., Mans, B.J., Ribeiro, J.M.		Authors: Andersen, J.F., Chang, B.W., Xu, X., Mans, B.J., Ribeiro, J.M.

	Description: Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus		Description: Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus

OCA: Protected "4ge1" [edit=sysop:move=sysop]

OCA — Wed, 08 Aug 2012 05:01:57 GMT

Protected "4ge1" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:01, 8 August 2012

OCA: New page: '''Unreleased structure''' The entry 4ge1 is ON HOLD Authors: Andersen, J.F., Chang, B.W., Xu, X., Mans, B.J., Ribeiro, J.M. Description: Structure of the tryptamine complex of the ami...

OCA — Wed, 08 Aug 2012 05:01:56 GMT

New page: '''Unreleased structure''' The entry 4ge1 is ON HOLD Authors: Andersen, J.F., Chang, B.W., Xu, X., Mans, B.J., Ribeiro, J.M. Description: Structure of the tryptamine complex of the ami...

New page

'''Unreleased structure'''

The entry 4ge1 is ON HOLD

Authors: Andersen, J.F., Chang, B.W., Xu, X., Mans, B.J., Ribeiro, J.M.

Description: Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus