4gel - Revision history

OCA at 13:58, 8 November 2023

OCA — Wed, 08 Nov 2023 13:58:09 GMT

←Older revision		Revision as of 13:58, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GEL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.756Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gel OCA], [https://pdbe.org/4gel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gel RCSB], [https://www.ebi.ac.uk/pdbsum/4gel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gel ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gel OCA], [https://pdbe.org/4gel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gel RCSB], [https://www.ebi.ac.uk/pdbsum/4gel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gel ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:52, 26 October 2022

OCA — Wed, 26 Oct 2022 06:52:54 GMT

←Older revision		Revision as of 06:52, 26 October 2022
Line 1:		Line 1:

	==Crystal structure of Zucchini==		==Crystal structure of Zucchini==
-	<StructureSection load='4gel' size='340' side='right' caption='[[4gel]], [[Resolution\|resolution]] 1.76Å' scene=''>	+	<StructureSection load='4gel' size='340' side='right'caption='[[4gel]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gel]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gem\|4gem]], [[4gen\|4gen]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gel OCA], [https://pdbe.org/4gel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gel RCSB], [https://www.ebi.ac.uk/pdbsum/4gel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gel ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zuc, CG12314 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gel OCA], [~~http~~://pdbe.org/4gel PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gel RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gel PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gel ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ZUC_DROME ZUC_DROME]] Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.<ref>PMID:17543859</ref> <ref>PMID:19812547</ref> <ref>PMID:20818334</ref> <ref>PMID:20966047</ref> <ref>PMID:20966049</ref> <ref>PMID:20559422</ref> <ref>PMID:21397848</ref>	+	[https://www.uniprot.org/uniprot/ZUC_DROME ZUC_DROME] Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.<ref>PMID:17543859</ref> <ref>PMID:19812547</ref> <ref>PMID:20818334</ref> <ref>PMID:20966047</ref> <ref>PMID:20966049</ref> <ref>PMID:20559422</ref> <ref>PMID:21397848</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
-	[[Category: Fukuhara, S]]	+	[[Category: Large Structures]]
-	[[Category: Ishitani, R]]	+	[[Category: Fukuhara S]]
-	[[Category: Nishimasu, H]]	+	[[Category: Ishitani R]]
-	[[Category: Nureki, O]]	+	[[Category: Nishimasu H]]
-	~~[[Category: Hydrolase]]~~	+	[[Category: Nureki O]]
-	~~[[Category: Nuclease]]~~	+
-	~~[[Category: Phospholipase d]]~~	+
-	~~[[Category: Pirna~~]]	+

OCA at 17:16, 4 August 2016

OCA — Thu, 04 Aug 2016 17:16:06 GMT

←Older revision		Revision as of 17:16, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Zucchini==		==Crystal structure of Zucchini==
	<StructureSection load='4gel' size='340' side='right' caption='[[4gel]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='4gel' size='340' side='right' caption='[[4gel]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GEL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gem\|4gem]], [[4gen\|4gen]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gem\|4gem]], [[4gen\|4gen]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zuc, CG12314 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 ~~Drosophila melanogaster~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zuc, CG12314 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gel RCSB], [http://www.ebi.ac.uk/pdbsum/4gel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gel OCA], [http://pdbe.org/4gel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gel RCSB], [http://www.ebi.ac.uk/pdbsum/4gel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gel ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gel" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Fukuhara, S]]		[[Category: Fukuhara, S]]
	[[Category: Ishitani, R]]		[[Category: Ishitani, R]]

OCA at 17:27, 24 December 2014

OCA — Wed, 24 Dec 2014 17:27:28 GMT

←Older revision		Revision as of 17:27, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gel\| PDB~~=4gel \| ~~SCENE~~= }}	+	==Crystal structure of Zucchini==
-	===~~Crystal~~ structure of ~~Zucchini~~===	+	<StructureSection load='4gel' size='340' side='right' caption='[[4gel]], [[Resolution\|resolution]] 1.76Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23064230}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GEL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gem\|4gem]], [[4gen\|4gen]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">zuc, CG12314 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gel RCSB], [http://www.ebi.ac.uk/pdbsum/4gel PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZUC_DROME ZUC_DROME]] Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.<ref>PMID:17543859</ref> <ref>PMID:19812547</ref> <ref>PMID:20818334</ref> <ref>PMID:20966047</ref> <ref>PMID:20966049</ref> <ref>PMID:20559422</ref> <ref>PMID:21397848</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PIWI-interacting RNAs (piRNAs) silence transposons to maintain genome integrity in animal germ lines. piRNAs are classified as primary and secondary piRNAs, depending on their biogenesis machinery. Primary piRNAs are processed from long non-coding RNA precursors transcribed from piRNA clusters in the genome through the primary processing pathway. Although the existence of a ribonuclease participating in this pathway has been predicted, its molecular identity remained unknown. Here we show that Zucchini (Zuc), a mitochondrial phospholipase D (PLD) superfamily member, is an endoribonuclease essential for primary piRNA biogenesis. We solved the crystal structure of Drosophila melanogaster Zuc (DmZuc) at 1.75 A resolution. The structure revealed that DmZuc has a positively charged, narrow catalytic groove at the dimer interface, which could accommodate a single-stranded, but not a double-stranded, RNA. DmZuc and the mouse homologue MmZuc (also known as Pld6 and MitoPLD) showed endoribonuclease activity for single-stranded RNAs in vitro. The RNA cleavage products bear a 5'-monophosphate group, a hallmark of mature piRNAs. Mutational analyses revealed that the conserved active-site residues of DmZuc are critical for the ribonuclease activity in vitro, and for piRNA maturation and transposon silencing in vivo. We propose a model for piRNA biogenesis in animal germ lines, in which the Zuc endoribonuclease has a key role in primary piRNA maturation.

-	~~==Function==~~	+	Structure and function of Zucchini endoribonuclease in piRNA biogenesis.,Nishimasu H, Ishizu H, Saito K, Fukuhara S, Kamatani MK, Bonnefond L, Matsumoto N, Nishizawa T, Nakanaga K, Aoki J, Ishitani R, Siomi H, Siomi MC, Nureki O Nature. 2012 Nov 8;491(7423):284-7. doi: 10.1038/nature11509. Epub 2012 Oct 14. PMID:23064230<ref>PMID:23064230</ref>
-	~~[[http://www.uniprot.org/uniprot/ZUC_DROME ZUC_DROME]] Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis~~ of ~~cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the~~ piRNA ~~metabolic process. Plays a key role in primary~~ biogenesis ~~of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization~~. ~~piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons~~. ~~Involved in trans-silencing effect~~ (~~TSE~~)~~, a homology~~-~~dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis~~.~~<ref>PMID~~:~~17543859<~~/~~ref><ref>~~PMID:~~19812547</ref><ref>PMID:20818334</ref><ref>PMID:20966047</ref><ref>PMID:20966049</ref><ref>PMID:20559422</ref>~~<ref>PMID:~~21397848~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4gel]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Fukuhara, S.]]	+	[[Category: Fukuhara, S]]
-	[[Category: Ishitani, R.]]	+	[[Category: Ishitani, R]]
-	[[Category: Nishimasu, H.]]	+	[[Category: Nishimasu, H]]
-	[[Category: Nureki, O.]]	+	[[Category: Nureki, O]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nuclease]]		[[Category: Nuclease]]
	[[Category: Phospholipase d]]		[[Category: Phospholipase d]]
	[[Category: Pirna]]		[[Category: Pirna]]

OCA at 07:39, 27 March 2013

OCA — Wed, 27 Mar 2013 07:39:43 GMT

←Older revision		Revision as of 07:39, 27 March 2013
Line 1:		Line 1:
-	[[Image:4gel.jpg\|left\|200px]]
-
	{{STRUCTURE_4gel\| PDB=4gel \| SCENE= }}		{{STRUCTURE_4gel\| PDB=4gel \| SCENE= }}
-
	===Crystal structure of Zucchini===		===Crystal structure of Zucchini===
		+	{{ABSTRACT_PUBMED_23064230}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ZUC_DROME ZUC_DROME]] Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.<ref>PMID:17543859</ref><ref>PMID:19812547</ref><ref>PMID:20818334</ref><ref>PMID:20966047</ref><ref>PMID:20966049</ref><ref>PMID:20559422</ref><ref>PMID:21397848</ref>

	==About this Structure==		==About this Structure==
	[[4gel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA].		[[4gel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Fukuhara, S.]]		[[Category: Fukuhara, S.]]

OCA at 07:13, 17 October 2012

OCA — Wed, 17 Oct 2012 07:13:50 GMT

←Older revision		Revision as of 07:13, 17 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gel.jpg\|left\|200px]]

-	~~The entry~~ 4gel ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gel\| PDB=4gel \| SCENE= }}

-	~~Authors: Nishimasu, H., Fukuhara, S., Ishitani, R., Nureki, O.~~	+	===Crystal structure of Zucchini===

-	~~Description: Crystal~~ structure ~~of Zucchini~~	+
		+	==About this Structure==
		+	[[4gel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEL OCA].
		+	[[Category: Drosophila melanogaster]]
		+	[[Category: Fukuhara, S.]]
		+	[[Category: Ishitani, R.]]
		+	[[Category: Nishimasu, H.]]
		+	[[Category: Nureki, O.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nuclease]]
		+	[[Category: Phospholipase d]]
		+	[[Category: Pirna]]

OCA at 06:51, 10 October 2012

OCA — Wed, 10 Oct 2012 06:51:51 GMT

←Older revision		Revision as of 06:51, 10 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gel is ON HOLD	+	The entry 4gel is ON HOLD until Paper Publication

	Authors: Nishimasu, H., Fukuhara, S., Ishitani, R., Nureki, O.		Authors: Nishimasu, H., Fukuhara, S., Ishitani, R., Nureki, O.

	Description: Crystal structure of Zucchini		Description: Crystal structure of Zucchini

OCA: Protected "4gel" [edit=sysop:move=sysop]

OCA — Wed, 08 Aug 2012 05:02:30 GMT

Protected "4gel" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:02, 8 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gel is ON HOLD Authors: Nishimasu, H., Fukuhara, S., Ishitani, R., Nureki, O. Description: Crystal structure of Zucchini

OCA — Wed, 08 Aug 2012 05:02:29 GMT

New page: '''Unreleased structure''' The entry 4gel is ON HOLD Authors: Nishimasu, H., Fukuhara, S., Ishitani, R., Nureki, O. Description: Crystal structure of Zucchini

New page

'''Unreleased structure'''

The entry 4gel is ON HOLD

Authors: Nishimasu, H., Fukuhara, S., Ishitani, R., Nureki, O.

Description: Crystal structure of Zucchini