4gg9 - Revision history

OCA at 15:45, 14 March 2024

OCA — Thu, 14 Mar 2024 15:45:57 GMT

←Older revision		Revision as of 15:45, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gg9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GG9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gg9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GG9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WW:4-{2-[(CYCLOHEXYLMETHYL)AMINO]ETHYL}-2-[(THIOPHEN-2-YLMETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0WW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.48Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WW:4-{2-[(CYCLOHEXYLMETHYL)AMINO]ETHYL}-2-[(THIOPHEN-2-YLMETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0WW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gg9 OCA], [https://pdbe.org/4gg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gg9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gg9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gg9 OCA], [https://pdbe.org/4gg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gg9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gg9 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:55, 26 October 2022

OCA — Wed, 26 Oct 2022 06:55:10 GMT

←Older revision		Revision as of 06:55, 26 October 2022
Line 3:		Line 3:
	<StructureSection load='4gg9' size='340' side='right'caption='[[4gg9]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='4gg9' size='340' side='right'caption='[[4gg9]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gg9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Zymmo Zymmo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GG9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gg9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GG9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0WW:4-{2-[(CYCLOHEXYLMETHYL)AMINO]ETHYL}-2-[(THIOPHEN-2-YLMETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0WW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WW:4-{2-[(CYCLOHEXYLMETHYL)AMINO]ETHYL}-2-[(THIOPHEN-2-YLMETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0WW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s1g\|3s1g]], [[3sm0\|3sm0]], [[3tll\|3tll]], [[4gh1\|4gh1]], [[4gh3\|4gh3]], [[4ghr\|4ghr]], [[4gi4\|4gi4]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gg9 OCA], [https://pdbe.org/4gg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gg9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gg9 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tgt, ZMO0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264203 ZYMMO])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gg9 OCA], [~~http~~://pdbe.org/4gg9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gg9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gg9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gg9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]	+	[https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

	==See Also==		==See Also==
-	*[[TRNA-guanine transglycosylase\|TRNA-guanine transglycosylase]]	+	*[[TRNA-guanine transglycosylase 3D structures\|TRNA-guanine transglycosylase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Zymmo~~]]	+	[[Category: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]]
-	[[Category: Immekus, F]]	+	[[Category: Immekus F]]
-	[[Category: Klebe, G]]	+	[[Category: Klebe G]]
-	~~[[Category: Biosynthesis]]~~	+
-	~~[[Category: Glycosyltransferase]]~~	+
-	~~[[Category: Queuosine]]~~	+
-	~~[[Category: Tim barrel]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex]]~~	+
-	~~[[Category: Trna processing~~]]	+

OCA at 11:54, 17 July 2019

OCA — Wed, 17 Jul 2019 11:54:37 GMT

←Older revision		Revision as of 11:54, 17 July 2019
Line 1:		Line 1:

	==tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor==		==tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor==
-	<StructureSection load='4gg9' size='340' side='right' caption='[[4gg9]], [[Resolution\|resolution]] 1.48Å' scene=''>	+	<StructureSection load='4gg9' size='340' side='right'caption='[[4gg9]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gg9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymmo Zymmo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GG9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gg9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymmo Zymmo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GG9 FirstGlance]. <br>
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Zymmo]]		[[Category: Zymmo]]
	[[Category: Immekus, F]]		[[Category: Immekus, F]]

OCA at 08:59, 4 August 2016

OCA — Thu, 04 Aug 2016 08:59:22 GMT

←Older revision		Revision as of 08:59, 4 August 2016
Line 1:		Line 1:
		+
	==tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor==		==tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor==
	<StructureSection load='4gg9' size='340' side='right' caption='[[4gg9]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='4gg9' size='340' side='right' caption='[[4gg9]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gg9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Zymomonas_mobilis_subsp._mobilis_zm4_=_atcc_31821 Zymomonas mobilis subsp. mobilis zm4 = atcc 31821~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GG9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gg9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymmo Zymmo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GG9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0WW:4-{2-[(CYCLOHEXYLMETHYL)AMINO]ETHYL}-2-[(THIOPHEN-2-YLMETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0WW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0WW:4-{2-[(CYCLOHEXYLMETHYL)AMINO]ETHYL}-2-[(THIOPHEN-2-YLMETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0WW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s1g\|3s1g]], [[3sm0\|3sm0]], [[3tll\|3tll]], [[4gh1\|4gh1]], [[4gh3\|4gh3]], [[4ghr\|4ghr]], [[4gi4\|4gi4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s1g\|3s1g]], [[3sm0\|3sm0]], [[3tll\|3tll]], [[4gh1\|4gh1]], [[4gh3\|4gh3]], [[4ghr\|4ghr]], [[4gi4\|4gi4]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tgt, ZMO0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264203 ~~Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tgt, ZMO0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264203 ZYMMO])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gg9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gg9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gg9 OCA], [http://pdbe.org/4gg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gg9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gg9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Zymomonas mobilis subsp. mobilis zm4 = atcc 31821~~]]	+	[[Category: Zymmo]]
	[[Category: Immekus, F]]		[[Category: Immekus, F]]
	[[Category: Klebe, G]]		[[Category: Klebe, G]]

OCA at 07:35, 25 December 2014

OCA — Thu, 25 Dec 2014 07:35:44 GMT

←Older revision		Revision as of 07:35, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gg9\| PDB=4gg9 \| SCENE= }}~~	+	==tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor==
-	===tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor===	+	<StructureSection load='4gg9' size='340' side='right' caption='[[4gg9]], [[Resolution\|resolution]] 1.48Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[4gg9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_zm4_=_atcc_31821 Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GG9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0WW:4-{2-[(CYCLOHEXYLMETHYL)AMINO]ETHYL}-2-[(THIOPHEN-2-YLMETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0WW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s1g\|3s1g]], [[3sm0\|3sm0]], [[3tll\|3tll]], [[4gh1\|4gh1]], [[4gh3\|4gh3]], [[4ghr\|4ghr]], [[4gi4\|4gi4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tgt, ZMO0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264203 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gg9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gg9 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]		[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4gg9~~]] ~~is a 1 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_zm4_=_atcc_31821 Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA].	+	*[[TRNA-guanine transglycosylase\|TRNA-guanine transglycosylase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]]		[[Category: Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]]
-	[[Category: Immekus, F.]]	+	[[Category: Immekus, F]]
-	[[Category: Klebe, G.]]	+	[[Category: Klebe, G]]
	[[Category: Biosynthesis]]		[[Category: Biosynthesis]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]

OCA at 10:56, 4 September 2013

OCA — Wed, 04 Sep 2013 10:56:13 GMT

←Older revision		Revision as of 10:56, 4 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4gg9\| PDB=4gg9 \| SCENE= }}
		+	===tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor===

-	~~The entry 4gg9~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

-	~~Authors~~: Immekus, F., Klebe, G.	+	==About this Structure==
-		+	[[4gg9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_zm4_=_atcc_31821 Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG9 OCA].
-	~~Description~~: ~~tRNA Guanine Transglycosylase in complex with thiophene~~-~~substituted lin-benzohypoxanthine~~ inhibitor	+	[[Category: Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]]
		+	[[Category: Immekus, F.]]
		+	[[Category: Klebe, G.]]
		+	[[Category: Biosynthesis]]
		+	[[Category: Glycosyltransferase]]
		+	[[Category: Queuosine]]
		+	[[Category: Tim barrel]]
		+	[[Category: Transferase-transferase inhibitor complex]]
		+	[[Category: Trna processing]]

OCA at 05:34, 22 August 2012

OCA — Wed, 22 Aug 2012 05:34:18 GMT

←Older revision		Revision as of 05:34, 22 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gg9 is ON HOLD	+	The entry 4gg9 is ON HOLD until Paper Publication

	Authors: Immekus, F., Klebe, G.		Authors: Immekus, F., Klebe, G.

	Description: tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor		Description: tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor

OCA: Protected "4gg9" [edit=sysop:move=sysop]

OCA — Wed, 15 Aug 2012 05:25:30 GMT

Protected "4gg9" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:25, 15 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gg9 is ON HOLD Authors: Immekus, F., Klebe, G. Description: tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanth...

OCA — Wed, 15 Aug 2012 05:25:29 GMT

New page: '''Unreleased structure''' The entry 4gg9 is ON HOLD Authors: Immekus, F., Klebe, G. Description: tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanth...

New page

'''Unreleased structure'''

The entry 4gg9 is ON HOLD

Authors: Immekus, F., Klebe, G.

Description: tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor