4giv - Revision history

OCA at 11:31, 1 March 2024

OCA — Fri, 01 Mar 2024 11:31:39 GMT

←Older revision		Revision as of 11:31, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4giv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GIV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4giv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GIV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4GI:HYDROXY(OXO)[3-({(2S)-2-[(3-PHENYLPROPOXY)CARBONYL]PIPERIDIN-1-YL}SULFONYL)PHENYL]AMMONIUM'>4GI</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4GI:HYDROXY(OXO)[3-({(2S)-2-[(3-PHENYLPROPOXY)CARBONYL]PIPERIDIN-1-YL}SULFONYL)PHENYL]AMMONIUM'>4GI</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4giv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4giv OCA], [https://pdbe.org/4giv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4giv RCSB], [https://www.ebi.ac.uk/pdbsum/4giv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4giv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4giv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4giv OCA], [https://pdbe.org/4giv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4giv RCSB], [https://www.ebi.ac.uk/pdbsum/4giv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4giv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q3JK38_BURP1 Q3JK38_BURP1] [https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST] Not known; suppressor of MIF2 mutations.		[https://www.uniprot.org/uniprot/Q3JK38_BURP1 Q3JK38_BURP1] [https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST] Not known; suppressor of MIF2 mutations.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Macrophage infectivity potentiators (Mips) are immunophilin proteins and essential virulence factors for a range of pathogenic organisms. We applied a structural biology approach to characterize a Mip from Burkholderia pseudomallei (BpML1), the causative agent of melioidosis. Crystal structure and nuclear magnetic resonance analyses of BpML1 in complex with known macrocyclics and other derivatives led to the identification of a key chemical scaffold. This scaffold possesses inhibitory potency for BpML1 without the immunosuppressive components of related macrocyclic agents. Biophysical characterization of a compound series with this scaffold allowed binding site specificity in solution and potency determinations for rank ordering the set. The best compounds in this series possessed a low-micromolar affinity for BpML1, bound at the site of enzymatic activity, and inhibited a panel of homologous Mip proteins from other pathogenic bacteria, without demonstrating toxicity in human macrophages. Importantly, the in vitro activity of BpML1 was reduced by these compounds, leading to decreased macrophage infectivity and intracellular growth of Burkholderia pseudomallei. These compounds offer the potential for activity against a new class of antimicrobial targets and present the utility of a structure-based approach for novel antimicrobial drug discovery.
-
-	A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.,Begley DW, Fox D 3rd, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, Barnes SR, Moen SO, Raymond AC, Stacy R, Myler PJ, Staker BL, Harmer NJ, Norville IH, Holzgrabe U, Sarkar-Tyson M, Edwards TE, Lorimer DD Antimicrob Agents Chemother. 2014 Mar;58(3):1458-67. doi: 10.1128/AAC.01875-13., Epub 2013 Dec 23. PMID:24366729<ref>PMID:24366729</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4giv" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:58, 26 October 2022

OCA — Wed, 26 Oct 2022 06:58:59 GMT

←Older revision		Revision as of 06:58, 26 October 2022
Line 1:		Line 1:

	==Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183==		==Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183==
-	<StructureSection load='4giv' size='340' side='right' caption='[[4giv]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='4giv' size='340' side='right'caption='[[4giv]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4giv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Burp1 Burp1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GIV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4giv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GIV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GI:HYDROXY(OXO)[3-({(2S)-2-[(3-PHENYLPROPOXY)CARBONYL]PIPERIDIN-1-YL}SULFONYL)PHENYL]AMMONIUM'>4GI</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4GI:HYDROXY(OXO)[3-({(2S)-2-[(3-PHENYLPROPOXY)CARBONYL]PIPERIDIN-1-YL}SULFONYL)PHENYL]AMMONIUM'>4GI</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2keo\|2keo]], [[2ko7\|2ko7]], [[2l2s\|2l2s]], [[3vaw\|3vaw]], [[3uqb\|3uqb]], [[3uqa\|3uqa]], [[4dz3\|4dz3]], [[4dz2\|4dz2]], [[3uf8\|3uf8]], [[4fn2\|4fn2]], [[4g50\|4g50]], [[4ggq\|4ggq]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4giv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4giv OCA], [https://pdbe.org/4giv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4giv RCSB], [https://www.ebi.ac.uk/pdbsum/4giv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4giv ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BURPS1710b_A0907, SMT3, YDR510W, D9719.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=320372 BURP1])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4giv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4giv OCA], [~~http~~://pdbe.org/4giv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4giv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4giv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4giv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations.	+	[https://www.uniprot.org/uniprot/Q3JK38_BURP1 Q3JK38_BURP1] [https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST] Not known; suppressor of MIF2 mutations.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Burp1~~]]	+	[[Category: Burkholderia pseudomallei 1710b]]
-	[[Category: ~~Peptidylprolyl isomerase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Structural genomic]]~~	+	[[Category: Saccharomyces cerevisiae S288C]]
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Ssgcid~~]]	+

OCA at 17:13, 5 August 2016

OCA — Fri, 05 Aug 2016 17:13:24 GMT

←Older revision		Revision as of 17:13, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183==		==Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183==
	<StructureSection load='4giv' size='340' side='right' caption='[[4giv]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='4giv' size='340' side='right' caption='[[4giv]], [[Resolution\|resolution]] 2.45Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BURPS1710b_A0907, SMT3, YDR510W, D9719.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=320372 BURP1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BURPS1710b_A0907, SMT3, YDR510W, D9719.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=320372 BURP1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4giv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4giv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4giv RCSB], [http://www.ebi.ac.uk/pdbsum/4giv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4giv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4giv OCA], [http://pdbe.org/4giv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4giv RCSB], [http://www.ebi.ac.uk/pdbsum/4giv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4giv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4giv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:20, 25 December 2014

OCA — Thu, 25 Dec 2014 04:20:00 GMT

←Older revision		Revision as of 04:20, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4giv\| PDB=4giv \| SCENE= }}~~	+	==Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183==
-	===Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183===	+	<StructureSection load='4giv' size='340' side='right' caption='[[4giv]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	{~~{ABSTRACT_PUBMED_24366729}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4giv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burp1 Burp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GIV FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GI:HYDROXY(OXO)[3-({(2S)-2-[(3-PHENYLPROPOXY)CARBONYL]PIPERIDIN-1-YL}SULFONYL)PHENYL]AMMONIUM'>4GI</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2keo\|2keo]], [[2ko7\|2ko7]], [[2l2s\|2l2s]], [[3vaw\|3vaw]], [[3uqb\|3uqb]], [[3uqa\|3uqa]], [[4dz3\|4dz3]], [[4dz2\|4dz2]], [[3uf8\|3uf8]], [[4fn2\|4fn2]], [[4g50\|4g50]], [[4ggq\|4ggq]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BURPS1710b_A0907, SMT3, YDR510W, D9719.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=320372 BURP1])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4giv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4giv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4giv RCSB], [http://www.ebi.ac.uk/pdbsum/4giv PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations.		[[http://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Macrophage infectivity potentiators (Mips) are immunophilin proteins and essential virulence factors for a range of pathogenic organisms. We applied a structural biology approach to characterize a Mip from Burkholderia pseudomallei (BpML1), the causative agent of melioidosis. Crystal structure and nuclear magnetic resonance analyses of BpML1 in complex with known macrocyclics and other derivatives led to the identification of a key chemical scaffold. This scaffold possesses inhibitory potency for BpML1 without the immunosuppressive components of related macrocyclic agents. Biophysical characterization of a compound series with this scaffold allowed binding site specificity in solution and potency determinations for rank ordering the set. The best compounds in this series possessed a low-micromolar affinity for BpML1, bound at the site of enzymatic activity, and inhibited a panel of homologous Mip proteins from other pathogenic bacteria, without demonstrating toxicity in human macrophages. Importantly, the in vitro activity of BpML1 was reduced by these compounds, leading to decreased macrophage infectivity and intracellular growth of Burkholderia pseudomallei. These compounds offer the potential for activity against a new class of antimicrobial targets and present the utility of a structure-based approach for novel antimicrobial drug discovery.

-	~~==About this Structure==~~	+	A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.,Begley DW, Fox D 3rd, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, Barnes SR, Moen SO, Raymond AC, Stacy R, Myler PJ, Staker BL, Harmer NJ, Norville IH, Holzgrabe U, Sarkar-Tyson M, Edwards TE, Lorimer DD Antimicrob Agents Chemother. 2014 Mar;58(3):1458-67. doi: 10.1128/AAC.01875-13., Epub 2013 Dec 23. PMID:24366729<ref>PMID:24366729</ref>
-	~~[[4giv]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Burp1 Burp1]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4GIV OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024366729</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Burp1]]		[[Category: Burp1]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]

OCA at 13:30, 12 March 2014

OCA — Wed, 12 Mar 2014 13:30:57 GMT

←Older revision		Revision as of 13:30, 12 March 2014
Line 1:		Line 1:
-	[[Image:4giv.jpg\|left\|200px]]
-
	{{STRUCTURE_4giv\| PDB=4giv \| SCENE= }}		{{STRUCTURE_4giv\| PDB=4giv \| SCENE= }}
-
	===Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183===		===Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183===
		+	{{ABSTRACT_PUBMED_24366729}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations.

	==About this Structure==		==About this Structure==
-	[[4giv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Burkholderia_pseudomallei,_saccharomyces_cerevisiae Burkholderia pseudomallei, saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIV OCA].	+	[[4giv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burp1 Burp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIV OCA].
-	[[Category: ~~Burkholderia pseudomallei, saccharomyces cerevisiae~~]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:024366729</ref><references group="xtra"/><references/>
		+	[[Category: Burp1]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA at 05:43, 5 September 2012

OCA — Wed, 05 Sep 2012 05:43:19 GMT

←Older revision		Revision as of 05:43, 5 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4giv.jpg\|left\|200px]]

-	~~The entry~~ 4giv ~~is ON HOLD~~	+	{{STRUCTURE_4giv\| PDB=4giv \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183===

-	~~Description: Crystal structure of~~ a ~~SMT fusion Peptidyl-prolyl cis-trans isomerase~~ with ~~surface mutation D44G~~ from Burkholderia pseudomallei ~~complexed with CJ183~~	+
		+	==About this Structure==
		+	[[4giv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei,_saccharomyces_cerevisiae Burkholderia pseudomallei, saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIV OCA].
		+	[[Category: Burkholderia pseudomallei, saccharomyces cerevisiae]]
		+	[[Category: Peptidylprolyl isomerase]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Isomerase]]
		+	[[Category: Protein binding]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]

OCA: Protected "4giv" [edit=sysop:move=sysop]

OCA — Wed, 15 Aug 2012 05:27:59 GMT

Protected "4giv" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 15 August 2012

OCA: New page: '''Unreleased structure''' The entry 4giv is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of a SMT fusion Peptidyl...

OCA — Wed, 15 Aug 2012 05:27:58 GMT

New page: '''Unreleased structure''' The entry 4giv is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of a SMT fusion Peptidyl...

New page

'''Unreleased structure'''

The entry 4giv is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183