4gli - Revision history

OCA at 15:49, 14 March 2024

OCA — Thu, 14 Mar 2024 15:49:59 GMT

←Older revision		Revision as of 15:49, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gli]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gli]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [https://pdbe.org/4gli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [https://www.ebi.ac.uk/pdbsum/4gli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gli ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.903Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [https://pdbe.org/4gli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [https://www.ebi.ac.uk/pdbsum/4gli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gli ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/SMN_HUMAN SMN_HUMAN]		[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/SMN_HUMAN SMN_HUMAN]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The survival motor neuron (SMN) protein forms the oligomeric core of a multiprotein complex that functions in spliceosomal snRNP biogenesis. Loss of function mutations in the SMN gene cause spinal muscular atrophy (SMA), a leading genetic cause of infant mortality. Nearly half of the known SMA patient missense mutations map to the SMN YG-box, a highly conserved oligomerization domain of unknown structure that contains a (YxxG)(3) motif. Here, we report that the SMN YG-box forms helical oligomers similar to the glycine zippers found in transmembrane channel proteins. A network of tyrosine-glycine packing between helices drives formation of soluble YG-box oligomers, providing a structural basis for understanding SMN oligomerization and for relating defects in oligomerization to the mutations found in SMA patients. These results have important implications for advancing our understanding of SMN function and glycine zipper-mediated helix-helix interactions.
-
-	The Survival Motor Neuron Protein Forms Soluble Glycine Zipper Oligomers.,Martin R, Gupta K, Ninan NS, Perry K, Van Duyne GD Structure. 2012 Sep 25. pii: S0969-2126(12)00327-9. doi:, 10.1016/j.str.2012.08.024. PMID:23022347<ref>PMID:23022347</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4gli" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:04, 26 October 2022

OCA — Wed, 26 Oct 2022 07:04:09 GMT

←Older revision		Revision as of 07:04, 26 October 2022
Line 1:		Line 1:

	==Crystal Structure of Human SMN YG-Dimer==		==Crystal Structure of Human SMN YG-Dimer==
-	<StructureSection load='4gli' size='340' side='right' caption='[[4gli]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4gli' size='340' side='right'caption='[[4gli]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gli]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GLI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gli]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLI FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, SMN, SMN1, SMN2, SMNC, SMNT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [https://pdbe.org/4gli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [https://www.ebi.ac.uk/pdbsum/4gli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gli ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [~~http~~://pdbe.org/4gli PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gli PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gli ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.	+	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/SMN_HUMAN SMN_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Escherichia coli]]
-	[[Category: ~~Duyne, G D.Van~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Martin, R S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Perry, K~~]]	+	[[Category: Martin RS]]
-	[[Category: ~~Soluble glycine zipper~~]]	+	[[Category: Perry K]]
-	[[Category: ~~Splicing]]~~	+	[[Category: Van Duyne GD]]
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 18:23, 5 August 2016

OCA — Fri, 05 Aug 2016 18:23:53 GMT

←Older revision		Revision as of 18:23, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Human SMN YG-Dimer==		==Crystal Structure of Human SMN YG-Dimer==
	<StructureSection load='4gli' size='340' side='right' caption='[[4gli]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4gli' size='340' side='right' caption='[[4gli]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GLI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GLI FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, SMN, SMN1, SMN2, SMNC, SMNT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, SMN, SMN1, SMN2, SMNC, SMNT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [http://www.ebi.ac.uk/pdbsum/4gli PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [http://pdbe.org/4gli PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [http://www.ebi.ac.uk/pdbsum/4gli PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gli ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gli" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Duyne, G D.Van]]		[[Category: Duyne, G D.Van]]
	[[Category: Martin, R S]]		[[Category: Martin, R S]]

OCA at 04:48, 25 December 2014

OCA — Thu, 25 Dec 2014 04:48:25 GMT

←Older revision		Revision as of 04:48, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [http://www.ebi.ac.uk/pdbsum/4gli PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [http://www.ebi.ac.uk/pdbsum/4gli PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:20, 10 December 2014

OCA — Wed, 10 Dec 2014 09:20:46 GMT

←Older revision		Revision as of 09:20, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4gli.~~png~~\|~~left\|200px~~]]	+	==Crystal Structure of Human SMN YG-Dimer==
		+	<StructureSection load='4gli' size='340' side='right' caption='[[4gli]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GLI FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, SMN, SMN1, SMN2, SMNC, SMNT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [http://www.ebi.ac.uk/pdbsum/4gli PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The survival motor neuron (SMN) protein forms the oligomeric core of a multiprotein complex that functions in spliceosomal snRNP biogenesis. Loss of function mutations in the SMN gene cause spinal muscular atrophy (SMA), a leading genetic cause of infant mortality. Nearly half of the known SMA patient missense mutations map to the SMN YG-box, a highly conserved oligomerization domain of unknown structure that contains a (YxxG)(3) motif. Here, we report that the SMN YG-box forms helical oligomers similar to the glycine zippers found in transmembrane channel proteins. A network of tyrosine-glycine packing between helices drives formation of soluble YG-box oligomers, providing a structural basis for understanding SMN oligomerization and for relating defects in oligomerization to the mutations found in SMA patients. These results have important implications for advancing our understanding of SMN function and glycine zipper-mediated helix-helix interactions.

-	~~{{STRUCTURE_4gli\| PDB=4gli \| SCENE= }}~~	+	The Survival Motor Neuron Protein Forms Soluble Glycine Zipper Oligomers.,Martin R, Gupta K, Ninan NS, Perry K, Van Duyne GD Structure. 2012 Sep 25. pii: S0969-2126(12)00327-9. doi:, 10.1016/j.str.2012.08.024. PMID:23022347<ref>PMID:23022347</ref>

-	~~===Crystal Structure~~ of ~~Human SMN YG-Dimer===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23022347}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4gli]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Duyne, G D.Van.]]	+	[[Category: Duyne, G D.Van]]
-	[[Category: Martin, R S.]]	+	[[Category: Martin, R S]]
-	[[Category: Perry, K.]]	+	[[Category: Perry, K]]
	[[Category: Soluble glycine zipper]]		[[Category: Soluble glycine zipper]]
	[[Category: Splicing]]		[[Category: Splicing]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 14:46, 28 November 2012

OCA — Wed, 28 Nov 2012 14:46:01 GMT

←Older revision		Revision as of 14:46, 28 November 2012
Line 1:		Line 1:
-	[[Image:4gli.~~jpg~~\|left\|200px]]	+	[[Image:4gli.png\|left\|200px]]

	{{STRUCTURE_4gli\| PDB=4gli \| SCENE= }}		{{STRUCTURE_4gli\| PDB=4gli \| SCENE= }}
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[4gli]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA].	+	[[4gli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA].
		+	[[Category: Homo sapiens]]
	[[Category: Duyne, G D.Van.]]		[[Category: Duyne, G D.Van.]]
	[[Category: Martin, R S.]]		[[Category: Martin, R S.]]

OCA at 06:57, 17 October 2012

OCA — Wed, 17 Oct 2012 06:57:50 GMT

←Older revision		Revision as of 06:57, 17 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gli.jpg\|left\|200px]]

-	~~The entry~~ 4gli ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gli\| PDB=4gli \| SCENE= }}

-	~~Authors: Martin, R.S., Perry, K., Van Duyne, G.D.~~	+	===Crystal Structure of Human SMN YG-Dimer===

-	~~Description: Crystal~~ Structure ~~of Human SMN YG~~-~~Dimer~~	+	{{ABSTRACT_PUBMED_23022347}}
		+
		+	==About this Structure==
		+	[[4gli]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA].
		+	[[Category: Duyne, G D.Van.]]
		+	[[Category: Martin, R S.]]
		+	[[Category: Perry, K.]]
		+	[[Category: Soluble glycine zipper]]
		+	[[Category: Splicing]]
		+	[[Category: Sugar binding protein]]

OCA at 04:54, 5 September 2012

OCA — Wed, 05 Sep 2012 04:54:20 GMT

←Older revision		Revision as of 04:54, 5 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gli is ON HOLD	+	The entry 4gli is ON HOLD until Paper Publication

-	Authors: Martin, R.S., Van Duyne, G.D.	+	Authors: Martin, R.S., Perry, K., Van Duyne, G.D.

	Description: Crystal Structure of Human SMN YG-Dimer		Description: Crystal Structure of Human SMN YG-Dimer

OCA: Protected "4gli" [edit=sysop:move=sysop]

OCA — Wed, 22 Aug 2012 05:36:52 GMT

Protected "4gli" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:36, 22 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gli is ON HOLD Authors: Martin, R.S., Van Duyne, G.D. Description: Crystal Structure of Human SMN YG-Dimer

OCA — Wed, 22 Aug 2012 05:36:51 GMT

New page: '''Unreleased structure''' The entry 4gli is ON HOLD Authors: Martin, R.S., Van Duyne, G.D. Description: Crystal Structure of Human SMN YG-Dimer

New page

'''Unreleased structure'''

The entry 4gli is ON HOLD

Authors: Martin, R.S., Van Duyne, G.D.

Description: Crystal Structure of Human SMN YG-Dimer