4gmq - Revision history

OCA at 11:32, 1 March 2024

OCA — Fri, 01 Mar 2024 11:32:54 GMT

←Older revision		Revision as of 11:32, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gmq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gmq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmq OCA], [https://pdbe.org/4gmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmq RCSB], [https://www.ebi.ac.uk/pdbsum/4gmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmq OCA], [https://pdbe.org/4gmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmq RCSB], [https://www.ebi.ac.uk/pdbsum/4gmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/G0RYD6_CHATD G0RYD6_CHATD]		[https://www.uniprot.org/uniprot/G0RYD6_CHATD G0RYD6_CHATD]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Ribosome-associated chaperones act in early folding events during protein synthesis. Structural information is available for prokaryotic chaperones (such as trigger factor), but structural understanding of these processes in eukaryotes lags far behind. Here we present structural analyses of the eukaryotic ribosome-associated complex (RAC) from Saccharomyces cerevisiae and Chaetomium thermophilum, consisting of heat-shock protein 70 (Hsp70) Ssz1 and the Hsp40 Zuo1. RAC is an elongated complex that crouches over the ribosomal tunnel exit and seems to be stabilized in a distinct conformation by expansion segment ES27. A unique alpha-helical domain in Zuo1 mediates ribosome interaction of RAC near the ribosomal proteins L22e and L31e and ribosomal RNA helix H59. The crystal structure of the Ssz1 ATPase domain bound to ATP-Mg(2+) explains its catalytic inactivity and suggests that Ssz1 may act before the RAC-associated chaperone Ssb. Our study offers insights into the interplay between RAC, the ER membrane-integrated Hsp40-type protein ERj1 and the signal-recognition particle.
-
-	Structural characterization of a eukaryotic chaperone-the ribosome-associated complex.,Leidig C, Bange G, Kopp J, Amlacher S, Aravind A, Wickles S, Witte G, Hurt E, Beckmann R, Sinning I Nat Struct Mol Biol. 2012 Dec 2. doi: 10.1038/nsmb.2447. PMID:23202586<ref>PMID:23202586</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4gmq" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:06, 26 October 2022

OCA — Wed, 26 Oct 2022 07:06:14 GMT

←Older revision		Revision as of 07:06, 26 October 2022
Line 1:		Line 1:

	==Ribosome-binding domain of Zuo1==		==Ribosome-binding domain of Zuo1==
-	<StructureSection load='4gmq' size='340' side='right' caption='[[4gmq]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='4gmq' size='340' side='right'caption='[[4gmq]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gmq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chatd Chatd~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GMQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gmq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMQ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0006310, Zuo1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmq OCA], [https://pdbe.org/4gmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmq RCSB], [https://www.ebi.ac.uk/pdbsum/4gmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmq OCA], [~~http~~://pdbe.org/4gmq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gmq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gmq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G0RYD6_CHATD G0RYD6_CHATD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chatd~~]]	+	[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
-	[[Category: ~~Bange, G~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Kopp, J~~]]	+	[[Category: Bange G]]
-	[[Category: ~~Sinning, I~~]]	+	[[Category: Kopp J]]
-	[[Category: ~~Co-translational chaperone]]~~	+	[[Category: Sinning I]]
-	~~[[Category: Ribosome binding]]~~	+
-	~~[[Category: Ribosome-binding protein~~]]	+

OCA at 19:56, 15 December 2016

OCA — Thu, 15 Dec 2016 19:56:44 GMT

←Older revision		Revision as of 19:56, 15 December 2016
Line 1:		Line 1:
		+
	==Ribosome-binding domain of Zuo1==		==Ribosome-binding domain of Zuo1==
	<StructureSection load='4gmq' size='340' side='right' caption='[[4gmq]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4gmq' size='340' side='right' caption='[[4gmq]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gmq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Chaetomium_thermophilum_var._thermophilum_dsm_1495 Chaetomium thermophilum var. thermophilum dsm 1495~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gmq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMQ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0006310, Zuo1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 ~~Chaetomium thermophilum var. thermophilum DSM 1495~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0006310, Zuo1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gmq RCSB], [http://www.ebi.ac.uk/pdbsum/4gmq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmq OCA], [http://pdbe.org/4gmq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gmq RCSB], [http://www.ebi.ac.uk/pdbsum/4gmq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gmq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chaetomium thermophilum var. thermophilum dsm 1495~~]]	+	[[Category: Chatd]]
	[[Category: Bange, G]]		[[Category: Bange, G]]
	[[Category: Kopp, J]]		[[Category: Kopp, J]]

OCA at 09:05, 15 February 2015

OCA — Sun, 15 Feb 2015 09:05:43 GMT

←Older revision		Revision as of 09:05, 15 February 2015
Line 1:		Line 1:
-	[[~~Image:~~4gmq.~~png~~\|~~left\|200px~~]]	+	==Ribosome-binding domain of Zuo1==
		+	<StructureSection load='4gmq' size='340' side='right' caption='[[4gmq]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gmq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_dsm_1495 Chaetomium thermophilum var. thermophilum dsm 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMQ FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0006310, Zuo1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 Chaetomium thermophilum var. thermophilum DSM 1495])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gmq RCSB], [http://www.ebi.ac.uk/pdbsum/4gmq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ribosome-associated chaperones act in early folding events during protein synthesis. Structural information is available for prokaryotic chaperones (such as trigger factor), but structural understanding of these processes in eukaryotes lags far behind. Here we present structural analyses of the eukaryotic ribosome-associated complex (RAC) from Saccharomyces cerevisiae and Chaetomium thermophilum, consisting of heat-shock protein 70 (Hsp70) Ssz1 and the Hsp40 Zuo1. RAC is an elongated complex that crouches over the ribosomal tunnel exit and seems to be stabilized in a distinct conformation by expansion segment ES27. A unique alpha-helical domain in Zuo1 mediates ribosome interaction of RAC near the ribosomal proteins L22e and L31e and ribosomal RNA helix H59. The crystal structure of the Ssz1 ATPase domain bound to ATP-Mg(2+) explains its catalytic inactivity and suggests that Ssz1 may act before the RAC-associated chaperone Ssb. Our study offers insights into the interplay between RAC, the ER membrane-integrated Hsp40-type protein ERj1 and the signal-recognition particle.

-	~~{{STRUCTURE_4gmq\| PDB=4gmq \| SCENE= }}~~	+	Structural characterization of a eukaryotic chaperone-the ribosome-associated complex.,Leidig C, Bange G, Kopp J, Amlacher S, Aravind A, Wickles S, Witte G, Hurt E, Beckmann R, Sinning I Nat Struct Mol Biol. 2012 Dec 2. doi: 10.1038/nsmb.2447. PMID:23202586<ref>PMID:23202586</ref>

-	~~===Ribosome-binding domain~~ of ~~Zuo1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23202586}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4gmq]] is a 1 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_dsm_1495 Chaetomium thermophilum var. thermophilum dsm 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMQ OCA].	+	</StructureSection>
	[[Category: Chaetomium thermophilum var. thermophilum dsm 1495]]		[[Category: Chaetomium thermophilum var. thermophilum dsm 1495]]
-	[[Category: Bange, G.]]	+	[[Category: Bange, G]]
-	[[Category: Kopp, J.]]	+	[[Category: Kopp, J]]
-	[[Category: Sinning, I.]]	+	[[Category: Sinning, I]]
	[[Category: Co-translational chaperone]]		[[Category: Co-translational chaperone]]
	[[Category: Ribosome binding]]		[[Category: Ribosome binding]]
	[[Category: Ribosome-binding protein]]		[[Category: Ribosome-binding protein]]

OCA at 07:36, 2 January 2013

OCA — Wed, 02 Jan 2013 07:36:15 GMT

←Older revision		Revision as of 07:36, 2 January 2013
Line 1:		Line 1:
-	[[Image:4gmq.~~jpg~~\|left\|200px]]	+	[[Image:4gmq.png\|left\|200px]]

	{{STRUCTURE_4gmq\| PDB=4gmq \| SCENE= }}		{{STRUCTURE_4gmq\| PDB=4gmq \| SCENE= }}
Line 5:		Line 5:
	===Ribosome-binding domain of Zuo1===		===Ribosome-binding domain of Zuo1===

		+	{{ABSTRACT_PUBMED_23202586}}

	==About this Structure==		==About this Structure==

OCA at 11:00, 5 December 2012

OCA — Wed, 05 Dec 2012 11:00:49 GMT

←Older revision		Revision as of 11:00, 5 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gmq.jpg\|left\|200px]]

-	~~The entry~~ 4gmq ~~is ON HOLD~~	+	{{STRUCTURE_4gmq\| PDB=4gmq \| SCENE= }}

-	~~Authors: Kopp, J., Bange, G., Sinning, I.~~	+	===Ribosome-binding domain of Zuo1===

-	~~Description~~: Ribosome-binding ~~domain of Zuo1~~	+
		+	==About this Structure==
		+	[[4gmq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_dsm_1495 Chaetomium thermophilum var. thermophilum dsm 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMQ OCA].
		+	[[Category: Chaetomium thermophilum var. thermophilum dsm 1495]]
		+	[[Category: Bange, G.]]
		+	[[Category: Kopp, J.]]
		+	[[Category: Sinning, I.]]
		+	[[Category: Co-translational chaperone]]
		+	[[Category: Ribosome binding]]
		+	[[Category: Ribosome-binding protein]]

OCA at 09:01, 21 November 2012

OCA — Wed, 21 Nov 2012 09:01:07 GMT

←Older revision		Revision as of 09:01, 21 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gmq is ON HOLD ~~until Paper Publication~~	+	The entry 4gmq is ON HOLD

	Authors: Kopp, J., Bange, G., Sinning, I.		Authors: Kopp, J., Bange, G., Sinning, I.

	Description: Ribosome-binding domain of Zuo1		Description: Ribosome-binding domain of Zuo1

OCA at 04:54, 5 September 2012

OCA — Wed, 05 Sep 2012 04:54:49 GMT

←Older revision		Revision as of 04:54, 5 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gmq is ON HOLD	+	The entry 4gmq is ON HOLD until Paper Publication

	Authors: Kopp, J., Bange, G., Sinning, I.		Authors: Kopp, J., Bange, G., Sinning, I.

	Description: Ribosome-binding domain of Zuo1		Description: Ribosome-binding domain of Zuo1

OCA: Protected "4gmq" [edit=sysop:move=sysop]

OCA — Wed, 22 Aug 2012 05:38:08 GMT

Protected "4gmq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:38, 22 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gmq is ON HOLD Authors: Kopp, J., Bange, G., Sinning, I. Description: Ribosome-binding domain of Zuo1

OCA — Wed, 22 Aug 2012 05:38:07 GMT

New page: '''Unreleased structure''' The entry 4gmq is ON HOLD Authors: Kopp, J., Bange, G., Sinning, I. Description: Ribosome-binding domain of Zuo1

New page

'''Unreleased structure'''

The entry 4gmq is ON HOLD

Authors: Kopp, J., Bange, G., Sinning, I.

Description: Ribosome-binding domain of Zuo1