4gmx - Revision history

OCA at 07:06, 26 October 2022

OCA — Wed, 26 Oct 2022 07:06:28 GMT

←Older revision		Revision as of 07:06, 26 October 2022
Line 1:		Line 1:

	==Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1==		==Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1==
-	<StructureSection load='4gmx' size='340' side='right' caption='[[4gmx]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4gmx' size='340' side='right'caption='[[4gmx]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gmx]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GMX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gmx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K85:PROPAN-2-YL+3-{3-[3-METHOXY-5-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOL-1-YL}PROPANOATE'>K85</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K85:PROPAN-2-YL+3-{3-[3-METHOXY-5-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOL-1-YL}PROPANOATE'>K85</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gpt\|4gpt]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmx OCA], [https://pdbe.org/4gmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmx RCSB], [https://www.ebi.ac.uk/pdbsum/4gmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmx ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), CRM1, KAP124, XPO1, YGR218W, G8514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmx OCA], [~~http~~://pdbe.org/4gmx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gmx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gmx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES). [[http://www.uniprot.org/uniprot/YRB1_YEAST YRB1_YEAST]] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.	+	[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Exportin\|Exportin]]	+	*[[Exportin 3D structures\|Exportin 3D structures]]
-	*[[GTP-binding protein\|GTP-binding protein]]	+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 18824~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Chook, Y M~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Sun, Q~~]]	+	[[Category: Chook YM]]
-	[[Category: ~~Crm1]]~~	+	[[Category: Sun Q]]
-	~~[[Category: Heat repeat]]~~	+
-	~~[[Category: Kpt185]]~~	+
-	~~[[Category: Nuclear]]~~	+
-	~~[[Category: Protein export]]~~	+
-	~~[[Category: Protein transport-inhibitor complex~~]]	+

OCA at 21:04, 5 August 2016

OCA — Fri, 05 Aug 2016 21:04:13 GMT

←Older revision		Revision as of 21:04, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1==		==Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1==
	<StructureSection load='4gmx' size='340' side='right' caption='[[4gmx]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4gmx' size='340' side='right' caption='[[4gmx]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gmx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gmx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K85:PROPAN-2-YL+3-{3-[3-METHOXY-5-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOL-1-YL}PROPANOATE'>K85</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K85:PROPAN-2-YL+3-{3-[3-METHOXY-5-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOL-1-YL}PROPANOATE'>K85</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gpt\|4gpt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gpt\|4gpt]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~]), CRM1, KAP124, XPO1, YGR218W, G8514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), CRM1, KAP124, XPO1, YGR218W, G8514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gmx RCSB], [http://www.ebi.ac.uk/pdbsum/4gmx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmx OCA], [http://pdbe.org/4gmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gmx RCSB], [http://www.ebi.ac.uk/pdbsum/4gmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gmx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Atcc 18824]]
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Human]]
	[[Category: Chook, Y M]]		[[Category: Chook, Y M]]
	[[Category: Sun, Q]]		[[Category: Sun, Q]]

OCA at 21:53, 25 December 2014

OCA — Thu, 25 Dec 2014 21:53:34 GMT

←Older revision		Revision as of 21:53, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4gmx.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1==
		+	<StructureSection load='4gmx' size='340' side='right' caption='[[4gmx]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gmx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K85:PROPAN-2-YL+3-{3-[3-METHOXY-5-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOL-1-YL}PROPANOATE'>K85</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gpt\|4gpt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), CRM1, KAP124, XPO1, YGR218W, G8514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gmx RCSB], [http://www.ebi.ac.uk/pdbsum/4gmx PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES). [[http://www.uniprot.org/uniprot/YRB1_YEAST YRB1_YEAST]] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nuclear export protein XPO1 is over-expressed in cancer, leading to the cytoplasmic mislocalization of multiple tumor suppressor proteins. Existing XPO1-targeting agents lack selectivity and have been associated with significant toxicity. Small molecule selective inhibitors of nuclear export (SINEs) were designed that specifically inhibit XPO1. Genetic experiments and X-ray structures demonstrate that SINE covalently bind to a cysteine residue in the cargo-binding groove of XPO1, thereby inhibiting nuclear export of cargo proteins. The clinical relevance of SINEs was explored in chronic lymphocytic leukemia (CLL), a disease associated with recurrent XPO1 mutations. Evidence is presented that SINEs can restore normal regulation to the majority of the dysregulated pathways in CLL both in vitro and in vivo and induce apoptosis of CLL cells with a favorable therapeutic index, with enhanced killing of genomically high-risk CLL cells that are typically unresponsive to traditional therapies. More importantly, SINE slows disease progression, and improves overall survival in the Emu-TCL1-SCID mouse model of CLL with minimal weight loss or other toxicities. Together, these findings demonstrate that XPO1 is a valid target in CLL with minimal effects on normal cells and provide a basis for the development of SINEs in CLL and related hematologic malignancies.

-	~~{{STRUCTURE_4gmx\| PDB=4gmx \| SCENE= }}~~	+	Selective inhibitors of nuclear export (SINE) show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.,Lapalombella R, Sun Q, Williams K, Tangeman L, Jha S, Zhong Y, Goettl V, Mahoney E, Berglund C, Gupta S, Farmer A, Mani R, Johnson AJ, Lucas D, Mo X, Daelemans D, Sandanayaka V, Shechter S, McCauley D, Shacham S, Kauffman M, Chook YM, Byrd JC Blood. 2012 Oct 3. PMID:23034282<ref>PMID:23034282</ref>

-	~~===Crystal structure~~ of ~~KPT185 in complex with CRM1-Ran-RanBP1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23034282}}~~	+	==See Also==
-		+	*[[Exportin\|Exportin]]
-	==~~About this Structure~~==	+	*[[GTP-binding protein\|GTP-binding protein]]
-	[[~~4gmx~~]] ~~is a 3 chain structure with sequence from~~ [~~http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and~~ [~~http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]~~. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=4GMX OCA].~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Chook, Y M.]]	+	[[Category: Chook, Y M]]
-	[[Category: Sun, Q.]]	+	[[Category: Sun, Q]]
	[[Category: Crm1]]		[[Category: Crm1]]
	[[Category: Heat repeat]]		[[Category: Heat repeat]]

OCA at 21:34, 12 December 2012

OCA — Wed, 12 Dec 2012 21:34:32 GMT

←Older revision		Revision as of 21:34, 12 December 2012
Line 1:		Line 1:
-	[[Image:4gmx.~~jpg~~\|left\|200px]]	+	[[Image:4gmx.png\|left\|200px]]

	{{STRUCTURE_4gmx\| PDB=4gmx \| SCENE= }}		{{STRUCTURE_4gmx\| PDB=4gmx \| SCENE= }}

OCA at 06:56, 17 October 2012

OCA — Wed, 17 Oct 2012 06:56:03 GMT

←Older revision		Revision as of 06:56, 17 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gmx.jpg\|left\|200px]]

-	~~The entry~~ 4gmx ~~is ON HOLD~~	+	{{STRUCTURE_4gmx\| PDB=4gmx \| SCENE= }}

-	~~Authors: Sun, Q., Chook, Y.M.~~	+	===Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1===

-	~~Description~~: Nuclear ~~Transport~~ complex	+	{{ABSTRACT_PUBMED_23034282}}
		+
		+	==About this Structure==
		+	[[4gmx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMX OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Chook, Y M.]]
		+	[[Category: Sun, Q.]]
		+	[[Category: Crm1]]
		+	[[Category: Heat repeat]]
		+	[[Category: Kpt185]]
		+	[[Category: Nuclear]]
		+	[[Category: Protein export]]
		+	[[Category: Protein transport-inhibitor complex]]

OCA at 04:47, 29 August 2012

OCA — Wed, 29 Aug 2012 04:47:40 GMT

←Older revision		Revision as of 04:47, 29 August 2012
Line 3:		Line 3:
	The entry 4gmx is ON HOLD		The entry 4gmx is ON HOLD

-	Authors: Sun, ~~Qingxiang~~, Chook, ~~Yuh Min~~	+	Authors: Sun, Q., Chook, Y.M.

	Description: Nuclear Transport complex		Description: Nuclear Transport complex

OCA: Protected "4gmx" [edit=sysop:move=sysop]

OCA — Wed, 22 Aug 2012 05:38:19 GMT

Protected "4gmx" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:38, 22 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gmx is ON HOLD Authors: Sun, Qingxiang, Chook, Yuh Min Description: Nuclear Transport complex

OCA — Wed, 22 Aug 2012 05:38:18 GMT

New page: '''Unreleased structure''' The entry 4gmx is ON HOLD Authors: Sun, Qingxiang, Chook, Yuh Min Description: Nuclear Transport complex

New page

'''Unreleased structure'''

The entry 4gmx is ON HOLD

Authors: Sun, Qingxiang, Chook, Yuh Min

Description: Nuclear Transport complex