4gnd - Revision history

OCA at 14:00, 8 November 2023

OCA — Wed, 08 Nov 2023 14:00:36 GMT

←Older revision		Revision as of 14:00, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gnd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GND FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gnd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GND FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.27Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnd OCA], [https://pdbe.org/4gnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gnd RCSB], [https://www.ebi.ac.uk/pdbsum/4gnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gnd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnd OCA], [https://pdbe.org/4gnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gnd RCSB], [https://www.ebi.ac.uk/pdbsum/4gnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gnd ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:06, 26 October 2022

OCA — Wed, 26 Oct 2022 07:06:58 GMT

←Older revision		Revision as of 07:06, 26 October 2022
Line 1:		Line 1:

	==Crystal Structure of NSD3 tandem PHD5-C5HCH domains==		==Crystal Structure of NSD3 tandem PHD5-C5HCH domains==
-	<StructureSection load='4gnd' size='340' side='right' caption='[[4gnd]], [[Resolution\|resolution]] 2.27Å' scene=''>	+	<StructureSection load='4gnd' size='340' side='right'caption='[[4gnd]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gnd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GND FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gnd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GND FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gne\|4gne]], [[4gnf\|4gnf]], [[4gng\|4gng]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnd OCA], [https://pdbe.org/4gnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gnd RCSB], [https://www.ebi.ac.uk/pdbsum/4gnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gnd ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WHSC1L1, NSD3, DC28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnd OCA], [~~http~~://pdbe.org/4gnd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gnd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gnd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gnd ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.	+	[https://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>	+	[https://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4gnd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4gnd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Histone-lysine N-methyltransferase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: He, C]]	+	[[Category: He C]]
-	[[Category: Li, F]]	+	[[Category: Li F]]
-	[[Category: Shi, Y]]	+	[[Category: Shi Y]]
-	[[Category: Wu, J]]	+	[[Category: Wu J]]
-	~~[[Category: Histone]]~~	+
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Zinc finger~~]]	+

OCA at 14:38, 15 November 2017

OCA — Wed, 15 Nov 2017 14:38:54 GMT

←Older revision		Revision as of 14:38, 15 November 2017
Line 23:		Line 23:
	</div>		</div>
	<div class="pdbe-citations 4gnd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4gnd" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Histone methyltransferase\|Histone methyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:35, 5 August 2016

OCA — Fri, 05 Aug 2016 17:35:53 GMT

←Older revision		Revision as of 17:35, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of NSD3 tandem PHD5-C5HCH domains==		==Crystal Structure of NSD3 tandem PHD5-C5HCH domains==
	<StructureSection load='4gnd' size='340' side='right' caption='[[4gnd]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='4gnd' size='340' side='right' caption='[[4gnd]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gnd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GND FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gnd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GND FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gne\|4gne]], [[4gnf\|4gnf]], [[4gng\|4gng]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gne\|4gne]], [[4gnf\|4gnf]], [[4gng\|4gng]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WHSC1L1, NSD3, DC28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WHSC1L1, NSD3, DC28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gnd RCSB], [http://www.ebi.ac.uk/pdbsum/4gnd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnd OCA], [http://pdbe.org/4gnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gnd RCSB], [http://www.ebi.ac.uk/pdbsum/4gnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gnd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gnd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: He, C]]		[[Category: He, C]]
	[[Category: Li, F]]		[[Category: Li, F]]

OCA at 11:22, 21 December 2014

OCA — Sun, 21 Dec 2014 11:22:08 GMT

←Older revision		Revision as of 11:22, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gnd\| PDB=4gnd \| SCENE= }}~~	+	==Crystal Structure of NSD3 tandem PHD5-C5HCH domains==
-	===Crystal Structure of NSD3 tandem PHD5-C5HCH domains===	+	<StructureSection load='4gnd' size='340' side='right' caption='[[4gnd]], [[Resolution\|resolution]] 2.27Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23269674}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4gnd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GND FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gne\|4gne]], [[4gnf\|4gnf]], [[4gng\|4gng]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WHSC1L1, NSD3, DC28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gnd RCSB], [http://www.ebi.ac.uk/pdbsum/4gnd PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.		[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The NSD (nuclear receptor SET domain-containing) family members, consisting of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1), are SET domain-containing methyltransferases and aberrant expression of each member has been implicated in multiple diseases. They have specific mono- and dimethylase activities for H3K36, whereas play nonredundant roles during development. Aside from the well characterized catalytic SET domain, NSD proteins have multiple potential chromatin-binding motifs that are clinically relevant, including the fifth plant homeodomain (PHD5) and the adjacent Cys-His-rich domain (C5HCH) located at the C terminus. Herein, we report the crystal structures of the PHD5-C5HCH module of NSD3, in the free state and in complex with H3(1-7) (H3 residues 1-7), H3(1-15) (H3 residues 1-15), and H3(1-15)K9me3 (H3 residues 1-15 with trimethylation on K9) peptides. These structures reveal that the PHD5 and C5HCH domains fold into a novel integrated PHD-PHD-like structural module with H3 peptide bound only on the surface of PHD5 and provide the molecular basis for the recognition of unmodified H3K4 and trimethylated H3K9 by NSD3 PHD5. Structural studies and binding assays show that differences exist in histone binding specificity of the PHD5 domain between three members of the NSD family. For NSD2, the PHD5-C5HCH:H3 N terminus interaction is largely conserved, although with a stronger preference for unmethylated H3K9 (H3K9me0) than trimethylated H3K9 (H3K9me3), and NSD1 PHD5-C5HCH does not bind to H3 peptides. Our results shed light on how NSD proteins that mediate H3K36 methylation are localized to specific genomic sites and provide implications for the mechanism of functional diversity of NSD proteins.

-	~~==Function==~~	+	The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition.,He C, Li F, Zhang J, Wu J, Shi Y J Biol Chem. 2013 Feb 15;288(7):4692-703. doi: 10.1074/jbc.M112.426148. Epub 2012, Dec 26. PMID:23269674<ref>PMID:23269674</ref>
-	~~[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone~~ methyltransferase~~. Preferentially methylates 'Lys~~-~~4' and 'Lys~~-~~27' of~~ histone H3. ~~H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation~~, ~~while 'Lys~~-~~27' is a mark for transcriptional repression~~.<ref>PMID:~~16682010~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4gnd]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023269674</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Histone methyltransferase\|Histone methyltransferase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: He, C.]]	+	[[Category: He, C]]
-	[[Category: Li, F.]]	+	[[Category: Li, F]]
-	[[Category: Shi, Y.]]	+	[[Category: Shi, Y]]
-	[[Category: Wu, J.]]	+	[[Category: Wu, J]]
	[[Category: Histone]]		[[Category: Histone]]
	[[Category: Nuclear protein]]		[[Category: Nuclear protein]]

OCA at 08:42, 4 September 2013

OCA — Wed, 04 Sep 2013 08:42:49 GMT

←Older revision		Revision as of 08:42, 4 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4gnd\| PDB=4gnd \| SCENE= }}		{{STRUCTURE_4gnd\| PDB=4gnd \| SCENE= }}
	===Crystal Structure of NSD3 tandem PHD5-C5HCH domains===		===Crystal Structure of NSD3 tandem PHD5-C5HCH domains===
		+	{{ABSTRACT_PUBMED_23269674}}

	==Disease==		==Disease==
-	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.	+	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.

	==Function==		==Function==
-	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>	+	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>

	==About this Structure==		==About this Structure==
Line 12:		Line 13:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023269674</ref><references group="xtra"/><references/>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 02:36, 25 March 2013

OCA — Mon, 25 Mar 2013 02:36:44 GMT

←Older revision		Revision as of 02:36, 25 March 2013
Line 1:		Line 1:
-	[[Image:4gnd.jpg\|left\|200px]]
-
	{{STRUCTURE_4gnd\| PDB=4gnd \| SCENE= }}		{{STRUCTURE_4gnd\| PDB=4gnd \| SCENE= }}
-
	===Crystal Structure of NSD3 tandem PHD5-C5HCH domains===		===Crystal Structure of NSD3 tandem PHD5-C5HCH domains===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>

	==About this Structure==		==About this Structure==
	[[4gnd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA].		[[4gnd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 09:36, 2 January 2013

OCA — Wed, 02 Jan 2013 09:36:50 GMT

←Older revision		Revision as of 09:36, 2 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gnd.jpg\|left\|200px]]

-	~~The entry~~ 4gnd ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gnd\| PDB=4gnd \| SCENE= }}

-	~~Authors: Li, F., He, C., Wu, J., Shi, Y.~~	+	===Crystal Structure of NSD3 tandem PHD5-C5HCH domains===

-	~~Description: Crystal~~ Structure ~~of NSD3 tandem PHD5~~-~~C5HCH domains~~	+
		+	==About this Structure==
		+	[[4gnd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GND OCA].
		+	[[Category: Histone-lysine N-methyltransferase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: He, C.]]
		+	[[Category: Li, F.]]
		+	[[Category: Shi, Y.]]
		+	[[Category: Wu, J.]]
		+	[[Category: Histone]]
		+	[[Category: Nuclear protein]]
		+	[[Category: Transcription]]
		+	[[Category: Transferase]]
		+	[[Category: Zinc finger]]

OCA at 04:51, 12 September 2012

OCA — Wed, 12 Sep 2012 04:51:47 GMT

←Older revision		Revision as of 04:51, 12 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gnd is ON HOLD	+	The entry 4gnd is ON HOLD until Paper Publication

	Authors: Li, F., He, C., Wu, J., Shi, Y.		Authors: Li, F., He, C., Wu, J., Shi, Y.

	Description: Crystal Structure of NSD3 tandem PHD5-C5HCH domains		Description: Crystal Structure of NSD3 tandem PHD5-C5HCH domains

OCA at 04:55, 5 September 2012

OCA — Wed, 05 Sep 2012 04:55:08 GMT

←Older revision		Revision as of 04:55, 5 September 2012
Line 3:		Line 3:
	The entry 4gnd is ON HOLD		The entry 4gnd is ON HOLD

-	Authors: Li, F., He, C., Wu, J, Shi, Y	+	Authors: Li, F., He, C., Wu, J., Shi, Y.

	Description: Crystal Structure of NSD3 tandem PHD5-C5HCH domains		Description: Crystal Structure of NSD3 tandem PHD5-C5HCH domains