4gos - Revision history

OCA at 07:08, 26 October 2022

OCA — Wed, 26 Oct 2022 07:08:36 GMT

←Older revision		Revision as of 07:08, 26 October 2022
Line 3:		Line 3:
	<StructureSection load='4gos' size='340' side='right'caption='[[4gos]], [[Resolution\|resolution]] 1.59Å' scene=''>		<StructureSection load='4gos' size='340' side='right'caption='[[4gos]], [[Resolution\|resolution]] 1.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GOS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GOS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [https://pdbe.org/4gos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [https://www.ebi.ac.uk/pdbsum/4gos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gos ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [~~http~~://pdbe.org/4gos PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gos PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gos ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/VTCN1_HUMAN VTCN1_HUMAN]] Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.<ref>PMID:15878339</ref> <ref>PMID:16606666</ref> <ref>PMID:17875732</ref> <ref>PMID:17509674</ref> [UniProtKB:Q7TSP5]	+	[https://www.uniprot.org/uniprot/VTCN1_HUMAN VTCN1_HUMAN] Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.<ref>PMID:15878339</ref> <ref>PMID:16606666</ref> <ref>PMID:17875732</ref> <ref>PMID:17509674</ref> [UniProtKB:Q7TSP5]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Almo~~, S C~~]]	+	[[Category: Almo SC]]
-	[[Category: Bhosle, R]]	+	[[Category: Bhosle R]]
-	~~[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]~~	+	[[Category: Nathenson SG]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Ramagopal U]]
-	[[Category: Nathenson~~, S G~~]]	+	[[Category: Toro R]]
-	[[Category: Ramagopal, U]]	+	[[Category: Vigdorovich V]]
-	[[Category: Toro, R]]	+
-	[[Category: Vigdorovich, V]]	+
-	~~[[Category: Adaptive immunity]]~~	+
-	~~[[Category: Atoms-to-animals: the immune function network]]~~	+
-	~~[[Category: Cell surface]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Ifn]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunity]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Immunoglobulin variable-like domain]]~~	+
-	~~[[Category: Nysgrc]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Psi-biology~~]]	+

OCA at 07:20, 27 March 2019

OCA — Wed, 27 Mar 2019 07:20:40 GMT

←Older revision		Revision as of 07:20, 27 March 2019
Line 1:		Line 1:

	==Crystal structure of human B7-H4 IgV-like domain==		==Crystal structure of human B7-H4 IgV-like domain==
-	<StructureSection load='4gos' size='340' side='right' caption='[[4gos]], [[Resolution\|resolution]] 1.59Å' scene=''>	+	<StructureSection load='4gos' size='340' side='right'caption='[[4gos]], [[Resolution\|resolution]] 1.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://pdbe.org/4gos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://pdbe.org/4gos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gos ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Bhosle, R]]		[[Category: Bhosle, R]]
Line 31:		Line 34:
	[[Category: Vigdorovich, V]]		[[Category: Vigdorovich, V]]
	[[Category: Adaptive immunity]]		[[Category: Adaptive immunity]]
		+	[[Category: Atoms-to-animals: the immune function network]]
	[[Category: Cell surface]]		[[Category: Cell surface]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
		+	[[Category: Ifn]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunity]]		[[Category: Immunity]]

OCA at 03:34, 10 December 2016

OCA — Sat, 10 Dec 2016 03:34:09 GMT

←Older revision		Revision as of 03:34, 10 December 2016
Line 3:		Line 3:
	<StructureSection load='4gos' size='340' side='right' caption='[[4gos]], [[Resolution\|resolution]] 1.59Å' scene=''>		<StructureSection load='4gos' size='340' side='right' caption='[[4gos]], [[Resolution\|resolution]] 1.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://pdbe.org/4gos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://pdbe.org/4gos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/VTCN1_HUMAN VTCN1_HUMAN]] Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.<ref>PMID:15878339</ref> <ref>PMID:16606666</ref> <ref>PMID:17875732</ref> <ref>PMID:17509674</ref> [UniProtKB:Q7TSP5]		[[http://www.uniprot.org/uniprot/VTCN1_HUMAN VTCN1_HUMAN]] Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.<ref>PMID:15878339</ref> <ref>PMID:16606666</ref> <ref>PMID:17875732</ref> <ref>PMID:17509674</ref> [UniProtKB:Q7TSP5]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	B7x (B7-H4 or B7S1) is a member of the B7 family that can inhibit T cell function. B7x protein is absent in most normal human tissues and immune cells, but it is overexpressed in human cancers and often correlates with negative clinical outcome. The expression pattern and function of B7x suggest that it may be a potent immunosuppressive pathway in human cancers. Here, we determined the crystal structure of the human B7x immunoglobulin variable (IgV) domain at 1.59 A resolution and mapped the epitopes recognized by monoclonal antibodies. We developed an in vivo system to screen therapeutic monoclonal antibodies against B7x and found that the clone 1H3 significantly inhibited growth of B7x-expressing tumors in vivo via multiple mechanisms. Furthermore, the surviving mice given 1H3 treatment were resistant to tumor rechallenge. Our data suggest that targeting B7x on tumors is a promising cancer immunotherapy and humanized 1H3 may be efficacious for immunotherapy of human cancers.
		+
		+	Structure and cancer immunotherapy of the B7 family member B7x.,Jeon H, Vigdorovich V, Garrett-Thomson SC, Janakiram M, Ramagopal UA, Abadi YM, Lee JS, Scandiuzzi L, Ohaegbulam KC, Chinai JM, Zhao R, Yao Y, Mao Y, Sparano JA, Almo SC, Zang X Cell Rep. 2014 Nov 6;9(3):1089-98. doi: 10.1016/j.celrep.2014.09.053. Epub 2014, Oct 30. PMID:25437562<ref>PMID:25437562</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4gos" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Bhosle, R]]		[[Category: Bhosle, R]]

OCA at 15:40, 4 August 2016

OCA — Thu, 04 Aug 2016 15:40:26 GMT

←Older revision		Revision as of 15:40, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human B7-H4 IgV-like domain==		==Crystal structure of human B7-H4 IgV-like domain==
	<StructureSection load='4gos' size='340' side='right' caption='[[4gos]], [[Resolution\|resolution]] 1.59Å' scene=''>		<StructureSection load='4gos' size='340' side='right' caption='[[4gos]], [[Resolution\|resolution]] 1.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://pdbe.org/4gos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Bhosle, R]]		[[Category: Bhosle, R]]

OCA at 16:31, 24 December 2014

OCA — Wed, 24 Dec 2014 16:31:00 GMT

←Older revision		Revision as of 16:31, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VTCN1_HUMAN VTCN1_HUMAN]] Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.<ref>PMID:15878339</ref> <ref>PMID:16606666</ref> <ref>PMID:17875732</ref> <ref>PMID:17509674</ref> [UniProtKB:Q7TSP5]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Almo, S C.]]	+	[[Category: Almo, S C]]
-	[[Category: Bhosle, R.]]	+	[[Category: Bhosle, R]]
-	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]	+	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
-	[[Category: ~~NYSGRC, New York~~ Structural ~~Genomics Research Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Nathenson, S G.]]	+	[[Category: Nathenson, S G]]
-	[[Category: Ramagopal, U.]]	+	[[Category: Ramagopal, U]]
-	[[Category: Toro, R.]]	+	[[Category: Toro, R]]
-	[[Category: Vigdorovich, V.]]	+	[[Category: Vigdorovich, V]]
	[[Category: Adaptive immunity]]		[[Category: Adaptive immunity]]
	[[Category: Cell surface]]		[[Category: Cell surface]]
Line 26:		Line 30:
	[[Category: Immunoglobulin domain]]		[[Category: Immunoglobulin domain]]
	[[Category: Immunoglobulin variable-like domain]]		[[Category: Immunoglobulin variable-like domain]]
-	[[Category: New york structural genomics research consortium]]
	[[Category: Nysgrc]]		[[Category: Nysgrc]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
	[[Category: Psi-biology]]		[[Category: Psi-biology]]
-	[[Category: Structural genomic]]

OCA at 10:20, 16 June 2014

OCA — Mon, 16 Jun 2014 10:20:41 GMT

←Older revision		Revision as of 10:20, 16 June 2014
Line 1:		Line 1:
-	~~[[Image:4gos.jpg\|left\|200px]]~~	+	==Crystal structure of human B7-H4 IgV-like domain==
-		+	<StructureSection load='4gos' size='340' side='right' caption='[[4gos]], [[Resolution\|resolution]] 1.59Å' scene=''>
-	~~{{STRUCTURE_4gos\| PDB=4gos \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br>
-	===Crystal structure of human B7-H4 IgV-like domain===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA].	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]

OCA at 05:23, 12 September 2012

OCA — Wed, 12 Sep 2012 05:23:35 GMT

←Older revision		Revision as of 05:23, 12 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gos.jpg\|left\|200px]]

-	~~The entry~~ 4gos ~~is ON HOLD~~	+	{{STRUCTURE_4gos\| PDB=4gos \| SCENE= }}

-	~~Authors: Vigdorovich, V., Ramagopal, U., Bhosle, R., Toro, R., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC)~~	+	===Crystal structure of human B7-H4 IgV-like domain===

-	~~Description: Crystal~~ structure ~~of human B7~~-~~H4 IgV~~-like domain	+
		+	==About this Structure==
		+	[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Almo, S C.]]
		+	[[Category: Bhosle, R.]]
		+	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
		+	[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
		+	[[Category: Nathenson, S G.]]
		+	[[Category: Ramagopal, U.]]
		+	[[Category: Toro, R.]]
		+	[[Category: Vigdorovich, V.]]
		+	[[Category: Adaptive immunity]]
		+	[[Category: Cell surface]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Immune system]]
		+	[[Category: Immunity]]
		+	[[Category: Immunoglobulin domain]]
		+	[[Category: Immunoglobulin variable-like domain]]
		+	[[Category: New york structural genomics research consortium]]
		+	[[Category: Nysgrc]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-biology]]
		+	[[Category: Structural genomic]]

OCA: Protected "4gos" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2012 04:49:12 GMT

Protected "4gos" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:49, 29 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gos is ON HOLD Authors: Vigdorovich, V., Ramagopal, U., Bhosle, R., Toro, R., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Co...

OCA — Wed, 29 Aug 2012 04:49:11 GMT

New page: '''Unreleased structure''' The entry 4gos is ON HOLD Authors: Vigdorovich, V., Ramagopal, U., Bhosle, R., Toro, R., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Co...

New page

'''Unreleased structure'''

The entry 4gos is ON HOLD

Authors: Vigdorovich, V., Ramagopal, U., Bhosle, R., Toro, R., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC)

Description: Crystal structure of human B7-H4 IgV-like domain