4gqi - Revision history

OCA at 11:33, 1 March 2024

OCA — Fri, 01 Mar 2024 11:33:50 GMT

←Older revision		Revision as of 11:33, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gqi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gqi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M49:N-{(3R)-3-[2-(ACETYLAMINO)ETHYL]-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL}ACETAMIDE'>M49</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.948Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M49:N-{(3R)-3-[2-(ACETYLAMINO)ETHYL]-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL}ACETAMIDE'>M49</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqi OCA], [https://pdbe.org/4gqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqi RCSB], [https://www.ebi.ac.uk/pdbsum/4gqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqi OCA], [https://pdbe.org/4gqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqi RCSB], [https://www.ebi.ac.uk/pdbsum/4gqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>		[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	New 5-acetamido-substituted melatonin derivatives were efficiently synthesized in excellent yields via Knoevenagel condensation. The relative binding affinity of new synthesized compounds to MT3 receptor was tested via enzymatic assays and the X-ray structures of the most potent compounds were determined in complex with MT3.
-
-	Synthesis of novel capital EM, Cyrilliccapital TE, Cyrillic3 receptor ligands via an unusual Knoevenagel condensation.,Volkova MS, Jensen KC, Lozinskaya NA, Sosonyuk SE, Proskurnina MV, Mesecar AD, Zefirov NS Bioorg Med Chem Lett. 2012 Dec 15;22(24):7578-81. doi:, 10.1016/j.bmcl.2012.10.005. Epub 2012 Oct 17. PMID:23131339<ref>PMID:23131339</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4gqi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Quinone reductase\|Quinone reductase]]	+	*[[Quinone reductase 3D structures\|Quinone reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:10, 26 October 2022

OCA — Wed, 26 Oct 2022 07:10:38 GMT

←Older revision		Revision as of 07:10, 26 October 2022
Line 1:		Line 1:

	==Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation==		==Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation==
-	<StructureSection load='4gqi' size='340' side='right' caption='[[4gqi]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='4gqi' size='340' side='right'caption='[[4gqi]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gqi]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GQI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gqi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M49:N-{(3R)-3-[2-(ACETYLAMINO)ETHYL]-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL}ACETAMIDE'>M49</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M49:N-{(3R)-3-[2-(ACETYLAMINO)ETHYL]-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL}ACETAMIDE'>M49</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gr9\|4gr9]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqi OCA], [https://pdbe.org/4gqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqi RCSB], [https://www.ebi.ac.uk/pdbsum/4gqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqi ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqi OCA], [~~http~~://pdbe.org/4gqi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gqi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gqi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqi ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>	+	[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4gqi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4gqi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Quinone reductase\|Quinone reductase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Jensen, K C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lozinskaya, N A~~]]	+	[[Category: Jensen KC]]
-	[[Category: ~~Mesecar, A D~~]]	+	[[Category: Lozinskaya NA]]
-	[[Category: ~~Proskurnina, M V~~]]	+	[[Category: Mesecar AD]]
-	[[Category: ~~Sosonyuk, S E~~]]	+	[[Category: Proskurnina MV]]
-	[[Category: ~~Volkova, M S~~]]	+	[[Category: Sosonyuk SE]]
-	[[Category: ~~Zefirov, N S~~]]	+	[[Category: Volkova MS]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Zefirov NS]]

OCA at 08:31, 15 November 2017

OCA — Wed, 15 Nov 2017 08:31:47 GMT

←Older revision		Revision as of 08:31, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4gqi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4gqi" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Quinone reductase\|Quinone reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:57, 5 August 2016

OCA — Fri, 05 Aug 2016 10:57:39 GMT

←Older revision		Revision as of 10:57, 5 August 2016
Line 1:		Line 1:
		+
	==Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation==		==Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation==
	<StructureSection load='4gqi' size='340' side='right' caption='[[4gqi]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4gqi' size='340' side='right' caption='[[4gqi]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M49:N-{(3R)-3-[2-(ACETYLAMINO)ETHYL]-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL}ACETAMIDE'>M49</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M49:N-{(3R)-3-[2-(ACETYLAMINO)ETHYL]-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL}ACETAMIDE'>M49</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gr9\|4gr9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gr9\|4gr9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gqi RCSB], [http://www.ebi.ac.uk/pdbsum/4gqi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqi OCA], [http://pdbe.org/4gqi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gqi RCSB], [http://www.ebi.ac.uk/pdbsum/4gqi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gqi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Jensen, K C]]		[[Category: Jensen, K C]]
	[[Category: Lozinskaya, N A]]		[[Category: Lozinskaya, N A]]

OCA at 01:47, 25 December 2014

OCA — Thu, 25 Dec 2014 01:47:53 GMT

←Older revision		Revision as of 01:47, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gqi RCSB], [http://www.ebi.ac.uk/pdbsum/4gqi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gqi RCSB], [http://www.ebi.ac.uk/pdbsum/4gqi PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:07, 21 December 2014

OCA — Sun, 21 Dec 2014 11:07:09 GMT

←Older revision		Revision as of 11:07, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gqi\| PDB=4gqi \| SCENE= }}~~	+	==Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation==
-	===Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation===	+	<StructureSection load='4gqi' size='340' side='right' caption='[[4gqi]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23131339}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M49:N-{(3R)-3-[2-(ACETYLAMINO)ETHYL]-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL}ACETAMIDE'>M49</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gr9\|4gr9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gqi RCSB], [http://www.ebi.ac.uk/pdbsum/4gqi PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	New 5-acetamido-substituted melatonin derivatives were efficiently synthesized in excellent yields via Knoevenagel condensation. The relative binding affinity of new synthesized compounds to MT3 receptor was tested via enzymatic assays and the X-ray structures of the most potent compounds were determined in complex with MT3.

-	~~==Function==~~	+	Synthesis of novel capital EM, Cyrilliccapital TE, Cyrillic3 receptor ligands via an unusual Knoevenagel condensation.,Volkova MS, Jensen KC, Lozinskaya NA, Sosonyuk SE, Proskurnina MV, Mesecar AD, Zefirov NS Bioorg Med Chem Lett. 2012 Dec 15;22(24):7578-81. doi:, 10.1016/j.bmcl.2012.10.005. Epub 2012 Oct 17. PMID:23131339<ref>PMID:23131339</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:~~18254726~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4gqi]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4GQI OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023131339</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Quinone reductase\|Quinone reductase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Jensen, K C.]]	+	[[Category: Jensen, K C]]
-	[[Category: Lozinskaya, N A.]]	+	[[Category: Lozinskaya, N A]]
-	[[Category: Mesecar, A D.]]	+	[[Category: Mesecar, A D]]
-	[[Category: Proskurnina, M V.]]	+	[[Category: Proskurnina, M V]]
-	[[Category: Sosonyuk, S E.]]	+	[[Category: Sosonyuk, S E]]
-	[[Category: Volkova, M S.]]	+	[[Category: Volkova, M S]]
-	[[Category: Zefirov, N S.]]	+	[[Category: Zefirov, N S]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 15:40, 10 July 2013

OCA — Wed, 10 Jul 2013 15:40:15 GMT

←Older revision		Revision as of 15:40, 10 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4gqi\| PDB=4gqi \| SCENE= }}
		+	===Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation===
		+	{{ABSTRACT_PUBMED_23131339}}

-	The ~~entry 4gqi is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>

-	~~Authors~~: ~~Volkova, M~~.S.~~, Jensen, K~~.~~C., Lozinskaya, N.A., Sosonyuk, S.E., Proskurnina, M.V., Mesecar, A~~.D.~~, Zefirov, N~~.S.	+	==About this Structure==
		+	[[4gqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQI OCA].

-	~~Description~~: ~~Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation~~	+	==Reference==
		+	<ref group="xtra">PMID:023131339</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Jensen, K C.]]
		+	[[Category: Lozinskaya, N A.]]
		+	[[Category: Mesecar, A D.]]
		+	[[Category: Proskurnina, M V.]]
		+	[[Category: Sosonyuk, S E.]]
		+	[[Category: Volkova, M S.]]
		+	[[Category: Zefirov, N S.]]
		+	[[Category: Oxidoreductase]]

OCA at 07:06, 24 October 2012

OCA — Wed, 24 Oct 2012 07:06:21 GMT

←Older revision		Revision as of 07:06, 24 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gqi is ON HOLD	+	The entry 4gqi is ON HOLD until Paper Publication

	Authors: Volkova, M.S., Jensen, K.C., Lozinskaya, N.A., Sosonyuk, S.E., Proskurnina, M.V., Mesecar, A.D., Zefirov, N.S.		Authors: Volkova, M.S., Jensen, K.C., Lozinskaya, N.A., Sosonyuk, S.E., Proskurnina, M.V., Mesecar, A.D., Zefirov, N.S.

	Description: Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation		Description: Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation

OCA: Protected "4gqi" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2012 04:50:56 GMT

Protected "4gqi" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:50, 29 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gqi is ON HOLD Authors: Volkova, M.S., Jensen, K.C., Lozinskaya, N.A., Sosonyuk, S.E., Proskurnina, M.V., Mesecar, A.D., Zefirov, N.S. Description...

OCA — Wed, 29 Aug 2012 04:50:55 GMT

New page: '''Unreleased structure''' The entry 4gqi is ON HOLD Authors: Volkova, M.S., Jensen, K.C., Lozinskaya, N.A., Sosonyuk, S.E., Proskurnina, M.V., Mesecar, A.D., Zefirov, N.S. Description...

New page

'''Unreleased structure'''

The entry 4gqi is ON HOLD

Authors: Volkova, M.S., Jensen, K.C., Lozinskaya, N.A., Sosonyuk, S.E., Proskurnina, M.V., Mesecar, A.D., Zefirov, N.S.

Description: Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation