4gqs - Revision history

OCA at 15:53, 14 March 2024

OCA — Thu, 14 Mar 2024 15:53:44 GMT

←Older revision		Revision as of 15:53, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.87Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [https://pdbe.org/4gqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [https://www.ebi.ac.uk/pdbsum/4gqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [https://pdbe.org/4gqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [https://www.ebi.ac.uk/pdbsum/4gqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqs ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN] Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.		[https://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN] Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	In order to identify structural features underlying the distinct substrate and inhibitor profiles of P450 2C19 relative to the closely related human enzymes, P450s 2C8 and 2C9, the atomic structure (PDB#4GQS) of cytochrome P450 2C19 complexed with the inhibitor (2-methyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-dimethylphenyl)methanone (PDB chemical component: 0XV) was determined to 2.87 A resolution by x-ray crystallography. The conformation of the peptide backbone of P450 2C19 is most similar to that of P450 2C8, but the substrate binding cavity of P450 2C8 is much larger than that of P450 2C19 due to differences in the amino acid residues that form the substrate binding cavities of the two enzymes. In contrast, the substrate binding cavity of P450 2C19 is much more similar in size to that of the structure of P450 2C9 flurbiprofen complex than to that of a modified P450 2C9 or that of P450 2C8. The cavities of P450 2C19 0XV complex and the P450 2C9 flurbiprofen complex differ, however, because the helix B-C loops of the two enzymes are dissimilar. These conformation differences reflect effects of adjacent structural elements that interact with the B-C loops and that differ between the two enzymes. The availability of a structure for 2C19 will facilitate computational approaches for predictions of substrate and inhibitor binding to this enzyme.
-
-	Structural characterization of human cytochrome P450 2C19: active site differences between P450's 2C8, 2C9 and 2C19.,Reynald RL, Sansen S, Stout CD, Johnson EF J Biol Chem. 2012 Nov 1. PMID:23118231<ref>PMID:23118231</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4gqs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]		*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:11, 26 October 2022

OCA — Wed, 26 Oct 2022 07:11:11 GMT

←Older revision		Revision as of 07:11, 26 October 2022
Line 1:		Line 1:

	==Structure of Human Microsomal Cytochrome P450 (CYP) 2C19==		==Structure of Human Microsomal Cytochrome P450 (CYP) 2C19==
-	<StructureSection load='4gqs' size='340' side='right' caption='[[4gqs]], [[Resolution\|resolution]] 2.87Å' scene=''>	+	<StructureSection load='4gqs' size='340' side='right'caption='[[4gqs]], [[Resolution\|resolution]] 2.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9o\|1r9o]], [[1og2\|1og2]], [[1og5\|1og5]], [[1pq2\|1pq2]], [[2nnj\|2nnj]], [[2nni\|2nni]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [https://pdbe.org/4gqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [https://www.ebi.ac.uk/pdbsum/4gqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqs ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2C19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [~~http~~://pdbe.org/4gqs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gqs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN]] Resistance to clopidogrel;Antidepressant or antipsychotics toxicity or dose selection;Voriconazole toxicity.	+	[https://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN] Resistance to clopidogrel;Antidepressant or antipsychotics toxicity or dose selection;Voriconazole toxicity.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN]] Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.	+	[https://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN] Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:

	==See Also==		==See Also==
-	*[[Cytochrome P450\|Cytochrome P450]]	+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Johnson, E F~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Reynald, R L~~]]	+	[[Category: Johnson EF]]
-	[[Category: ~~Sansen, S~~]]	+	[[Category: Reynald RL]]
-	[[Category: ~~Stout, C D~~]]	+	[[Category: Sansen S]]
-	[[Category: ~~Drug metabolizing enzyme]]~~	+	[[Category: Stout CD]]
-	~~[[Category: Heme protein]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 20:04, 15 December 2016

OCA — Thu, 15 Dec 2016 20:04:47 GMT

←Older revision		Revision as of 20:04, 15 December 2016
Line 1:		Line 1:
		+
	==Structure of Human Microsomal Cytochrome P450 (CYP) 2C19==		==Structure of Human Microsomal Cytochrome P450 (CYP) 2C19==
	<StructureSection load='4gqs' size='340' side='right' caption='[[4gqs]], [[Resolution\|resolution]] 2.87Å' scene=''>		<StructureSection load='4gqs' size='340' side='right' caption='[[4gqs]], [[Resolution\|resolution]] 2.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9o\|1r9o]], [[1og2\|1og2]], [[1og5\|1og5]], [[1pq2\|1pq2]], [[2nnj\|2nnj]], [[2nni\|2nni]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9o\|1r9o]], [[1og2\|1og2]], [[1og5\|1og5]], [[1pq2\|1pq2]], [[2nnj\|2nnj]], [[2nni\|2nni]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2C19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2C19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [http://www.ebi.ac.uk/pdbsum/4gqs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [http://pdbe.org/4gqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [http://www.ebi.ac.uk/pdbsum/4gqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqs ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN]] Resistance to clopidogrel;Antidepressant or antipsychotics toxicity or dose selection;Voriconazole toxicity.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN]] Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gqs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Johnson, E F]]		[[Category: Johnson, E F]]
	[[Category: Reynald, R L]]		[[Category: Reynald, R L]]

OCA at 09:45, 10 December 2014

OCA — Wed, 10 Dec 2014 09:45:35 GMT

←Older revision		Revision as of 09:45, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4gqs.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of Human Microsomal Cytochrome P450 (CYP) 2C19==
		+	<StructureSection load='4gqs' size='340' side='right' caption='[[4gqs]], [[Resolution\|resolution]] 2.87Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9o\|1r9o]], [[1og2\|1og2]], [[1og5\|1og5]], [[1pq2\|1pq2]], [[2nnj\|2nnj]], [[2nni\|2nni]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2C19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [http://www.ebi.ac.uk/pdbsum/4gqs PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In order to identify structural features underlying the distinct substrate and inhibitor profiles of P450 2C19 relative to the closely related human enzymes, P450s 2C8 and 2C9, the atomic structure (PDB#4GQS) of cytochrome P450 2C19 complexed with the inhibitor (2-methyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-dimethylphenyl)methanone (PDB chemical component: 0XV) was determined to 2.87 A resolution by x-ray crystallography. The conformation of the peptide backbone of P450 2C19 is most similar to that of P450 2C8, but the substrate binding cavity of P450 2C8 is much larger than that of P450 2C19 due to differences in the amino acid residues that form the substrate binding cavities of the two enzymes. In contrast, the substrate binding cavity of P450 2C19 is much more similar in size to that of the structure of P450 2C9 flurbiprofen complex than to that of a modified P450 2C9 or that of P450 2C8. The cavities of P450 2C19 0XV complex and the P450 2C9 flurbiprofen complex differ, however, because the helix B-C loops of the two enzymes are dissimilar. These conformation differences reflect effects of adjacent structural elements that interact with the B-C loops and that differ between the two enzymes. The availability of a structure for 2C19 will facilitate computational approaches for predictions of substrate and inhibitor binding to this enzyme.

-	~~{{STRUCTURE_4gqs\| PDB=4gqs \| SCENE= }}~~	+	Structural characterization of human cytochrome P450 2C19: active site differences between P450's 2C8, 2C9 and 2C19.,Reynald RL, Sansen S, Stout CD, Johnson EF J Biol Chem. 2012 Nov 1. PMID:23118231<ref>PMID:23118231</ref>

-	~~===Structure~~ of ~~Human Microsomal Cytochrome P450 (CYP) 2C19===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23118231}}~~	+	==See Also==
-		+	*[[Cytochrome P450\|Cytochrome P450]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4gqs~~]] ~~is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Johnson, E F.]]	+	[[Category: Johnson, E F]]
-	[[Category: Reynald, R L.]]	+	[[Category: Reynald, R L]]
-	[[Category: Sansen, S.]]	+	[[Category: Sansen, S]]
-	[[Category: Stout, C D.]]	+	[[Category: Stout, C D]]
	[[Category: Drug metabolizing enzyme]]		[[Category: Drug metabolizing enzyme]]
	[[Category: Heme protein]]		[[Category: Heme protein]]
	[[Category: Monooxygenase]]		[[Category: Monooxygenase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 09:20, 16 January 2013

OCA — Wed, 16 Jan 2013 09:20:56 GMT

←Older revision		Revision as of 09:20, 16 January 2013
Line 1:		Line 1:
-	[[Image:4gqs.~~jpg~~\|left\|200px]]	+	[[Image:4gqs.png\|left\|200px]]

	{{STRUCTURE_4gqs\| PDB=4gqs \| SCENE= }}		{{STRUCTURE_4gqs\| PDB=4gqs \| SCENE= }}
Line 5:		Line 5:
	===Structure of Human Microsomal Cytochrome P450 (CYP) 2C19===		===Structure of Human Microsomal Cytochrome P450 (CYP) 2C19===

		+	{{ABSTRACT_PUBMED_23118231}}

	==About this Structure==		==About this Structure==

OCA at 06:42, 14 November 2012

OCA — Wed, 14 Nov 2012 06:42:43 GMT

←Older revision		Revision as of 06:42, 14 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gqs.jpg\|left\|200px]]

-	~~The entry~~ 4gqs ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gqs\| PDB=4gqs \| SCENE= }}

-	~~Authors: Reynald, R.L., Sansen, S., Stout, C.D., Johnson, E.F.~~	+	===Structure of Human Microsomal Cytochrome P450 (CYP) 2C19===

-	~~Description:~~ Structure ~~of Human Microsomal Cytochrome P450 (CYP) 2C19~~	+
		+	==About this Structure==
		+	[[4gqs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Johnson, E F.]]
		+	[[Category: Reynald, R L.]]
		+	[[Category: Sansen, S.]]
		+	[[Category: Stout, C D.]]
		+	[[Category: Drug metabolizing enzyme]]
		+	[[Category: Heme protein]]
		+	[[Category: Monooxygenase]]
		+	[[Category: Oxidoreductase]]

OCA at 20:08, 26 September 2012

OCA — Wed, 26 Sep 2012 20:08:06 GMT

←Older revision		Revision as of 20:08, 26 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gqs is ON HOLD	+	The entry 4gqs is ON HOLD until Paper Publication

	Authors: Reynald, R.L., Sansen, S., Stout, C.D., Johnson, E.F.		Authors: Reynald, R.L., Sansen, S., Stout, C.D., Johnson, E.F.

	Description: Structure of Human Microsomal Cytochrome P450 (CYP) 2C19		Description: Structure of Human Microsomal Cytochrome P450 (CYP) 2C19

OCA: Protected "4gqs" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2012 04:51:13 GMT

Protected "4gqs" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:51, 29 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gqs is ON HOLD Authors: Reynald, R.L., Sansen, S., Stout, C.D., Johnson, E.F. Description: Structure of Human Microsomal Cytochrome P450 (CYP) 2C1...

OCA — Wed, 29 Aug 2012 04:51:12 GMT

New page: '''Unreleased structure''' The entry 4gqs is ON HOLD Authors: Reynald, R.L., Sansen, S., Stout, C.D., Johnson, E.F. Description: Structure of Human Microsomal Cytochrome P450 (CYP) 2C1...

New page

'''Unreleased structure'''

The entry 4gqs is ON HOLD

Authors: Reynald, R.L., Sansen, S., Stout, C.D., Johnson, E.F.

Description: Structure of Human Microsomal Cytochrome P450 (CYP) 2C19