4grm - Revision history

OCA at 07:12, 26 October 2022

OCA — Wed, 26 Oct 2022 07:12:55 GMT

←Older revision		Revision as of 07:12, 26 October 2022
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	<StructureSection load='4grm' size='340' side='right'caption='[[4grm]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4grm' size='340' side='right'caption='[[4grm]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4grm]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GRM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4grm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRM FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qh3\|3qh3]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4grm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grm OCA], [https://pdbe.org/4grm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4grm RCSB], [https://www.ebi.ac.uk/pdbsum/4grm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4grm ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4grm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grm OCA], [~~http~~://pdbe.org/4grm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4grm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4grm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4grm ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baker~~, B M~~]]	+	[[Category: Baker BM]]
-	[[Category: Borbulevych~~, O Y~~]]	+	[[Category: Borbulevych OY]]
-	[[Category: Scott~~, D R]]~~	+	[[Category: Scott DR]]
-	~~[[Category: C134 modification]]~~	+
-	~~[[Category: Cross-reactivity]]~~	+
-	~~[[Category: High-affinity tcr]]~~	+
-	~~[[Category: Hla-a2]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Mhc class i]]~~	+
-	~~[[Category: Nonapeptide]]~~	+
-	~~[[Category: Tax peptide]]~~	+
-	~~[[Category: Tcr a6~~]]	+

OCA at 09:36, 5 February 2020

OCA — Wed, 05 Feb 2020 09:36:29 GMT

←Older revision		Revision as of 09:36, 5 February 2020
Line 1:		Line 1:

	==The crystal structure of the high affinity TCR A6==		==The crystal structure of the high affinity TCR A6==
-	<StructureSection load='4grm' size='340' side='right' caption='[[4grm]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4grm' size='340' side='right'caption='[[4grm]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4grm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4grm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRM FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Baker, B M]]		[[Category: Baker, B M]]
	[[Category: Borbulevych, O Y]]		[[Category: Borbulevych, O Y]]

OCA at 17:20, 4 August 2016

OCA — Thu, 04 Aug 2016 17:20:07 GMT

←Older revision		Revision as of 17:20, 4 August 2016
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		+
	==The crystal structure of the high affinity TCR A6==		==The crystal structure of the high affinity TCR A6==
	<StructureSection load='4grm' size='340' side='right' caption='[[4grm]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4grm' size='340' side='right' caption='[[4grm]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4grm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4grm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qh3\|3qh3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qh3\|3qh3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4grm RCSB], [http://www.ebi.ac.uk/pdbsum/4grm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grm OCA], [http://pdbe.org/4grm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4grm RCSB], [http://www.ebi.ac.uk/pdbsum/4grm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4grm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4grm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Baker, B M]]		[[Category: Baker, B M]]
	[[Category: Borbulevych, O Y]]		[[Category: Borbulevych, O Y]]

OCA at 11:12, 21 December 2014

OCA — Sun, 21 Dec 2014 11:12:10 GMT

←Older revision		Revision as of 11:12, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4grm~~\| ~~PDB~~=4grm \| ~~SCENE~~= }}	+	==The crystal structure of the high affinity TCR A6==
-	===The ~~crystal~~ structure of the high affinity TCR ~~A6===~~	+	<StructureSection load='4grm' size='340' side='right' caption='[[4grm]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23805144}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4grm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRM FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qh3\|3qh3]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4grm RCSB], [http://www.ebi.ac.uk/pdbsum/4grm PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Natural T cell receptors (TCRs) generally bind to their cognate pMHC molecules with weak affinity and fast kinetics, limiting their use as therapeutic agents. Using phage display, we have engineered a high affinity version of the A6 wild-type TCR (A6wt), specific for the human leukocyte antigen (HLA-A( *)0201) complexed with human T cell lymphotropic virus type 111-19 peptide (A2-Tax). Mutations in just 4 residues in the CDR3beta loop region of the A6wt TCR were selected that improved binding to A2-Tax by nearly 1000-fold. Biophysical measurements of this mutant TCR (A6c134) demonstrated that the enhanced binding was derived through favorable enthalpy and a slower off-rate. The structure of the free A6c134 TCR and the A6c134/A2-Tax complex revealed a native binding mode, similar to the A6wt/A2-Tax complex. However, concordant with the more favorable binding enthalpy, the A6c134 TCR made increased contacts with the Tax peptide compared with the A6wt/A2-Tax complex, demonstrating a peptide-focused mechanism for the enhanced affinity that directly involved the mutated residues in the A6c134 TCR CDR3beta loop. This peptide-focused enhanced TCR binding may represent an important approach for developing antigen specific high affinity TCR reagents for use in T cell based therapies.

-	~~==About this Structure==~~	+	Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode.,Cole DK, Sami M, Scott DR, Rizkallah PJ, Borbulevych OY, Todorov PT, Moysey RK, Jakobsen BK, Boulter JM, Baker BM, Yi Li Front Immunol. 2013 Jun 26;4:168. doi: 10.3389/fimmu.2013.00168. Print 2013. PMID:23805144<ref>PMID:23805144</ref>
-	~~[[4grm]] is~~ a 4 ~~chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4GRM OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023805144</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Baker, B M.]]	+	[[Category: Baker, B M]]
-	[[Category: Borbulevych, O Y.]]	+	[[Category: Borbulevych, O Y]]
-	[[Category: Scott, D R.]]	+	[[Category: Scott, D R]]
	[[Category: C134 modification]]		[[Category: C134 modification]]
	[[Category: Cross-reactivity]]		[[Category: Cross-reactivity]]

OCA at 15:43, 10 July 2013

OCA — Wed, 10 Jul 2013 15:43:00 GMT

←Older revision		Revision as of 15:43, 10 July 2013
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4grm\| PDB=4grm \| SCENE= }}
		+	===The crystal structure of the high affinity TCR A6===
		+	{{ABSTRACT_PUBMED_23805144}}

-	~~The entry~~ 4grm is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4grm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRM OCA].

-	~~Authors~~: Borbulevych, O.Y., Scott, D.R.~~, Baker, B.M.~~	+	==Reference==
-		+	<ref group="xtra">PMID:023805144</ref><references group="xtra"/><references/>
-	~~Description~~: ~~The crystal structure of the high~~ affinity ~~TCR A6~~	+	[[Category: Homo sapiens]]
		+	[[Category: Baker, B M.]]
		+	[[Category: Borbulevych, O Y.]]
		+	[[Category: Scott, D R.]]
		+	[[Category: C134 modification]]
		+	[[Category: Cross-reactivity]]
		+	[[Category: High-affinity tcr]]
		+	[[Category: Hla-a2]]
		+	[[Category: Immune system]]
		+	[[Category: Mhc class i]]
		+	[[Category: Nonapeptide]]
		+	[[Category: Tax peptide]]
		+	[[Category: Tcr a6]]

OCA at 13:18, 20 February 2013

OCA — Wed, 20 Feb 2013 13:18:30 GMT

←Older revision		Revision as of 13:18, 20 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4grm is ON HOLD	+	The entry 4grm is ON HOLD until Paper Publication

	Authors: Borbulevych, O.Y., Scott, D.R., Baker, B.M.		Authors: Borbulevych, O.Y., Scott, D.R., Baker, B.M.

	Description: The crystal structure of the high affinity TCR A6		Description: The crystal structure of the high affinity TCR A6

OCA at 20:08, 26 September 2012

OCA — Wed, 26 Sep 2012 20:08:15 GMT

←Older revision		Revision as of 20:08, 26 September 2012
Line 3:		Line 3:
	The entry 4grm is ON HOLD		The entry 4grm is ON HOLD

-	Authors: Borbulevych, O.Y., Scott, D., Baker, B.M.	+	Authors: Borbulevych, O.Y., Scott, D.R., Baker, B.M.

	Description: The crystal structure of the high affinity TCR A6		Description: The crystal structure of the high affinity TCR A6

OCA at 04:52, 12 September 2012

OCA — Wed, 12 Sep 2012 04:52:56 GMT

←Older revision		Revision as of 04:52, 12 September 2012
Line 3:		Line 3:
	The entry 4grm is ON HOLD		The entry 4grm is ON HOLD

-	Authors: Borbulevych, O.Y, Scott, D., Baker, B.M.	+	Authors: Borbulevych, O.Y., Scott, D., Baker, B.M.

	Description: The crystal structure of the high affinity TCR A6		Description: The crystal structure of the high affinity TCR A6

OCA: Protected "4grm" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 04:57:01 GMT

Protected "4grm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4grm is ON HOLD Authors: Borbulevych, O.Y, Scott, D., Baker, B.M. Description: The crystal structure of the high affinity TCR A6

OCA — Wed, 05 Sep 2012 04:57:00 GMT

New page: '''Unreleased structure''' The entry 4grm is ON HOLD Authors: Borbulevych, O.Y, Scott, D., Baker, B.M. Description: The crystal structure of the high affinity TCR A6

New page

'''Unreleased structure'''

The entry 4grm is ON HOLD

Authors: Borbulevych, O.Y, Scott, D., Baker, B.M.

Description: The crystal structure of the high affinity TCR A6