4grr - Revision history

OCA at 11:34, 1 March 2024

OCA — Fri, 01 Mar 2024 11:34:09 GMT

←Older revision		Revision as of 11:34, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4grr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4grr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AVR:(2R)-2-AMINO-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]PROPAN-1-ONE'>AVR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.47Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AVR:(2R)-2-AMINO-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]PROPAN-1-ONE'>AVR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4grr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grr OCA], [https://pdbe.org/4grr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4grr RCSB], [https://www.ebi.ac.uk/pdbsum/4grr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4grr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4grr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grr OCA], [https://pdbe.org/4grr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4grr RCSB], [https://www.ebi.ac.uk/pdbsum/4grr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4grr ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:12, 26 October 2022

OCA — Wed, 26 Oct 2022 07:12:58 GMT

←Older revision		Revision as of 07:12, 26 October 2022
Line 1:		Line 1:

	==characterization of N- and C- terminus mutants of human MIF==		==characterization of N- and C- terminus mutants of human MIF==
-	<StructureSection load='4grr' size='340' side='right' caption='[[4grr]], [[Resolution\|resolution]] 1.47Å' scene=''>	+	<StructureSection load='4grr' size='340' side='right'caption='[[4grr]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4grr]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GRR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4grr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AVR:(2R)-2-AMINO-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]PROPAN-1-ONE'>AVR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AVR:(2R)-2-AMINO-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]PROPAN-1-ONE'>AVR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4grn\|4grn]], [[4gro\|4gro]], [[4grp\|4grp]], [[4grq\|4grq]], [[4gru\|4gru]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4grr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grr OCA], [https://pdbe.org/4grr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4grr RCSB], [https://www.ebi.ac.uk/pdbsum/4grr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4grr ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4grr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grr OCA], [~~http~~://pdbe.org/4grr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4grr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4grr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4grr ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>

	==See Also==		==See Also==
-	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]	+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Fan, C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lolis, E~~]]	+	[[Category: Fan C]]
-	[[Category: ~~Alpha/beta mixture]]~~	+	[[Category: Lolis E]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Isomerase~~]]	+

OCA at 14:21, 4 August 2016

OCA — Thu, 04 Aug 2016 14:21:41 GMT

←Older revision		Revision as of 14:21, 4 August 2016
Line 1:		Line 1:
-	{{STRUCTURE_4grr\| PDB=4grr \| SCENE= }}
-	===characterization of N- and C- terminus mutants of human MIF===

-	==Disease==	+	==characterization of N- and C- terminus mutants of human MIF==
		+	<StructureSection load='4grr' size='340' side='right' caption='[[4grr]], [[Resolution\|resolution]] 1.47Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4grr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AVR:(2R)-2-AMINO-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]PROPAN-1-ONE'>AVR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4grn\|4grn]], [[4gro\|4gro]], [[4grp\|4grp]], [[4grq\|4grq]], [[4gru\|4gru]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grr OCA], [http://pdbe.org/4grr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4grr RCSB], [http://www.ebi.ac.uk/pdbsum/4grr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4grr ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
-
-	==About this Structure==
-	[[4grr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRR OCA].

	==See Also==		==See Also==
	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]		*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Fan, C.]]	+	[[Category: Fan, C]]
-	[[Category: Lolis, E.]]	+	[[Category: Lolis, E]]
	[[Category: Alpha/beta mixture]]		[[Category: Alpha/beta mixture]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 07:25, 2 April 2014

OCA — Wed, 02 Apr 2014 07:25:32 GMT

←Older revision		Revision as of 07:25, 2 April 2014
Line 9:		Line 9:

	==About this Structure==		==About this Structure==
-	[[4grr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRR OCA].	+	[[4grr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRR OCA].
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]

	==Reference==		==Reference==
	<references group="xtra"/><references/>		<references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fan, C.]]		[[Category: Fan, C.]]
	[[Category: Lolis, E.]]		[[Category: Lolis, E.]]

OCA at 08:17, 29 September 2013

OCA — Sun, 29 Sep 2013 08:17:11 GMT

←Older revision		Revision as of 08:17, 29 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4grr\| PDB=4grr \| SCENE= }}
		+	===characterization of N- and C- terminus mutants of human MIF===

-	~~The~~ entry ~~4grr is ON HOLD until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

-	~~Authors~~: ~~Fan~~, C., ~~Lolis, E~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>

-	~~Description~~: ~~characterization of N~~-~~and~~ C~~-terminus mutants of human MIF~~	+	==About this Structure==
		+	[[4grr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRR OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Fan, C.]]
		+	[[Category: Lolis, E.]]
		+	[[Category: Alpha/beta mixture]]
		+	[[Category: Cytokine]]
		+	[[Category: Isomerase]]

OCA at 04:53, 12 September 2012

OCA — Wed, 12 Sep 2012 04:53:00 GMT

←Older revision		Revision as of 04:53, 12 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4grr is ON HOLD	+	The entry 4grr is ON HOLD until Paper Publication

	Authors: Fan, C., Lolis, E.		Authors: Fan, C., Lolis, E.

	Description: characterization of N-and C-terminus mutants of human MIF		Description: characterization of N-and C-terminus mutants of human MIF

OCA: Protected "4grr" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 04:57:09 GMT

Protected "4grr" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4grr is ON HOLD Authors: Fan, C., Lolis, E. Description: characterization of N-and C-terminus mutants of human MIF

OCA — Wed, 05 Sep 2012 04:57:08 GMT

New page: '''Unreleased structure''' The entry 4grr is ON HOLD Authors: Fan, C., Lolis, E. Description: characterization of N-and C-terminus mutants of human MIF

New page

'''Unreleased structure'''

The entry 4grr is ON HOLD

Authors: Fan, C., Lolis, E.

Description: characterization of N-and C-terminus mutants of human MIF