4gru - Revision history

OCA at 11:34, 1 March 2024

OCA — Fri, 01 Mar 2024 11:34:09 GMT

←Older revision		Revision as of 11:34, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gru]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gru]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.92Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gru OCA], [https://pdbe.org/4gru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gru RCSB], [https://www.ebi.ac.uk/pdbsum/4gru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gru ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gru OCA], [https://pdbe.org/4gru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gru RCSB], [https://www.ebi.ac.uk/pdbsum/4gru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gru ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:13, 26 October 2022

OCA — Wed, 26 Oct 2022 07:13:00 GMT

←Older revision		Revision as of 07:13, 26 October 2022
Line 1:		Line 1:

	==crystallographic and biological characterization of N- and C- terminus mutants of human MIF==		==crystallographic and biological characterization of N- and C- terminus mutants of human MIF==
-	<StructureSection load='4gru' size='340' side='right' caption='[[4gru]], [[Resolution\|resolution]] 1.92Å' scene=''>	+	<StructureSection load='4gru' size='340' side='right'caption='[[4gru]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gru]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GRU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gru]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4grn\|4grn]], [[4gro\|4gro]], [[4grp\|4grp]], [[4grq\|4grq]], [[4grr\|4grr]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gru OCA], [https://pdbe.org/4gru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gru RCSB], [https://www.ebi.ac.uk/pdbsum/4gru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gru ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gru OCA], [~~http~~://pdbe.org/4gru PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gru RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gru PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gru ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>

	==See Also==		==See Also==
-	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]	+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Fan, C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lolis, E~~]]	+	[[Category: Fan C]]
-	[[Category: ~~Alpha/beta mixture]]~~	+	[[Category: Lolis E]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Isomerase~~]]	+

OCA at 08:45, 4 August 2016

OCA — Thu, 04 Aug 2016 08:45:52 GMT

←Older revision		Revision as of 08:45, 4 August 2016
Line 1:		Line 1:
-	{{STRUCTURE_4gru\| PDB=4gru \| SCENE= }}
-	===crystallographic and biological characterization of N- and C- terminus mutants of human MIF===

-	==Disease==	+	==crystallographic and biological characterization of N- and C- terminus mutants of human MIF==
		+	<StructureSection load='4gru' size='340' side='right' caption='[[4gru]], [[Resolution\|resolution]] 1.92Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gru]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4grn\|4grn]], [[4gro\|4gro]], [[4grp\|4grp]], [[4grq\|4grq]], [[4grr\|4grr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gru OCA], [http://pdbe.org/4gru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gru RCSB], [http://www.ebi.ac.uk/pdbsum/4gru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gru ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
-
-	==About this Structure==
-	[[4gru]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRU OCA].

	==See Also==		==See Also==
	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]		*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Fan, C.]]	+	[[Category: Fan, C]]
-	[[Category: Lolis, E.]]	+	[[Category: Lolis, E]]
	[[Category: Alpha/beta mixture]]		[[Category: Alpha/beta mixture]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 06:58, 2 April 2014

OCA — Wed, 02 Apr 2014 06:58:28 GMT

←Older revision		Revision as of 06:58, 2 April 2014
Line 9:		Line 9:

	==About this Structure==		==About this Structure==
-	[[4gru]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRU OCA].	+	[[4gru]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRU OCA].
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]

	==Reference==		==Reference==
	<references group="xtra"/><references/>		<references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fan, C.]]		[[Category: Fan, C.]]
	[[Category: Lolis, E.]]		[[Category: Lolis, E.]]

OCA at 08:17, 29 September 2013

OCA — Sun, 29 Sep 2013 08:17:12 GMT

←Older revision		Revision as of 08:17, 29 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4gru\| PDB=4gru \| SCENE= }}
		+	===crystallographic and biological characterization of N- and C- terminus mutants of human MIF===

-	~~The~~ entry ~~4gru is ON HOLD until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

-	~~Authors~~: ~~Fan~~, C., ~~Lolis, E~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>

-	~~Description~~: crystallographic ~~and biological characterization of N~~-~~and~~ C~~-terminus mutants of human MIF~~	+	==About this Structure==
		+	[[4gru]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRU OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Fan, C.]]
		+	[[Category: Lolis, E.]]
		+	[[Category: Alpha/beta mixture]]
		+	[[Category: Cytokine]]
		+	[[Category: Isomerase]]

OCA: Protected "4gru" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 04:57:12 GMT

Protected "4gru" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gru is ON HOLD until Paper Publication Authors: Fan, C., Lolis, E. Description: crystallographic and biological characterization of N-and C-termin...

OCA — Wed, 05 Sep 2012 04:57:11 GMT

New page: '''Unreleased structure''' The entry 4gru is ON HOLD until Paper Publication Authors: Fan, C., Lolis, E. Description: crystallographic and biological characterization of N-and C-termin...

New page

'''Unreleased structure'''

The entry 4gru is ON HOLD until Paper Publication

Authors: Fan, C., Lolis, E.

Description: crystallographic and biological characterization of N-and C-terminus mutants of human MIF