4gsl - Revision history

OCA at 15:55, 14 March 2024

OCA — Thu, 14 Mar 2024 15:55:22 GMT

←Older revision		Revision as of 15:55, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gsl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gsl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.703Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsl OCA], [https://pdbe.org/4gsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsl RCSB], [https://www.ebi.ac.uk/pdbsum/4gsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsl OCA], [https://pdbe.org/4gsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsl RCSB], [https://www.ebi.ac.uk/pdbsum/4gsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/ATG7_YEAST ATG7_YEAST] E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.<ref>PMID:9759731</ref> <ref>PMID:8224160</ref> <ref>PMID:7593182</ref> <ref>PMID:10233148</ref> <ref>PMID:10233150</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref> <ref>PMID:12965207</ref> <ref>PMID:15277523</ref>		[https://www.uniprot.org/uniprot/ATG7_YEAST ATG7_YEAST] E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.<ref>PMID:9759731</ref> <ref>PMID:8224160</ref> <ref>PMID:7593182</ref> <ref>PMID:10233148</ref> <ref>PMID:10233150</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref> <ref>PMID:12965207</ref> <ref>PMID:15277523</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Core functions of autophagy are mediated by ubiquitin-like protein (UBL) cascades, in which a homodimeric E1 enzyme, Atg7, directs the UBLs Atg8 and Atg12 to their respective E2 enzymes, Atg3 and Atg10. Crystallographic and mutational analyses of yeast (Atg7-Atg3)(2) and (Atg7-Atg10)(2) complexes reveal noncanonical, multisite E1-E2 recognition in autophagy. Atg7's unique N-terminal domain recruits distinctive elements from the Atg3 and Atg10 'backsides'. This, along with E1 and E2 conformational variability, allows presentation of 'frontside' Atg3 and Atg10 active sites to the catalytic cysteine in the C-terminal domain from the opposite Atg7 protomer in the homodimer. Despite different modes of binding, the data suggest that common principles underlie conjugation in both noncanonical and canonical UBL cascades, whereby flexibly tethered E1 domains recruit E2s through surfaces remote from their active sites to juxtapose the E1 and E2 catalytic cysteines.
-
-	Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.,Kaiser SE, Mao K, Taherbhoy AM, Yu S, Olszewski JL, Duda DM, Kurinov I, Deng A, Fenn TD, Klionsky DJ, Schulman BA Nat Struct Mol Biol. 2012 Nov 11. doi: 10.1038/nsmb.2415. PMID:23142976<ref>PMID:23142976</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4gsl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:15, 26 October 2022

OCA — Wed, 26 Oct 2022 07:15:08 GMT

←Older revision		Revision as of 07:15, 26 October 2022
Line 1:		Line 1:

	==Crystal structure of an Atg7-Atg3 crosslinked complex==		==Crystal structure of an Atg7-Atg3 crosslinked complex==
-	<StructureSection load='4gsl' size='340' side='right' caption='[[4gsl]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4gsl' size='340' side='right'caption='[[4gsl]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gsl]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GSL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gsl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APG7, ATG7, CVT2, YHR171W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), APG3, ATG3, AUT1, N2040, YNR007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsl OCA], [https://pdbe.org/4gsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsl RCSB], [https://www.ebi.ac.uk/pdbsum/4gsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsl ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsl OCA], [~~http~~://pdbe.org/4gsl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gsl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gsl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsl ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ATG7_YEAST ATG7_YEAST]] E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.<ref>PMID:9759731</ref> <ref>PMID:8224160</ref> <ref>PMID:7593182</ref> <ref>PMID:10233148</ref> <ref>PMID:10233150</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref> <ref>PMID:12965207</ref> <ref>PMID:15277523</ref> [[http://www.uniprot.org/uniprot/ATG3_YEAST ATG3_YEAST]] E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt).<ref>PMID:9023185</ref> <ref>PMID:8224160</ref> <ref>PMID:8050581</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref> <ref>PMID:15277523</ref>	+	[https://www.uniprot.org/uniprot/ATG7_YEAST ATG7_YEAST] E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.<ref>PMID:9759731</ref> <ref>PMID:8224160</ref> <ref>PMID:7593182</ref> <ref>PMID:10233148</ref> <ref>PMID:10233150</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref> <ref>PMID:12965207</ref> <ref>PMID:15277523</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Autophagy-related protein\|Autophagy-related protein]]	+	*[[Autophagy-related protein 3D structures\|Autophagy-related protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Baker's yeast~~]]	+	[[Category: Large Structures]]
-	[[Category: Deng, A]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: Duda~~, D M~~]]	+	[[Category: Deng A]]
-	[[Category: Fenn~~, T D~~]]	+	[[Category: Duda DM]]
-	[[Category: Kaiser~~, S E~~]]	+	[[Category: Fenn TD]]
-	[[Category: Klionsky~~, D J~~]]	+	[[Category: Kaiser SE]]
-	[[Category: Kurinov, I]]	+	[[Category: Klionsky DJ]]
-	[[Category: Mao, K]]	+	[[Category: Kurinov I]]
-	[[Category: Olszewski~~, J L~~]]	+	[[Category: Mao K]]
-	[[Category: Schulman~~, B A~~]]	+	[[Category: Olszewski JL]]
-	[[Category: Taherbhoy~~, A M~~]]	+	[[Category: Schulman BA]]
-	[[Category: Yu, S]]	+	[[Category: Taherbhoy AM]]
-	~~[[Category: Protein transport]]~~	+	[[Category: Yu S]]
-	~~[[Category: Ubiquitin-like protein activation enzyme]]~~	+
-	~~[[Category: Ubiquitin-like protein transfer enzyme~~]]	+

OCA at 23:14, 5 August 2016

OCA — Fri, 05 Aug 2016 23:14:24 GMT

←Older revision		Revision as of 23:14, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of an Atg7-Atg3 crosslinked complex==		==Crystal structure of an Atg7-Atg3 crosslinked complex==
	<StructureSection load='4gsl' size='340' side='right' caption='[[4gsl]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4gsl' size='340' side='right' caption='[[4gsl]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gsl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gsl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APG7, ATG7, CVT2, YHR171W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~]), APG3, ATG3, AUT1, N2040, YNR007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APG7, ATG7, CVT2, YHR171W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), APG3, ATG3, AUT1, N2040, YNR007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gsl RCSB], [http://www.ebi.ac.uk/pdbsum/4gsl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsl OCA], [http://pdbe.org/4gsl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gsl RCSB], [http://www.ebi.ac.uk/pdbsum/4gsl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gsl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Autophagy-related protein\|Autophagy-related protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae s288c~~]]	+	[[Category: Baker's yeast]]
	[[Category: Deng, A]]		[[Category: Deng, A]]
	[[Category: Duda, D M]]		[[Category: Duda, D M]]

OCA at 22:46, 25 December 2014

OCA — Thu, 25 Dec 2014 22:46:38 GMT

←Older revision		Revision as of 22:46, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4gsl.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of an Atg7-Atg3 crosslinked complex==
		+	<StructureSection load='4gsl' size='340' side='right' caption='[[4gsl]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gsl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APG7, ATG7, CVT2, YHR171W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c]), APG3, ATG3, AUT1, N2040, YNR007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gsl RCSB], [http://www.ebi.ac.uk/pdbsum/4gsl PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATG7_YEAST ATG7_YEAST]] E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.<ref>PMID:9759731</ref> <ref>PMID:8224160</ref> <ref>PMID:7593182</ref> <ref>PMID:10233148</ref> <ref>PMID:10233150</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref> <ref>PMID:12965207</ref> <ref>PMID:15277523</ref> [[http://www.uniprot.org/uniprot/ATG3_YEAST ATG3_YEAST]] E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt).<ref>PMID:9023185</ref> <ref>PMID:8224160</ref> <ref>PMID:8050581</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref> <ref>PMID:15277523</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Core functions of autophagy are mediated by ubiquitin-like protein (UBL) cascades, in which a homodimeric E1 enzyme, Atg7, directs the UBLs Atg8 and Atg12 to their respective E2 enzymes, Atg3 and Atg10. Crystallographic and mutational analyses of yeast (Atg7-Atg3)(2) and (Atg7-Atg10)(2) complexes reveal noncanonical, multisite E1-E2 recognition in autophagy. Atg7's unique N-terminal domain recruits distinctive elements from the Atg3 and Atg10 'backsides'. This, along with E1 and E2 conformational variability, allows presentation of 'frontside' Atg3 and Atg10 active sites to the catalytic cysteine in the C-terminal domain from the opposite Atg7 protomer in the homodimer. Despite different modes of binding, the data suggest that common principles underlie conjugation in both noncanonical and canonical UBL cascades, whereby flexibly tethered E1 domains recruit E2s through surfaces remote from their active sites to juxtapose the E1 and E2 catalytic cysteines.

-	~~{{STRUCTURE_4gsl\| PDB=4gsl \| SCENE= }}~~	+	Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.,Kaiser SE, Mao K, Taherbhoy AM, Yu S, Olszewski JL, Duda DM, Kurinov I, Deng A, Fenn TD, Klionsky DJ, Schulman BA Nat Struct Mol Biol. 2012 Nov 11. doi: 10.1038/nsmb.2415. PMID:23142976<ref>PMID:23142976</ref>

-	~~===Crystal structure~~ of ~~an Atg7-Atg3 crosslinked complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23142976}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4gsl]] is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSL OCA].~~	+	</StructureSection>
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
-	[[Category: Deng, A.]]	+	[[Category: Deng, A]]
-	[[Category: Duda, D M.]]	+	[[Category: Duda, D M]]
-	[[Category: Fenn, T D.]]	+	[[Category: Fenn, T D]]
-	[[Category: Kaiser, S E.]]	+	[[Category: Kaiser, S E]]
-	[[Category: Klionsky, D J.]]	+	[[Category: Klionsky, D J]]
-	[[Category: Kurinov, I.]]	+	[[Category: Kurinov, I]]
-	[[Category: Mao, K.]]	+	[[Category: Mao, K]]
-	[[Category: Olszewski, J L.]]	+	[[Category: Olszewski, J L]]
-	[[Category: Schulman, B A.]]	+	[[Category: Schulman, B A]]
-	[[Category: Taherbhoy, A M.]]	+	[[Category: Taherbhoy, A M]]
-	[[Category: Yu, S.]]	+	[[Category: Yu, S]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Ubiquitin-like protein activation enzyme]]		[[Category: Ubiquitin-like protein activation enzyme]]
	[[Category: Ubiquitin-like protein transfer enzyme]]		[[Category: Ubiquitin-like protein transfer enzyme]]

OCA at 14:22, 28 November 2012

OCA — Wed, 28 Nov 2012 14:22:43 GMT

←Older revision		Revision as of 14:22, 28 November 2012
Line 1:		Line 1:
-	[[Image:4gsl.~~jpg~~\|left\|200px]]	+	[[Image:4gsl.png\|left\|200px]]

	{{STRUCTURE_4gsl\| PDB=4gsl \| SCENE= }}		{{STRUCTURE_4gsl\| PDB=4gsl \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of an Atg7-Atg3 crosslinked complex===		===Crystal structure of an Atg7-Atg3 crosslinked complex===

		+	{{ABSTRACT_PUBMED_23142976}}

	==About this Structure==		==About this Structure==

OCA at 06:59, 14 November 2012

OCA — Wed, 14 Nov 2012 06:59:07 GMT

←Older revision		Revision as of 06:59, 14 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gsl.jpg\|left\|200px]]

-	~~The entry~~ 4gsl ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gsl\| PDB=4gsl \| SCENE= }}

-	~~Authors: Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D.J., Schulman, B.A.~~	+	===Crystal structure of an Atg7-Atg3 crosslinked complex===

-	~~Description: Crystal~~ structure ~~of an Atg7~~-~~Atg3 crosslinked complex~~	+
		+	==About this Structure==
		+	[[4gsl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSL OCA].
		+	[[Category: Saccharomyces cerevisiae s288c]]
		+	[[Category: Deng, A.]]
		+	[[Category: Duda, D M.]]
		+	[[Category: Fenn, T D.]]
		+	[[Category: Kaiser, S E.]]
		+	[[Category: Klionsky, D J.]]
		+	[[Category: Kurinov, I.]]
		+	[[Category: Mao, K.]]
		+	[[Category: Olszewski, J L.]]
		+	[[Category: Schulman, B A.]]
		+	[[Category: Taherbhoy, A M.]]
		+	[[Category: Yu, S.]]
		+	[[Category: Protein transport]]
		+	[[Category: Ubiquitin-like protein activation enzyme]]
		+	[[Category: Ubiquitin-like protein transfer enzyme]]

OCA at 06:53, 10 October 2012

OCA — Wed, 10 Oct 2012 06:53:33 GMT

←Older revision		Revision as of 06:53, 10 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gsl is ON HOLD	+	The entry 4gsl is ON HOLD until Paper Publication

	Authors: Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D.J., Schulman, B.A.		Authors: Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D.J., Schulman, B.A.

-	Description: ~~E1 E2~~ complex 1	+	Description: Crystal structure of an Atg7-Atg3 crosslinked complex

OCA at 04:53, 12 September 2012

OCA — Wed, 12 Sep 2012 04:53:09 GMT

←Older revision		Revision as of 04:53, 12 September 2012
Line 5:		Line 5:
	Authors: Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D.J., Schulman, B.A.		Authors: Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D.J., Schulman, B.A.

-	Description: ~~E1E2~~ complex 1	+	Description: E1 E2 complex 1

OCA: Protected "4gsl" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 04:57:58 GMT

Protected "4gsl" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gsl is ON HOLD Authors: Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D...

OCA — Wed, 05 Sep 2012 04:57:57 GMT

New page: '''Unreleased structure''' The entry 4gsl is ON HOLD Authors: Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D...

New page

'''Unreleased structure'''

The entry 4gsl is ON HOLD

Authors: Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D.J., Schulman, B.A.

Description: E1E2 complex 1