4gso - Revision history

OCA at 07:15, 26 October 2022

OCA — Wed, 26 Oct 2022 07:15:38 GMT

←Older revision		Revision as of 07:15, 26 October 2022
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	<StructureSection load='4gso' size='340' side='right'caption='[[4gso]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4gso' size='340' side='right'caption='[[4gso]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gso]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GSO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gso]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gso OCA], [~~http~~://pdbe.org/4gso PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gso RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gso PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gso ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gso OCA], [https://pdbe.org/4gso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gso RCSB], [https://www.ebi.ac.uk/pdbsum/4gso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gso ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/VSP1_BOTJR VSP1_BOTJR]] Thrombin-like enzyme that shows clotting activity upon human plasma. Shows specific fibrinogenolytic activity for Aalpha chain (FGA). Hydrolyzes fibrin, BAPNA and TAME, as well as chromogenic artificial substrates of the blood coagulation cascasde: S-27654 for factor X (F10), S-2302 for kallikrein (KLK), factor XIa (F11), and XIIa (F12), and S-2266 for kallikrein and factor XIa (F11). Subcutaneous injection into mice induces a mild edema. Intravenous and intramuscular injection reduce plasma fibrinogen concentration and increase the levels of fibrin(ogen) degradation products. Intramuscular injection also promotes an increase in the expression of proMMP-9, but is unable to activate it.<ref>PMID:17292935</ref> <ref>PMID:17466550</ref> <ref>PMID:17996740</ref>	+	[https://www.uniprot.org/uniprot/VSP1_BOTJR VSP1_BOTJR] Thrombin-like enzyme that shows clotting activity upon human plasma. Shows specific fibrinogenolytic activity for Aalpha chain (FGA). Hydrolyzes fibrin, BAPNA and TAME, as well as chromogenic artificial substrates of the blood coagulation cascasde: S-27654 for factor X (F10), S-2302 for kallikrein (KLK), factor XIa (F11), and XIIa (F12), and S-2266 for kallikrein and factor XIa (F11). Subcutaneous injection into mice induces a mild edema. Intravenous and intramuscular injection reduce plasma fibrinogen concentration and increase the levels of fibrin(ogen) degradation products. Intramuscular injection also promotes an increase in the expression of proMMP-9, but is unable to activate it.<ref>PMID:17292935</ref> <ref>PMID:17466550</ref> <ref>PMID:17996740</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Bothrops jararacussu]]		[[Category: Bothrops jararacussu]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arni~~, R K~~]]	+	[[Category: Arni RK]]
-	[[Category: Mariutti, R]]	+	[[Category: Mariutti R]]
-	[[Category: Murakami~~, M T~~]]	+	[[Category: Murakami MT]]
-	[[Category: Sanata~~, S V~~]]	+	[[Category: Sanata SV]]
-	[[Category: Souza~~, T C.A B~~]]	+	[[Category: Souza TCAB]]
-	[[Category: Ullah, A]]	+	[[Category: Ullah A]]
-	[[Category: Zanphorlin~~, L M]]~~	+	[[Category: Zanphorlin LM]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Thrombin-like enzyme~~]]	+

OCA at 08:15, 27 March 2019

OCA — Wed, 27 Mar 2019 08:15:46 GMT

←Older revision		Revision as of 08:15, 27 March 2019
Line 1:		Line 1:

	==structure of Jararacussin-I==		==structure of Jararacussin-I==
-	<StructureSection load='4gso' size='340' side='right' caption='[[4gso]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4gso' size='340' side='right'caption='[[4gso]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gso]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gso]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSO FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Bothrops jararacussu]]		[[Category: Bothrops jararacussu]]
		+	[[Category: Large Structures]]
	[[Category: Arni, R K]]		[[Category: Arni, R K]]
	[[Category: Mariutti, R]]		[[Category: Mariutti, R]]

OCA at 08:15, 4 August 2016

OCA — Thu, 04 Aug 2016 08:15:13 GMT

←Older revision		Revision as of 08:15, 4 August 2016
Line 1:		Line 1:
		+
	==structure of Jararacussin-I==		==structure of Jararacussin-I==
	<StructureSection load='4gso' size='340' side='right' caption='[[4gso]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4gso' size='340' side='right' caption='[[4gso]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gso]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gso]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gso RCSB], [http://www.ebi.ac.uk/pdbsum/4gso PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gso OCA], [http://pdbe.org/4gso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gso RCSB], [http://www.ebi.ac.uk/pdbsum/4gso PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gso ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gso" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:31, 24 December 2014

OCA — Wed, 24 Dec 2014 07:31:37 GMT

←Older revision		Revision as of 07:31, 24 December 2014
Line 1:		Line 1:
-	[[~~Image~~:4gso.~~png\|left\|200px~~]]	+	==structure of Jararacussin-I==
		+	<StructureSection load='4gso' size='340' side='right' caption='[[4gso]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gso]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSO FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gso RCSB], [http://www.ebi.ac.uk/pdbsum/4gso PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VSP1_BOTJR VSP1_BOTJR]] Thrombin-like enzyme that shows clotting activity upon human plasma. Shows specific fibrinogenolytic activity for Aalpha chain (FGA). Hydrolyzes fibrin, BAPNA and TAME, as well as chromogenic artificial substrates of the blood coagulation cascasde: S-27654 for factor X (F10), S-2302 for kallikrein (KLK), factor XIa (F11), and XIIa (F12), and S-2266 for kallikrein and factor XIa (F11). Subcutaneous injection into mice induces a mild edema. Intravenous and intramuscular injection reduce plasma fibrinogen concentration and increase the levels of fibrin(ogen) degradation products. Intramuscular injection also promotes an increase in the expression of proMMP-9, but is unable to activate it.<ref>PMID:17292935</ref> <ref>PMID:17466550</ref> <ref>PMID:17996740</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Snake venom serine proteinases (SVSPs) are hemostatically-active toxins that perturb the maintenance and regulation of both the blood coagulation cascade and fibrinolytic feedback system at specific points, and hence, are widely used as tools in pharmacological and clinical diagnosis. The crystal structure of a thrombin-like enzyme (TLE) from Bothrops jararacussu venom (Jararacussin-I) was determined at 2.48 A resolution. This is the first crystal structure of a TLE and permits structural comparisons with both the Agkistrodon contortrix contortrix Protein C Activator (ACC-C) and the Trimeresurus stejnegeri plasminogen activator (TSV-PA). Despite the highly conserved overall fold, significant differences in the amino acid compositions and three-dimensional conformations of the loops surrounding the active site significantly alter the molecular topography and charge distribution profile of the catalytic interface. In contrast to other SVSPs, the catalytic interface of Jararacussin-I is highly negatively charged, which contributes to its unique macromolecular selectivity.

-	~~{{STRUCTURE_4gso\| PDB=4gso \| SCENE= }}~~	+	Crystal structure of Jararacussin-I: The highly negatively charged catalytic interface contributes to macromolecular selectivity in snake venom thrombin-like enzymes.,Ullah A, Souza TC, Zanphorlin LM, Mariutti RB, Santana VS, Murakami MT, Arni RK Protein Sci. 2012 Nov 8. doi: 10.1002/pro.2189. PMID:23139169<ref>PMID:23139169</ref>

-	~~===structure~~ of ~~Jararacussin-I===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23139169}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4gso]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSO OCA].~~	+	</StructureSection>
	[[Category: Bothrops jararacussu]]		[[Category: Bothrops jararacussu]]
-	[[Category: Arni, R K.]]	+	[[Category: Arni, R K]]
-	[[Category: Mariutti, R.]]	+	[[Category: Mariutti, R]]
-	[[Category: Murakami, M T.]]	+	[[Category: Murakami, M T]]
-	[[Category: Sanata, S V.]]	+	[[Category: Sanata, S V]]
-	[[Category: Souza, T C.A B.]]	+	[[Category: Souza, T C.A B]]
-	[[Category: Ullah, A.]]	+	[[Category: Ullah, A]]
-	[[Category: Zanphorlin, L M.]]	+	[[Category: Zanphorlin, L M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Thrombin-like enzyme]]		[[Category: Thrombin-like enzyme]]

OCA at 08:07, 2 January 2013

OCA — Wed, 02 Jan 2013 08:07:47 GMT

←Older revision		Revision as of 08:07, 2 January 2013
Line 1:		Line 1:
-	[[Image:4gso.~~jpg~~\|left\|200px]]	+	[[Image:4gso.png\|left\|200px]]

	{{STRUCTURE_4gso\| PDB=4gso \| SCENE= }}		{{STRUCTURE_4gso\| PDB=4gso \| SCENE= }}

OCA at 21:11, 12 December 2012

OCA — Wed, 12 Dec 2012 21:11:52 GMT

←Older revision		Revision as of 21:11, 12 December 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4gso.jpg\|left\|200px]]

-	~~The entry~~ 4gso ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gso\| PDB=4gso \| SCENE= }}

-	~~Authors: Ullah, A., Souza, T.C.A.B., Zanphorlin, L.M., Mariutti, R., Sanata, S.V., Murakami, M.T., Arni, R.K.~~	+	===structure of Jararacussin-I===

-	~~Description:~~ structure ~~of Jararacussin~~-I	+	{{ABSTRACT_PUBMED_23139169}}
		+
		+	==About this Structure==
		+	[[4gso]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSO OCA].
		+	[[Category: Bothrops jararacussu]]
		+	[[Category: Arni, R K.]]
		+	[[Category: Mariutti, R.]]
		+	[[Category: Murakami, M T.]]
		+	[[Category: Sanata, S V.]]
		+	[[Category: Souza, T C.A B.]]
		+	[[Category: Ullah, A.]]
		+	[[Category: Zanphorlin, L M.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Thrombin-like enzyme]]

OCA at 09:01, 21 November 2012

OCA — Wed, 21 Nov 2012 09:01:46 GMT

←Older revision		Revision as of 09:01, 21 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gso is ON HOLD	+	The entry 4gso is ON HOLD until Paper Publication

	Authors: Ullah, A., Souza, T.C.A.B., Zanphorlin, L.M., Mariutti, R., Sanata, S.V., Murakami, M.T., Arni, R.K.		Authors: Ullah, A., Souza, T.C.A.B., Zanphorlin, L.M., Mariutti, R., Sanata, S.V., Murakami, M.T., Arni, R.K.

	Description: structure of Jararacussin-I		Description: structure of Jararacussin-I

OCA: Protected "4gso" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 04:58:03 GMT

Protected "4gso" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gso is ON HOLD Authors: Ullah, A., Souza, T.C.A.B., Zanphorlin, L.M., Mariutti, R., Sanata, S.V., Murakami, M.T., Arni, R.K. Description: structur...

OCA — Wed, 05 Sep 2012 04:58:02 GMT

New page: '''Unreleased structure''' The entry 4gso is ON HOLD Authors: Ullah, A., Souza, T.C.A.B., Zanphorlin, L.M., Mariutti, R., Sanata, S.V., Murakami, M.T., Arni, R.K. Description: structur...

New page

'''Unreleased structure'''

The entry 4gso is ON HOLD

Authors: Ullah, A., Souza, T.C.A.B., Zanphorlin, L.M., Mariutti, R., Sanata, S.V., Murakami, M.T., Arni, R.K.

Description: structure of Jararacussin-I